Predicting bacteremia in children with fever and chemotherapy-induced neutropenia

Pediatric Infectious Disease Journal

Volumn 23, Issue 1, 2004, Pages 61-67

  Ammann, Roland A ^a   Hirt, Andreas ^a   Lüthy, Annette Ridolfi ^a   Aebi, Christoph ^a  

^a UNIVERSITY OF BERN   (Switzerland)

Author keywords

Bacteremia; Chemotherapy; Children and adolescents; Fever and neutropenia; Gram negative bacteremia; Prediction

Indexed keywords

ANTIBIOTIC AGENT; ANTINEOPLASTIC AGENT;

ADOLESCENT; ANTIMICROBIAL THERAPY; ARTICLE; BACTEREMIA; CANCER PATIENT; CHILD; COHORT ANALYSIS; COMPARATIVE STUDY; CONFIDENCE INTERVAL; CRITICAL ILLNESS; EMERGENCY TREATMENT; FEMALE; FEVER; FOLLOW UP; GRAM NEGATIVE BACTERIUM; GRAM NEGATIVE INFECTION; HOSPITALIZATION; HUMAN; IATROGENIC DISEASE; INFECTION RISK; MAJOR CLINICAL STUDY; MALE; NEOPLASM; NEUTROPENIA; NONHUMAN; PREDICTION AND FORECASTING; PRESCHOOL CHILD; PRIORITY JOURNAL; RETROSPECTIVE STUDY; RISK; RISK ASSESSMENT; SENSITIVITY AND SPECIFICITY; SURVIVAL;

ADOLESCENT; ANTI-BACTERIAL AGENTS; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; BACTEREMIA; CHILD; CHILD, PRESCHOOL; COHORT STUDIES; CONFIDENCE INTERVALS; CRITICAL ILLNESS; DRUG THERAPY, COMBINATION; EMERGENCY TREATMENT; FEMALE; FEVER; FOLLOW-UP STUDIES; GRAM-NEGATIVE BACTERIAL INFECTIONS; HUMANS; MALE; NEOPLASMS; NEUTROPENIA; ODDS RATIO; PREDICTIVE VALUE OF TESTS; RETROSPECTIVE STUDIES; RISK ASSESSMENT; SEVERITY OF ILLNESS INDEX; SURVIVAL ANALYSIS;

EID: 0842347666     PISSN: 08913668     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.inf.0000106782.30100.4f     Document Type: Article

References (27)

