Experimental hyperleptinemia acutely increases vasoconstrictory sympathetic nerve activity in healthy humans

Journal of Clinical Endocrinology and Metabolism

Volumn 98, Issue 3, 2013, Pages

  Machleidt, Felix ^a   Simon, Paul ^a   Krapalis, Alexander F ^a   Hallschmid, Manfred ^b   Lehnert, Hendrik ^a   Sayk, Friedhelm ^a,c  

^a UNIVERSITY HOSPITAL SCHLESWIG HOLSTEIN   (Germany)

^b UNIVERSITY OF TÜBINGEN   (Germany)

^c UNIVERSITY OF LÜBECK   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ADRENALIN; ALPHA INTERMEDIN; CATECHOLAMINE; LEPTIN; MELANOCORTIN RECEPTOR; NORADRENALIN;

ARTICLE; BLOOD PRESSURE; BODY FAT; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOUBLE BLIND PROCEDURE; FAT MASS; HEART RATE; HUMAN; HYPERLEPTINEMIA; HYPERTENSION; MALE; MUSCLE SYMPATHETIC NERVE ACTIVITY; OBESITY; PRESSORECEPTOR REFLEX; PRIORITY JOURNAL; STIMULUS RESPONSE; SYMPATHETIC NERVE; VASOCONSTRICTION;

ACUTE DISEASE; ADULT; BLOOD PRESSURE; CROSS-OVER STUDIES; DOUBLE-BLIND METHOD; HEART RATE; HUMANS; HYPERTENSION; INJECTIONS, INTRAVENOUS; LEPTIN; MALE; MUSCLE, SKELETAL; OBESITY; PRESSORECEPTORS; SYMPATHETIC NERVOUS SYSTEM; VASOCONSTRICTION; YOUNG ADULT;

EID: 84874922581     PISSN: 0021972X     EISSN: 19457197     Source Type: Journal    
DOI: 10.1210/jc.2012-3009     Document Type: Article

References (19)

1. Doll S, Paccaud F, Bovet P, Burnier M, Wietlisbach V. Body mass index, abdominal adiposity and blood pressure: consistency of their association across developing and developed countries. Int J Obes Relat Metab Disord. 2002;26:48-57. (Pubitemid 34098669)
2. Davy KP, Orr JS. Sympathetic nervous system behavior in human obesity. Neurosci Biobehav Rev. 2009;33(2):116-124.
3. Gentile CL, Orr JS, Davy BM, Davy KP. Modest weight gain is associated with sympathetic neural activation in nonobese humans. Am J Physiol Regul Integr Comp Physiol. 2007;292(5):R1834-R1838. (Pubitemid 46708538)
4. Lambert E, Straznicky NE, Dawood T, et al. Change in sympathetic nerve firing pattern associated with dietary weight loss in the metabolic syndrome. Front Physiol. 2011;2:52.
5. Shibao C, Gamboa A, Diedrich A, et al. Autonomic contribution to blood pressure and metabolism in obesity. Hypertension. 2007;49(1):27-33. (Pubitemid 46360337)
6. Bełtowski J. Role of leptin in blood pressure regulation and arterial hypertension. J Hypertens. 2006;24(5):789-801. (Pubitemid 43670444)
7. Haynes WG, Morgan DA, Walsh SA, Mark AL, Sivitz WI. Receptormediated regional sympathetic nerve activation by leptin. J Clin Invest. 1997;100(2):270-278. (Pubitemid 27349073)
8. Shek EW, Brands MW, Hall JE. Chronic leptin infusion increases arterial pressure. Hypertension. 1998;31:409-414.
9. Snitker S, Pratley RE, Nicolson M, Tataranni PA, Ravussin E. Relationship between muscle sympathetic nerve activity and plasma leptin concentration. Obes Res. 1997;5(4):338-340. (Pubitemid 127702713)
10. Ozata M, Ozdemir IC, Licinio J. Human leptin deficiency caused by a missense mutation: multiple endocrine defects, decreased sympathetic tone, and immune system dysfunction indicate new targets for leptin action, greater central than peripheral resistance to the effects of leptin, and spontaneous correction of leptin-mediated defects. J Clin Endocrinol Metab. 1999;84(10):3686-3695. (Pubitemid 30645226)
11. Sayk F, Heutling D, Dodt C, et al. Sympathetic function in human carriers of melanocortin-4 receptor gene mutations. J Clin Endocrinol Metab. 2010;95(4):1998-2002.
12. Greenfield JR, Miller JW, Keogh JM, et al. Modulation of blood pressure by central melanocortinergic pathways. N Engl J Med. 2009;360(1):44-52.
13. Sayk F, Vietheer A, Schaaf B, et al. Endotoxemia causes central downregulation of sympathetic vasomotor tone in healthy humans. Am J Physiol Regul Integr Comp Physiol. 2008;295(3):R891- R898.
14. Grassi G, Seravalle G, Dell'Oro R, Turri C, Bolla GB, Mancia G. Adrenergic and reflex abnormalities in obesity-related hypertension. Hypertension. 2000;36(4):538-542.
15. Kimura K, Tsuda K, Baba A, et al. Involvement of nitric oxide in endothelium-dependent arterial relaxation by leptin. Biochem Biophys Res Commun. 2000;273(2):745-749. (Pubitemid 30599054)
16. Momin AU, Melikian N, Shah AM, et al. Leptin is an endothelial- independent vasodilator in humans with coronary artery disease: evidence for tissue specificity of leptin resistance. Eur Heart J. 2006;27:2294-2299. (Pubitemid 44453572)
17. Kassab S, Kato T, Wilkins FC, Chen R, Hall JE, Granger JP. Renal denervation attenuates the sodium retention and hypertension associated with obesity. Hypertension. 1995;25:893-897.
18. Jones A, McMillan MR, Jones RW, et al. Adiposity is associated with blunted cardiovascular, neuroendocrine and cognitive responses to acute mental stress. PLoS One. 2012;7(6):e39143.
19. Lambert E, Straznicky N, Eikelis N, et al. Gender differences in sympathetic nervous activity: influence of body mass and blood pressure. J Hypertens. 2007;25(7):1411-1419. (Pubitemid 46918828)