Catalpol decreases peroxynitrite formation and consequently exerts cardioprotective effects against ischemia/reperfusion insult

Pharmaceutical Biology

Volumn 51, Issue 4, 2013, Pages 463-473

  Huang, Chaolian ^a   Cui, Yongliang ^a   Ji, Lele ^b   Zhang, Wei ^c   Li, Rong ^d   Ma, Lei ^d   Xing, Wenjuan ^b   Zhou, Heping ^d   Chen, Baoying ^c   Yu, Jun ^b   Zhang, Haifeng ^b  

^a TSINGHUA UNIVERSITY   (China)

^b FOURTH MILITARY MEDICAL UNIVERSITY   (China)

^c FOURTH MILITARY MEDICAL UNIVERSITY   (China)

^d FOURTH MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Akt; ENOS; INOS; Myocardial ischemia reperfusion injury; Nitrative stress; Oxidative stress

Indexed keywords

CATALPOL; ENDOTHELIAL NITRIC OXIDE SYNTHASE; INDUCIBLE NITRIC OXIDE SYNTHASE; PEROXYNITRITE; PROTEIN KINASE B; SUPEROXIDE; URIC ACID; WORTMANNIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; APOPTOSIS; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; DRUG STRUCTURE; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; HEART FUNCTION; HEART INFARCTION SIZE; HEART MUSCLE CELL; HEART MUSCLE ISCHEMIA; HEART MUSCLE NECROSIS; HEART MUSCLE REPERFUSION; HEART PROTECTION; MALE; NITRATIVE STRESS; NONHUMAN; OXIDATIVE STRESS; PROTEIN EXPRESSION; RAT;

ANIMALS; ANTIOXIDANTS; APOPTOSIS; CARDIOTONIC AGENTS; DISEASE MODELS, ANIMAL; DOWN-REGULATION; ENZYME ACTIVATION; FREE RADICAL SCAVENGERS; INJECTIONS, INTRAPERITONEAL; IRIDOID GLUCOSIDES; MALE; MYOCARDIAL INFARCTION; MYOCARDIAL REPERFUSION INJURY; MYOCARDIUM; NECROSIS; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; NITRIC OXIDE SYNTHASE TYPE III; OXIDATIVE STRESS; PEROXYNITROUS ACID; PHOSPHATIDYLINOSITOL 3-KINASE; PHOSPHORYLATION; PROTEIN KINASE INHIBITORS; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RATS, SPRAGUE-DAWLEY; TIME FACTORS; TYROSINE;

EID: 84875123353     PISSN: 13880209     EISSN: 17445116     Source Type: Journal    
DOI: 10.3109/13880209.2012.740052     Document Type: Article

References (32)

