An information theoretical analysis of nanoscale molecular gap junction communication channel between cardiomyocytes

IEEE Transactions on Nanotechnology

Volumn 12, Issue 2, 2013, Pages 129-136

  Kilinc, Deniz ^a   Akan, Ozgur B ^a  

^a KOÇ UNIVERSITY   (Turkey)

Author keywords

Cardiac disease; cardiomyocyte; gap junction(GJ); molecular communication(MC)

Indexed keywords

CARDIAC DISEASE; CARDIOMYOCYTES; CLOSED-FORM EXPRESSION; GAP JUNCTIONS; INFORMATION TRANSMISSION; MOLECULAR COMMUNICATION; PROPAGATION DELAYS; PROPAGATION FAILURE;

CHANNEL CAPACITY; COMMUNICATION; COMMUNICATION CHANNELS (INFORMATION THEORY); NANOTECHNOLOGY;

DIAGNOSIS;

EID: 84874998792     PISSN: 1536125X     EISSN: None     Source Type: Journal    
DOI: 10.1109/TNANO.2012.2233212     Document Type: Article

References (27)

1. S. Hiyama, Y. Moritani, T. Suda, R. Egashira, A. Enomoto, M. Moore, and T. Nakano, "Molecular Communication," presented at the Nano Science and Technology Institute Nanotech., Anaheim, CA, 2005.
2. M. Gregori and I. F. Akyildiz, "A new nanonetwork architecture using flagellated bacteria and catalytic nanomotors," IEEE JSAC, vol. 28, no. 4, pp. 612-619, May 2010.
3. I. F. Akyildiz, F. Brunetti, and C. Blazquez, "Nanonetworks: A new communication paradigm," Comput. Netw., vol. 52, no. 12, pp. 2260-2279, 2008.
4. R. A. Freitas, Nanomedicine, Vol. I: Basic Capabilities. Austin, Texas: Landes Bioscience, 1999.
5. L. P. Giné and I. F. Akyildiz, "Molecular communication options for long range nanonetworks," Comput. Netw., vol. 53, no. 16, pp. 2753-2766, Nov. 2009.
6. M. Kuscu and O. B. Akan, "A physical channel model and analysis for nanoscale molecular communications with förster resonance energy transfer," IEEE Trans. Nanotechnol., vol. 11, no. 1, pp. 200-207, Jan. 2012.
7. N. M. Kumar and N. B. Gilula, "The gap junction communication channel," Cell, vol. 84, pp. 381-388, 1996. (Pubitemid 26060720)
8. T. Nakano T. Suda, T. Koujin, T. Haraguchi and Y. Hiraoka, "Molecular communication through gap junction channels," Trans. Comput. Syst. Biol. X, vol. 5410, pp. 81-99, 2008.
9. G. Sohl and K. Willecke, "Gap junctions and the connexin protein family," Cardiovasc. Res., vol. 62, pp. 228-232, 2004. (Pubitemid 38496536)
10. C. H. Luo and Y. A. Rudy, "A dynamic model of the cardiac ventricular action potential-Part I: Simulations of ionic currents and concentration changes," Circ. Res., vol. 74, pp. 1071-1096, 1994.
11. J. P. Keener, "The effects of discrete gap junction coupling on propagation in myocardium," J. Theor. Biol., vol. 148, pp. 49-82, 1991.
12. G. W. Beeler and H. Reuter, "Reconstruction of the action potential of myocardial fibres," J. Physiol., vol. 268, pp. 177-210, 1977. (Pubitemid 8115094)
13. S. Baigent, S. Jaroslav, and A. Warner, "Modeling the effect of gap junction nonlinearities in systems of coupled cells," J. Theor. Biol., vol. 186, pp. 223-239, 1997. (Pubitemid 27263276)
14. F. F. Bukauskas, A. Bukauskiene, M. V. L. Bennett, and V. K. Verselis, "Gating properties of gap junction channels assembled from connexin43 and connexin43 fused with green fluorescent protein," Biophys. J., vol. 81, pp. 137-152, 2001. (Pubitemid 32605958)
15. V. Valiunas, R. Weingart, and P. R. Brink, "Formation of heterotypic gap junction channels by connexins 40 and 43," Circ. Res., vol. 86, pp. E42-E49, 2000.
16. H. Z. Wang, J. Li, L. F. Lemanski, and R. D. Veenstra, "Gating of mammalian cardiac gap junction channels by transjunctional voltage," Biophys. J., vol. 63, pp. 139-151, 1992.
17. L. T. Izu, W. G. Wier, and C. W. Balke, "Evolution of Cardiac Calcium Waves from Stochastic Calcium Sparks, "Biophys. J., vol. 80, pp. 103-120, Jan. 2001.
18. C. E. Shannon, "A mathematical theory of communication," Bell Syst. Te c h. J., vol. 27, pp. 379-423, Jul. 1948.
19. S. Rohr, "Role of gap junctions in the propagation of the cardiac action potential," Cardiovasc. Res., vol. 62, pp. 309-322, 2004. (Pubitemid 38496544)
20. D. E. Gutstein, G. E. Morley, H. Tamaddon, D. Vaidya, M. D. Schneider, J. Chen, K. R. Chien, H. Stuhlmann, and G. I. Fishman, "Conduction slowing and sudden arrhythmic death in mice with cardiac-restricted inactivation of connexin 43," Circ. Res., vol. 88, pp. 333-339, 2001. (Pubitemid 32173758)
21. D. L. Lerner, K. A. Yamada, R. B. Schuessler, and J. E. Saffitz, "Accelerated onset and increased incidence of ventricular arrhythmias induced by ischemia in Cx43-deficient mice," Circuits, vol. 101, pp. 547-552, 2000. (Pubitemid 30080870)
22. A. M. Gerdes, S. E. Kellerman, J. A. Moore, K. E. Muffly, L. C. Clark, P. Y. Reaves, K. B. Malec, P. P. McKeown, and D. D. Schocken, "Structural remodeling of cardiac myocytes from patients with chronic ischemic heart disease," Circuits, vol. 86, pp. 426-430, 1992.
23. K. Amann, M. Breitbach, E. Ritz, and G. Mall, "Myocyte/capillary mismatch in the heart of uremic patients," J. Amer. Soc. Nephrol., vol. 9, pp. 1018-1022, 1998.
24. W. C. D. Mello, "Cell swelling, impulse conduction, and cardiac arrhythmias in the failing heart. Opposite effects of angiotensin II and angiotensin (1-7) on cell volume regulation," Mol. Cell. Biochem., vol. 330, pp. 211-217, 2009.
25. D. M. Bers, "Calcium and cardiac rhythms: Physiological and pathophys-iological," Circ. Res., vol. 90, pp. 14-17, 2002. (Pubitemid 34074602)
26. J. T. Nguyen, X. Li, and F. Lu, "The electrocardiogram and clinical cardiac electrophysiology," in Proc. Card. Electrophysiol. Methods Models, 2010, pp. 91-116.
27. J. K. Donahue, M. Strom, and I. D. Greener, "Introduction to transla-tional research," in Proc. Card. Electrophysiol. Methods Models, 2010, pp. 441-455.