DICAM inhibits angiogenesis via suppression of AKT and p38 MAP kinase signalling

Cardiovascular Research

Volumn 98, Issue 1, 2013, Pages 73-82

  Han, Seung Woo ^a,b   Jung, Youn Kwan ^a   Lee, Eun Ju ^a   Park, Hye Ri ^a   Kim, Gun Woo ^a,b   Jeong, Jae Hwan ^c   Han, Min Su ^c   Choi, Je Yong ^c  

^a Fatima Research Institute   (South Korea)

^b Daegu Fatima Hospital   (South Korea)

^c Kyungpook National University School of Medicine   (South Korea)

Author keywords

Angiogenesis; Apoptosis; DICAM; Integrin v 3; VEGF

Indexed keywords

BETA ACTIN; CASPASE 8; CELL ADHESION MOLECULE; DUAL IMMUNOGLOBULIN DOMAIN CONTAINING ADHESION MOLECULE; MITOGEN ACTIVATED PROTEIN KINASE P38; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN BCL 2; PROTEIN KINASE B; UNCLASSIFIED DRUG; VASCULOTROPIN; VITRONECTIN; VITRONECTIN RECEPTOR;

ANGIOGENESIS; APOPTOSIS; ARTICLE; CELL FRACTIONATION; CELL MIGRATION; CELL PROLIFERATION; CELL VIABILITY; DOWN REGULATION; ENDOTHELIUM CELL; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; UMBILICAL VEIN ENDOTHELIAL CELL; UPREGULATION; WOUND HEALING;

ANIMALS; APOPTOSIS; CELL ADHESION MOLECULES; CELL MOVEMENT; CELL PROLIFERATION; FOCAL ADHESION PROTEIN-TYROSINE KINASES; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; INTEGRIN ALPHAVBETA3; MICE; MICE, INBRED C57BL; NEOVASCULARIZATION, PHYSIOLOGIC; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHATIDYLINOSITOL 3-KINASES; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VITRONECTIN;

EID: 84875145377     PISSN: 00086363     EISSN: 17553245     Source Type: Journal    
DOI: 10.1093/cvr/cvt019     Document Type: Article

References (35)