1. Hann I, Viscoli C, Paesmans M, Gaya H, Glauser M. A comparison of outcome from febrile neutropenic episodes in children compared with adults: Results from four EORTC studies, International Antimicrobial Therapy Cooperative Group (IATCG) of the European Organization for Research and Treatment of Cancer (EORTC). Br J Haematol 1997;99:580-8.
2. Pizzo PA, Robichaud KJ, Wesley R, Commers JR. Fever in the pediatric and young adult patient with cancer: a prospective study of 1001 episodes. Medicine (Baltimore) 1982;61:153-65.
3. Rackoff WR, Gonin R, Robinson C, Kreissman SG, Breitfeld PB. Predicting the risk of bacteremia in children with fever and neutropenia. J Clin Oncol 1996;14:919-24.
4. Lucas KG, Brown AE, Armstrong D, Chapman D, Heller G. The identification of febrile, neutropenic children with neoplastic disease at low risk for bacteremia and complications of sepsis. Cancer 1996;77:791-8.
5. Chiu HH, Huang LM, Lee PI, Lee CY. Bacteremia and fungemia in hematological and oncological children with neutropenic fever: two-year study in a medical center. J Microbiol Immunol Infect 1998;31:101-6.
6. Klaassen RJ, Goodmann TR, Pham B, Doyle JJ. "Low-risk" prediction rule for pediatric oncology patients presenting with fever and neutropenia. J Clin Oncol 2000;18:1012-19.
7. Santolaya ME, Alvarez AM, Becker A, et al. Prospective, multicenter evaluation of risk factors associated with invasive bacterial infection in children with cancer, neutropenia, and fever. J Clin Oncol 2001;19:3415-21.
8. Baorto EP, Aquino VM, Mullen CA, Buchanan GR, DeBaun MR. Clinical parameters associated with low bacteremia risk in 1100 pediatric oncology patients with fever and neutropenia. Cancer 2001;92:909-13.
9. Alexander SW, Walsh TJ, Freifeld AG, Pizzo PA. Infectious complications in pediatric cancer patients. In: Pizzo PA, Poplack DG, eds. Principles and practice of pediatric oncology. 4th ed. Philadelphia: Lippincott Williams & Wilkins, 2002:1239-83.
10. Ariffin H, Navaratnam P, Lin HP. Surveillance study of bacteraemic episodes in febrile neutropenic children. Int J Clin Pract 2002;56:237-40.
11. Madsen K, Rosenman M, Hui S, Breitfeld PP. Value of electronic data for model validation and refinement: bacteremia risk in children with fever and neutropenia. J Pediatr Hematol Oncol 2002;24:256-62.
12. Santolaya ME, Alvarez AM, Aviles CL, et al. Prospective evaluation of a model of prediction of invasive bacterial infection risk among children with cancer, fever, and neutropenia. Clin Infect Dis 2002;35:678-83.
13. Aquino VM, Pappo A, Buchanan GR, Tkaczewski I, Mustafa MM. The changing epidemiology of bacteremia in neutropenic children with cancer. Pediatr Infect Dis J 1995;14:140-3.
14. Alexander SW, Wade KC, Hibberd PL, Parsons SK. Evaluation of risk prediction criteria for episodes of febrile neutropenia in children with cancer. J Pediatr Hematol Oncol 2002;24:38-42.
15. Aquino VM, Herrera L, Sandler ES, Buchanan GR. Feasibility of oral ciprofloxacin for the outpatient management of febrile neutropenia in selected children with cancer. Cancer 2000;88:1710-14.
16. Charnas R, Ridolfi Lüthy A, Ruch W. Once daily ceftriaxone plus amikacin vs. three times daily ceftazidime plus amikacin for treatment of febrile neutropenic children with cancer. Pediatr Infect Dis J 1997;16:346-53.
17. Ammann RA, Hirt A, Ridolfi Lüthy A, Aebi C. Identification of children presenting with fever in chemotherapy-induced neutropenia at low risk for severe bacterial infection. Med Pediatr Oncol 2003;41:436-43.
18. Adamkiewicz TV, Lorenzana A, Doyle J, Richardson S. Peripheral vs. central blood cultures in patients admitted to a pediatric oncology ward. Pediatr Infect Dis J 1999;18:556-8.
19. Breiman L, Friedman JH, Olshen RA, Stone CJ. Classification and regression trees. Monterey, CA: Wadsworth and Brooks/Cole, 1984.
20. Zhang H, Singer B. Recursive partitioning in the health sciences. Berlin: Springer, 1999.
21. Stone M, Cross-validation choice and assessment of statistical predictions. J Royal Statist Soc B 1974;36:111-47.
22. Breiman L. Bagging predictors. Machine Learning 1996;24: 123-40.
23. Efron B, Tibshirani RJ. An introduction to the bootstrap. Boca Raton: Chapman, Hall, 1993.
24. Hanley JA, McNeil BJ. The meaning and use of the area under a receiver operating characteristic (ROC) curve. Radiology 1982;143:29-36.
25. Talcott JA, Siegel RD, Finberg R, Goldman L. Risk assessment in cancer patients with fever and neutropenia: a prospective, two-center validation of a prediction rule. J Clin Oncol 1992;10:316-22.
26. Altman DG. Practical statistics for medical research. London: Chapman and Hall, 1991.
27. Klastersky J, Paesmans M, Rubenstein EB, et al. The Multinational Association for Supportive Care in Cancer risk index: a multinational scoring system for identifying low-risk febrile neutropenic cancer patients. J Clin Oncol 2000;18:3038-51.