Adenovirus-mediated anti-sense extracellular signal-regulated kinase 2 gene therapy inhibits activation of vascular smooth muscle cells and angiogenesis, and ameliorates transplant arteriosclerosis

Transplantation Proceedings

Volumn 45, Issue 2, 2013, Pages 639-642

  Zhao, B ^a   Li, X ^a   Dai, X ^a   Gong, N ^a  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOVIRUS VECTOR; ALPHA ACTIN; ANGIOGENESIS INHIBITOR; BETA GALACTOSIDASE; CYCLOOXYGENASE 2; MITOGEN ACTIVATED PROTEIN KINASE 1; PLATELET DERIVED GROWTH FACTOR BB;

ALLOGRAFT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIANGIOGENIC ACTIVITY; ANTIANGIOGENIC GENE THERAPY; ANTISENSE THERAPY; ARTERIOSCLEROSIS; ARTICLE; CELL ACTIVATION; CELL FUNCTION; CELL MIGRATION; CELLULAR SECRETION; CONTROLLED STUDY; IMMUNOHISTOCHEMISTRY; ISOGRAFT; NONHUMAN; PRIORITY JOURNAL; RAT; SMOOTH MUSCLE FIBER; TRANSPLANT ARTERIOSCLEROSIS; VASCULAR SMOOTH MUSCLE;

ADENOVIRIDAE; ANIMALS; AORTA, ABDOMINAL; ARTERIOSCLEROSIS; CELL MOVEMENT; CELL PROLIFERATION; CYCLOOXYGENASE 2; DNA, ANTISENSE; GENETIC THERAPY; GENETIC VECTORS; MITOGEN-ACTIVATED PROTEIN KINASE 1; MUSCLE, SMOOTH, VASCULAR; MYOCYTES, SMOOTH MUSCLE; NEOINTIMA; NEOVASCULARIZATION, PATHOLOGIC; PROTO-ONCOGENE PROTEINS C-SIS; RATS; RATS, INBRED BN; RATS, INBRED LEW; TRANSDUCTION, GENETIC;

EID: 84875126654     PISSN: 00411345     EISSN: 18732623     Source Type: Journal    
DOI: 10.1016/j.transproceed.2012.04.042     Document Type: Article

References (9)

1. H. Mizuguchi, M.A. Kay A simple method for constructing E1- and E1/E4-deleted recombinant adenoviral vectors Hum Gene Ther 10 1999 2013
2. X.L. Chen, Z.S. Chen, Z. Ding Antisense extracellular signal-regulated kinase-2 gene therapy inhibits platelet-derived growth factor-induced proliferation, migration and transforming growth factor-beta(1) expression in vascular smooth muscle cells and attenuates transplant vasculopathy Transpl Int 21 2008 30
3. P. Cohen The search for physiological substrates of MAP and SAP kinases in mammalian cells Trends Cell Biol 7 1997 353
4. F. Bost, M. Aouadi, L. Caron The extracellular signal-regulated kinase isoform ERK1 is specifically required for in vitro and in vivo adipogenesis Diabetes 54 2005 402
5. A.V. Sterpetti, A. Cucina, S. Lepidi Progression and regression of myointimal hyperplasia in experimental vein grafts depends on platelet-derived growth factor and basic fibroblastic growth factor production J Vasc Surg 23 1996 568
6. Z. Ding, Z. Chen, X. Chen Adenovirus-mediated anti-sense ERK2 gene therapy inhibits tubular epithelial-mesenchymal transition and ameliorates renal allograft fibrosis Transpl Immunol 25 2011 34
7. K.B. Lemström, P.K. Koskinen Expression and localization of platelet-derived growth factor 1 ligand and receptor protein during acute and chronic rejection of rat cardiac allografts Circulation 96 1997 1240
8. Q. Xiao, L. Zeng, Z. Zhang Stem cell-derived Sca-1+ progenitors differentiate into smooth muscle cells, which is mediated by collagen IV-integrin alpha1/beta1/alphav and PDGF receptor pathways Am J Physiol Cell Physiol 292 2007 342
9. M. Majima, I. Itayashi, M. Muramatsu COX-2 enhances bFGF-induced angiogenesis through induction of VEGF in rat sponge implants Br J Pharmacol 130 2000 641