Moderate-intensity aerobic training program improves insulin sensitivity and inflammatory markers in a pilot study of morbidly obese minority teens

Pediatric Exercise Science

Volumn 25, Issue 1, 2013, Pages 12-26

  Many, Gina ^a   Hurtado, Maria Eugenia ^a   Tanner, Charles ^b   Houmard, Joseph ^b   Gordish Dressman, Heather ^a   Park, Jung Jun ^a   Uwaifo, Gabriel ^c   Kraus, William ^d   Hagberg, James ^e   Hoffman, Eric ^a  

^a CHILDREN'S NATIONAL MEDICAL CENTER   (United States)

^b EAST CAROLINA UNIVERSITY   (United States)

^c GEORGETOWN UNIVERSITY   (United States)

^d DUKE UNIVERSITY   (United States)

^e UNIVERSITY OF MARYLAND   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LEPTIN; MONOCYTE CHEMOTACTIC PROTEIN 1; PEROXIDASE; RESISTIN; TUMOR NECROSIS FACTOR RECEPTOR;

ADOLESCENT; AFRICAN AMERICAN; ARTICLE; BLOOD; BODY COMPOSITION; BODY WEIGHT; CLINICAL TRIAL; ETHNOLOGY; EXERCISE; EXERCISE TEST; FEMALE; GLUCOSE TOLERANCE TEST; HISPANIC; HUMAN; INSULIN RESISTANCE; KINESIOTHERAPY; MALE; MORBID OBESITY; NONPARAMETRIC TEST; OXYGEN CONSUMPTION; PATHOPHYSIOLOGY; PHYSIOLOGY; PILOT STUDY;

ADOLESCENT; AFRICAN AMERICANS; BODY COMPOSITION; BODY WEIGHT; CHEMOKINE CCL2; EXERCISE; EXERCISE TEST; EXERCISE THERAPY; FEMALE; GLUCOSE TOLERANCE TEST; HISPANIC AMERICANS; HUMANS; INSULIN RESISTANCE; LEPTIN; MALE; OBESITY, MORBID; OXYGEN CONSUMPTION; PEROXIDASE; PILOT PROJECTS; RECEPTORS, TUMOR NECROSIS FACTOR; RESISTIN; STATISTICS, NONPARAMETRIC;

EID: 84875146014     PISSN: 08998493     EISSN: 15432920     Source Type: Journal    
DOI: 10.1123/pes.25.1.12     Document Type: Article

References (44)

