Low molecular weight heparin inhibits plasma thrombin generation via direct targeting of factor IXa: A rebuttal

Journal of Thrombosis and Haemostasis

Volumn 11, Issue 3, 2013, Pages 564-564

  Hemker, H C ^a   Beguin S ^a  

^a MAASTRICHT UNIVERSITY   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ANTITHROMBIN; BLOOD CLOTTING FACTOR 9A; HEPARIN; LOW MOLECULAR WEIGHT HEPARIN; THROMBIN;

LETTER; PRIORITY JOURNAL;

ANTICOAGULANTS; ANTITHROMBIN PROTEINS; BLOOD COAGULATION; FACTOR IXA; HEPARIN, LOW-MOLECULAR-WEIGHT; HUMANS; POLYSACCHARIDES; THROMBIN;

EID: 84874972882     PISSN: 15387933     EISSN: 15387836     Source Type: Journal    
DOI: 10.1111/jth.12116     Document Type: Letter

References (6)

1. Buyue Y, Misenheimer TM, Sheehan JP. Low molecular weight heparin inhibits plasma thrombin generation via direct targeting of factor IXa: contribution of the serpin-independent mechanism. J Thromb Haemost 2012, 10:2086-98
2. Béguin S, Lindhout T, Hemker HC. The mode of action of heparin in plasma. Thromb Haemost 1988; 60: 457-62.
3. Béguin S, Welzel D, Al Dieri R, Hemker HC. Conjectures and refutations on the mode of action of heparins. The limited importance of anti-factor Xa activity as a pharmaceutical mechanism and a yardstick for therapy. Haemostasis 1999; 29: 170-8.
4. Hemker HC, Béguin S. Mode of action of heparin and related drugs. Semin Thromb Hemost 1991; 17(Suppl. 1): 29-34.
5. 2+ ions; why the anti-Xa activity of LMW heparins is about two times overestimated. Thromb Haemost 1993; 70: 717-18.
6. Béguin S, Dol F, Hemker HC. Factor IXa inhibition contributes to the heparin effect. Thromb Haemost 1991; 66: 306-9.