Placental transfer of persistent organic pollutants: A preliminary study on mother-newborn pairs

International Journal of Environmental Research and Public Health

Volumn 10, Issue 2, 2013, Pages 699-711

  Porpora, Maria Grazia ^a   Lucchini, Renato ^b   Abballe, Annalisa ^c   Ingelido, Anna Maria ^c   Valentini, Silvia ^c   Fuggetta, Eliana ^a   Cardi, Veronica ^a   Ticino, Adele ^a   Marra, Valentina ^c   Fulgenzi, Anna Rita ^c   De Felip, Elena ^c  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

^b POLICLINICO UMBERTO I   (Italy)

^c ISTITUTO SUPERIORE DI SANITÀ   (Italy)

Author keywords

HCB; In utero exposure; P; P' DDE; Perfluorooctane sulfonate (PFOS); Perfluorooctanoic acid (PFOA); Placental transfer; Polychlorinated biphenyls (PCBs); HCH

Indexed keywords

1,1 DICHLORO 2,2 BIS(4 CHLOROPHENYL)ETHYLENE; 2,2',4,4',5,5' HEXACHLOROBIPHENYL; BETA HEXACHLOROCYCLOHEXANE; HEXACHLOROBENZENE; PERFLUORO COMPOUND; PERFLUOROOCTANESULFONIC ACID; PERFLUOROOCTANOIC ACID; PESTICIDE; POLYCHLORINATED BIPHENYL 101; POLYCHLORINATED BIPHENYL 118; POLYCHLORINATED BIPHENYL 138; POLYCHLORINATED BIPHENYL 156; POLYCHLORINATED BIPHENYL 180; POLYCHLORINATED BIPHENYL 28; POLYCHLORINATED BIPHENYL 52; POLYCHLORINATED BIPHENYL DERIVATIVE; UNCLASSIFIED DRUG;

BLOOD; CONCENTRATION (COMPOSITION); DDE; HCH; HEXACHLOROBENZENE; PCB; POLLUTANT TRANSPORT; POLLUTION EXPOSURE; PREGNANCY; QUANTITATIVE ANALYSIS;

ADULT; APGAR SCORE; ARTICLE; BLOOD LEVEL; BLOOD PLACENTA BARRIER; CAUCASIAN; EMBRYOTOXICITY; FEMALE; FETUS OUTCOME; HUMAN; ITALY; MATERNAL SERUM; MOTHER FETUS RELATIONSHIP; NEWBORN; PLACENTAL TRANSFER; POLLUTION TRANSPORT; PREGNANT WOMAN; PRENATAL EXPOSURE; UMBILICAL CORD BLOOD;

ITALY; LAZIO; ROMA [LAZIO]; ROME;

EID: 84874886827     PISSN: 16617827     EISSN: 16604601     Source Type: Journal    
DOI: 10.3390/ijerph10020699     Document Type: Article

References (51)

