Enhanced neuroprotective effects of co-administration of g-csf with simvastatin on intracerebral hemorrhage in rats

Turkish Neurosurgery

Volumn 22, Issue 6, 2012, Pages 732-739

  Guo, Xiaohe ^a   Bu, Xingyao ^a   Jiang, Jindou ^a   Cheng, Peixun ^a   Yan, Zhaoyue ^a  

^a HENAN PROVINCIAL PEOPLE'S HOSPITAL   (China)

Author keywords

Granulocyte colony stimulating factor; Hematoma; Rat; Simvastatin

Indexed keywords

EID: 84874926766     PISSN: 10195149     EISSN: None     Source Type: Journal    
DOI: 10.5137/1019-5149.JTN.6177-12.1     Document Type: Article

References (20)

1. Anik I, Secer HI, Anik Y, Duz B, Gonul E: Meta-analyses of intracerebral hematoma treatment. Turk Neurosurg 21(1): 6-14, 2011
2. Chen J, Li Y, Wang L, Zhang Z, Lu D, Lu M, Chopp M: Therapeutic benefit of intravenous administration of bone marrow stromal cells after cerebral ischemia in rats. Stroke 32: 1005-1011, 2001
3. Choi JK, Kim KH, Park H, Park SR, Choi BH: Granulocyte macrophage-colony stimulating factor shows anti-apoptotic activity in neural progenitor cells via JAK/STAT5-Bcl-2 pathway. Apoptosis 16:127-134, 2011
4. Cui X, Chen J, Zacharek A: Nitric oxide donor upregulation of stromal cell-derived factor-1/chemokine (CXC motif) receptor 4 enhances bone marrow stromal cell migration into ischemic brain after stroke. Stem Cells 25:2777-2785, 2007
5. Deng J, Zou ZM, Zhou TL, Su YP, Ai GP, Wang JP, Xu H, Dong SW: Bone marrow mesenchymal stem cells can be mobilized into peripheral blood by G-CSF in vivo and integrate into traumatically injured cerebral tissue. Neurol Sci 32:641-651, 2011
6. Dietrich MO, Andrews ZB, Horvath TL: Exercise-induced synaptogenesis in the hippocampus is dependent on UCP2-regulated mitochondrial adaptation. J Neurosci 28: 10766-10771, 2008
7. Jasinska M, Owczarek J, Orszulak-Michalak D: Statins: A new insight into their mechanisms of action and consequent pleiotropic effects. Pharmacol Rep 59:483-499, 2007
8. Karki K, Knight RA, Han Y, Yang D, Zhang J, Ledbetter KA, Chopp M, Seyfried DM: Simvastatin and atorvastatin improve neurological outcome after experimental intracerebral hemorrhage. Stroke 40:3384-3389, 2009
9. Ko ML, Chen CF, Peng PH, Peng YH: Simvastatin upregulates Bcl-2 expression and protects retinal neurons from early ischemia/reperfusion injury in the rat retina. Exp Eye Res 93:580-585, 2011
10. Martins AJ, Spanton S, Sheikh HI, Kim SO: The antiinflammatory role of granulocyte colony-stimulating factor in macrophage-dendritic cell crosstalk after Lactobacillus rhamnosus GR-1 exposure. J Leukoc Biol 89:907-915, 2011
11. Park HK, Chu K, Lee ST, Jung KH, Kim EH, Lee KB, Song YM, Jeong SW, Kim M, Roh JK: Granulocyte colony-stimulating factor induces sensorimotor recovery in intracerebral hemorrhage. Brain Res 1041:125-131, 2005
12. Qureshi AI, Tuhrim S, Broderick JP: Spontaneous intracerebral hemorrhage. N Engl J Med 344:1450-1460, 2001
13. Sanli AM, Serbes G, Caliskan M, Kaptanoglu E, Sargon MF, Kilinc K, Besalti O, Sekerci Z: Effect of granulocyte-colony stimulating factor on spinal cord tissue after experimental contusion injury. J Clin Neurosci 17:1548-1552, 2010
14. Sehara Y, Hayashi T, Deguchi K, Zhang H, Tsuchiya A, Yamashita T, Lukic V, Nagai M, Kamiya T, Abe K: Potentiation of neurogenesis and angiogenesis by G-CSF after focal cerebral ischemia in rats. Brain Res 1058:120-128, 2005
15. Seyfried D, Ding J, Han Y, Li Y, Chen J, Chopp M: Effects of intravenous administration of human bone marrow stromal cells after intracerebral hemorrhage in rats. J Neurosurg 104: 313-318, 2006
16. Solaroglu I, Tsubokawa T, Cahill J, Zhang JH: Anti-apoptotic effect of granulocyte-colony stimulating factor after focal cerebral ischemia in the rat. Neuroscience 143:965-974, 2006
17. Tamura M, Hattori K, Nomura H, Oheda M, Kubota N, Imazeki I, Ono M, Ueyama Y, Nagata S, Shirafuji N: Induction of neutrophilic granulocytosis in mice by administration of purified human native granulocyte colony-stimulating factor (G-CSF). Biochem Biophys Res Commun 142:454-460, 1987
18. Wu H, Lu D, Jiang H, Xiong Y, Qu C, Li B, Mahmood A, Zhou D, Chopp M: Simvastatin-mediated upregulation of VEGF and BDNF, activation of the PI3K/Akt pathway, and increase of neurogenesis are associated with therapeutic improvement after traumatic brain injury. J Neurotrauma 25:130-139, 2008
19. Xu J, Liu X, Chen J, Zacharek A, Cui X, Savant-Bhonsale S, Liu Z, Chopp M: Simvastatin enhances bone marrow stromal cell differentiation into endothelial cells via notch signaling pathway. Am J Physiol Cell Physiol 296:C535-543.2009
20. Zhang L, Schallert T, Zhang ZG, Jiang Q, Arniego P, Li Q, Lu M, Chopp M: A test for detecting long-term sensorimotor dysfunction in the mouse after focal cerebral ischemia. J Neurosci Methods 117: 207-214, 2002