Bone mineral density deficits in childhood cancer survivors: Pathophysiology, prevalence, screening, and management

Korean Journal of Pediatrics

Volumn 56, Issue 2, 2013, Pages 60-67

  Kang, Min Jae ^a   Lim, Jung Sub ^b  

^a Seoul National University Hospital   (South Korea)

^b Korea Cancer Center Hospital   (South Korea)

Author keywords

Bone mineral density; Cancer; Fractures; Risk factors

Indexed keywords

ALKYLATING AGENT; ASPARAGINASE; CALCITRIOL; CALCIUM; CORTICOSTEROID; DAUNORUBICIN; ETOPOSIDE; IFOSFAMIDE; METHOTREXATE; SEX HORMONE; VINCRISTINE; VITAMIN D;

ACUTE LYMPHOBLASTIC LEUKEMIA; BONE DENSITY; BONE MASS; BRAIN TUMOR; CANCER SURVIVOR; CHILD; CHILDHOOD CANCER; COMPUTER ASSISTED TOMOGRAPHY; DRUG MEGADOSE; DUAL ENERGY X RAY ABSORPTIOMETRY; FANCONI RENOTUBULAR SYNDROME; FOLLOW UP; FRACTURE; GENETIC PREDISPOSITION; GROWTH HORMONE DEFICIENCY; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMAN; HYPOGONADISM; LONG TERM SURVIVAL; LYMPHOMA; NEUROPATHY; OSTEOLYSIS; OSTEOPENIA; OSTEOPOROSIS; RECOMMENDED DRUG DOSE; REVIEW; RISK FACTOR; SCREENING; SOLID TUMOR;

EID: 84875081445     PISSN: 17381061     EISSN: 20927258     Source Type: Journal    
DOI: 10.3345/kjp.2013.56.2.60     Document Type: Review

References (69)

