A Diels-Alder modulated approach to control and sustain the release of dexamethasone and induce osteogenic differentiation of human mesenchymal stem cells

Biomaterials

Volumn 34, Issue 16, 2013, Pages 4150-4158

  Koehler, Kenneth C ^a   Alge, Daniel L ^a,b   Anseth, Kristi S ^a,b   Bowman, Christopher N ^a  

^a UCB 450   (United States)

^b UNIVERSITY OF COLORADO   (United States)

Author keywords

Controlled release; Drug delivery; Human mesenchymal stem cells; Hydrogel; Osteogenesis; Peptide

Indexed keywords

ALKALINE PHOSPHATASE ACTIVITY; CONTROLLED RELEASE; HUMAN MESENCHYMAL STEM CELLS; HUMAN MESENCHYMAL STEM CELLS (HMSCS); OSTEOGENESIS; OSTEOGENIC DIFFERENTIATION; POLY(ETHYLENE GLYCOL) HYDROGEL; REACTION-DIFFUSION MODELS;

AROMATIC COMPOUNDS; BIOMIMETICS; CONTROLLED DRUG DELIVERY; DRUG DELIVERY; DRUG PRODUCTS; ENZYME INHIBITION; ORGANIC POLLUTANTS; PEPTIDES; PHOSPHATASES; POLYETHYLENE GLYCOLS; STEM CELLS; THREE DIMENSIONAL COMPUTER GRAPHICS;

HYDROGELS;

ALKALINE PHOSPHATASE; DEXAMETHASONE; DEXAMETHASONE DERIVATIVE; FURAN CONTAINING DEXAMETHASONE PEPTIDE; MACROGOL; MALEIMIDE; UNCLASSIFIED DRUG;

ARTICLE; BONE DEVELOPMENT; BONE MINERALIZATION; CELL CULTURE; CELL DIFFERENTIATION; CELL ENCAPSULATION; CONTROLLED STUDY; DIELS ALDER REACTION; DRUG EFFICACY; DRUG RELEASE; ENZYME ACTIVITY; EXTRACELLULAR MATRIX; HUMAN; HUMAN CELL; HYDROGEL; MESENCHYMAL STEM CELL; OSTEOBLAST; PRIORITY JOURNAL; SUSTAINED DRUG RELEASE;

CELL CULTURE TECHNIQUES; CELL DIFFERENTIATION; COMPUTER SIMULATION; CYCLOADDITION REACTION; DELAYED-ACTION PREPARATIONS; DEXAMETHASONE; HUMANS; HYDROGEL; MESENCHYMAL STROMAL CELLS; OSTEOGENESIS; PEPTIDES;

ALNUS;

EID: 84874952972     PISSN: 01429612     EISSN: 18785905     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2013.02.020     Document Type: Article

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