Amplification target ADRM1: Role as an oncogene and therapeutic target for ovarian cancer

International Journal of Molecular Sciences

Volumn 14, Issue 2, 2013, Pages 3094-3109

  Fejzo, Marlena S ^a   Anderson, Lee ^a   von Euw, Erika M ^a   Kalous, Ondrej ^a   Avliyakulov, Nuraly K ^a   Haykinson, Michael J ^a   Konecny, Gottfried E ^a   Finn, Richard S ^a   Slamon, Dennis J ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

ADRM1; Oncogene; Ovarian cancer

Indexed keywords

GENOMIC DNA; SMALL INTERFERING RNA; VESICULAR MONOAMINE TRANSPORTER 1;

ADRM1 GENE; AMPLICON; ARTICLE; CANCER CELL CULTURE; CANCER GROWTH; CELL MIGRATION; CELL PROLIFERATION; CELL SURVIVAL; COMPARATIVE GENOMIC HYBRIDIZATION; CONTROLLED STUDY; DNA MICROARRAY; DRUG TARGETING; FEMALE; GENE AMPLIFICATION; GENE FUNCTION; GENE OVEREXPRESSION; GENE SILENCING; HUMAN; HUMAN CELL; HUMAN TISSUE; MAT1 GENE; ONCOGENE; OVARY CANCER; PROTEIN DEFECT; RNA INTERFERENCE;

EID: 84875085823     PISSN: 16616596     EISSN: 14220067     Source Type: Journal    
DOI: 10.3390/ijms14023094     Document Type: Article

References (28)

