A new local variant (ST764) of the globally disseminated ST5 lineage of hospital-associated methicillin-resistant Staphylococcus aureus (MRSA) carrying the virulence determinants of community-associated MRSA

Antimicrobial Agents and Chemotherapy

Volumn 57, Issue 4, 2013, Pages 1589-1595

  Takano, Tomomi ^a   Hung, Wei Chun ^a   Shibuya, Michiko ^a   Higuchi, Wataru ^a   Iwao, Yasuhisa ^a   Nishiyama, Akihito ^a   Reva, Ivan ^a   Khokhlova, Olga E ^a   Yabe, Shizuka ^a   Ozaki, Kyoko ^a   Takano, Misao ^a   Yamamoto, Tatsuo ^a  

^a NIIGATA UNIVERSITY GRADUATE SCHOOL OF MEDICAL AND DENTAL SCIENCES   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

PANTON VALENTINE LEUKOCIDIN; STAPHYLOCOCCUS ENTEROTOXIN B; SUPERANTIGEN;

ADULT; ARTICLE; BACTERIAL VIRULENCE; BACTERIUM ISOLATION; CONTROLLED STUDY; CYTOLYSIS; GENE CASSETTE; GENE EXPRESSION; GENE ISOLATION; GENE SEQUENCE; GENETIC ANALYSIS; HOSPITAL INFECTION; HOUSEHOLD; HUMAN; MAJOR CLINICAL STUDY; MALE; MEDICAL STUDENT; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; NECROTIZING FASCIITIS; PRIORITY JOURNAL; PROPHAGE;

BACTERIAL PROTEINS; ENTEROTOXINS; GENOME, BACTERIAL; METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS; VIRULENCE;

EID: 84875178631     PISSN: 00664804     EISSN: 10986596     Source Type: Journal    
DOI: 10.1128/AAC.01147-12     Document Type: Article

References (62)

