The par toxin-antitoxin system from Enterococcus faecalis plasmid pAD1 and its chromosomal homologs

RNA Biology

Volumn 9, Issue 12, 2012, Pages 1498-1503

  Weaver, Keith E ^a  

^a UNIVERSITY OF SOUTH DAKOTA   (United States)

Author keywords

Antisense RNA; Peptide toxins; Plasmid stability; Post segregational killing; Toxin antitoxin

Indexed keywords

BACTERIAL RNA; FST PAD 1 TOXIN; NISIN; TOXIN; UNCLASSIFIED DRUG;

BACTERIAL MEMBRANE; CELL DIVISION; CELL FUNCTION; CELL NUCLEUS; ENTEROCOCCUS FAECALIS; GENE LOCUS; GENE OVEREXPRESSION; GENETIC ORGANIZATION; HOK L SOK SYSTEM; MICROBIOLOGY; NONHUMAN; PAR TOXIN ANTITOXIN SYSTEM; PLASMID; PLASMID PAD 1; PROTEIN RNA BINDING; REVIEW; RNA DEGRADATION; RNA SEQUENCE; RNA STABILITY; RNA STRUCTURE; RNA TRANSLATION;

EID: 84875174921     PISSN: 15476286     EISSN: 15558584     Source Type: Journal    
DOI: 10.4161/rna.22311     Document Type: Review

References (33)

