Psychotropic drugs and risk of motor vehicle accidents: A population-based case-control study

British Journal of Clinical Pharmacology

Volumn 75, Issue 4, 2013, Pages 1125-1133

  Chang, Chia Ming ^a   Wu, Erin Chia Hsuan ^b   Chen, Chuan Yu ^c   Wu, Kuan Yi ^a   Liang, Hsin Yi ^a   Chau, Yeuk Lun ^a   Wu, Chi Shin ^d   Lin, Keh Ming ^e   Tsai, Hui Ju ^e,f  

^a CHANG GUNG UNIVERSITY   (Taiwan)

^b TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^c NATIONAL YANG MING UNIVERSITY   (Taiwan)

^d FAR EASTERN MEMORIAL HOSPITAL   (Taiwan)

^e NATIONAL HEALTH RESEARCH INSTITUTES   (Taiwan)

^f NORTHWESTERN UNIVERSITY   (United States)

Author keywords

Antidepressants; Antipsychotics; Benzodiazepines; Motor vehicle accidents; Psychotropic drugs; Z drugs

Indexed keywords

AMISULPRIDE; ANTIDEPRESSANT AGENT; ARIPIPRAZOLE; BENZODIAZEPINE DERIVATIVE; CENTRAL NERVOUS SYSTEM AGENTS; CHLORPROMAZINE; CHLORPROTHIXENE; CLOPENTHIXOL; CLOTIAPINE; CLOZAPINE; DROPERIDOL; FLUPENTIXOL; FLUPHENAZINE; HALOPERIDOL; LOXAPINE; NEUROLEPTIC AGENT; OLANZAPINE; PERPHENAZINE; PIMOZIDE; PSYCHOTROPIC AGENT; QUETIAPINE; RISPERIDONE; SULPIRIDE; THIORIDAZINE; TIOTIXENE; TRIFLUOPERAZINE; UNCLASSIFIED DRUG; UNINDEXED DRUG; Z DRUG; ZIPRASIDONE; ZOTEPINE;

ADULT; ARTICLE; CHARLSON COMORBIDITY INDEX; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFICACY; DRUG EXPOSURE; DRUG SAFETY; DRUG USE; FEMALE; HEALTH SERVICE; HUMAN; MAJOR CLINICAL STUDY; MALE; MEDICAL RECORD; OUTPATIENT DEPARTMENT; POPULATION BASED CASE CONTROL STUDY; PRESCRIPTION; PRIORITY JOURNAL; PSYCHIATRIC DEPARTMENT; PSYCHOPHARMACOLOGY; RISK ASSESSMENT; RISK FACTOR; TRAFFIC ACCIDENT; URBAN POPULATION;

ACCIDENTS, TRAFFIC; ADOLESCENT; ADULT; AGED; ANTIDEPRESSIVE AGENTS; ANTIPSYCHOTIC AGENTS; BENZODIAZEPINES; CASE-CONTROL STUDIES; DATABASES, FACTUAL; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HUMANS; HYPNOTICS AND SEDATIVES; MALE; MIDDLE AGED; TAIWAN;

EID: 84875072275     PISSN: 03065251     EISSN: 13652125     Source Type: Journal    
DOI: 10.1111/j.1365-2125.2012.04410.x     Document Type: Article

References (40)