1. Carmeliet P. Angiogenesis in health and disease. Nat Med 2003;9:653-660.
2. Adams RH, Alitalo K. Molecular regulation of angiogenesis and lymphangiogenesis. Nat Rev Mol Cell Biol 2007;8:464-478.
3. Avraamides CJ, Garmy-Susini B, Varner JA. Integrins in angiogenesis and lymphangiogenesis. Nat Rev Cancer 2008;8:604-617.
4. Brooks PC, Clark RA, Cheresh DA. Requirement of vascular integrin alpha v beta 3 for angiogenesis. Science 1994;264:569-571.
5. Gao B, Saba TM, Tsan MF. Role of alpha(v)beta(3)-integrin in TNF-alpha-induced endothelial cell migration. Am J Physiol Cell Physiol 2002;283:C1196-1205.
6. Tsopanoglou NE, Andriopoulou P, Maragoudakis ME. On the mechanism of thrombin-induced angiogenesis: involvement of alphavbeta3-integrin. Am J Physiol Cell Physiol 2002;283:C1501-1510.
7. Kireeva ML, Lam SC, Lau LF. Adhesion of human umbilical vein endothelial cells to the immediate-early gene product Cyr61 is mediated through integrin alphavbeta3. J Biol Chem 1998;273:3090-3096.
8. Li Y, Sun L, Xu H, Fang Z, YaoW, GuoWet al. Angiopoietin-like protein 3 modulates barrier properties of human glomerular endothelial cells through a possible signaling pathway involving phosphatidylinositol-3 kinase/protein kinase B and integrin alphaVbeta3. Acta Biochim Biophys Sin (Shanghai) 2008;40:459-465.
9. Penta K, Varner JA, Liaw L, Hidai C, Schatzman R, Quertermous T. Del1 induces integrin signaling and angiogenesis by ligation of alphaVbeta3. J Biol Chem 1999;274: 11101-11109.
10. Cui R, Takahashi F, Ohashi R, Gu T, Yoshioka M, Nishio K et al. Abrogation of the interaction between osteopontin and alphavbeta3 integrin reduces tumor growth of human lung cancer cells in mice. Lung Cancer 2007;57:302-310.
11. Hodivala-Dilke KM, Reynolds AR, Reynolds LE. Integrins in angiogenesis: multitalented molecules in a balancing act. Cell Tissue Res 2003;314:131-144.
12. Silvestre JS, Thery C, Hamard G, Boddaert J, Aguilar B, Delcayre A et al. Lactadherin promotes VEGF-dependent neovascularization. Nat Med 2005;11:499-506.
13. Huang MT, Mason JC, Birdsey GM, Amsellem V, Gerwin N, Haskard DO et al. Endothelial intercellular adhesion molecule (ICAM)-2 regulates angiogenesis. Blood 2005; 106:1636-1643.
14. Cooke VG, Naik MU, Naik UP. Fibroblast growth factor-2 failed to induce angiogenesis in junctional adhesion molecule-A-deficient mice. Arterioscler Thromb Vasc Biol 2006;26:2005-2011.
15. Lamagna C, Hodivala-Dilke KM, Imhof BA, Aurrand-Lions M. Antibody against junctional adhesion molecule-C inhibits angiogenesis and tumor growth. Cancer Res 2005;65:5703-5710.
16. Cao G, Fehrenbach ML, Williams JT, Finklestein JM, Zhu JX, Delisser HM. Angiogenesis in platelet endothelial cell adhesion molecule-1-null mice. Am J Pathol 2009;175: 903-915.
17. Hall H, Djonov V, Ehrbar M, Hoechli M, Hubbell JA. Heterophilic interactions between cell adhesion molecule L1 and alphavbeta3-integrin induce HUVEC process extension in vitro and angiogenesis in vivo. Angiogenesis 2004;7:213-223.
18. Jung YK, Han SW, Kim GW, Jeong JH, Kim HJ, Choi JY. DICAM inhibits osteoclast differentiation through attenuation of the integrin alphaVbeta3 pathway. J Bone Miner Res 2012;27:2024-2034.
19. Jung YK, Jin JS, Jeong JH, Kim HN, Park NR, Choi JY. DICAM, a novel dual immunoglobulin domain containing cell adhesion molecule interacts with alphavbeta3 integrin. J Cell Physiol 2008;216:603-614.
20. Kim HN, Min WK, Jeong JH, Kim SG, Kim JR, Kim SY et al. Combination of Runx2 and BMP2 increases conversion of human ligamentum flavum cells into osteoblastic cells. BMB Rep 2011;44:446-451.
21. Jeong JH, Jung YK, Kim HJ, Jin JS, Kim HN, Kang SM et al. The gene for aromatase, a rate-limiting enzyme for local estrogen biosynthesis, is a downstream target gene of Runx2 in skeletal tissues. Mol Cell Biol 2010;30:2365-2375.
22. Olsson AK, Dimberg A, Kreuger J, Claesson-Welsh L. VEGF receptor signaling-in control of vascular function. Nat Rev Mol Cell Biol 2006;7:359-371.
23. Soldi R, Mitola S, Strasly M, Defilippi P, Tarone G, Bussolino F. Role of alphavbeta3 integrin in the activation of vascular endothelial growth factor receptor-2. EMBO J 1999;18:882-892.
24. Mahabeleshwar GH, Feng W, Reddy K, Plow EF, Byzova TV. Mechanisms of integrin-vascular endothelial growth factor receptor cross-activation in angiogenesis. Circ Res 2007;101:570-580.
25. Reynolds AR, Reynolds LE, Nagel TE, Lively JC, Robinson SD, Hicklin DJ et al. Elevated Flk1 (vascular endothelial growth factor receptor 2) signaling mediates enhanced angiogenesis in beta3-integrin-deficient mice. Cancer Res 2004;64: 8643-8650.
26. Reynolds LE, Wyder L, Lively JC, Taverna D, Robinson SD, Huang X et al. Enhanced pathological angiogenesis in mice lacking beta3 integrin or beta3 and beta5 integrins. Nat Med 2002;8:27-34.
27. Kaneko Y, Kitazato K, Basaki Y. Integrin-linked kinase regulates vascular morphogenesis induced by vascular endothelial growth factor. J Cell Sci 2004;117:407-415.
28. Xie W, Zhao M, Zhou W, Guo L, Huang L, Yu W et al. Targeting of integrin-linked kinase with small interfering RNA inhibits VEGF-induced angiogenesis in retinal endothelial cells. Ophthalmic Res 2012;49:139-149.
29. Liu ZJ, Snyder R, Soma A, Shirakawa T, Ziober BL, Fairman RM et al. VEGF-A and alphaVbeta3 integrin synergistically rescue angiogenesis via N-Ras and PI3-K signaling in human microvascular endothelial cells. FASEB J 2003;17:1931-1933.
30. Adams JM. Ways of dying: multiple pathways to apoptosis. Genes Dev 2003;17: 2481-2495.
31. Zhang CL, Song F, Zhang J, Song QH. Hypoxia-induced Bcl-2 expression in endothelial cells via p38 MAPK pathway. Biochem Biophys Res Commun 2010;394:976-980.
32. Bialik S, Cryns VL, Drincic A, Miyata S, Wollowick AL, Srinivasan A et al. The mitochondrial apoptotic pathway is activated by serum and glucose deprivation in cardiac myocytes. Circ Res 1999;85:403-414.
33. Naik MU, Naik UP. Junctional adhesion molecule-A-induced endothelial cell migration on vitronectin is integrin alpha v beta 3 specific. J Cell Sci 2006;119:490-499.
34. Naik MU, Mousa SA, Parkos CA, Naik UP. Signaling through JAM-1 and alphavbeta3 is required for the angiogenic action of bFGF: dissociation of the JAM-1 and alphavbeta3 complex. Blood 2003;102:2108-2114.
35. Rabquer BJ, Amin MA, Teegala N, Shaheen MK, Tsou PS, Ruth JH et al. Junctional adhesion molecule-C is a soluble mediator of angiogenesis. J Immunol 2010;185: 1777-1785.