1. Grundmann H, Aires-de-Sousa M, Boyce J, Tiemersma E. 2006. Emergence and resurgence of meticillin-resistant Staphylococcus aureus as a public-health threat. Lancet 368:874-885.
2. International Working Group on the Classification of Staphylococcal Cassette Chromosome Elements (IWG-SCC). 2009. Classification of staphylococcal cassette chromosome mec (SCCmec): guidelines for reporting novel SCCmec elements. Antimicrob. Agents Chemother. 53: 4961-4967.
3. Noto MJ, Kreiswirth BN, Monk AB, Archer GL. 2008. Gene acquisition at the insertion site for SCCmec, the genomic island conferring methicillin resistance in Staphylococcus aureus. J. Bacteriol. 190:1276 -1283.
4. Aires de Sousa M, Conceição T, Simas C, de Lencastre H. 2005. Comparison of genetic backgrounds of methicillin-resistant and -susceptible Staphylococcus aureus isolates from Portuguese hospitals and the community. J. Clin. Microbiol. 43:5150 -5157.
5. Enright MC, Robinson DA, Randle G, Feil EJ, Grundmann H, Spratt BG. 2002. The evolutionary history of methicillin-resistant Staphylococcus aureus (MRSA). Proc. Natl. Acad. Sci. U. S. A. 99:7687-7692.
6. Oliveira DC, Tomasz A, de Lencastre H. 2001. The evolution of pandemic clones of methicillin-resistant Staphylococcus aureus: identification of two ancestral genetic backgrounds and the associated mec elements. Microb. Drug Resist. 7:349 -361.
7. Coombs GW, Van Gessel H, Pearson JC, Godsell MR, O'Brien FG, Christiansen KJ. 2007. Controlling a multicenter outbreak involving the New York/Japan methicillin-resistant Staphylococcus aureus clone. Infect. Control Hosp. Epidemiol. 28:845- 852.
8. Oliveira DC, Tomasz A, de Lencastre H. 2002. Secrets of success of a human pathogen: molecular evolution of pandemic clones of meticillinresistant Staphylococcus aureus. Lancet Infect. Dis. 2:180 -189.
9. Tanaka T, Okuzumi K, Iwamoto A, Hiramatsu K. 1995. A retrospective study of methicillin-resistant Staphylococcus aureus clinical strains in Tokyo University Hospital. J. Infect. Chemother. 1:40-49.
10. de Lencastre H, Severina EP, Roberts RB, Kreiswirth BN, Tomasz A, Initiative Pilot Study Group BARG. 1996. Testing the efficacy of a molecular surveillance network: methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus faecium (VREF) genotypes in six hospitals in the metropolitan New York City area. Microb. Drug Resist. 2:343-351.
11. Roberts RB, Chung M, de Lencastre H, Hargrave J, Tomasz A, Nicolau DP, John JF, Jr, Korzeniowski O, Tri-State Collaborative Study Group MRSA. 2000. Distribution of methicillin-resistant Staphylococcus aureus clones among health care facilities in Connecticut, New Jersey, and Pennsylvania. Microb. Drug Resist. 6:245-251.
12. Aires de Sousa M, de Lencastre H, Santos Sanches I, Kikuchi K, Totsuka K, Tomasz A. 2000. Similarity of antibiotic resistance patterns and molecular typing properties of methicillin-resistant Staphylococcus aureus isolates widely spread in hospitals in New York City and in a hospital in Tokyo, Japan. Microb. Drug Resist. 6:253-258.
13. Cha HY, Moon DC, Choi CH, Oh JY, Jeong YS, Lee YC, Seol SY, Cho DT, Chang HH, Kim SW, Lee JC. 2005. Prevalence of the ST239 clone of methicillin- resistant Staphylococcus aureus and differences in antimicrobial susceptibilities of ST239 and ST5 clones identified in a Korean hospital. J. Clin. Microbiol. 43:3610 -3614.
14. Conceição T, Aires-de-Sousa M, Füzi M, Tóth Á, Pászti J, Ungvári E, van Leeuwen WB, van Belkum A, Grundmann H, de Lencastre H. 2007. Replacement of methicillin-resistant Staphylococcus aureus clones in Hungary over time: a 10-year surveillance study. Clin. Microbiol. Infect. 13: 971-979.
15. Ip M, Yung RW, Ng TK, Luk WK, Tse C, Hung P, Enright M, Lyon DJ. 2005. Contemporary methicillin-resistant Staphylococcus aureus clones in Hong Kong. J. Clin. Microbiol. 43:5069 -5073.
16. Simor AE, Ofner-Agostini M, Bryce E, McGeer A, Paton S, Mulvey MR, Canadian Hospital Epidemiology Committee and Canadian Nosocomial Infection Surveillance Program Health Canada. 2002. Laboratory characterization of methicillin-resistant Staphylococcus aureus in Canadian hospitals: results of 5 years of National Surveillance, 1995-1999. J. Infect. Dis. 186:652- 660.