1. Murray CJ, Lopez AD. Global mortality, disability, and the contribution of risk factors: global burden of disease study. Lancet 1997; 349: 1436-1442.
2. Health statistics, Department of Health. 2011 Available at http://www.doh.gov.tw/CHT2006/DM/DM2_2.aspx?now_fod_list_no=10359&class_no=440&level_no=3 (last accessed 2 January 2011).
3. Traffic accident statistics: Bureau of Police, Department of Internal Affair. 2012 Available at http://www.hpb.gov.tw/files/11-1000-148-1.php (last accessed 19 June 2012).
4. Dassanayake T, Michie P, Carter G, Jones A. Effects of benzodiazepines, antidepressants and opioids on driving: a systematic review and meta-analysis of epidemiological and experimental evidence. Drug Saf 2011; 34: 125-156.
5. Ravera S, van Rein N, de Gier JJ, de Jong-van den Berg LT. Road traffic accidents and psychotropic medication use in the Netherlands: a case-control study. Br J Clin Pharmacol 2011; 72: 505-513.
6. Gibson JE, Hubbard RB, Smith CJ, Tata LJ, Britton JR, Fogarty AW. Use of self-controlled analytical techniques to assess the association between use of prescription medications and the risk of motor vehicle crashes. Am J Epidemiol 2009; 169: 761-768.
7. Neutel CI. Risk of traffic accident injury after a prescription for a benzodiazepine. Ann Epidemiol 1995; 5: 239-244.
8. Barbone F, McMahon AD, Davey PG, Morris AD, Reid IC, McDevitt DG, MacDonald TM. Association of road-traffic accidents with benzodiazepine use. Lancet 1998; 352: 1331-1336.
9. Thomas RE. Benzodiazepine use and motor vehicle accidents. Systematic review of reported association. Can Fam Physician 1998; 44: 799-808.
10. O'Neill D. Benzodiazepines and driver safety. Lancet 1998; 352: 1324-1325.
11. McGwin G Jr, Sims RV, Pulley L, Roseman JM. Relations among chronic medical conditions, medications, and automobile crashes in the elderly: a population-based case-control study. Am J Epidemiol 2000; 152: 424-431.
12. Kurzthaler I, Wambacher M, Golser K, Sperner G, Sperner-Unterweger B, Haidekker A, Pavlic M, Kemmler G, Fleischhacker WW. Alcohol and/or benzodiazepine use in injured road users. Hum Psychopharmacol 2003; 18: 361-367.
13. Kelly E, Darke S, Ross J. A review of drug use and driving: epidemiology, impairment, risk factors and risk perceptions. Drug Alcohol Rev 2004; 23: 319-344.
14. Engeland A, Skurtveit S, Morland J. Risk of road traffic accidents associated with the prescription of drugs: a registry-based cohort study. Ann Epidemiol 2007; 17: 597-602.
15. Ray WA, Fought RL, Decker MD. Psychoactive drugs and the risk of injurious motor vehicle crashes in elderly drivers. Am J Epidemiol 1992; 136: 873-883.
16. Ramaekers JG. Antidepressants and driver impairment: empirical evidence from a standard on-the-road test. J Clin Psychiatry 2003; 64: 20-29.
17. Wingen M, Ramaekers JG, Schmitt JA. Driving impairment in depressed patients receiving long-term antidepressant treatment. Psychopharmacology (Berl) 2006; 188: 84-91.
18. Bramness JG, Skurtveit S, Neutel CI, Morland J, Engeland A. Minor increase in risk of road traffic accidents after prescriptions of antidepressants: a study of population registry data in Norway. J Clin Psychiatry 2008; 69: 1099-1103.
19. Judd LL. The effect of antipsychotic drugs on driving and driving related psychomotor functions. Accid Anal Prev 1985; 17: 319-322.
20. Are benzodiazepines a risk factor for road accidents? 'Benzodiazepine/Driving' Collaborative Group. Drug Alcohol Depend 1993; 33: 19-22.
21. Brunnauer A, Laux G, Geiger E, Moller HJ. The impact of antipsychotics on psychomotor performance with regards to car driving skills. J Clin Psychopharmacol 2004; 24: 155-160.
