Impossible or merely difficult? Two grand challenges from a biologist's perspective

ACS Medicinal Chemistry Letters

Volumn 4, Issue 3, 2013, Pages 316-318

  Roth, Bryan L ^a  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

deorphanization; GPCR; In silico screening; obesity; polypharmacology

Indexed keywords

AMFEBUTAMONE; ANTIOBESITY AGENT; FENFLURAMINE; G PROTEIN COUPLED RECEPTOR; HISTAMINE RECEPTOR; NALTREXONE; OSTEOCALCIN; PHENTERMINE; SEROTONIN 2C AGONIST; SEROTONIN AGONIST; SEROTONIN RECEPTOR; TETRAHYDROLIPSTATIN;

COMPUTER MODEL; CONFORMATIONAL TRANSITION; DRUG APPROVAL; DRUG CONFORMATION; DRUG DESIGN; DRUG EFFICACY; DRUG MECHANISM; DRUG SAFETY; DRUG SCREENING; FOOD AND DRUG ADMINISTRATION; OBESITY; POLYPHARMACY; PRIORITY JOURNAL; REVIEW; WEIGHT REDUCTION;

EID: 84875162420     PISSN: None     EISSN: 19485875     Source Type: Journal    
DOI: 10.1021/ml4000386     Document Type: Review

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