KCNJ2 mutation in short QT syndrome 3 results in atrial fibrillation and ventricular proarrhythmia

Proceedings of the National Academy of Sciences of the United States of America

Volumn 110, Issue 11, 2013, Pages 4291-4296

  Deo, Makarand ^a   Ruan, Yanfei ^b   Pandit, Sandeep V ^c   Shah, Kushal ^a   Berenfeld, Omer ^b   Blaufox, Andrew ^d   Cerrone, Marina ^b   Noujaim, Sami F ^e   Denegri, Marco ^f   Jalife, José ^c   Priori, Silvia G ^b,f,g  

^a NORFOLK STATE UNIVERSITY   (United States)

^b NEW YORK UNIVERSITY   (United States)

^c UNIVERSITY OF MICHIGAN   (United States)

^d Northwell Health   (United States)

^e TUFTS MEDICAL CENTER   (United States)

^f IRCCS   (Italy)

^g UNIVERSITY OF PAVIA   (Italy)

Author keywords

Cellular electrophysiology; Channelopathies; Computer models; Genetics; Ion channels

Indexed keywords

INWARDLY RECTIFYING POTASSIUM CHANNEL SUBUNIT KIR2.1;

ARTICLE; CASE REPORT; CHILD; COMPUTER SIMULATION; ELECTROCARDIOGRAM; EMBRYO; GENE MUTATION; GENETIC SCREENING; HEART ATRIUM FIBRILLATION; HEART VENTRICLE ARRHYTHMIA; HETEROZYGOTE; HOMOZYGOTE; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; MALE; PATCH CLAMP; PHENOTYPE; PRIORITY JOURNAL; PROTEIN ASSEMBLY; QT INTERVAL; SCHOOL CHILD; SHORT QT SYNDROME; SHORT QT SYNDROME TYPE 3; SODIUM CURRENT; ST SEGMENT; T WAVE; WHOLE CELL; WILD TYPE;

AMINO ACID SUBSTITUTION; ARRHYTHMIAS, CARDIAC; ATRIAL FIBRILLATION; CHILD; COMPUTER SIMULATION; HEART CONDUCTION SYSTEM; HEART DEFECTS, CONGENITAL; HEK293 CELLS; HUMANS; MALE; MUSCLE PROTEINS; MUTATION, MISSENSE; MYOCARDIUM; POTASSIUM CHANNELS, INWARDLY RECTIFYING; PROTEIN MULTIMERIZATION;

EID: 84875009425     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1218154110     Document Type: Article

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