1. Centers for Disease Control and Prevention (CDC). How much physical activity do children need? 2011 [cited 2012]; Available from: http://www.cdc.gov/physicalactivity/everyone/guidelines/children. html.
2. Balagopal, P., D. George, N. Patton, et al. Lifestyle-only intervention attenuates the inflammatory state associated with obesity: a randomized controlled study in adolescents. J. Pediatr. 146:342-348, 2005. PubMed doi:10.1016/j.jpeds.2004.11.033 (Pubitemid 40341743)
3. Balagopal, P., D. George, N. Patton, et al. Lifestyle-only intervention attenuates the inflammatory state associated with obesity: a randomized controlled study in adolescents. J. Pediatr. 146:342-348, 2005. PubMed doi:10.1016/j.jpeds.2004.11.033 (Pubitemid 40341743)
4. Balagopal, P., D. George, S. Sweeten, et al. Response of fractional synthesis rate (FSR) of fibrinogen, concentration of D-dimer and fibrinolytic balance to physical activity-based intervention in obese children. J. Thromb. Haemost. 6:1296-1303, 2008. PubMed doi:10.1111/j.1538-7836.2008.03037.x (Pubitemid 352022550)
5. Balagopal, P. B., S. S. Gidding, L. M. Buckloh, et al. Changes in circulating satiety hormones in obese children: a randomized controlled physical activity-based intervention study. Obesity (Silver Spring). 18:1747-1753, 2010. PubMed doi:10.1038/oby.2009.498
6. Barnes, K. M., and J. L. Miner. Role of resistin in insulin sensitivity in rodents and humans. Curr. Protein Pept. Sci. 10:96-107, 2009. PubMed doi:10.2174/138920309787315239
7. Bell, L. M., K. Watts, A. Siafarikas, et al. Exercise alone reduces insulin resistance in obese children independently of changes in body composition. J. Clin. Endocrinol. Metab. 92:4230-4235, 2007. PubMed doi:10.1210/jc.2007-0779 (Pubitemid 350074736)
8. Beltowski, J., G. Wojcicka, A. Jamroz-Wisniewska, and A. Wojtak. Chronic hyper-leptinemia induces resistance to acute natriuretic and NO-mimetic effects of leptin. Peptides. 31:155-163, 2010. PubMed doi:10.1016/j.peptides.2009.10.012
9. Bergman, R. N., I. D. Hope, Y. J. Yang, et al. Assessment of insulin sensitivity in vivo: a critical review. Diabetes Metab. Rev. 5:411-429, 1989. PubMed doi:10.1002/dmr.5610050501 (Pubitemid 19194684)
10. Biro, F. M., and M. Wien. Childhood obesity and adult morbidities. Am. J. Clin. Nutr. 91:1499S-1505S, 2010. PubMed doi:10.3945/ajcn. 2010.28701B
11. Camhi, S. M., M. L. Stefanick, P. M. Ridker, and D. R. Young. Changes in C-reactive protein from low-fat diet and/or physical activity in men and women with and without metabolic syndrome. Metabolism. 59:54-61, 2010. PubMed doi:10.1016/j. metabol.2009.07.008
12. Cinti, S., G. Mitchell, G. Barbatelli, et al. Adipocyte death defines macrophage localization and function in adipose tissue of obese mice and humans. J. Lipid Res. 46:2347-2355, 2005. PubMed doi:10.1194/jlr. M500294-JLR200 (Pubitemid 41532523)
13. Conwell, L. S., S. G. Trost, L. Spence, W. J. Brown, and J. A. Batch. The feasibility of a home-based moderate-intensity physical activity intervention in obese children and adolescents. Br. J. Sports Med. 44:250-255, 2010. PubMed doi:10.1136/bjsm.2008.046359
14. Danesh, J., J. G. Wheeler, G. M. Hirschfield, et al. C-reactive protein and other circulating markers of inflammation in the prediction of coronary heart disease. N. Engl. J. Med. 350:1387-1397, 2004. PubMed doi:10.1056/ NEJMoa032804 (Pubitemid 38419992)
15. De Ferranti, S. D., K. Gauvreau, D. S. Ludwig, J. W. Newburger, and N. Rifai. Inflamma-tion and changes in metabolic syndrome abnormalities in US adolescents: findings from the 1988-1994 and 1999-2000 National Health and Nutrition Examination Surveys. Clin. Chem. 52:1325-1330, 2006. PubMed doi:10.1373/clinchem.2006.067181 (Pubitemid 43956024)
16. Ferguson, M. A., B. Gutin, S. Owens, P. Barbeau, R. P. Tracy, and M. Litaker. Effects of physical training and its cessation on the hemostatic system of obese children. Am. J. Clin. Nutr. 69:1130-1134, 1999. PubMed (Pubitemid 29252044)
17. Glowinska, B., M. Urban, A. Koput, and M. Galar. New atherosclerosis risk factors in obese, hypertensive and diabetic children and adolescents. Atherosclerosis. 167:275-286, 2003. PubMed doi:10.1016/S0021-9150 (03) 00003-0 (Pubitemid 36773527)
18. Gutin, B., N. Cucuzzo, S. Islam, C. Smith, and M. E. Stachura. Physical training, lifestyle education, and coronary risk factors in obese girls. Med. Sci. Sports Exerc. 28:19-23, 1996. PubMed (Pubitemid 26031718)
19. Hotamisligil, G. S., D. L. Murray, L. N. Choy, and B. M. Spiegelman. Tumor necrosis factor alpha inhibits signaling from the insulin receptor. Proc. Natl. Acad. Sci. USA. 91:4854-4858, 1994. PubMed doi:10.1073/pnas.91.11.4854 (Pubitemid 24177748)
20. Hotamisligil, G. S., N. S. Shargill, and B. M. Spiegelman. Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance. Science. 259:87-91, 1993. PubMed doi:10.1126/science.7678183 (Pubitemid 23036092)
21. Houmard, J. A., C. J. Tanner, C. A. Slentz, B. D. Duscha, J. S. McCartney, and W. E. Kraus. Effect of the volume and intensity of exercise training on insulin sensitivity. J. Appl. Physiol. 96:101-106, 2004. PubMed doi:10.1152/japplphysiol.00707.2003 (Pubitemid 38031988)
22. Jones, T. E., J. L. Basilio, P. M. Brophy, M. R. McCammon, and R. C. Hickner. Long-term exercise training in overweight adolescents improves plasma peptide YY and resistin. Obesity (Silver Spring). 17:1189-1195, 2009. PubMed