1. Robison LL, Armstrong GT, Boice JD, Chow EJ, Davies SM, Donaldson SS, et al. The Childhood Cancer Survivor Study: a National Cancer Institute-supported resource for outcome and intervention research. J Clin Oncol 2009;27:2308-18.
2. National Cancer Registration and Statistics System. Annual report of cancer statistics in Korea [Internet]. Goyang: Korea Central Cancer Registry; [c2012] [cited 2010 Dec 1]. Available from: http://ncrs.cancer.go.kr/index.do.
3. Speechley KN, Barrera M, Shaw AK, Morrison HI, Maunsell E. Health-related quality of life among child and adolescent survivors of childhood cancer. J Clin Oncol 2006;24:2536-43.
4. Robison LL, Green DM, Hudson M, Meadows AT, Mertens AC, Packer RJ, et al. Long-term outcomes of adult survivors of childhood cancer. Cancer 2005;104(11 Suppl):2557-64.
5. Stava CJ, Jimenez C, Vassilopoulou-Sellin R. Endocrine sequelae of cancer and cancer treatments. J Cancer Surviv 2007;1:261-74.
6. Cooper C, Westlake S, Harvey N, Javaid K, Dennison E, Hanson M. Review: developmental origins of osteoporotic fracture. Osteoporos Int 2006;17:337-47.
7. van der Sluis IM, van den Heuvel-Eibrink MM, Hahlen K, Krenning EP, de Muinck Keizer-Schrama SM. Altered bone mineral density and body composition, and increased fracture risk in childhood acute lymphoblastic leukemia. J Pediatr 2002;141:204-10.
8. Rizzoli R, Bianchi ML, Garabedian M, McKay HA, Moreno LA. Maximizing bone mineral mass gain during growth for the prevention of fractures in the adolescents and the elderly. Bone 2010;46:294-305.
9. Mora S, Gilsanz V. Establishment of peak bone mass. Endocrinol Metab Clin North Am 2003;32:39-63.
10. Lim JS, Hwang JS, Lee JA, Kim DH, Park KD, Cheon GJ, et al. Bone mineral density according to age, bone age, and pubertal stages in Korean children and adolescents. J Clin Densitom 2010;13:68-76.
11. Aisenberg J, Hsieh K, Kalaitzoglou G, Whittam E, Heller G, Schneider R, et al. Bone mineral density in young adult survivors of childhood cancer. J Pediatr Hematol Oncol 1998;20:241-5.
12. Barr RD, Simpson T, Webber CE, Gill GJ, Hay J, Eves M, et al. Osteopenia in children surviving brain tumours. Eur J Cancer 1998;34:873-7.
13. Children's Oncology Group. Long-term follow-up guidelines for survivors of childhood, adolescent, and young adult cancers, ver. 3.0 [Internet]. [Philadelphia]: Children's Oncology Group; [c2012] [cited 2012 Oct 15]. Available from: http://www.survivor shipguidelines.org.
14. Kang MJ, Kim SM, Lee YA, Shin CH, Yang SW, Lim JS. Risk factors for osteoporosis in long-term survivors of intracranial germ cell tumors. Osteoporos Int 2012;23:1921-9.
15. Sala A, Talsma D, Webber C, Posgate S, Atkinson S, Barr R. Bone mineral status after treatment of malignant lymphoma in childhood and adolescence. Eur J Cancer Care (Engl) 2007;16:373-9.
16. Holzer G, Krepler P, Koschat MA, Grampp S, Dominkus M, Kotz R. Bone mineral density in long-term survivors of highly malignant osteosarcoma. J Bone Joint Surg Br 2003;85:231-7.
17. Cohen LE, Gordon JH, Popovsky EY, Sainath NN, Feldman HA, Kieran MW, et al. Bone density in post-pubertal adolescent survivors of childhood brain tumors. Pediatr Blood Cancer 2012; 58:959-63.
18. Sklar C. Reproductive physiology and treatment-related loss of sex hormone production. Med Pediatr Oncol 1999;33:2-8.
19. Benmiloud S, Steffens M, Beauloye V, de Wandeleer A, Devogelaer JP, Brichard B, et al. Long-term effects on bone mineral density of different therapeutic schemes for acute lymphoblastic leukemia or non-Hodgkin lymphoma during childhood. Horm Res Paediatr 2010;74:241-50.
20. Hoorweg-Nijman JJ, Kardos G, Roos JC, van Dijk HJ, Netelenbos C, Popp-Snijders C, et al. Bone mineral density and markers of bone turnover in young adult survivors of childhood lymphoblastic leukaemia. Clin Endocrinol (Oxf) 1999;50:237-44.
21. Thomas IH, Donohue JE, Ness KK, Dengel DR, Baker KS, Gurney JG. Bone mineral density in young adult survivors of acute lymphoblastic leukemia. Cancer 2008;113:3248-56.
22. Kelly J, Damron T, Grant W, Anker C, Holdridge S, Shaw S, et al. Cross-sectional study of bone mineral density in adult survivors of solid pediatric cancers. J Pediatr Hematol Oncol 2005;27:248-53.
23. Pfeilschifter J, Diel IJ. Osteoporosis due to cancer treatment: pathogenesis and management. J Clin Oncol 2000;18:1570-93.
24. Krishnamoorthy P, Freeman C, Bernstein ML, Lawrence S, Rodd C. Osteopenia in children who have undergone posterior fossa or craniospinal irradiation for brain tumors. Arch Pediatr Adolesc Med 2004;158:491-6.