1. Weaver KE, Clewell DB, An F. Identification, characterization, and nucleotide sequence of a region of Enterococcus faecalis pheromone-responsive plasmid pAD1 capable of autonomous replication. J Bacteriol 1993; 175:1900-9; PMID:8384618. (Pubitemid 23097497)
2. Weaver KE, Clewell DB. Construction of Enterococcus faecalis pAD1 miniplasmids: identification of a minimal pheromone response regulatory region and evaluation of a novel pheromone-dependent growth inhibition. Plasmid 1989; 22:106-19; PMID:2516332; http://dx.doi.org/10.1016/0147-619X(89)90020-6. (Pubitemid 20042846)
3. Weaver KE, Jensen KD, Colwell A, Sriram SI. Functional analysis of the Enterococcus faecalis plas-mid pAD1-encoded stability determinant par. Mol Microbiol 1996; 20:53-63; PMID:8861204; http://dx.doi.org/10.1111/j.1365-2958. 1996.tb02488.x. (Pubitemid 26124789)
4. Weaver KE, Tritle DJ. Identification and characterization of an Enterococcus faecalis plasmid pAD1-encod-ed stability determinant which produces two small RNA molecules necessary for its function. Plasmid 1994; 32:168-81; PMID:7531349; http://dx.doi. org/10.1006/plas.1994.1053. (Pubitemid 24324182)
5. Greenfield TJ, Weaver KE. Antisense RNA regulation of the pAD1 par post-segregational killing system requires interaction at the 5' and 3' ends of the RNAs. Mol Microbiol 2000; 37:661-70; PMID:10931359; http://dx.doi.org/10. 1046/j.1365-2958.2000.02034.x. (Pubitemid 30611846)
6. Greenfield TJ, Ehli E, Kirshenmann T, Franch T, Gerdes K, Weaver KE. The antisense RNA of the par locus of pAD1 regulates the expression of a 33-amino-acid toxic peptide by an unusual mechanism. Mol Microbiol 2000; 37:652-60; PMID:10931358; http://dx.doi.org/10.1046/j.1365-2958.2000.02035.x. (Pubitemid 30611845)
7. Weaver KE. Enterococcus faecalis plasmid pAD1 replication and maintenance. Dev Biol Stand 1995; 85:89-98; PMID:8586250.
8. Weaver KE, Walz KD, Heine MS. Isolation of a derivative of Escherichia coli-Enterococcus faecalis shuttle vector pAM401 temperature sensitive for maintenance in E. faecalis and its use in evaluating the mechanism of pAD1 par-dependent plasmid stabilization. Plasmid 1998; 40:225-32; PMID:9806859; http://dx.doi. org/10.1006/plas.1998.1368. (Pubitemid 28527321)
9. Fozo EM, Makarova KS, Shabalina SA, Yutin N, Koonin EV, Storz G. Abundance of type I toxin-antitoxin systems in bacteria: searches for new candidates and discovery of novel families. Nucleic Acids Res 2010; 38:3743-59; PMID:20156992; http://dx.doi. org/10.1093/nar/gkq054.
10. Kwong SM, Jensen SO, Firth N. Prevalence of Fst-like toxin-antitoxin systems. Microbiology 2010; 156:975-7, discussion 977; PMID:20150240; http://dx.doi. org/10.1099/mic.0.038323-0.
11. Weaver KE, Reddy SG, Brinkman CL, Patel S, Bayles K W, Endres JL. Identification and characterization of a family of toxin-antitoxin systems related to the Enterococcus faecalis plasmid pAD1 par addiction module. Microbiology 2009; 155:2930-40; PMID:19542006; http://dx.doi.org/10.1099/mic.0. 030932-0.
12. Franch T, Petersen M, Wagner EGH, Jacobsen J P, Gerdes K. Antisense RNA regulation in prokaryotes: rapid RNA/RNA interaction facilitated by a general U-turn loop structure. J Mol Biol 1999; 294:1115-25; PMID:10600370; http://dx.doi.org/10.1006/jmbi.1999.3306. (Pubitemid 30008785)
13. Greenfield TJ, Franch T, Gerdes K, Weaver KE. Antisense RNA regulation of the par post-segrega-tional killing system: structural analysis and mechanism of binding of the antisense RNA, RNAII and its target, RNAI. Mol Microbiol 2001; 42:527-37; PMID:11703673; http://dx.doi.org/10.1046/j.1365-2958.2001.02663.x. (Pubitemid 32990139)
14. Brantl S. Bacterial chromosome-encoded small regulatory RNAs. Future Microbiol 2009; 4:85-103; PMID:19207102; http://dx.doi. org/10.2217/17460913.4. 1.85.
15. Shokeen S, Patel S, Greenfield TJ, Brinkman C, Weaver KE. Translational regulation by an intramolecular stem-loop is required for intermolecular RNA regulation of the par addiction module. J Bacteriol 2008; 190:6076-83; PMID:18641135; http://dx.doi.org/10.1128/JB.00660-08.
16. Shokeen S, Greenfield TJ, Ehli EA, Rasmussen J, Perrault BE, Weaver KE. An intramolecular upstream helix ensures the stability of a toxin-encoding RNA in Enterococcus faecalis. J Bacteriol 2009; 191:1528-36; PMID:19103923; http://dx.doi.org/10.1128/JB.01316-08.