17. Velazquez-Meza ME, Aires de Sousa M, Echaniz-Aviles G, Solórzano- Santos F, Miranda-Novales G, Silva-Sanchez J, de Lencastre H. 2004. Surveillance of methicillin-resistant Staphylococcus aureus in a pediatric hospital in Mexico City during a 7-year period (1997 to 2003): clonal evolution and impact of infection control. J. Clin. Microbiol. 42:3877- 3880.
18. Centers for Disease Control and Prevention. 1981. Communityacquired methicillin-resistant Staphylococcus aureus infections - Michigan. MMWR Morb. Mortal. Wkly. Rep. 30:185-187.
19. Centers for Disease Control and Prevention. 1999. Four pediatric deaths from community-acquired methicillin-resistant Staphylococcus aureus - Minnesota and North Dakota, 1997-1999. MMWR Morb. Mortal. Wkly. Rep. 48:707-710.
20. Klevens RM, Morrison MA, Nadle J, Petit S, Gershman K, Ray S, Harrison LH, Lynfield R, Dumyati G, Townes JM, Craig AS, Zell ER, Fosheim GE, McDougal LK, Carey RB, Fridkin SK. 2007. Invasive methicillin-resistant Staphylococcus aureus infections in the United States. JAMA 298:1763-1771.
21. Yamamoto T, Nishiyama A, Takano T, Yabe S, Higuchi W, Razvina O, Shi D. 2010. Community-acquired methicillin-resistant Staphylococcus aureus: community transmission, pathogenesis, and drug resistance. J. Infect. Chemother. 16:225-254.
22. Diep BA, Gill SR, Chang RF, Phan TH, Chen JH, Davidson MG, Lin F, Lin J, Carleton HA, Mongodin EF, Sensabaugh GF, Perdreau- Remington F. 2006. Complete genome sequence of USA300, an epidemic clone of community-acquired meticillin-resistant Staphylococcus aureus. Lancet 367:731-739.
23. McDougal LK, Fosheim GE, Nicholson A, Bulens SN, Limbago BM, Shearer JE, Summers AO, Patel JB. 2010. Emergence of resistance among USA300 methicillin-resistant Staphylococcus aureus isolates causing invasive disease in the United States. Antimicrob. Agents Chemother. 54: 3804-3811.
24. Liu C, Bayer A, Cosgrove SE, Daum RS, Fridkin SK, Gorwitz RJ, Kaplan SL, Karchmer AW, Levine DP, Murray BE, Rybak JM, Talan DA, Chambers HF. 2011. Clinical practice guidelines by the Infectious Diseases Society of America for the treatment of methicillin-resistant Staphylococcus aureus infections in adults and children: executive summary. Clin. Infect. Dis. 52:285-292.
25. Zetola N, Francis JS, Nuermberger EL, Bishai WR. 2005. Communityacquired meticillin-resistant Staphylococcus aureus: an emerging threat. Lancet Infect. Dis. 5:275-286.
26. Diep BA, Otto M. 2008. The role of virulence determinants in community- associated MRSA pathogenesis. Trends Microbiol. 16:361-369.
27. Diep BA, Stone GG, Basuino L, Graber CJ, Miller A, des Etages SA, Jones A, Palazzolo-Ballance AM, Perdreau-Remington F, Sensabaugh GF, DeLeo FR, Chambers HF. 2008. The arginine catabolic mobile element and staphylococcal chromosomal cassette mec linkage: convergence of virulence and resistance in the USA300 clone of methicillin-resistant Staphylococcus aureus. J. Infect. Dis. 197:1523-1530.
28. Miragaia M, de Lencastre H, Perdreau-Remington F, Chambers HF, Higashi J, Sullam PM, Lin J, Wong KI, King KA, Otto M, Sensabaugh GF, Diep BA. 2009. Genetic diversity of arginine catabolic mobile element in Staphylococcus epidermidis. PLoS One 4:e7722. doi:10.1371/journal .pone.0007722.
29. Wang R, Braughton KR, Kretschmer D, Bach TH, Queck SY, Li M, Kennedy AD, Dorward DW, Klebanoff SJ, Peschel A, DeLeo FR, Otto M. 2007. Identification of novel cytolytic peptides as key virulence determinants for community-associated MRSA. Nat. Med. 13:1510 -1514.
30. Löffler B, Hussain M, Grundmeier M, Brück M, Holzinger D, Varga G, Roth J, Kahl BC, Proctor RA, Peters G. 2010. Staphylococcus aureus Panton- Valentine leukocidin is a very potent cytotoxic factor for human neutrophils. PLoS Pathog. 6:e1000715. doi:10.1371/journal.ppat.1000715.
31. Kuroda M, Ohta T, Uchiyama I, Baba T, Yuzawa H, Kobayashi I, Cui L, Oguchi A, Aoki K, Nagai Y, Lian J, Ito T, Kanamori M, Matsumaru H, Maruyama A, Murakami H, Hosoyama A, Mizutani-Ui Y, Takahashi NK, Sawano T, Inoue R, Kaito C, Sekimizu K, Hirakawa H, Kuhara S, Goto S, Yabuzaki J, Kanehisa M, Yamashita A, Oshima K, Furuya K, Yoshino C, Shiba T, Hattori M, Ogasawara N, Hayashi H, Hiramatsu K. 2001. Whole genome sequencing of meticillin-resistant Staphylococcus aureus. Lancet 357:1225-1240.
