Absence of bi-directional cross-resistance of thrombopoietin receptor agonists in chronic refractory immune thrombocytopenia: Possible role of MPL polymorphisms

British Journal of Haematology

Volumn 161, Issue 1, 2013, Pages 142-144

  Polverelli, Nicola ^a   Palandri, Francesca ^a   Iacobucci, Ilaria ^a   Catani, Lucia ^a   Martinelli, Giovanni ^a   Vianelli, Nicola ^a  

^a UNIVERSITY OF BOLOGNA   (Italy)

Author keywords

Eltrombopag; Immune thrombocytopenia; Romiplostim

Indexed keywords

AZATHIOPRINE; CORTICOSTEROID; CYCLOPHOSPHAMIDE; CYCLOSPORIN; DANAZOL; ELTROMBOPAG; IMMUNOGLOBULIN; PREDNISONE; RECOMBINANT THROMBOPOIETIN; RETICULIN; RITUXIMAB; ROMIPLOSTIM; THROMBOPOIETIN RECEPTOR AGONIST; UNCLASSIFIED DRUG; VINCRISTINE;

ADULT; AGED; BONE MARROW BIOPSY; CASE REPORT; CHROMOSOME 1; CHRONIC REFRACTORY IMMUNE THROMBOCYTOPENIA; COMORBIDITY; CROSS RESISTANCE; DRUG DOSE ESCALATION; DRUG MEGADOSE; FEMALE; HUMAN; LETTER; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM; SPLENECTOMY; THROMBOCYTOPENIA; TREATMENT RESPONSE;

ADULT; AGED; AUTOIMMUNE DISEASES; BENZOATES; DRUG RESISTANCE; DRUG THERAPY, COMBINATION; FEMALE; HUMANS; HYDRAZINES; POLYMORPHISM, SINGLE NUCLEOTIDE; PYRAZOLES; RECEPTORS, FC; RECEPTORS, THROMBOPOIETIN; RECOMBINANT FUSION PROTEINS; THROMBOCYTOPENIA; THROMBOPOIETIN;

EID: 84875053836     PISSN: 00071048     EISSN: 13652141     Source Type: Journal    
DOI: 10.1111/bjh.12186     Document Type: Letter

References (8)

1. Aoki, T., Harada, Y., Matsubara, E., Suzuki, T., Oyama, T., Kasai, M., Uchida, T. & Ogura, M. (2012) Thrombopoietin receptor agonists in refractory immune thrombocytopenia: differential responses to eltrombopag and romiplostim: a case report and possible explanations. Journal of Clinical Pharmacy and Therapeutics, 37, 729-732.
2. Bussel, J.B., Kuter, D.J., Pullarkat, V., Lyons, R.M., Guo, M. & Nichol, J.L. (2009) Safety and efficacy of long-term treatment with romiplostim in thrombocytopenic patients with chronic ITP. Blood, 113, 2161-2171.
3. Cheng, G., Saleh, M.N., Marcher, C., Vasey, S., Mayer, B., Aivado, M., Arning, M., Stone, N.L. & Bussel, J.B. (2011) Eltrombopag for management of chronic immune thrombocytopenia (RAISE): a 6-month, randomised, phase 3 study. Lancet, 377, 393-402.
4. Erhardt, J.A., Erickson-Miller, C.L., Aivado, M., Abboud, M., Pillarisetti, K. & Toomey, J.R. (2009) Comparative analyses of the small molecule thrombopoietin receptor agonist Eltrombopag and thrombopoietin on in vitro platelet function. Experimental Hematolology, 37, 1030-1037.
5. Garnock-Jones, K.P. & Keam, S.J. (2009) Eltrombopag. Drugs, 69, 567-576.
6. Kuter, D.J. (2011) Romiplostim. Cancer Treatment and Research, 157, 267-288.
7. Rodeghiero, F., Stasi, R., Gernsheimer, T., Michel, M., Provan, D., Arnold, D.M., Bussel, J.B., Cines, D.B., Chong, B.H., Cooper, N., Godeau, B., Lechner, K., Mazzucconi, M.G., McMillan, R., Sanz, M.A., Imbach, P., Blanchette, V., Kühne, T., Ruggeri, M. & George, J.N. (2009) Standardization of terminology, definitions and outcome criteria in immune thrombocytopenic purpura of adults and children: report from an international working group. Blood, 113, 2386-2393.
8. Van den Oudenrijn, S., De Haas, M. & Von dem Borne, A.E. (2001) Screening for c-mpl mutations in patients with congenital amegakaryocytic thrombocytopenia identifies a polymorphism. Blood, 97, 3675-3676.