Cervical lymph node metastases of squamous cell carcinoma from an unknown primary site: A favourable prognosis subset of patients with CUP

Clinical and Translational Oncology

Volumn 11, Issue 6, 2009, Pages 340-

  Pavlidis, Nicholas ^a   Pentheroudakis, George ^a   Plataniotis, George ^b  

^a UNIVERSITY HOSPITAL OF IOANNINA   (Greece)

^b ABERDEEN ROYAL INFIRMARY   (United Kingdom)

Author keywords

Cancer of unknown primary; Cervical metastases; Squamous cell carcinoma

Indexed keywords

ANTINEOPLASTIC AGENT; TUMOR MARKER;

ADJUVANT THERAPY; ALCOHOLISM; CANCER OF UNKNOWN PRIMARY SITE; CHEMISTRY; CLINICAL TRIAL; DIAGNOSTIC IMAGING; FEMALE; GENE EXPRESSION PROFILING; HUMAN; LYMPH NODE METASTASIS; LYMPHADENECTOMY; MALE; METASTASIS; METHODOLOGY; MULTIMODALITY CANCER THERAPY; NECK; NECK DISSECTION; PATHOLOGY; PROGNOSIS; REVIEW; RISK FACTOR; SMOKING; SQUAMOUS CELL CARCINOMA; TONSILLECTOMY; TUMOR RECURRENCE;

ALCOHOLISM; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; CARCINOMA, SQUAMOUS CELL; CLINICAL TRIALS AS TOPIC; COMBINED MODALITY THERAPY; DIAGNOSTIC IMAGING; FEMALE; GENE EXPRESSION PROFILING; HUMANS; LYMPH NODE EXCISION; LYMPHATIC METASTASIS; MALE; NECK; NECK DISSECTION; NEOPLASM RECURRENCE, LOCAL; NEOPLASMS, UNKNOWN PRIMARY; PROGNOSIS; RADIOTHERAPY, ADJUVANT; RISK FACTORS; SMOKING; TONSILLECTOMY; TUMOR MARKERS, BIOLOGICAL;

EID: 84875044476     PISSN: 1699048X     EISSN: 16993055     Source Type: Journal    
DOI: 10.1007/s12094-009-0367-1     Document Type: Review

References (58)