25. Halton JM, Atkinson SA, Fraher L, Webber CE, Cockshott WP, Tam C, et al. Mineral homeostasis and bone mass at diagnosis in children with acute lymphoblastic leukemia. J Pediatr 1995;126: 557-64.
26. Arikoski P, Komulainen J, Riikonen P, Voutilainen R, Knip M, Kroger H. Alterations in bone turnover and impaired development of bone mineral density in newly diagnosed children with cancer: a 1-year prospective study. J Clin Endocrinol Metab 1999;84:3174-81.
27. Mandel K, Atkinson S, Barr RD, Pencharz P. Skeletal morbidity in childhood acute lymphoblastic leukemia. J Clin Oncol 2004;22: 1215-21.
28. Wheeler DL, Vander Griend RA, Wronski TJ, Miller GJ, Keith EE, Graves JE. The short-and long-term effects of methotrexate on the rat skeleton. Bone 1995;16:215-21.
29. Syed F, Khosla S. Mechanisms of sex steroid effects on bone. Biochem Biophys Res Commun 2005;328:688-96.
30. Davies JH, Evans BA, Jenney ME, Gregory JW. Effects of chemotherapeutic agents on the function of primary human osteoblast-like cells derived from children. J Clin Endocrinol Metab 2003;88: 6088-97.
31. Hopewell JW. Radiation-therapy effects on bone density. Med Pediatr Oncol 2003;41:208-11.
32. Wasilewski-Masker K, Kaste SC, Hudson MM, Esiashvili N, Mattano LA, Meacham LR. Bone mineral density deficits in survivors of childhood cancer: long-term follow-up guidelines and review of the literature. Pediatrics 2008;121:e705-13.
33. Wagner LM, Neel MD, Pappo AS, Merchant TE, Poquette CA, Rao BN, et al. Fractures in pediatric Ewing sarcoma. J Pediatr Hematol Oncol 2001;23:568-71.
34. Carroll PV, Christ ER, Bengtsson BA, Carlsson L, Christiansen JS, Clemmons D, et al. Growth hormone deficiency in adulthood and the effects of growth hormone replacement: a review. Growth Hormone Research Society Scientific Committee. J Clin Endocrinol Metab 1998;83:382-95.
35. Roman J, Villaizan CJ, Garcia-Foncillas J, Azcona C, Salvador J, Sierrasesumaga L. Chemotherapy-induced growth hormone deficiency in children with cancer. Med Pediatr Oncol 1995;25:90-5.
36. Baroncelli GI, Bertelloni S, Sodini F, Saggese G. Longitudinal changes of lumbar bone mineral density (BMD) in patients with GH deficiency after discontinuation of treatment at final height; timing and peak values for lumbar BMD. Clin Endocrinol (Oxf) 2004;60:175-84.
37. Mattano L. The skeletal remains: porosis and necrosis of bone in the marrow transplantation setting. Pediatr Transplant 2003;7 Suppl 3:71-5.
38. Le Meignen M, Auquier P, Barlogis V, Sirvent N, Contet A, Simeoni MC, et al. Bone mineral density in adult survivors of childhood acute leukemia: impact of hematopoietic stem cell transplantation and other treatment modalities. Blood 2011;118:1481-9.
39. Tauchmanova L, Colao A, Lombardi G, Rotoli B, Selleri C. Bone loss and its management in long-term survivors from allogeneic stem cell transplantation. J Clin Endocrinol Metab 2007;92:4536-45.
40. Haddy TB, Mosher RB, Reaman GH. Osteoporosis in survivors of acute lymphoblastic leukemia. Oncologist 2001;6:278-85.
41. Davies JH, Evans BA, Jones E, Evans WD, Jenney ME, Gregory JW. Osteopenia, excess adiposity and hyperleptinaemia during 2 years of treatment for childhood acute lymphoblastic leukaemia without cranial irradiation. Clin Endocrinol (Oxf) 2004;60:358-65.
42. Tillmann V, Darlington AS, Eiser C, Bishop NJ, Davies HA. Male sex and low physical activity are associated with reduced spine bone mineral density in survivors of childhood acute lymphoblastic leukemia. J Bone Miner Res 2002;17:1073-80.
43. Kaste SC, Jones-Wallace D, Rose SR, Boyett JM, Lustig RH, Rivera GK, et al. Bone mineral decrements in survivors of childhood acute lymphoblastic leukemia: frequency of occurrence and risk factors for their development. Leukemia 2001;15:728-34.
44. Muller HL, Schneider P, Bueb K, Etavard-Gorris N, Gebhardt U, Kolb R, et al. Volumetric bone mineral density in patients with childhood craniopharyngioma. Exp Clin Endocrinol Diabetes 2003;111:168-73.
45. Gurney JG, Kadan-Lottick NS, Packer RJ, Neglia JP, Sklar CA, Punyko JA, et al. Endocrine and cardiovascular late effects among adult survivors of childhood brain tumors: Childhood Cancer Survivor Study. Cancer 2003;97:663-73.
46. Odame I, Duckworth J, Talsma D, Beaumont L, Furlong W, Webber C, et al. Osteopenia, physical activity and health-related quality of life in survivors of brain tumors treated in childhood. Pediatr Blood Cancer 2006;46:357-62.