1. McGlynn, K.A.; Abnet, C.C.; Zhang, M.; Sun, X.D.; Fan, J.H.; O'Brien, T.R.; Wei, W.-Q.; Ortiz-Conde, B.A.; Dawsey, S.M., Weber, J.-P. et al. Serum concentrations of 1,1,1-trichloro2,2-bis(p-chlorophenyl)ethane (DDT) and 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (DDE) and risk of primary liver cancer. J. Nat. Cancer Inst. 2006, 98, 1005-1010.
2. Pavuk, M.; Cerhan, J.R.; Lynch, C.F.; Kocan, A.; Petrik, J.; Chovancova, J. Case-control study of PCBs, other organochlorines and breast cancer in Eastern Slovakia. J. Expo. Anal. Environ. Epidemiol. 2003, 13, 267-275.
3. Cohn, B.A.; Terry, M.B.; Plumb, M.; Cirillo, P.M. Exposure to polychlorinated biphenyl (PCB) congeners measured shortly after giving birth and subsequent risk of maternal breast cancer before age 50. Breast Cancer Res. Treat. 2012, 136, 267-275.
4. Recio-Vega, R.; Mendez-Henandez, A.; Padua Gabriel, A.; Jacobo-Avila, A.; Portales-Castanedo, A.; Hernandez-Gonzalez, S.; Gallegos-Arreola, M.P.; Ocampo-Gomeza, G. Potentially estrogenic polychlorinated biphenyls congeners serum levels and its relation with lung cancer. J. Appl. Toxicol. 2012, doi: 10.1002/jat.2763.
5. Freeman, M.D.; Kohles, S.S. Plasma levels of polychlorinated biphenyls, non-Hodgkin lymphoma, and causation. J. Environ. Public Health 2012, 2012, doi: 10.1155/2012/258981.
6. Schantz, S.L.; Gardiner, J.C.; Gasior, D.M.; Sweeney, A.M.; Humphrey, H.E.; McCaffrey, R.J. Motor function in aging Great Lakes fisheaters. Environ. Res. 1999, 80, S46-S56.
7. Schantz, S.L.; Gasior, D.M.; Polverejan, E.; McCaffrey, R.J.; Sweeney, A.M.; Humphrey, H.E.; Gardiner, J.C. Impairments of memory and learning in older adults exposed to polychlorinated biphenyls via consumption of Great Lakes fish. Environ. Health Perspect. 2001, 109, 605-611.
8. Ayotte, P.; Giroux, S.; Dewailly, É.; Hernandez, A.M.; Farias, P.; Danis, R.; Villanueva Díaz, C. DDT spraying for malaria control and reproductive function in Mexican men. Epidemiology 2001, 12, 366-367.
9. Dalvie, M.A.; Myers, J.E.; Thompson, M.L.; Robins, T.G.; Dyer, S.; Riebow, J.; Molekwa, J.; Jeebhay, M.; Millar, R.; Kruger, P. The long-term effects of DDT exposure on semen, fertility and sexual function of malaria vector control workers in Limpopo Province, South Africa. Environ. Res. 2004, 96, 1-8.
10. Martin, L.A. Differential effects of polychlorinated biphenyl (PCB) mixtures and congeners on the disposition of thyroxine(T4). Ph.D. Dissertation, Rutgers the State University of New Jersey, New Brunswick, NJ, USA, 2002.
11. Porpora, M.G.; Medda, E.; Abballe, A.; Bolli, S.; De Angelis, I.; di Domenico, A.; Ferro, A.; Ingelido, A.M.; Maggi, A.; Panici, P.B.; De Felip, E. Endometriosis and organochlorinated environmental pollutants: A case-control study on Italian women of reproductive age. Environ. Health Perspect. 2009, 117, 1070-1075.
12. Noakes, P.S.; Taylor, P.; Wilkinson, S.; Prescott, S.L. The relationship between persistent organic pollutants in maternal and neonatal tissues and immune responses to allergens: A novel exploratory study. Chemosphere 2006, 63, 1304-1311.
13. Schug, T.T.; Janesick, A.; Blumberg, B.; Heindel, J.J. Endocrine disrupting chemicals and disease susceptibility. J. Steroid Biochem. Mol. Biol. 2011, 127, 204-215.
14. OECD. Co-Operation on Existing Chemicals. Hazard Assessment of Perfluorooctane Sulfonate (PFOS) and its Salts. OECD (Organization for Economic Co-operation and Development): Paris, France, 2002, ENV/JM/RD 17/FINAL.
15. Kennedy, G.L.; Butenhoff, J.L.; Olsen, G.W.; O'Connor, J.C.; Seacat, A.M.; Perkins, R.G.; Biegel, L.B.; Murphy S.R.; Farrar, D.G. The toxicology of perfluorooctanoate. Crit. Rev. Toxicol. 2004, 34, 351-384.
16. US EPA. Draft Risk Assessment of the Potential Human Health Effects Associated with Exposure to Perfluorooctanoic Acid and its Salts. OPPT Review. Available online: http://www.epa.gov/oppt/pfoa/pubs/pfoarisk.pdf (accessed on 6 February 2013).
17. Lau, C.; Anitole, K.; Hodes, C.; Lai, D.; Pfahles-Hutchens, A.; Seed, J. Perfluoroalkyl acids: A review of monitoring and toxicological findings. Toxicol. Sci. 2007, 99, 366-394.
18. Andersen, M.E.; