Influence of Vitamin C and Vitamin E on testicular zinc content and testicular toxicity in lead exposed albino rats

BMC Pharmacology and Toxicology

Volumn 13, Issue , 2012, Pages

  Ayinde, Oluseyi C ^a   Ogunnowo, Sunday ^a   Ogedegbe, Rita A ^a  

^a UNIVERSITY OF LAGOS   (Nigeria)

Author keywords

Lead; Oxidative stress; Testicular toxicity; Vitamin C; Vitamin E; Zinc

Indexed keywords

ALPHA TOCOPHEROL; ANDROGEN; ASCORBIC ACID; CATALASE; FOLLITROPIN; GLUTATHIONE; LEAD; LUTEINIZING HORMONE; NITRIC OXIDE; SUPEROXIDE DISMUTASE; TESTOSTERONE; ZINC; ANTIOXIDANT;

ANDROGEN BLOOD LEVEL; ANIMAL MODEL; ARTICLE; BODY WEIGHT; CELL DEGENERATION; CELL STRUCTURE; CONTROLLED STUDY; ENZYME ACTIVITY; FOLLITROPIN BLOOD LEVEL; HISTOLOGY; LIPID PEROXIDATION; LUTEINIZING HORMONE BLOOD LEVEL; MALE; MOUSE; NONHUMAN; OXIDATIVE STRESS; REPRODUCTION; REPRODUCTIVE TOXICITY; SEMEN ANALYSIS; SEMINIFEROUS TUBULE EPITHELIUM; SPERMATOZOON COUNT; SPERMATOZOON MOTILITY; SYSTEMATIC REVIEW; TESTIS; TESTOSTERONE BLOOD LEVEL; ANIMAL; DRUG COMBINATION; DRUG EFFECT; ENZYMOLOGY; LEAD POISONING; METABOLISM; ORAL DRUG ADMINISTRATION; PATHOLOGY; POLLUTANT; RAT; SPERMATOZOON; SPRAGUE DAWLEY RAT;

ADMINISTRATION, ORAL; ANIMALS; ANTIOXIDANTS; ASCORBIC ACID; DRUG THERAPY, COMBINATION; ENVIRONMENTAL POLLUTANTS; LEAD; LEAD POISONING; LIPID PEROXIDATION; MALE; OXIDATIVE STRESS; RATS; RATS, SPRAGUE-DAWLEY; SPERM COUNT; SPERM MOTILITY; SPERMATOZOA; TESTIS; VITAMIN E; ZINC;

MLCS; MLOWN;

EID: 84875126334     PISSN: 20506511     EISSN: None     Source Type: Journal    
DOI: 10.1186/2050-6511-13-17     Document Type: Article

References (45)