47. Lewiecki EM, Gordon CM, Baim S, Leonard MB, Bishop NJ, Bianchi ML, et al. International Society for Clinical Densitometry 2007 Adult and Pediatric Official Positions. Bone 2008;43:1115-21.
48. Halton JM, Atkinson SA, Fraher L, Webber C, Gill GJ, Dawson S, et al. Altered mineral metabolism and bone mass in children during treatment for acute lymphoblastic leukemia. J Bone Miner Res 1996;11:1774-83.
49. van der Sluis IM, van den Heuvel-Eibrink MM, Hahlen K, Krenning EP, de Muinck Keizer-Schrama SM. Bone mineral density, body composition, and height in long-term survivors of acute lymphoblastic leukemia in childhood. Med Pediatr Oncol 2000;35:415-20.
50. Marinovic D, Dorgeret S, Lescoeur B, Alberti C, Noel M, Czernichow P, et al. Improvement in bone mineral density and body composition in survivors of childhood acute lymphoblastic leukemia: a 1-year prospective study. Pediatrics 2005;116:e102-8.
51. Jarfelt M, Fors H, Lannering B, Bjarnason R. Bone mineral density and bone turnover in young adult survivors of childhood acute lymphoblastic leukaemia. Eur J Endocrinol 2006;154:303-9.
52. Brennan BM, Rahim A, Adams JA, Eden OB, Shalet SM. Reduced bone mineral density in young adults following cure of acute lymphoblastic leukaemia in childhood. Br J Cancer 1999;79: 1859-63.
53. Brennan BM, Mughal Z, Roberts SA, Ward K, Shalet SM, Eden TO, et al. Bone mineral density in childhood survivors of acute lymphoblastic leukemia treated without cranial irradiation. J Clin Endocrinol Metab 2005;90:689-94.
54. van Beek RD, van den Heuvel-Eibrink MM, Hakvoort-Cammel FG, van den Bos C, van der Pal HJ, Krenning EP, et al. Bone mineral density, growth, and thyroid function in long-term survivors of pediatric Hodgkin's lymphoma treated with chemotherapy only. J Clin Endocrinol Metab 2009;94:1904-9.
55. Ruza E, Sierrasesumaga L, Azcona C, Patino-Garcia A. Bone mineral density and bone metabolism in children treated for bone sarcomas. Pediatr Res 2006;59:866-71.
56. Muller C, Winter CC, Rosenbaum D, Boos J, Gosheger G, Hardes J, et al. Early decrements in bone density after completion of neoadjuvant chemotherapy in pediatric bone sarcoma patients. BMC Musculoskelet Disord 2010;11:287.
57. Othman F, Guo CY, Webber C, Atkinson SA, Barr RD. Osteopenia in survivors of Wilms tumor. Int J Oncol 2002;20:827-33.
58. Al-Tonbary YA, El-Ziny MA, Elsharkawy AA, El-Hawary AK, El-Ashry R, Fouda AE. Bone mineral density in newly diagnosed children with neuroblastoma. Pediatr Blood Cancer 2011;56:202-5.
59. Daniels MW, Wilson DM, Paguntalan HG, Hoffman AR, Bachrach LK. Bone mineral density in pediatric transplant recipients. Transplantation 2003;76:673-8.
60. Kashyap A, Kandeel F, Yamauchi D, Palmer JM, Niland JC, Molina A, et al. Effects of allogeneic bone marrow transplantation on recipient bone mineral density: a prospective study. Biol Blood Marrow Transplant 2000;6(3A):344-51.
61. Kaste SC, Shidler TJ, Tong X, Srivastava DK, Rochester R, Hudson MM, et al. Bone mineral density and osteonecrosis in survivors of childhood allogeneic bone marrow transplantation. Bone Marrow Transplant 2004;33:435-41.
62. Ebeling PR, Thomas DM, Erbas B, Hopper JL, Szer J, Grigg AP. Mechanisms of bone loss following allogeneic and autologous hemopoietic stem cell transplantation. J Bone Miner Res 1999;14: 342-50.
63. Da Silva AN, Heras-Herzig A, Schiff D. Bone health in patients with brain tumors. Surg Neurol 2007;68:525-33.
64. Rhee SY, Hwang YC, Chung HY, Woo JT. Vitamin D and diabetes in Koreans: analyses based on the fourth Korea National Health and Nutrition Examination Survey (KNHANES), 2008-2009. Diabet Med 2012;29:1003-10.
65. Holick MF, Binkley NC, Bischoff-Ferrari HA, Gordon CM, Hanley DA, Heaney RP, et al. Guidelines for preventing and treating vitamin D deficiency and insufficiency revisited. J Clin Endocrinol Metab 2012;97:1153-8.
66. Kaste SC, Rai SN, Fleming K, McCammon EA, Tylavsky FA, Danish RK, et al. Changes in bone mineral density in survivors of childhood acute lymphoblastic leukemia. Pediatr Blood Cancer 2006;46:77-87.
67. Goldbloom EB, Cummings EA, Yhap M. Osteoporosis at presentation of childhood ALL: management with pamidronate. Pediatr Hematol Oncol 2005;22:543-50.
68. Barr RD, Guo CY, Wiernikowski J, Webber C, Wright M, Atkinson S. Osteopenia in children with acute lymphoblastic leukemia: a pilot study of amelioration with Pamidronate. Med Pediatr Oncol 2002;39:44-6.
69. Patterson BC, Wasilewski-Masker K, Ryerson AB, Mertens A, Meacham L. Endocrine health problems detected in 519 patients evaluated in a pediatric cancer survivor program. J Clin Endocrinol Metab 2012;97:810-8.