1. Pavlidis N, Briasoulis E, Hainsworth J, Greco FA (2003) Diagnostic and therapeutic management of cancer of unknown primary. Eur J Cancer 39:1990-2005. (Pubitemid 37297755)
2. Comess MS, Beahrs OH, Dockerty MB (1957) Cervical metastasis from occult carcinoma. Surg Gynecol Obstet 104:607-617.
3. Jereczek-Fossa BA, Jassem J, Orecchia R (2004) Cervical lymph node metastases of squamous cell carcinoma from an unknown primary. Cancer Treat Rev 30: 153-164. (Pubitemid 38418053)
4. Grau C, Johansen LV, Jakobsen J et al (2000) Cervical lymph node metastases from unknown primary tumours. Results from a national survey by the Danish Society for Head and Neck Oncology. Radiother Oncol 55:121-129.
5. Psyrri A, Di Maio D (2008) Human papillomavirus in cervical and head neck cancer. Nat Clin Pract Oncol 5:24-31. (Pubitemid 351512426)
6. Haas I, Hoffmann KT, Enger R, Ganzer U (2002) Diagnostic strategies in cervical carcinoma of an unknown primary (CUP). Eur Arch Otorhinolaryngol 259:325-333. (Pubitemid 34762310)
7. Califano J, Westra W, Koch W et al (1999) Unknown primary head and neck squamous cell carcinoma: molecular identifi cation of the site of origin. J Natl Cancer Inst 91:599-603.
8. Deshpande AM, Wong DT (2008) Molecular mechanisms of head and neck cancer. Expert Rev Anticancer Ther 8:799-809.
9. Seiwert T, Cohen E (2008) Targeting angiogenesis in head and neck cancer. Semin Oncol 35:274-285. (Pubitemid 351787696)
10. Pentheroudakis G, Briasoulis E, Pavlidis N (2007) Cancer of unknown primary site: missing primary or missing biology? Oncologist 12:418-425. (Pubitemid 46698719)
11. Pentheroudakis G, Pavlidis N (2006) Perspectives for targeted therapies in cancer of unknown primary site. Cancer Treat Rev 32:637-644. (Pubitemid 44645027)
12. de Braud F, Al-Sarraf M (1993) Diagnosis and management of squamous cell carcinoma of unknown primary tumor site of the neck. Semin Oncol 20:273-278. (Pubitemid 23171897)
13. Molinari R, Cantu G, Ghiesa F et al (1997) A statistical approach to detection of the primary cancer based on the site of neck lymph node metastases. Tumori 63:267-282.
14. Mui S, Li T, Rasgon M et al (1997) Efficacy and cost effectiveness of multihole fine-needle aspiration of squamous cell carcinoma or head and neck masses. Laryngoscope 107:759-764. (Pubitemid 27250999)
15. Pisharodi LR (1997) False negative diagnosis in fi ne needle aspiration of squamous cell carcinoma of head and neck. Diagn Cytopathol 17:70-73.
16. Mendenhall W, Mancuso A, Parsons J et al (1998) Diagnostic evaluation of squamous cell carcinoma metastatic to cervical lymph nodes from an unknown head and neck primary site. Head Neck 20:739-744. (Pubitemid 28462831)
17. Lee WY, Hsiao JR, Jin YT et al (2000) Epstein- Barr virus detection in neck metastases by in situ hybridization in fine-needle aspiration cytologic studies: an aid diffentiating the primary site. Head Neck 22:336-340.
18. Gillison ML, Koch WM, Capone RB et al (2000) Evidence for a casual association between human papillomavirus and a subset of head and neck cancers. J Natl Cancer Inst 92:709-720. (Pubitemid 30365531)
19. Adams JR, O'Brien CJ (2002) Unknown primary squamous cell carcinoma of the head and neck: a review of diagnosis, treatment and outcomes. Asian J Surg 25:188-193. (Pubitemid 34595866)
20. Mancuso AA (1984) Cervical lymph node metastases: oncologic imaging and diagnosis. Int J Rad Onc Biol Phys 10:411-423. (Pubitemid 14110177)
21. Muraki AS, Mancuso AA, Harnsberger HR (1984) Metastatic cervical adenopathy from tumours of unknown origin: the role of CT. Radiology 152:749-753. (Pubitemid 14060626)
22. Tien RD, Hesselink JR, Chu PK, Jerzy S (1991) Improved detection and delineation of head and neck lesions with fat suppression spin-echo MR imaging. AJNR Am J Neuroradiol 12:19-24.
23. Kassel EE, Keller MA, Kucharczyk W (1989) MRI of the floor of the mouth, tongue and orohypopharynx. Radiol Clin North Am 2:331-351. (Pubitemid 19071807)
24. Rusthoven KE, Koshy M, Paulino AC (2004) The role of fluorodeoxyglucose positron emission tomography in cervical lymph node metastases from an unknown primary tumor. Cancer 101:2641-2649. (Pubitemid 39532297)
25. Johansen J, Eigtved A, Buchwald C et al (2002) Implication of 18F-fluoro-2-deoxy-D-glucose position emission tomography on management of carcinoma of un-known primary in the head and neck: a Danish cohort study. Laryngoscope 112:2009-2014. (Pubitemid 35283464)
26. Fleming AJ Jr, Smith SP Jr, Paul CM et al (2007) Impact of [18F]-2-fluorodeoxyglucose-positron emission tomography/computed tomography on previously untreated head and neck cancer patients. Laryngoscope 117:1173-1179. (Pubitemid 47015665)
27. Delgado-Bolton R, Fernandez-Perez C, Gonzalez- Matez A, Carreras JL (2003) Metaanalysis of the performance of FDG-PET in primary tumour detection in un-known primary tumours. J Nucl Med 44:1301-1314.
28. Wartski M, Le Stanc E, Gontier E et al (2007) In search of an unknown primary tumour presenting with cervical metastases: performance of hybrid FDG-PET-CT. Nucl Med Common 28:365-371. (Pubitemid 46569169)
29. Kwee TC, Kwee RM (2009) Combined FDGPET/CT for the detection of un-known primary tumors: systematic review and metaanalysis. Eur Radiol 19:731-744.
30. Beldi D, Jereczek-Fossa BA, D'Onofrio A et al. (2007) Role of radiotherapy in the treatment of cervical lymph node metastases from an unknown primary site: retrospective analysis of 113 patients. Int J Radiat Oncol Biol Phys 69:1051- 1058. (Pubitemid 47625836)
31. Huang CC, Tseng FY, Yeh TH et al (2008) Prognostic factors of unknown primary head and neck squamous cell carcinoma. Otolaryngol Head Neck Surg 139:429-435.