32. Takizawa Y, Taneike I, Nakagawa S, Oishi T, Nitahara Y, Iwakura N, Ozaki K, Takano M, Nakayama T, Yamamoto T. 2005. A Panton- Valentine leucocidin (PVL)-positive community-acquired methicillin- resistant Staphylococcus aureus (MRSA) strain, another such strain carrying a multiple-drug resistance plasmid, and other more typical PVL-negative MRSA strains found in Japan. J. Clin. Microbiol. 43: 3356 -3363.
33. Tenover FC, McDougal LK, Goering RV, Killgore G, Projan SJ, Patel JB, Dunman PM. 2006. Characterization of a strain of communityassociated methicillin-resistant Staphylococcus aureus widely disseminated in the United States. J. Clin. Microbiol. 44:108 -118.
34. Shibuya Y, Hara M, Higuchi W, Takano T, Iwao Y, Yamamoto T. 2008. Emergence of the community-acquired methicillin-resistant Staphylococcus aureus USA300 clone in Japan. J. Infect. Chemother. 14:439-441.
35. Yabe S, Takano T, Higuchi W, Mimura S, Kurosawa Y, Yamamoto T. 2010. Spread of the community-acquired methicillin-resistant Staphylococcus aureus USA300 clone among family members in Japan. J. Infect. Chemother. 16:372-374.
36. Mine Y, Higuchi W, Taira K, Nakasone I, Tateyama M, Yamamoto T, Uezato H, Takahashi K. 2011. Nosocomial outbreak of multidrugresistant USA300 methicillin-resistant Staphylococcus aureus causing severe furuncles and carbuncles in Japan. J. Dermatol. 38:1167-1171.
37. Takano T, Higuchi W, Otsuka T, Baranovich T, Enany S, Saito K, Isobe H, Dohmae S, Ozaki K, Takano M, Iwao Y, Shibuya M, Okubo T, Yabe S, Shi D, Reva I, Teng LJ, Yamamoto T. 2008. Novel characteristics of community-acquired methicillin-resistant Staphylococcus aureus strains belonging to multilocus sequence type 59 in Taiwan. Antimicrob. Agents Chemother. 52:837- 845.
38. Enright MC, Day NP, Davies CE, Peacock SJ, Spratt BG. 2000. Multilocus sequence typing for characterization of methicillin-resistant and methicillin-susceptible clones of Staphylococcus aureus. J. Clin. Microbiol. 38:1008 -1015.
39. Shopsin B, Gomez M, Montgomery SO, Smith DH, Waddington M, Dodge DE, Bost DA, Riehman M, Naidich S, Kreiswirth BN. 1999. Evaluation of protein A gene polymorphic region DNA sequencing for typing of Staphylococcus aureus strains. J. Clin. Microbiol. 37:3556 -3563.
40. Gilot P, Lina G, Cochard T, Poutrel B. 2002. Analysis of the genetic variability of genes encoding the RNA III-activating components Agr and TRAP in a population of Staphylococcus aureus strains isolated from cows with mastitis. J. Clin. Microbiol. 40:4060-4067.
41. Strommenger B, Cuny C, Werner G, Witte W. 2004. Obvious lack of association between dynamics of epidemic methicillin-resistant Staphylococcus aureus in central Europe and agr specificity groups. Eur. J. Clin. Microbiol. Infect. Dis. 23:15-19.
42. Kondo Y, Ito T, Ma XX, Watanabe S, Kreiswirth BN, Etienne J, Hiramatsu K. 2007. Combination of multiplex PCRs for staphylococcal cassette chromosome mec type assignment: rapid identification system for mec, ccr, and major differences in junkyard regions. Antimicrob. Agents Chemother. 51:264 -274.
43. Diep BA, Carleton HA, Chang RF, Sensabaugh GF, Perdreau- Remington F. 2006. Roles of 34 virulence genes in the evolution of hospital- and community-associated strains of methicillin-resistant Staphylococcus aureus. J. Infect. Dis. 193:1495-1503.
44. Fluckiger U, Ulrich M, Steinhuber A, Doring G, Mack D, Landmann R, Goerke C, Wolz C. 2005. Biofilm formation, icaADBC transcription, and polysaccharide intercellular adhesin synthesis by staphylococci in a device- related infection model. Infect. Immun. 73:1811-1819.
45. Li M, Cheung GY, Hu J, Wang D, Joo HS, Deleo FR, Otto M. 2010. Comparative analysis of virulence and toxin expression of global community- associated methicillin-resistant Staphylococcus aureus strains. J. Infect. Dis. 202:1866 -1876.
46. Omoe K, Hu DL, Takahashi-Omoe H, Nakane A, Shinagawa K. 2003. Identification and characterization of a new staphylococcal enterotoxinrelated putative toxin encoded by two kinds of plasmids. Infect. Immun. 71:6088-6094.
