Different fever definitions and the rate of fever and neutropenia diagnosed in children with cancer: A retrospective two-center cohort study

Pediatric Blood and Cancer

Volumn 60, Issue 5, 2013, Pages 799-805

  Binz, Patrizia ^a   Bodmer, Nicole ^b   Leibundgut, Kurt ^a   Teuffel, Oliver ^a   Niggli, Felix K ^b   Ammann, Roland A ^a  

^a UNIVERSITY OF BERN   (Switzerland)

^b UNIVERSITY OF ZURICH   (Switzerland)

Author keywords

Chemotherapy; Fever definition; Fever in neutropenia; Infection; Pediatric oncology

Indexed keywords

AMIKACIN; ANTINEOPLASTIC AGENT; CEFTRIAXONE; MEROPENEM;

ADOLESCENT; ANTIBIOTIC THERAPY; ARTICLE; AXILLA TEMPERATURE; BACTEREMIA; BODY TEMPERATURE; CANCER CHEMOTHERAPY; CANCER PATIENT; CHILD; CHILDHOOD CANCER; COHORT ANALYSIS; DISEASE ASSOCIATION; DRUG EXPOSURE; EAR TEMPERATURE; FALSE NEGATIVE RESULT; FEBRILE NEUTROPENIA; FEMALE; HOSPITALIZED CHILD; HUMAN; MAJOR CLINICAL STUDY; MALE; PRESCHOOL CHILD; PRIORITY JOURNAL; RETROSPECTIVE STUDY; SCHOOL CHILD;

ADOLESCENT; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; BACTEREMIA; CHILD; CHILD, PRESCHOOL; COHORT STUDIES; FEMALE; FEVER; HUMANS; INFANT; INFANT, NEWBORN; MALE; MULTIVARIATE ANALYSIS; NEOPLASMS; NEUTROPENIA; QUALITY OF LIFE; RETROSPECTIVE STUDIES;

EID: 84874951390     PISSN: 15455009     EISSN: 15455017     Source Type: Journal    
DOI: 10.1002/pbc.24380     Document Type: Article

References (19)

1. Koh AY, Pizzo PA. Infectious complications in pediatric cancer patients. In: Pizzo PA, Poplack DG, editors. Pediatric oncology, 6th edition. Philadelphia: Wolters Kluwer/Lippincott Williams & Wilkins; 2011. pp 1190-1242.
2. Ammann RA, Bodmer N, Hirt A, et al. Predicting adverse events in children with fever and chemotherapy-induced neutropenia: The prospective multicenter SPOG 2003 FN study. J Clin Oncol 2010;28:2008-2014.
3. Teuffel O, Amir E, Alibhai SM, et al. Cost-effectiveness of outpatient management for febrile neutropenia in children with cancer. Pediatrics 2011;127:e279-e286.
4. Paulus S, Dobson S. Febrile neutropenia in children with cancer. In: Finn A, editor. Hot topics in infection and immunity in children V. New York: Springer; 2009. pp 185-204.
5. Phillips B, Selwood K, Lane SM, et al. Variation in policies for the management of febrile neutropenia in United Kingdom Children's Cancer Study Group centres. Arch Dis Child 2007;92:495-498.
6. Ammann RA, Tissing WJ, Phillips B. Rationalising the approach to children with fever in neutropenia. Curr Opin Infect Dis 2012;25:258-265.
7. Lehrnbecher T, Phillips R, Alexander S, et al. Guideline for the management of fever and neutropenia in children with cancer and/or undergoing hematopoietic stem-cell transplantation. J Clin Oncol (in press, DOI: 10.1200/JCO.2012.42.7161).
8. Wicki S, Keisker A, Aebi C, et al. Risk prediction of fever in neutropenia in children with cancer: A step towards individually tailored supportive therapy? Pediatr Blood Cancer 2008;51:778-783.
9. Agyeman P, Aebi C, Hirt A, et al. Predicting bacteremia in children with cancer and fever in chemotherapy-induced neutropenia: Results of the prospective multicenter SPOG 2003 FN study. Pediatr Infect Dis J 2011;30:e114-e119.
10. Kern WV, Cometta A, De Bock R, et al. Oral versus intravenous empirical antimicrobial therapy for fever in patients with granulocytopenia who are receiving cancer chemotherapy. International Antimicrobial Therapy Cooperative Group of the European Organization for Research and Treatment of Cancer. N Engl J Med 1999;341:312-318.
11. Schlapbach LJ, Aebi C, Otth M, et al. Serum levels of mannose-binding lectin and the risk of fever in neutropenia pediatric cancer patients. Pediatr Blood Cancer 2007;49:11-16.
12. Altman DG. Practical statistics for medical research. London: Chapman & Hall; 1991. 611 p.
13. Brown H, Prescott R. Applied mixed models in medicine. Chichester: Wiley; 2006. 455 pp.
14. Venables WN, Ripley BD. Modern applied statistics with S, 4th edition. New York: Springer; 2002.
15. Lüer S, Hirt A, Ritz N, et al. Mucormycosis in pediatric oncology patients. Swiss Med Wkly 2007;137:S26 (P51).
16. Nimah MM, Bshesh K, Callahan JD, et al. Infrared tympanic thermometry in comparison with other temperature measurement techniques in febrile children. Pediatr Crit Care Med 2006;7:48-55.
17. Rackoff WR, Gonin R, Robinson C, et al. Predicting the risk of bacteremia in children with fever and neutropenia. J Clin Oncol 1996;14:919-924.
18. Ammann RA, Hirt A, Ridolfi Luthy A, et al. Predicting bacteremia in children with fever and chemotherapy-induced neutropenia. Pediatr Infect Dis J 2004;23:61-67.
19. Macher E, Dubos F, Garnier N, et al. Predicting the risk of severe bacterial infection in children with chemotherapy-induced febrile neutropenia. Pediatr Blood Cancer 2010;55:662-667.