32. Coster JR, Foote RL, Olsen KD et al (1992) Cervical nodal metastasis of squamous cell carcinoma of unknown origin: indications for withholding radiation therapy. Int J Radiat Oncol Biol Phys 23:743-749.
33. Iganej S, Kagan R, Anderson P et al (2002) Metastatic squamous cell carcinoma of the neck from an unknown primary: management options and patterns of relapse. Head Neck 24:236-246. (Pubitemid 34193248)
34. Nieder C, Gregoire V, Ang K (2001) Cervical lymph node metastases from occult squamous cell carcinoma: cut down a tree to get an apple? Int J Radiat Oncol Biol Phys 50:727-733. (Pubitemid 32515327)
35. Colletier PJ, Garden AS, Morrison WH et al (1998) Postoperative radiation for squamous cell carcinoma metastatic to cervical lymph nodes from an unknown primary site: outcomes and patterns of failure. Head Neck 20:674-681. (Pubitemid 28462821)
36. Erkal HS, Mendenhall WM, Amdur RJ et al (2001) Squamous cell carcinomas metastatic to cervical lymph nodes from an unknown head-andneck mucosal site treated with radiation therapy alone or in combination with neck dissection. Int J Radiat Oncol Biol Phys 50:55-63.
37. Erkal HS, Mendenhall WM, Amdur RJ et al (2001) Squamous cell carcinomas metastatic to cervical lymph nodes from an unknown head-andneck mucosal site treated with radiation therapy with palliative intent. Radiother Oncol 59:319- 321. (Pubitemid 32432936)
38. Klop WM, Balm AJ, Keus RB et al (2000) Diagnosis and treatment of 39 patients with cervical lymph node metastases of squamous cell carcinoma of unknown origin referred to Netherlands Cancer Institute/Antoni van Leeuwenhoek Hospital, 1979-1998. Ned Tijdschr Geneeskd 144:1355-1360. (Pubitemid 30451158)
39. Jesse RH, Perez CA, Fletcher GH (1973) Cervical lymph node metastasis: unknown primary cancer. Cancer 31:854-859.
40. Bataini JP, Rodriguez J, Jaulerry C et al (1987) Treatment of metastatic neck nodes secondary to an occult epidermoid carcinoma of the head-andneck. Laryngoscope 97:1080-1084. (Pubitemid 18020200)
41. Maulard C, Housset M, Brunel P et al (1992) Postoperative radiation therapy for cervical lymph node metastases from an occult squamous cell carcinoma. Laryngoscope 102:884-890.
42. Lefebvre JL, Coche-Dequeant B, Van JT et al (1990) Cervical lymph nodes from an unknown primary tumour in 190 patients. Am J Surg 160:443-446. (Pubitemid 20346340)
43. Koch WM, Bhatti N, Williams MF, Eisele D (2001) Oncologic rationale for bilateral tonsillectomy in head and neck squamous cell carcinoma of unknown primary source. Otolaryngol Head Neck Surg 124:331-333. (Pubitemid 32230530)
44. Kothari P, Randhawa P, Farrell R (2008) Role of tonsillectomy in the search for a squamous cell carcinoma from an unknown primary in the head and neck. Br J Oral Maxillof Surg 46:283-287. (Pubitemid 351625794)
45. Adelstein DJ, Li Y, Adams GI et al (2003) An intergroup phase III comparison of standard radiation therapy and two schedules of concurrent chemoradiotherapy in patients with unresectable squamous cell head and neck cancer. J Clin Oncol 21:92-98.
46. Bernier J, Domenge C, Ozsahin M et al (2004) Postoperative irradiation with or without concomitant chemotherapy for locally advanced head and neck cancer. N Engl J Med 350:1945-1952. (Pubitemid 38580197)
47. Cooper JS, Pajak TF, Forastiere AA et al (2004) Postoperative concurrent radiotherapy and chemotherapy for high-risk squamous-cell carcinoma of the head and neck. N Engl J Med 350:1937-1944.
48. Forastiere AA, Goepfert H, Maor M et al (2003) Concurrent chemotherapy and radiotherapy for organ preservation in advanced laryngeal cancer. N Engl J Med 349:2091-2098. (Pubitemid 37464533)
49. Vermorken JB, Mesia R, Rivera F et al (2008) Platinum-based chemotherapy plus cetuximab in head and neck cancer. N Engl J Med 359:1116- 1127.
50. de Braud F, Heilbrun LK, Ahmed K et al (1989) Metastatic squamous cell carcinoma of an unknown primary localized to the neck. Advantages of an aggressive treatment. Cancer 64:510-515. (Pubitemid 19180415)
51. Argiris A, Smith SM, Stenson K et al (2003) Concurrent chemoradiotherapy for N2 or N3 squamous cell carcinoma of the head and neck from an occult primary. Ann Oncol 14:1306-1311. (Pubitemid 37039060)
52. Shehadeh NJ, Ensley JF, Kucuk O et al (2006) Benefit of postoperative chemoradiotherapy for patients with unknown primary squamous cell carcinoma of the head and neck. Head Neck 28:1090-1098. (Pubitemid 44871518)
53. Ganly I, Kaye SB (2000) Recurrent squamous cell carcinoma of the head and neck: overview of current therapy and future prospects. Ann Oncol 11:11-16. (Pubitemid 30084573)
54. Wong SJ, Machtay M, Li Y (2006) Locally recurrent, previously irradiated head and neck cancer: concurrent reirradiation and chemotherapy or chemotherapy alone? J Clin Oncol 24:2653- 2658. (Pubitemid 46622086)
55. McQuone S, Eisele D, Lee D et al (1998) Occult tonsillar carcinoma in the unknown primary. Laryngoscope 108:1605-1610.
56. Tong C, Luk M, Chow S et al (2002) Cervical nodal metastases from occult primary: undifferentiated carcinoma versus squamous cell carcinoma. Head Neck 24:361-369. (Pubitemid 34260040)
57. Pentheroudakis G, Golfi nopoulos V, Pavlidis N (2007) Switching benchmarks in cancer of unknown primary: from autopsy to microarray. Eur J Cancer 43:2026-2036. (Pubitemid 47380362)
58. Pentheroudakis G, Greco FA, Pavlidis N (2009) Molecular assignment of tissue of origin in cancer of unknown primary may not predict response to therapy or outcome: A systematic literature review. Cancer Treat Rev 35:221- 227.