1. Fejzo, M.S.; Dering, J.; Ginther, C.; Anderson, L.; Ramos, L.; Walsh, C.; Karlan, B.; Slamon, D.J. Comprehensive analysis of 20q13 genes in ovarian cancer identifies ADRM1 as amplification target. Genes Chromosomes Cancer 2008, 47, 873-883.
2. Lamerant, N.; Kieda, C. Adhesion properties of adhesion-regulating molecule 1 protein on endothelial cells. FEBS J. 2005, 272, 1833-1844.
3. Cherix, N.; Froquet, R.; Charette, S.J.; Blanc, C.; Letourneur, F.; Cosson, P. A Phg2-ADRM1 pathway participates in the nutrient-controlled developmental response in Dictyostelium. Mol. Biol. Cell 2006, 17, 4982-4987.
4. Hamazaki, J.; Iemura, S.; Natsume, T.; Yashiroda, H.; Tanaka, K.; Murata, S. A novel proteasome interacting protein recruits the deubiquitinating enzyme UCH37 to 26S proteasomes. EMBO J. 2006, 25, 4524-4536.
5. Qiu, X.B.; Ouyang, S.Y.; Li, C.J.; Miao, S.; Wang, L.; Goldberg, A.L. hRpn13/ADRM1/GP110 is a novel proteasome subunit that binds the deubiquitinating enzyme, UCH37. EMBO J. 2006, 25, 5742-5753.
6. Yang, J.M. Emerging roles of deubiquitinating enzymes in human cancer. Acta Pharmacol. Sin. 2007, 28, 1325-1330.
7. Al-Shami, A.; Jhaver, K.G.; Vogel, P.; Wilkins, C.; Humphries, J.; Davis, J.J.; Xu, N.; Potter, D.G.; Gerhardt, B.; Mullinax, R.; et al. Regulators of the proteasome pathway, Uch37 and Rpn13, play distinct roles in mouse development. PLoS One 2010, 5, e13654.
8. Simins, A.B.; Weighardt, H.; Weidner, K.M.; Weidle, U.H.; Holzmann, B. Functional cloning of ARM-1, an adhesion-regulating molecule upregulated in metastatic tumor cells. Clin. Exp. Metastasis 1999, 17, 641-648.
9. Pilarsky, C.; Wenzig, M.; Specht, T.; Saeger, H.D.; Grützmann, R. Identification and validation of commonly overexpressed genes in solid tumors by comparison of microarray data. Neoplasia 2004, 6, 744-750.
10. Chen, W.; Hu, X.T.; Shi, Q.L.; Zhang, F.B.; He, C. Silencing of ADRM1 by RNA interference suppresses proliferation of colorectal cancer cells. Zhonghua ZhongLiu ZaZhi 2009, 31, 815-819.
11. Chen, W.; Hu, X.T.; Shi, Q.L.; Zhang, F.B.; He, C. Knockdown of the novel proteasome subunit ADRM1 located on the 20q13 amplicon inhibits colorectal cancer cell migration, survival and tumorigenicity. Oncol. Rep. 2009, 21, 531-537.
12. Fejzo, M.S.; Ginther, C.; Dering, J.; Anderson, L.; Venkatessen, N.; Karlan, B.; Slamon, D.J. Knock-down of ovarian cancer amplification target ADRM1 leads to down regulation of GIPC1 and up-regulation of RECK. Genes Chromosomes Cancer 2011, 50, 434-441.
13. Jiao, Y.; Ou, W.; Meng, F.; Zhou, H.; Wang, A. Targeting HSP90 in ovarian cancers with multiple receptor tyrosine kinase coactivation. Mol. Cancer 2011, 10, 125.
14. Peyrat, J.F.; Messaoudi, S.; Brion, J.D.; Alami, M. Inhibitors of the heat shock protein 90: From cancer clinical trials to neurodegenerative diseases. Atlas Genet. Cytogenet. Oncol. Haematol. 2010. Available online: http://AtlasGeneticsOncology.org/Deep/HSP90inCancerTreatmentID20086.html (accessed on 25 January 2013).
15. Mikhailova, O.N.; Gulyaeva, L.F.; Prudnikov, A.V.; Gerasimov, A.V.; Krasilnikov, S.E. Estrogen-metabolizing gene polymorphisms in the assessment of female hormone-dependent cancer risk. Pharmacogenomics J. 2006, 6, 189-193.
16. Gulyaeva, L.F.; Mikhailova, O.N.; PustyInyak, V.O.; Kim, I.V., IV; Gerasimov, A.V.; Krasilnikov, S.E.; Filipenko, M.L.; Pechkovsky, E.V. Comparative analysis of SNP in estrogen-metabolizing enzymes for ovarian, endometrial, and breast cancers in Novosibirsk, Russia. Adv. Exp. Med. Biol. 2008, 617, 359-366.
17. Suzuki, Y.; Demoliere, C.; Kitamura, D.; Takeshita, H.; Deuschle, U.; Watanabe, T. HAX-1, a novel intracellular protein, localized on mitochondria, directly associates with HS1, a substrate of Src family tyrosine kinases. J. Immunol. 1997, 158, 2736-2744.
18. Han, Y.; Chen, Y.S.; Liu, Z.; Bodyak, N.; Rigor, D.; Bisping, E.; Pu, W.T.; Kang, P.M. Overexpression of HAX-1 protects cardiac myocytes from apoptosis through caspase-9 inhibition. Circ. Res. 2006, 99, 415-423.
19. Radhika, V.; Onesime, D.; Ha, J.H.; Dhanasekaran, N. Galpha13 stimulates cell migration through cortactin-interacting protein Hax-1. J. Biol. Chem. 2004, 279, 49406-49413.
20. Ramsay, A.G.; Keppler, M.D.; Jazayeri, M.; Thomas, G.J.; Parsons, M.; Violette, S.; Weinreb, P.; Hart, I.R.; Marshall, J.F. HS1-associated protein X-1 regulates carcinoma cell migration and invasion via clathrin-mediated endocytosis of integrin alphavbeta6. Cancer Res. 2007, 67, 5275-5284.
21. Lolli, G.; Johnson, L.N. CAK-Cyclin-dependent activating kinase: A key kinase in cell cycle control and a target for drugs? Cell Cycle 2005, 4, 572-577.
22. Long, J.; Luo, G.; Liu, C.; Cui, X.; Satoh, K.; Xiao, Z.; Zhang, B.; Xu, J.; Ni, Q.; Li, M.; et al. Development of a unique mouse model for pancreatic cancer lymphatic metastasis. Int. J. Oncol. 2012, 41, 1662-1668.
23. Liu, J.P.; Yuan, S.Z.; Zhang, S.N. Experimental study of MAT1 gene silencing mediated by siRNA in pancreatic cancer. Zhonghua Yi Xue Za Zhi 2007, 87, 2719-2723.
24. Sawiris, G.P.; Sherman-Baust, C.A.; Becker, K.G.; Cheadle, C.; Teichberg, D.; Morin, P.J. Development of a highly specialized cDNA array for the study and diagnosis of epithelial ovarian cancer. Cancer Res. 2002, 62, 2923-2928.
25. Darb-Esfahani, S.; Wirtz, R.M.; Sinn, B.V.; Budczies, J.; Noske, A.; Weichert, W.; Faggad, A.; Scharff, S.; Sehouli, J.; Oskay-Ozcelik, G.; et al. Estrogen receptor 1 mRNA is a prognostic factor in ovarian carcinoma: Determination by kinetic PCR in formalin-fixed paraffin-embedded tissue. Endocr. Relat. Cancer 2009, 16, 1229-1239.
26. Prisco, M.G.; Zannoni, G.F.; de Stefano, I.; Vellone, V.G.; Tortorella, L.; Fagotti, A.; Mereu, L.; Scambia, G.; Gallo, D. Prognostic role of metastasis tumor antigen 1 in patients with ovarian cancer: A clinical study. Hum. Pathol. 2012, 43, 282-288.
27. Jung, E.J.; Avliyakulov, N.K.; Boontheung, P.; Loo, J.A.; Nel, A.E. Pro-oxidative DEP chemicals induce heat shock proteins and an unfolding protein response in a bronchial epithelial cell line as determined by DIGE analysis. Proteomics 2007, 3, 3906-3918.
28. Mosessian, S.; Avliyakulov, N.K.; Mulholland, D.J.; Boontheung, P.; Loo, J.A.; Wu, H. Analysis of PTEN complex assembly and identification of heterogeneous nuclear ribonucleoprotein C as a component of the PTEN-associated complex. J. Biol. Chem. 2009, 284, 30159-30166.