47. Clinical and Laboratory Standards Institute. 2012. Performance standard for antimicrobial susceptibility testing; 22nd informational supplement, M100-S22. Clinical and Laboratory Standards Institute, Wayne, PA.
48. Yamamoto T, Takano T, Yabe S, Higuchi W, Iwao Y, Isobe H, Ozaki K, Takano M, Reva I, Nishiyama A. 2012. Super-sticky familial infections caused by Panton-Valentine leukocidin-positive ST22 communityacquired methicillin- resistant Staphylococcus aureus in Japan. J. Infect. Chemother. 18:187-198.
49. Goerke C, Pantucek R, Holtfreter S, Schulte B, Zink M, Grumann D, Broker BM, Doskar J, Wolz C. 2009. Diversity of prophages in dominant Staphylococcus aureus clonal lineages. J. Bacteriol. 191:3462-3468.
50. Provvedi R, Manganelli R, Pozzi G. 1996. Characterization of conjugative transposon Tn5251 of Streptococcus pneumoniae. FEMS Microbiol. Lett. 135:231-236.
51. Santoro F, Oggioni MR, Pozzi G, Iannelli F. 2010. Nucleotide sequence and functional analysis of the tet (M)-carrying conjugative transposon Tn5251 of Streptococcus pneumoniae. FEMS Microbiol. Lett. 308:150 -158.
52. Degnan BA, Palmer JM, Robson T, Jones CE, Fischer M, Glanville M, Mellor GD, Diamond AG, Kehoe MA, Goodacre JA. 1998. Inhibition of human peripheral blood mononuclear cell proliferation by Streptococcus pyogenes cell extract is associated with arginine deiminase activity. Infect. Immun. 66:3050 -3058.
53. Degnan BA, Fontaine MC, Doebereiner AH, Lee JJ, Mastroeni P, Dougan G, Goodacre JA, Kehoe MA. 2000. Characterization of an isogenic mutant of Streptococcus pyogenes Manfredo lacking the ability to make streptococcal acid glycoprotein. Infect. Immun. 68:2441-2448.
54. Coulter SN, Schwan WR, Ng EY, Langhorne MH, Ritchie HD, Westbrock- Wadman S, Hufnagle WO, Folger KR, Bayer AS, Stover CK. 1998. Staphylococcus aureus genetic loci impacting growth and survival in multiple infection environments. Mol. Microbiol. 30:393- 404.
55. Savolainen K, Paulin L, Westerlund-Wikstrom B, Foster TJ, Korhonen TK, Kuusela P. 2001. Expression of pls, a gene closely associated with the mecA gene of methicillin-resistant Staphylococcus aureus, prevents bacterial adhesion in vitro. Infect. Immun. 69:3013-3020.
56. Iwao Y, Ishii R, Tomita Y, Shibuya Y, Takano T, Hung WC, Higuchi W, Isobe H, Nishiyama A, Yano M, Matsumoto T, Ogata K, Okubo T, Khokhlova O, Ho PL, Yamamoto T. 2012. The emerging ST8 methicillin- resistant Staphylococcus aureus clone in the community in Japan: associated infections, genetic diversity, and comparative genomics. J. Infect. Chemother. 18:228 -240.
57. Iwao Y, Takano T, Higuchi W, Yamamoto T. 2012. A new staphylococcal cassette chromosome mec IV encoding a novel cell-wall-anchored surface protein in a major ST8 community-acquired methicillin-resistant Staphylococcus aureus clone in Japan. J. Infect. Chemother. 18:96 -104.
58. Shore AC, Rossney AS, Brennan OM, Kinnevey PM, Humphreys H, Sullivan DJ, Goering RV, Ehricht R, Monecke S, Coleman DC. 2011. Characterization of a novel arginine catabolic mobile element (ACME) and staphylococcal chromosomal cassette mec composite island with significant homology to Staphylococcus epidermidis ACME type II in methicillin- resistant Staphylococcus aureus genotype ST22-MRSA-IV. Antimicrob. Agents Chemother. 55:1896 -1905.
59. Novick RP, Christie GE, Penades Jr. 2010. The phage-related chromosomal islands of Gram-positive bacteria. Nat. Rev. Microbiol. 8:541-551.
60. Schlievert PM, Bohach GA. 2007. Staphylococcal and streptcoccal superantigens: an update, p 21-36. In Kotb M, Fraser JD (ed), Superantigens: molecular basis for their role in human diseases. ASM Press, Washington, DC.
61. Centers for Disease Control and Prevention. 2000. Biological and chemical terrorism: strategic plan for preparedness and response. Recommendations of theCDCStrategic Planning Workgroup.MMWRRecommend. Rep. 49(RR-4):1-14.
62. Vojtov N, Ross HF, Novick RP. 2002. Global repression of exotoxin synthesis by staphylococcal superantigens. Proc. Natl. Acad. Sci. U. S. A. 99:10102-10107.