Impact of physical parameters on particle size and reaction yield when using the ionic gelation method to obtain cationic polymeric chitosan-tripolyphosphate nanoparticles

International Journal of Pharmaceutics

Volumn 446, Issue 1-2, 2013, Pages 199-204

  Fabregas A ^a   Minarro M ^a   Garcia Montoya E ^a   Perez Lozano P ^a   Carrillo, C ^a   Sarrate, R ^a   Sanchez N ^a   Tico J R ^a   Sune Negre J M ^a  

^a UNIVERSITY OF BARCELONA   (Spain)

Author keywords

Cationic; Chitosan tripolyphosphate; Ionic gelation; Nanoparticles; Polymeric

Indexed keywords

CHITOSAN; NANOPARTICLE; POLYMER; TRIPOLYPHOSPHATE;

ARTICLE; ATOMIC FORCE MICROSCOPY; CHEMICAL REACTION; GELATION; MOLECULAR WEIGHT; PARTICLE SIZE; PHYSICAL PARAMETERS; PRIORITY JOURNAL; ZETA POTENTIAL;

CHITOSAN; DRUG COMPOUNDING; GELS; MICROSCOPY, ATOMIC FORCE; NANOPARTICLES; PARTICLE SIZE; POLYPHOSPHATES;

EID: 84874938265     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2013.02.015     Document Type: Article

References (17)

1. W. Abdelwahed, G. Degobert, S. Stainmesse, and H. Fessi Freeze-drying of nanoparticles: formulation, process and storage considerations Adv. Drug Deliv. Rev. 58 2006 1688 1713
2. S. Bozdag, K. Dillen, J. Vandervoort, and A. Ludwig The effect of freeze-drying with different cryoprotectants and gamma-irradiation sterilization on the characteristics of ciprofloxacin HCl-loaded poly(d,l-lactide-glycolide) nanoparticles J. Pharm. Pharmacol. 57 2005 699 707
3. C. Bulmer, A. Margaritis, and A. Xenocostas Production and characterization of novel chitosan nanoparticles for controlled release of rHu-erythropoietin Biochem. Eng. J. 68 2012 61 69
4. P. Calvo, C. Remuñán-López, J.L. Vila-Jato, and M.J. Alonso Novel hydrophilic chitosan-polyethylene oxide nanoparticles as protein carriers J. Appl. Polym. Sci. 63 1997 125 132
5. N. Csaba, M. Köping-Höggård, and M.J. Alonso Ionically crosslinked chitosan/tripolyphosphate nanoparticles for oligonucleotide and plasmid DNA delivery Int. J. Pharm. 382 2009 205 214
6. M. Dash, F. Chiellini, R.M. Ottenbrite, and E. Chiellini Chitosan-a versatile semi-synthetic polymer in biomedical applications Prog. Polym. Sci. 36 2011 981 1014
7. W. Fan, W. Yan, Z. Xu, and H. Ni Formation mechanism of monodisperse, low molecular weight chitosan nanoparticles by ionic gelation technique Colloids Surf. B: Biointerfaces 90 2012 21 27
8. Q. Gan, T. Wang, C. Cochrane, and P. McCarron Modulation of surface charge, particle size and morphological properties of chitosan-TPP nanoparticles intended for gene delivery Colloids Surf. B: Biointerfaces 44 2005 65 73
9. V.M. Gaspar, F. Sousa, J.A. Queiroz, and I.J. Correia Formulation of chitosan-TPP-pDNA nanocapsules for gene therapy applications Nanotechnology 22 2011 212 222
10. A.M. Ji, D. Su, O. Che, W.S. Li, L. Sun, Z.Y. Zhang, B. Yang, and F. Xu Functional gene silencing mediated by chitosan/siRNA nanocomplexes Nanotechnology 20 2009 10.1088/0957-4484/20/40/405103
11. F. Kong, G. Liu, B. Sun, S. Zhou, A. Zuo, R. Zhao, and D. Liang Phosphorylatable short peptide conjugated low molecular weight chitosan for efficient siRNA delivery and target gene silencing Int. J. Pharm. 422 2012 445 453
12. T. López-León, E.L.S. Carvalho, B. Seijo, J.L. Ortega-Vinuesa, and D. Bastos-González Physicochemical characterization of chitosan nanoparticles: electrokinetic and stability behavior J. Colloid Interface Sci. 283 2005 344 351
13. A. Nasti, N.M. Zaki, P. De Leonardis, S. Ungphaiboon, P. Sansongsak, M.G. Rimoli, and N. Tirelli Chitosan/TPP and chitosan/TPP-hyaluronic acid nanoparticles: systematic optimisation of the preparative process and preliminary biological evaluation Pharm. Res. 26 2009 1918 1930
14. M. Tsai, R. Chen, S. Bai, and W. Chen The storage stability of chitosan/tripolyphosphate nanoparticles in a phosphate buffer Carbohydr. Polym. 84 2011 756 761
15. C. Vauthier, B. Cabane, and D. Labarre How to concentrate nanoparticles and avoid aggregation? Eur. J. Pharm. Biopharm. 69 2008 466 475
16. A. Vila, A. Sánchez, M. Tobio, P. Calvo, and M.J. Alonso Design of biodegradable particles for protein delivery J. Control. Release 78 2002 15 24
17. W. Wang, Y. Du, Y. Qiu, X. Wang, Y. Hu, J. Yang, J. Cai, and J.F. Kennedy A new green technology for direct production of low molecular weight chitosan Carbohydr. Polym. 74 2008 127 132