22. Gustavsen I, Bramness JG, Skurtveit S, Engeland A, Neutel I, Morland J. Road traffic accident risk related to prescriptions of the hypnotics zopiclone, zolpidem, flunitrazepam and nitrazepam. Sleep Med 2008; 9: 818-822.
23. MacDonald TM. Association of road-traffic accidents with benzodiazepine use. Lancet 1998; 352: 2019-2020.
24. Movig KL, Mathijssen MP, Nagel PH, van Egmond T, de Gier JJ, Leufkens HG, Egberts AC. Psychoactive substance use and the risk of motor vehicle accidents. Accid Anal Prev 2004; 36: 631-636.
25. Hemmelgarn B, Suissa S, Huang A, Boivin JF, Pinard G. Benzodiazepine use and the risk of motor vehicle crash in the elderly. JAMA 1997; 278: 27-31.
26. Hebert C, Delaney JA, Hemmelgarn B, Levesque LE, Suissa S. Benzodiazepines and elderly drivers: a comparison of pharmacoepidemiological study designs. Pharmacoepidemiol Drug Saf 2007; 16: 845-849.
27. Natioanl Health Insurance Research Database (NHIRD). Available at http://w3.nhri.org.tw/nhird/ (last accessed 2 December 2011).
28. Yang YH, Lai JN, Lee CH, Wang JD, Chen PC. Increased risk of hospitalization related to motor vehicle accidents among people taking zolpidem: a case-crossover study. J Epidemiol 2011; 21: 37-43.
29. World Health Organization, Collaborating Centre for Drug Statistics Methodology. Guidelines for ATC Classification and DDD Assignment. Oslo 2009 [updated 19 December 2011]; Available at http://www.whocc.no/atc_ddd_index/ (last accessed 14 March 2012).
30. Sansone RA, Lam C, Wiederman MW. History of attempted suicide and reckless driving: a cross-sectional study in primary care. Prim Care Companion J Clin Psychiatry 2010; 12: PCC.09m00888.
31. Charlson ME, Pompei P, Ales KL, MacKenzie CR. A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chronic Dis 1987; 40: 373-383.
32. Yang CY, Chiu JF, Lin MC, Cheng MF. Geographic variations in mortality from motor vehicle crashes in Taiwan. J Trauma 1997; 43: 74-77.
33. Christophersen AS, Morland J. Frequent detection of benzodiazepines in drugged drivers in Norway. Traffic Inj Prev 2008; 9: 98-104.
34. Orriols L, Philip P, Moore N, Castot A, Gadegbeku B, Delorme B, Mallaret M, Lagarde E, CESIR Research Group. Benzodiazepine-like hypnotics and the associated risk of road traffic accidents. Clin Pharmacol Ther 2011; 89: 595-601.
35. De Las Cuevas C, Ramallo Y, Sanz EJ. Psychomotor performance and fitness to drive: the influence of psychiatric disease and its pharmacological treatment. Psychiatry Res 2010; 176: 236-241.
36. Orriols L, Delorme B, Gadegbeku B, Tricotel A, Contrand B, Laumon B, Salmi LR, Lagarde E, CESIR research group. Prescription medicines and the risk of road traffic crashes: a French registry-based study. PLoS Med 2010; 7: e1000366.
37. Hooper TI, DeBakey SF, Pearse L, Pratt S, Hoffman KJ. The use of electronic pharmacy data to investigate prescribed medications and fatal motor vehicle crashes in a military population, 2002-2006. Accid Anal Prev 2010; 42: 261-268.
38. Wylie KR, Thompson DJ, Wildgust HJ. Effects of depot neuroleptics on driving performance in chronic schizophrenic patients. J Neurol Neurosurg Psychiatry 1993; 56: 910-913.
39. Grabe HJ, Wolf T, Gratz S, Laux G. The influence of clozapine and typical neuroleptics on information processing of the central nervous system under clinical conditions in schizophrenic disorders: implications for fitness to drive. Neuropsychobiology 1999; 40: 196-201.
40. Brunnauer A, Laux G, Geiger E, Soyka M, Moller HJ. Antidepressants and driving ability: results from a clinical study. J Clin Psychiatry 2006; 67: 1776-1781.