Expression of Rac1, HIF-1α, and VEGF in gastric carcinoma: Correlation with angiogenesis and prognosis

Onkologie

Volumn 36, Issue 3, 2013, Pages 102-107

  Zhan, Hongjie ^a   Liang, Han ^a   Liu, Xiangyu ^a   Deng, Jingyu ^a   Wang, Baogui ^a   Hao, Xishan ^a  

^a TIANJIN MEDICAL UNIVERSITY   (China)

Author keywords

Gastrointestinal cancer; Hypoxia inducible factor 1; Microvessel density; Prognosis; Rac1; VEGF

Indexed keywords

CD34 ANTIGEN; HYPOXIA INDUCIBLE FACTOR 1ALPHA; RAC1 PROTEIN; VASCULOTROPIN;

ADULT; AGED; ANGIOGENESIS; ARTICLE; CANCER PROGNOSIS; DISEASE SEVERITY; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; MALE; PROTEIN EXPRESSION; STOMACH CARCINOMA; SURVIVAL TIME;

ADULT; AGED; CHINA; COMORBIDITY; FEMALE; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; MALE; MIDDLE AGED; NEOVASCULARIZATION, PATHOLOGIC; PREVALENCE; PROGNOSIS; RAC1 GTP-BINDING PROTEIN; REPRODUCIBILITY OF RESULTS; RISK ASSESSMENT; SENSITIVITY AND SPECIFICITY; STATISTICS AS TOPIC; STOMACH NEOPLASMS; SURVIVAL ANALYSIS; SURVIVAL RATE; TUMOR MARKERS, BIOLOGICAL; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 84875129885     PISSN: 0378584X     EISSN: 14230240     Source Type: Journal    
DOI: 10.1159/000348525     Document Type: Article

References (12)

1. Miyamoto N, Yamamoto H, Taniguchi H, Miyamoto C, Oki M, Adachi Y, Imai K, Shinomura Y: Differential expression of angiogenesis-related genes in human gastric cancers with and those without high-frequency microsatellite instability. Cancer Lett 2007;254:42-53.
2. Tzanakis N, Gazouli M, Rallis G, Giannopoulos G, Papaconstantinou I, Theodoropoulos G, Pikoulis E, Tsigris C, Karakitsos P, Peros G, Nikiteas N: Vascular endothelial growth factor polymorphisms in gastric cancer development, prognosis, and survival. J Surg Oncol 2006;94:624-630.
3. Koga H, Sakisaka S, Ohishi M, Kawaguchi T, Taniguchi E, Sasatomi K, Harada M, Kusaba T, Tanaka M, Kimura R, Nakashima Y, Nakashima O, Kojiro M, Kurohiji T, Sata M: Expression of cyclo-oxygenase-2 in human hepatocellular carcinoma: relevance to tumor dedifferentiation. Hepatology 1999;29:688-696.
4. Weidner N, Folkman J, Pozza F, Bevilacqua P, Allred EN, Moore DH, Meli S, Gasparini G: Tumor angiogenesis: a new significant and independent prognostic indicator in early-stage breast carcinoma. J Natl Cancer lnst l992;84:1875-l887.
5. Gonzalez E, Kou R, Michel T: Rac1 modulates sphingosine 1-phosphate-mediated activation of phosphoinositide 3-kinase/Akt signaling pathways in vascular endothelial cells. J Biol Chem 2006; 281:3210-3216.
6. Sawada N, Salomone S, Kim HH, Kwiatkowski DJ, Liao JK: Regulation of endothelial nitric oxide synthase and postnatal angiogenesis by Rac1. Circ Res 2008;103:360-368.
7. Lee TK, Poon RT, Yuen AP, Man K, Yang ZF, Guan XY, Fan ST: Rac activation is associated with hepatocellular carcinoma metastasis by up-regulation of vascular endothelial growth factor expression. Clin Cancer Res 2006;12:5082-5089.
8. Mizokami K, Kakeji Y, Oda S, Irie K, Yonemura T, Konishi F, Maehara Y: Clinicopathologic significance of hypoxia-inducible factor 1alpha over-expression in gastric carcinomas. J Surg Oncol 2006;94:149-154.
9. Yoshikawa T, Tsuburaya A, Miyagi Y, Sekiguchi H, Kimura M, Cho H, Kobayashi O: Up-regulation of hypoxia-inducible factor-1 alpha and VEGF mRNAs in peritoneal dissemination of patients with gastric cancer. Anticancer Res 2006;26:3849-3853.
10. Hirota K, Semenza GL: Rac1 activity is required for the activation of hypoxia-inducible factor 1. J Biol Chem 2001;276:21166-21172.
11. Xue Y, Bi F, Zhang X, Zhang S, Pan Y, Liu N, Shi Y, Yao X, Zheng Y, Fan D: Role of Rac1 and Cdc42 in hypoxia induced p53 and von Hippel-Lindau suppression and HIF-1alpha activation. Int J Cancer 2006;118:2965-2972.
12. Walch A, Seidl S, Hermannstädter C, Rauser S, Deplazes J, Langer R, von Weyhern CH, Sarbia M, Busch R, Feith M, Gillen S, Höfler H, Luber B: Combined analysis of Rac1, IQGAP1, Tiam1 and E-cadherin expression in gastric cancer. Mod Pathol 2008;21:544-552.