1. Beckman JS, Beckman TW, Chen J, Marshall PA, Freeman BA. (1990). Apparent hydroxyl radical production by peroxynitrite: Implications for endothelial injury from nitric oxide and superoxide. Proc Natl Acad Sci USA, 87, 1620-1624.
2. Falk JA, Aune SE, Kutala VK, Kuppusamy P, Angelos MG. (2007). Inhibition of peroxynitrite precursors, NO and O2, at the onset of reperfusion improves myocardial recovery. Resuscitation, 74, 508-515.
3. Gao F, Gao E, Yue TL, Ohlstein EH, Lopez BL, Christopher TA, Ma XL. (2002). Nitric oxide mediates the antiapoptotic efect of insulin in myocardial ischemia-reperfusion: The roles of PI3-kinase, Akt, and endothelial nitric oxide synthase phosphorylation. Circulation, 105, 1497-1502.
4. Gao X, Zhang H, Belmadani S, Wu J, Xu X, Elford H, Potter BJ, Zhang C. (2008). Role of TNF-alpha-induced reactive oxygen species in endothelial dysfunction during reperfusion injury. Am J Physiol Heart Circ Physiol, 295, H2242-H2249.
5. Hayashi Y, Sawa Y, Ohtake S, Fukuyama N, Nakazawa H, Matsuda H. (2001). Peroxynitrite formation from human myocardium after ischemia-reperfusion during open heart operation. Ann Torac Surg, 72, 571-576.
6. Ishida H, Ichimori K, Hirota Y, Fukahori M, Nakazawa H. (1996). Peroxynitrite-induced cardiac myocyte injury. Free Radic Biol Med, 20, 343-350.
7. Jiao XY, Gao E, Yuan Y, Wang Y, Lau WB, Koch W, Ma XL, Tao L. (2009). INO-4885 [5, 10, 15, 20-tetra[N-(benzyl-4'-carboxylate)-2-pyridinium]-21H, 23H-porphine iron(III) chloride], a peroxynitrite decomposition catalyst, protects the heart against reperfusion injury in mice. J Pharmacol Exp Ter, 328, 777-784.
8. Kim YM, Bombeck CA, Billiar TR. (1999). Nitric oxide as a bifunctional regulator of apoptosis. Circ Res, 84, 253-256.
9. Levrand S, Vannay-Bouchiche C, Pesse B, Pacher P, Feihl F, Waeber B, Liaudet L. (2006). Peroxynitrite is a major trigger of cardiomyocyte apoptosis in vitro and in vivo. Free Radic Biol Med, 41, 886-895.
10. Li DQ, Bao YM, Li Y, Wang CF, Liu Y, An LJ. (2006). Catalpol modulates the expressions of Bcl-2 and Bax and attenuates apoptosis in gerbils after ischemic injury. Brain Res, 1115, 179-185.
11. Li DQ, Bao YM, Zhao JJ, Liu CP, Liu Y, An LJ. (2004a). Neuroprotective properties of catalpol in transient global cerebral ischemia in gerbils: Dose-response, therapeutic time-window and long-term efcacy. Brain Res, 1029, 179-185.
12. Li DQ, Duan YL, Bao YM, Liu CP, Liu Y, An LJ. (2004b). Neuroprotection of catalpol in transient global ischemia in gerbils. Neurosci Res, 50, 169-177.
13. Li R, Wang WQ, Zhang H, Yang X, Fan Q, Christopher TA, Lopez BL, Tao L, Goldstein BJ, Gao F, Ma XL. (2007). Adiponectin improves endothelial function in hyperlipidemic rats by reducing oxidative/nitrative stress and diferential regulation of eNOS/iNOS activity. Am J Physiol Endocrinol Metab, 293, E1703-E1708.
14. Li Y, Bao Y, Jiang B, Wang Z, Liu Y, Zhang C, An L. (2008). Catalpol protects primary cultured astrocytes from in vitro ischemia-induced damage. Int J Dev Neurosci, 26, 309-317.
15. Liang JH, Li YN, Qi JS, Jia XX. (2010). Peroxynitrite-induced protein nitration is responsible for renal mitochondrial damage in diabetic rat. J Endocrinol Invest, 33, 140-146.
16. Lopez BL, Liu GL, Christopher TA, Ma XL. (1997). Peroxynitrite, the product of nitric oxide and superoxide, causes myocardial injury in the isolated perfused rat heart. Coron Artery Dis, 8, 149-153.
17. Ma XL, Lopez BL, Liu GL, Christopher TA, Ischiropoulos H. (1997). Peroxynitrite aggravates myocardial reperfusion injury in the isolated perfused rat heart. Cardiovasc Res, 36, 195-204.
18. Moens AL, Claeys MJ, Timmermans JP, Vrints CJ. (2005). Myocardial ischemia/reperfusion-injury, a clinical view on a complex pathophysiological process. Int J Cardiol, 100, 179-190.
19. Pacher P, Beckman JS, Liaudet L. (2007). Nitric oxide and peroxynitrite in health and disease. Physiol Rev, 87, 315-424.
20. Pacher P, Schulz R, Liaudet L, Szabó C. (2005). Nitrosative stress and pharmacological modulation of heart failure. Trends Pharmacol Sci, 26, 302-310.
21. Saeed SA, Waqar MA, Zubairi AJ, Bhurgri H, Khan A, Gowani SA, Waqar SN, Choudhary MI, Jalil S, Zaidi AH, Ara I. (2005). Myocardial ischaemia and reperfusion injury: reactive oxygen species and the role of neutrophil. J Coll Physicians Surg Pak, 15, 507-514.
22. Su H, Sun X, Ma H, Zhang HF, Yu QJ, Huang C, Wang XM, Luan RH, Jia GL, Wang HC, Gao F. (2007). Acute hyperglycemia exacerbates myocardial ischemia/reperfusion injury and blunts cardioprotective efect of GIK. Am J Physiol Endocrinol Metab, 293, E629-E635.
23. Tao L, Gao E, Jiao X, Yuan Y, Li S, Christopher TA, Lopez BL, Koch W, Chan L, Goldstein BJ, Ma XL. (2007). Adiponectin cardioprotection after myocardial ischemia/reperfusion involves the reduction of oxidative/nitrative stress. Circulation, 115, 1408-1416.
24. Tian YY, An LJ, Jiang L, Duan YL, Chen J, Jiang B. (2006). Catalpol protects dopaminergic neurons from LPS-induced neurotoxicity in mesencephalic neuron-glia cultures. Life Sci, 80, 193-199.
25. Virág L, Szabó E, Gergely P, Szabó C. (2003). Peroxynitrite-induced cytotoxicity: Mechanism and opportunities for intervention. Toxicol Lett, 140-141, 113-124.
26. Wang P, Zweier JL. (1996). Measurement of nitric oxide and peroxynitrite generation in the postischemic heart. Evidence for peroxynitrite-mediated reperfusion injury. J Biol Chem, 271, 29223-29230.
27. Wang XL, Liu HR, Tao L, Liang F, Yan L, Zhao RR, Lopez BL, Christopher TA, Ma XL. (2007). Role of iNOS-derived reactive nitrogen species and resultant nitrative stress in leukocytes-induced cardiomyocyte apoptosis after myocardial ischemia/reperfusion. Apoptosis, 12, 1209-1217.
28. Xie N, Zhang W, Li J, Liang H, Zhou H, Duan W, Xu X, Yu S, Zhang H, Yi D. (2011). a-Linolenic acid intake attenuates myocardial ischemia/reperfusion injury through anti-infammatory and anti-oxidative stress efects in diabetic but not normal rats. Arch Med Res, 42, 171-181.
29. Zhang HF, Fan Q, Qian XX, Lopez BL, Christopher TA, Ma XL, Gao F. (2004). Role of insulin in the anti-apoptotic efect of glucose-insulin-potassium in rabbits with acute myocardial ischemia and reperfusion. Apoptosis, 9, 777-783.
30. Zhang KR, Liu HT, Zhang HF, Zhang QJ, Li QX, Yu QJ, Guo WY, Wang HC, Gao F. (2007a). Long-term aerobic exercise protects the heart against ischemia/reperfusion injury via PI3 kinase-dependent and Akt-mediated mechanism. Apoptosis, 12, 1579-1588.
31. Zhang W, Wang R, Han SF, Bu L, Wang SW, Ma H, Jia GL. (2007b). Alpha-linolenic acid attenuates high glucose-induced apoptosis in cultured human umbilical vein endothelial cells via PI3K/Akt/eNOS pathway. Nutrition, 23, 762-770.
32. Zweier JL, Talukder MA. (2006). The role of oxidants and free radicals in reperfusion injury. Cardiovasc Res, 70, 181-190.