17. Mathy N, Bénard L, Pellegrini O, Daou R, Wen T, Condon C. 5'-to-3' exoribonuclease activity in bacteria: role of RNase J1 in rRNA maturation and 5' stability of mRNA. Cell 2007; 129:681-92; PMID:17512403; http://dx.doi.org/ 10.1016/j.cell.2007.02.051. (Pubitemid 46802375)
18. Weaver KE, Ehli EA, Nelson JS, Patel S. Antisense RNA regulation by stable complex formation in the Enterococcus faecalis plasmid pAD1 par addiction system. J Bacteriol 2004; 186:6400-8; PMID:15375120; http://dx.doi.org/10.1128/ JB.186.19.6400-6408.2004. (Pubitemid 39258121)
19. Ramirez-Peña E, Treviño J, Liu Z, Perez N, Sumby P. The group A Streptococcus small regulatory RNA FasX enhances streptokinase activity by increasing the stability of the ska mRNA transcript. Mol Microbiol 2010; 78:1332-47; PMID:21143309; http://dx.doi. org/10.1111/j.1365-2958.2010.07427.x.
20. Robertson HD. Escherichia coli ribonuclease III cleavage sites. Cell 1982; 30:669-72; PMID:6754088; http://dx.doi.org/10.1016/0092-8674(82)90270-7. (Pubitemid 13204655)
21. de Smit MH, van Duin J. Translational standby sites: how ribosomes may deal with the rapid folding kinetics of mRNA. J Mol Biol 2003; 331:737-43; PMID:12909006; http://dx.doi.org/10.1016/S0022-2836(03)00809-X. (Pubitemid 36945433)
22. Göbl C, Kosol S, Stockner T, Rückert HM, Zangger K. Solution structure and membrane binding of the toxin fst of the par addiction module. Biochemistry 2010; 49:6567-75; PMID:20677831; http://dx.doi. org/10.1021/bi1005128.
23. Patel S, Weaver KE. Addiction toxin Fst has unique effects on chromosome segregation and cell division in Enterococcus faecalis and Bacillus subtilis. J Bacteriol 2006; 188:5374-84; PMID:16855226; http://dx.doi. org/10.1128/JB.00513- 06. (Pubitemid 44157293)
24. Weaver KE, Weaver DM, Wells CL, Waters CM, Gardner ME, Ehli EA. Enterococcus faecalis plasmid pAD1-encoded Fst toxin affects membrane permeability and alters cellular responses to lantibiotics. J Bacteriol 2003; 185:2169-77; PMID:12644486; http://dx.doi.org/10.1128/JB.185.7.2169-2177.2003. (Pubitemid 36363177)
25. Wu LJ, Errington J. Nucleoid occlusion and bacterial cell division. Nat Rev Microbiol 2012; 10:8-12; PMID:22020262.
26. Pinho MG, Errington J. Dispersed mode of Staphylococcus aureus cell wall synthesis in the absence of the division machinery. Mol Microbiol 2003; 50:871-81; PMID:14617148; http://dx.doi. org/10.1046/j.1365-2958.2003.03719.x. (Pubitemid 37372250)
27. Morlot C, Zapun A, Dideberg O, Vernet T. Growth and division of Streptococcus pneumoniae: localization of the high molecular weight penicillin-binding proteins during the cell cycle. Mol Microbiol 2003; 50:845-55; PMID:14617146; http://dx.doi.org/10.1046/j.1365-2958.2003.03767.x. (Pubitemid 37372248)
28. Gerdes K, Rasmussen PB, Molin S. Unique type of plasmid maintenance function: postsegregational killing of plasmid-free cells. Proc Natl Acad Sci USA 1986; 83:3116-20; PMID:3517851; http://dx.doi. org/10.1073/pnas.83.10.3116. (Pubitemid 16042987)
29. Wiedemann I, Breukink E, van Kraaij C, Kuipers O P, Bierbaum G, de Kruijff B, et al. Specific binding of nisin to the peptidoglycan precursor lipid II combines pore formation and inhibition of cell wall biosynthesis for potent antibiotic activity. J Biol Chem 2001; 276:1772-9; PMID:11038353. (Pubitemid 32109649)
30. Fozo EM, Hemm MR, Storz G. Small toxic proteins and the antisense RNAs that repress them. Microbiol Mol Biol Rev 2008; 72:579-89; PMID:19052321; http://dx.doi.org/10.1128/MMBR.00025-08.
31. Palmer KL, Carniol K, Manson JM, Heiman D, Shea T, Young S, et al. High-quality draft genome sequences of 28 Enterococcus sp. isolates. J Bacteriol 2010; 192:2469-70; PMID:20207762; http://dx.doi. org/10.1128/JB.00153-10.
32. Kawano M, Oshima T, Kasai H, Mori H. Molecular characterization of long direct repeat (LDR) sequences expressing a stable mRNA encoding for a 35-ami-no-acid cell-killing peptide and a cis-encoded small antisense RNA in Escherichia coli. Mol Microbiol 2002; 45:333-49; PMID:12123448; http://dx.doi. org/10.1046/j.1365-2958.2002.03042.x. (Pubitemid 34779828)
33. Gerdes K, Wagner EGH. RNA antitoxins. Curr Opin Microbiol 2007; 10:117-24; PMID:17376733; http://dx.doi.org/10.1016/j.mib.2007.03.003. (Pubitemid 46590043)