Hypothesis: Local dNTP depletion as the cause of microsatellite repeat instability during replication

BioEssays

Volumn 35, Issue 4, 2013, Pages 305-305

  Leffak, Michael ^a  

^a WRIGHT STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA POLYMERASE; NUCLEOTIDE; PARATHION; REPETITIVE DNA;

ARTICLE; BACTERIUM; DEGENERATIVE DISEASE; DOWNSTREAM PROCESSING; GEL ELECTROPHORESIS; GENE REPLICATION; GENOMIC INSTABILITY; HUNTINGTON CHOREA; IN VITRO STUDY; IN VIVO STUDY; MICROSATELLITE INSTABILITY; MYOTONIC DYSTROPHY; SPINOCEREBELLAR DEGENERATION; STOICHIOMETRY; YEAST;

DEOXYRIBONUCLEOTIDES; DNA; DNA REPLICATION; MICROSATELLITE REPEATS; MINISATELLITE REPEATS; TRINUCLEOTIDE REPEATS;

EID: 84874962443     PISSN: 02659247     EISSN: 15211878     Source Type: Journal    
DOI: 10.1002/bies.201300026     Document Type: Article

References (6)

1. Bester AC, Roniger M, Oren YS, Im MM, et al. 2011. Nucleotide deficiency promotes genomic instability in early stages of cancer development. Cell 145: 435- 46.
2. Saldivar JC, Miuma S, Bene J, Hosseini SA, et al. 2012. Initiation of genome instability and preneoplastic processes through loss of Fhit expression. PLoS Genet 8: e1003077.
3. Barlow JH, Faryabi RB, Callen E, Wong N, et al. 2013. Identification of early replicating fragile sites that contribute to genome instability. Cell 152: 620- 32.
4. Gacy AM, Goellner G, Juranic N, Macura S, et al. 1995. Trinucleotide repeats that expand in human disease form hairpin structures in vitro. Cell 81: 533- 40.
5. Liu G, Chen X, Leffak M. 2013. Oligonucleotide binding to (CTG) (CAG) microsatellite repeats inhibits replication fork stalling, hairpin formation, and genome instability. Mol Cell Biol 33: 571- 81.
6. Kuzminov A. 2013. Inhibition of DNA synthesis facilitates expansion of low complexity repeats. BioEssays 35: 306- 13.