Vaccinia virus GLV-1h153 is a novel agent for detection and effective local control of positive surgical margins for breast cancer

Breast Cancer Research

Volumn 15, Issue 2, 2013, Pages

  Gholami, Sepideh ^a   Chen, Chun Hao ^a   Belin, Laurence J ^a   Lou, Emil ^b   Fujisawa, Sho ^a   Antonacci, Caroline ^a   Carew, Amanda ^a   Chen, Nanhai G ^c,d   De Brot, Marina ^a   Zanzonico, Pat B ^a   Szalay, Aladar A ^c,d,e   Fong, Yuman ^a  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^b UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d GENELUX CORPORATION   (United States)

^e UNIVERSITY OF WÜRZBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

GREEN FLUORESCENT PROTEIN; ONCOLYTIC VACCINIA VIRUS GLV1H 153; ONCOLYTIC VIRUS; PHOSPHATE BUFFERED SALINE; SODIUM IODIDE SYMPORTER; UNCLASSIFIED DRUG; COTRANSPORTER;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BREAST CANCER; CANCER CELL CULTURE; CANCER DIAGNOSIS; CANCER SURGERY; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CYTOTOXICITY; FEMALE; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; PROTEIN EXPRESSION; TREATMENT DURATION; VIRUS INFECTIVITY; VIRUS REPLICATION; ANIMAL; BREAST NEOPLASMS; CELL DEATH; ENZYME IMMUNOASSAY; GENETICS; METABOLISM; NEOPLASM, RESIDUAL; NUDE MOUSE; PATHOLOGY; PHYSIOLOGY; VACCINIA VIRUS; VIROLOGY;

ANIMALS; BREAST NEOPLASMS; CELL DEATH; FEMALE; GREEN FLUORESCENT PROTEINS; HUMANS; IMMUNOENZYME TECHNIQUES; MICE; MICE, NUDE; NEOPLASM, RESIDUAL; POSITRON-EMISSION TOMOGRAPHY; SYMPORTERS; VACCINIA VIRUS; VIRUS REPLICATION;

EID: 84875079820     PISSN: 14655411     EISSN: 1465542X     Source Type: Journal    
DOI: 10.1186/bcr3404     Document Type: Article

References (24)