1. Flora SJ, Mittal M, Mehta A. Heavy metal induced oxidative stress & its possible reversal by chelation therapy. Indian J Med Res 2008, 128(4):501-523.
2. Mostafa MH, Hoda SI, Yousria AM, Seham MA, Amal SA, Amany MH. Effect of Alpha Lipoic Acid and Vitamin E on Heavy Metals Intoxication in Male Albino Rats. J Am Sci 2010, 8:56-63.
3. Chowdhury RA. Recent Advances in Heavy Metals Induced Effect on Male Reproductive Function-A Retrospective. Al Ameen J Med Sci 2009, 2(2):37-42.
4. Hammond PB. Exposure of humans to lead. Annu Rev Pharmacol Toxicol 1977, 17:197-214.
5. Berrahal AA, Lasram M, El Elj N, Kerkeni A, Gharbi N, El-Fazaa S. Effect of age-dependent exposure to Lead on hepatotoxicity and nephrotoxocity in male rats. Environ Toxicol 2011, 26:68-78.
6. Moniem A, Dkhil M, Al-Quraishy S. Protective role of flaxseed oil against lead acetate induced oxidative stress in testes of adult rats. Afr J Biotechnol 2010, 9(42):7216-7223.
7. Singh RP, Shashwat S, Suman K. Free Radicals and Oxidative Stress in Neurodegenerative Diseases: Relevance of Dietary Antioxidants. Journal of Indian Academy of Clinical Medicine JIACM 2004, 5(3):218-225.
8. Mishra M, Acharya UR. Protective action of vitamins on the spermatogenesis in lead-treated Swiss mice. J Trace Elem Med Biol 2004, 18(2):173-178.
9. Bedwal RS, Bahugana A. Zinc, Copper and Selenium in reproduction. Experientaia 1994, 50:626-640.
10. Tuncer I, Sunar F, Toy H, Baltaci AK, Mogulkoc R. Histological effect of zinc and melatonin on rat testes. Bratisl Lek Listy 2011, 112(8):425-427.
11. Krause MV, Mahan KL. Food, Nutition, and Diet Therapy 1984, 71-133. W.B. Sanders company, 7.
12. Lewis-Jones DI, Aird IA, Biljan MM, Kingsland CR. Effects of sperm activity on zinc and fructose concentrations in seminal plasma. Hum Reprod 1996, 11(1):2465-2467.
13. Kartikeya M, Ashok A, Rakesh S. Oxidative stress & male infertility. Indian J Med Res 2009, 129:357-367.
14. El-Tohamy MM, El-Nattat WS. Effect of Antioxidant on Lead-Induced Oxidative Damage and Reproductive Dysfunction in Male Rabbits. J Am Sci 2010, 6(11):613-622.
15. Adeniyi TT, Ajayi GO, Akinloye OA. Effect of Ascobic acid and Allium sativum on Tissue lead level in female Rattus navigicus. Niger J Health Biomed Sci 2008, 7(2):38-41.
16. Calabrese EJ, Stoddard A, Leonard DA, Dinardi SE. The effects of vitamin C supplementation on blood and hair levels of cadmium, lead, and mercury. Ann NY Acad Sci 1987, 498:347-358.
17. Sugiyama M. Role of physiological antioxidants in chromium (VI)-induced cellular injury. Free Radical Biol Med 1992, 12:397-407.
18. Nathan E, Huang HF, Pogach L, Giglio W, Bogden JD, Seebode J. Lead acetate does not impair secretion of Sertoli cell function marker proteins in the adult Sprague Dawley rat. Arch Environ Health 1992, 47:370-375.
19. Abdel-Wahhab MA, Omara EA, Abdel-Galil MM, Hassan NS, Nada SA, Saeed A, Elsayed MM. Zizyphus spina-christi extract protects against aflatoxin b(1)-intitiated hepatic carcinogenicity. Afr J Tradit Complement Altern Med 2007, 4(3):248-256.
20. Salawu O, Adeeyo OA, Falokun OP, Yusuf UA, Oyerinde A, Adeleke AA. Tomato (Lycoperscion esculentum) prevents lead-induced testicular toxicity. J Hum Reprod Sci 2009, 2(1):30-34.
21. Vigeh M, Derek R, Ping-Chi H. How does lead induce male infertility. IJRM 2011, 9(1):1-8.
22. Afaf AE. Influence of Subchronic Exposure of Profenofos onBiochemical Markers and Microelements in Testicular Tissue of Rats. J Am 2009, 5(1):19-28.
23. Brooks DE. Effect of androgen on protein synthesis and secretion in various regions of the rat epididymis, as analysed by two dimensional gel electrophoresis. Mol Cell Endocrinol 1983, 29:255-270.
24. Afaf AE, Hanan AT. Chlorpyrifos (from different sources): Effect on Testicular Biochemistry of Male Albino Rats. J Am Sci 2010, 6(7):251-261.
25. Hamdi SA, Nassif OI, Ardawi MS. Effect of marginal or severe dietary zinc deficiency on testicular development and functions of the rat. Arch Androl 1997, 38:243-253.
26. Victery M, Thomas D, Schoeps P, Vander AJ. Lead imcreases urinary excretion in rats. Biological trace elements research 1982, 4:211-219.
27. Lidsky TI, Schneider JS. Lead neurotoxicity in children: basic mechanisms and clinical correlates. Brain 2003, 126:5-19.
28. Ait HN, Slimani M, Merad-Boudia B, Zaoui C. Reproductive toxicity of lead acetate in adult male rats. Am J Scientific Res 2009, 1(3):38-50.
29. El-tohamy MM. Reproductive potential in female and male domestic fowl exposed to lead acetate 2003, 113. Denver: Co-sponsored by the American Association of avian pathologist and the American veterinary Medicine Association, 17, XIII Congress of the World Veterinary poultry association, 19-23.
30. Imran A, Muhammad S, Khalid FY. Study of the effects of lead poisoning on the testes in albinos rats. Pakistan J Med Res 2003, 42(3):1-9.
31. Wang XJ, Zhang YM, Cui JS. Study of effects of lead acetate on reproductive function in male mice. Chin J Ind Med 2004, 17(4):237-239.
32. Jensen TK, Bonde JP, Joffe M. The influence of occupational exposure on male reproductive function. Occup Med 2006, 56(8):544-553.
33. Thoreux-Manlay A, de la Calle JFV, Olivier MF, Soufir JC, Masse R, Pinon-Lataillade G. Impairment of testicular endocrine function after lead intoxication in the adult rat. Toxicology 1995, 26:101-109.
34. Zhu H, Luo HL, Meng H, Zhang GJ. Effect of Vitamin E supplementation on development of reproductive organs in Boer goat. Anim Reprod Sci 2009, 113:93-101.
35. Morton AP, Partridge S, Blair JA. The intestinal uptake of lead. Chem Br 1985, 15:923-927.
36. Niazi S, Lim J, Bederka JP. Effect of ascorbic acid on the renal excretion of lead in rats. J Pharm 1982, 71:1189-1190.
37. Patra RC, Swarup D, Dwivedi SK. Antioxidant effects of alpha tocopherol, ascorbic acid and L-methionine on lead induced oxidative stress to the liver, kidney and brain in rats. Toxicology 2001, 162(2):81-88.
38. Tarin JJ, Brines J, Cano A. Antioxidants may protect against infertility. Hum Reprod 1998, 13:1415-1416.
39. Luna LG. Manual Histological staining methods of the armed forces institute of pathology 1968, 58-62. New York, USA: McGraw Hill Book Co.
40. Buege JA, Aust SD. Microsomal lipid peroxidation methods. Enzymol 1978, 52:302-310.
41. Ellman GL. Tissue sulfhudryl groups. Arch Biochem Biophys 1959, 82(1):70-77.
42. Sum M, Zigman S. An improved spectrophotometric assay for superoxide dismutase based on epinephrine autoxidation. Anal Biochem 1978, 90:81-89.
43. Cohen G, Kim M, Ogwa V. A modified catalase assay suitable for a plate reader 1996, 56. Order article via Infotrieve.
44. Lowry OH, Rosenbrough NJ, Parr AL, Fandall RJ. Protein measurement with Folin phenolreagent. J Biol Chem 1951, 1951(193):265-275.
45. Seed J, Chapin RE, Clegg ED, Dostal LA, Foote RH, Hurtt ME, et al. Methods for assessing sperm motility, morphology, and counts in the rat, rabbit, and dog: a consensus report. ILSI Risk Science Institute Expert Working Group on Sperm Evaluation. Reprod Toxicol 1996, 10:237-244.