23. Kelly, A. S., J. Steinberger, T. P. Olson, and D. R. Dengel. In the absence of weight loss, exercise training does not improve adipokines or oxidative stress in overweight children. Metabolism. 56:1005-1009, 2007. PubMed doi:10.1016/j.metabol.2007.03.009 (Pubitemid 46890985)
24. Kim, E. S., J. A. Im, K. C. Kim, et al. Improved insulin sensitivity and adiponectin level after exercise training in obese Korean youth. Obesity (Silver Spring). 15:3023-3030, 2007. PubMed doi:10.1038/oby.2007.360 (Pubitemid 351256664)
25. Kim, H. J., T. Higashimori, S. Y. Park, et al. Differential effects of interleukin-6 and -10 on skeletal muscle and liver insulin action in vivo. Diabetes. 53:1060-1067, 2004. PubMed doi:10.2337/diabetes.53.4.1060 (Pubitemid 38436619)
26. Lee, J. M. Why young adults hold the key to assessing the obesity epidemic in children. Arch. Pediatr. Adolesc. Med. 162:682-687, 2008. PubMed doi:10.1001/arch-pedi.162.7.682 (Pubitemid 351961562)
27. Lira, F. S., J. C. Rosa, A. S. Yamashita, C. H. Koyama, M. L. Batista, Jr., and M. Seelaender. Endurance training induces depot-specific changes in IL-10/TNF-alpha ratio in rat adipose tissue. Cytokine. 45:80-85, 2009. PubMed doi:10.1016/j.cyto.2008.10.018
28. Maffei, M., J. Halaas, E. Ravussin, et al. Leptin levels in human and rodent: measurement of plasma leptin and ob RNA in obese and weight-reduced subjects. Nat. Med. 1:1155-1161, 1995. PubMed doi:10.1038/nm1195-1155
29. Moon, Y. S., D. H. Kim, and D. K. Song. Serum tumor necrosis factor-alpha levels and components of the metabolic syndrome in obese adolescents. Metabolism. 53:863-867, 2004. PubMed doi:10.1016/j.metabol.2004.02.007 (Pubitemid 38829459)
30. Must, A., and R. S. Strauss. Risks and consequences of childhood and adolescent obesity. Int. J. Obes. Relat. Metab. Disord. 23(Suppl. 2):S2-S11, 1999. PubMed doi:10.1038/sj.ijo.0800852 (Pubitemid 29182357)
31. Nassis, G. P., K. Papantakou, K. Skenderi, et al. Aerobic exercise training improves insulin sensitivity without changes in body weight, body fat, adiponectin, and inflam-matory markers in overweight and obese girls. Metabolism. 54:1472-1479, 2005. PubMed doi:10.1016/j.metabol.2005.05.013 (Pubitemid 41527017)
32. Nassis, G. P., G. Psarra, and L. S. Sidossis. Central and total adiposity are lower in overweight and obese children with high cardiorespiratory fitness. Eur. J. Clin. Nutr. 59:137-141, 2005. PubMed doi:10.1038/sj.ejcn. 1602061 (Pubitemid 40104088)
33. Ounis, B. O., M. Elloumi, G. Lac, et al. Two-month effects of individualized exercise training with or without caloric restriction on plasma adipocytokine levels in obese female adolescents. Ann. Endocrinol. (Paris). 70:235-241, 2009. PubMed doi:10.1016/j.ando.2009.03.003
34. Owens, S., and B. Gutin. Exercise testing of the child with obesity. Pediatr. Cardiol. 20:79-83, 1999. PubMed doi:10.1007/s002469900405 (Pubitemid 29028768)
35. Pedersen, B. K. The diseasome of physical inactivity-and the role of myokines in muscle-fat cross talk. J. Physiol. 587:5559-5568, 2009. PubMed doi:10.1113/jphysiol.2009.179515
36. Qatanani, M., N. R. Szwergold, D. R. Greaves, R. S. Ahima, and M. A. Lazar. Macrophage-derived human resistin exacerbates adipose tissue inflammation and insulin resistance in mice. J. Clin. Invest. 119:531-539, 2009. PubMed doi:10.1172/JCI37273
37. Rosenbaum, M., C. Nonas, R. Weil, et al. School-based intervention acutely improves insulin sensitivity and decreases inflammatory markers and body fatness in junior high school students. J. Clin. Endocrinol. Metab. 92:504-508, 2007. PubMed doi:10.1210/jc.2006-1516
38. Rowland, T. W. Developmental exercise physiology. Champaign, IL: Human Kinetics, 1996, 269 pp.
39. Rubin, D. A., R. G. McMurray, J. S. Harrell, A. C. Hackney, D. E. Thorpe, and A. M. Haqq. The association between insulin resistance and cytokines in adolescents: the role of weight status and exercise. Metabolism. 57:683-690, 2008. PubMed doi:10.1016/j. metabol.2008.01.005 (Pubitemid 351608230)
40. Sola, E., A. Jover, A. Lopez-Ruiz, et al. Parameters of inflammation in morbid obesity: lack of effect of moderate weight loss. Obes. Surg. 19:571-576, 2009. PubMed doi:10.1007/s11695-008-9772-8
41. Tang, W., Y. Hong, M. A. Province, et al. Familial clustering for features of the metabolic syndrome: the National Heart, Lung, and Blood Institute (NHLBI) Family Heart Study. Diabetes Care. 29:631-636, 2006. PubMed doi:10.2337/diacare.29.03.06.dc05-0679 (Pubitemid 44115365)
42. Van der Heijden, G. J., G. Toffolo, E. Manesso, P. J. Sauer, and A. L. Sunehag. Aerobic exercise increases peripheral and hepatic insulin sensitivity in sedentary adolescents. J. Clin. Endocrinol. Metab. 94:4292-4299, 2009. PubMed doi:10.1210/jc.2009-1379
43. Vieira, V. J., R. J. Valentine, K. R. Wilund, N. Antao, T. Baynard, and J. A. Woods. Effects of exercise and low-fat diet on adipose tissue inflammation and metabolic complications in obese mice. Am. J. Physiol. Endocrinol. Metab. 296:E1164-E1171, 2009. PubMed doi:10.1152/ajpendo.00054.2009
44. Xu, H., G. T. Barnes, Q. Yang, et al. Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance. J. Clin. Invest. 112:1821-1830, 2003. PubMed (Pubitemid 38063705)