CO2 homeostasis is maintained in conscious humans by regulation of tidal volume, but not of respiratory rhythm

Respiratory Physiology and Neurobiology

Volumn 186, Issue 2, 2013, Pages 155-163

  Ohashi, Suguru ^a   Izumizaki, Masahiko ^a   Atsumi, Takashi ^b   Homma, Ikuo ^a  

^a SHOWA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b SHOWA UNIVERSITY FUJIGAOKA HOSPITAL   (Japan)

Author keywords

Behavior; Conscious humans; Hypocapnia; Respiratory frequency; Tidal volume

Indexed keywords

CARBON DIOXIDE;

ADULT; AIR CONDITIONING; ARTICLE; AUTONOMIC NERVOUS SYSTEM; BREATHING; BREATHING RATE; CONSCIOUSNESS; CONTROLLED STUDY; END TIDAL CARBON DIOXIDE TENSION; HOMEOSTASIS; HUMAN; HUMAN EXPERIMENT; LUNG FUNCTION; MALE; PRIORITY JOURNAL; RESPIRATORY RHYTHM; RESPIRATORY TRACT PARAMETERS; TIDAL VOLUME; BREATHING MECHANICS; LUNG GAS EXCHANGE; METABOLISM; MIDDLE AGED; PHYSIOLOGY;

ADULT; CARBON DIOXIDE; CONSCIOUSNESS; HOMEOSTASIS; HUMANS; MALE; MIDDLE AGED; PULMONARY GAS EXCHANGE; RESPIRATION; RESPIRATORY MECHANICS; TIDAL VOLUME; YOUNG ADULT;

EID: 84875019968     PISSN: 15699048     EISSN: 18781519     Source Type: Journal    
DOI: 10.1016/j.resp.2013.01.008     Document Type: Article

References (21)

1. Asmussen E. Regulation of respiration: " The Black Box" Acta Physiologica Scandinavica 1977, 99:85-90.
2. Chonan T., Mulholland M.B., Altose M.D., Cherniack N.S. Effects of changes in level and pattern of breathing on the sensation of dyspnea. Journal of Applied Physiology 1990, 69:1290-1295.
3. Clark J.M., Hagerman F.C., Gelfand R. Breathing patterns during submaximal and maximal exercise in elite oarsmen. Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology 1983, 55:440-446.
4. Duffin J., Mohan R.M., Vasiliou P., Stephenson R., Mahamed S. A model of the chemoreflex control of breathing in humans: model parameters measurement. Respiration Physiology 2000, 120:13-26.
5. Feldman J.L., Mitchell G.S., Nattie E.E. Breathing: rhythmicity, plasticity, chemosensitivity. Annual Review of Neuroscience 2003, 26:239-266.
6. Guyenet P.G., Bayliss D.A., Stornetta R.L., Fortuna M.G., Abbott S.B., DePuy S.D. Retrotrapezoid nucleus, respiratory chemosensitivity and breathing automaticity. Respiratory Physiology and Neurobiology 2009, 168:59-68.
7. Haouzi P., Bell H.J. Control of breathing and volitional respiratory rhythm in humans. Journal of Applied Physiology 2009, 106:904-910.
8. Homma I., Masaoka Y. Breathing rhythms and emotions. Experimental Physiology 2008, 93:1011-1021.
9. Hudson A.L., Gandevia S.C., Butler J.E. Common rostrocaudal gradient of output from human intercostal motoneurones during voluntary and automatic breathing. Respiratory Physiology and Neurobiology 2011, 175:20-28.
10. Izumizaki M., Masaoka Y., Homma I. Coupling of dyspnea perception and tachypneic breathing during hypercapnia. Respiratory Physiology and Neurobiology 2011, 179:276-286.
11. Masaoka Y., Hirasawa K., Yamane F., Hori T., Homma I. Effects of left amygdala lesions on respiration, skin conductance, heart rate, anxiety, and activity of the right amygdala during anticipation of negative stimulus. Behavior Modification 2003, 27:607-619.
12. Masaoka Y., Homma I. Expiratory time determined by individual anxiety levels in humans. Journal of Applied Physiology 1999, 86:1329-1336.
13. Masaoka Y., Homma I. The source generator of respiratory-related anxiety potential in the human brain. Neuroscience Letters 2000, 283:21-24.
14. Masaoka Y., Homma I. The effect of anticipatory anxiety on breathing and metabolism in humans. Respiration Physiology 2001, 128:171-177.
15. Masaoka Y., Koiwa N., Homma I. Inspiratory phase-locked alpha oscillation in human olfaction: source generators estimated by a dipole tracing method. The Journal of Physiology 2005, 566:979-997.
16. Onimaru H., Homma I. Spontaneous oscillatory burst activity in the piriform-amygdala region and its relation to in vitro respiratory activity in newborn rats. Neuroscience 2007, 144:387-394.
17. Onimaru H., Ikeda K., Kawakami K. Phox2b RTN/pFRG neurons and respiratory rhythmogenesis. Respiratory Physiology and Neurobiology 2009, 168:13-18.
18. Shea S.A. Behavioural and arousal-related influences on breathing in humans. Experimental Physiology 1996, 81:1-26.
19. Shea S.A., Andres L.P., Paydarfar D., Banzett R.B., Shannon D.C. Effect of mental activity on breathing in congenital central hypoventilation syndrome. Respiration Physiology 1993, 94:251-263.
20. Shea S.A., Walter J., Pelley C., Murphy K., Guz A. The effect of visual and auditory stimuli upon resting ventilation in man. Respiration Physiology 1987, 68:345-357.
21. Smith J.C., Abdala A.P., Rybak I.A., Paton J.F. Structural and functional architecture of respiratory networks in the mammalian brainstem. Philosophical Transactions of the Royal Society of London, Series B: Biological Sciences 2009, 364:2577-2587.