1. Balch GC, Mithani SK, Simpson JF, Kelley MC. Accuracy of intraoperative gross examination of surgical margin status in women undergoing partial mastectomy for breast malignancy. Am Surg 2005, 71:22-27; discussion 27-28.
2. Cabioglu N, Hunt KK, Sahin AA, Kuerer HM, Babiera GV, Singletary SE, Whitman GJ, Ross MI, Ames FC, Feig BW, Buchholz TA, Meric-Bernstam F. Role for intraoperative margin assessment in patients undergoing breast-conserving surgery. Ann Surg Oncol 2007, 14:1458-1471. 10.1245/s10434-006-9236-0, 17260108.
3. Buzdar AU, Ibrahim NK, Francis D, Booser DJ, Thomas ES, Theriault RL, Pusztai L, Green MC, Arun BK, Giordano SH, Cristofanilli M, Frye DK, Smith TL, Hunt KK, Singletary SE, Sahin AA, Ewer MS, Buchholz TA, Berry D, Hortobagyi GN. Significantly higher pathologic complete remission rate after neoadjuvant therapy with trastuzumab, paclitaxel, and epirubicin chemotherapy: results of a randomized trial in human epidermal growth factor receptor 2-positive operable breast cancer. J Clin Oncol 2005, 23:3676-3685. 10.1200/JCO.2005.07.032, 15738535.
4. Smitt MC, Nowels KW, Zdeblick MJ, Jeffrey S, Carlson RW, Stockdale FE, Goffinet DR. The importance of the lumpectomy surgical margin status in long-term results of breast conservation. Cancer 1995, 76:259-267. 10.1002/1097-0142(19950715)76:2<259::AID-CNCR2820760216>3.0.CO;2-2, 8625101.
5. Vaha-Koskela MJ, Heikkila JE, Hinkkanen AE. Oncolytic viruses in cancer therapy. Cancer Lett 2007, 254:178-216. 10.1016/j.canlet.2007.02.002, 17383089.
6. He S, Li P, Chen CH, Bakst RL, Chernichenko N, Yu YA, Chen N, Szalay AA, Yu Z, Fong Y, Wong RJ. Effective oncolytic vaccinia therapy for human sarcomas. J Surg Res 2012, 175:e53-60. 10.1016/j.jss.2011.11.1030, 22341347.
7. Yu YA, Shabahang S, Timiryasova TM, Zhang Q, Beltz R, Gentschev I, Goebel W, Szalay AA. Visualization of tumors and metastases in live animals with bacteria and vaccinia virus encoding light-emitting proteins. Nat Biotechnol 2004, 22:313-320. 10.1038/nbt937, 14990953.
8. Fenner F. Nature, nurture and my experience with smallpox eradication. Med J Aust 1999, 171:638-641.
9. Gholami S, Haddad D, Chen CH, Chen NG, Zhang Q, Zanzonico PB, Szalay AA, Fong Y. Novel therapy for anaplastic thyroid carcinoma cells using an oncolytic vaccinia virus carrying the human sodium iodide symporter. Surgery 2011, 150:1040-1047. 10.1016/j.surg.2011.09.010, 22136819.
10. Haddad D, Chen NG, Zhang Q, Chen CH, Yu YA, Gonzalez L, Carpenter SG, Carson J, Au J, Mittra A, Gonen M, Zanzonico PB, Fong Y, Szalay AA. Insertion of the human sodium iodide symporter to facilitate deep tissue imaging does not alter oncolytic or replication capability of a novel vaccinia virus. J Transl Med 2011, 9:36. 10.1186/1479-5876-9-36, 3080806, 21453532.
11. Jacobs L. Positive margins: the challenge continues for breast surgeons. Ann Surg Oncol 2008, 15:1271-1272. 10.1245/s10434-007-9766-0, 2277448, 18320287.
12. Veronesi U, Luini A, Galimberti V, Zurrida S. Conservation approaches for the management of stage I/II carcinoma of the breast: Milan Cancer Institute trials. World J Surg 1994, 18:70-75. 10.1007/BF00348194, 8197779.
13. van Dongen JA, Bartelink H, Fentiman IS, Lerut T, Mignolet F, Olthuis G, van der Schueren E, Sylvester R, Tong D, Winter J, van Zijl K. Factors influencing local relapse and survival and results of salvage treatment after breast-conserving therapy in operable breast cancer: EORTC trial 10801, breast conservation compared with mastectomy in TNM stage I and II breast cancer. Eur J Cancer 1992, 28A:801-805.
14. Anscher MS, Jones P, Prosnitz LR, Blackstock W, Hebert M, Reddick R, Tucker A, Dodge R, Leight G, Iglehart JD. Local failure and margin status in early-stage breast carcinoma treated with conservation surgery and radiation therapy. Ann Surg 1993, 218:22-28. 10.1097/00000658-199307000-00005, 1242896, 8328825.
15. Singletary SE. Surgical margins in patients with early-stage breast cancer treated with breast conservation therapy. Am J Surg 2002, 184:383-393. 10.1016/S0002-9610(02)01012-7, 12433599.
16. Schnitt SJ, Abner A, Gelman R, Connolly JL, Recht A, Duda RB, Eberlein TJ, Mayzel K, Silver B, Harris JR. The relationship between microscopic margins of resection and the risk of local recurrence in patients with breast cancer treated with breast-conserving surgery and radiation therapy. Cancer 1994, 74:1746-1751. 10.1002/1097-0142(19940915)74:6<1746::AID-CNCR2820740617>3.0.CO;2-Y, 8082077.
17. NIH Consensus Conference Treatment of early-stage breast cancer. JAMA 1991, 265:391-395. NIH Consensus Conference.
18. Klimberg VS, Harms S, Korourian S. Assessing margin status. Surg Oncol 1999, 8:77-84. 10.1016/S0960-7404(99)00031-6, 10732959.
19. Lin SF, Price DL, Chen CH, Brader P, Li S, Gonzalez L, Zhang Q, Yu YA, Chen N, Szalay AA, Fong Y, Wong RJ. Oncolytic vaccinia virotherapy of anaplastic thyroid cancer in vivo. J Clin Endocrinol Metab 2008, 93:4403-4407. 10.1210/jc.2008-0316, 18697871.
20. Rajecki M, Sarparanta M, Hakkarainen T, Tenhunen M, Diaconu I, Kuhmonen V, Kairemo K, Kanerva A, Airaksinen AJ, Hemminki A. SPECT/CT imaging of hNIS-expression after intravenous delivery of an oncolytic adenovirus and 131I. PLoS One 2012, 7:e32871. 10.1371/journal.pone.0032871, 3296755, 22412937.
21. Barton KN, Stricker H, Elshaikh MA, Pegg J, Cheng J, Zhang Y, Karvelis KC, Lu M, Movsas B, Freytag SO. Feasibility of adenovirus-mediated hNIS gene transfer and 131I radioiodine therapy as a definitive treatment for localized prostate cancer. Mol Ther 2011, 19:1353-1359. 10.1038/mt.2011.89, 3129572, 21587209.
22. Spitzweg C, Baker CH, Bergert ER, O'Connor MK, Morris JC. Image-guided radioiodide therapy of medullary thyroid cancer after carcinoembryonic antigen promoter-targeted sodium iodide symporter gene expression. Hum Gene Ther 2007, 18:916-924. 10.1089/hum.2007.081, 17931047.
23. Wapnir IL, van de Rijn M, Nowels K, Amenta PS, Walton K, Montgomery K, Greco RS, Dohan O, Carrasco N. Immunohistochemical profile of the sodium/iodide symporter in thyroid, breast, and other carcinomas using high density tissue microarrays and conventional sections. J Clin Endocrinol Metab 2003, 88:1880-1888. 10.1210/jc.2002-021544, 12679487.
24. Wapnir IL, Goris M, Yudd A, Dohan O, Adelman D, Nowels K, Carrasco N. The Na+/I- symporter mediates iodide uptake in breast cancer metastases and can be selectively down-regulated in the thyroid. Clin Cancer Res 2004, 10:4294-4302. 10.1158/1078-0432.CCR-04-0074, 15240514.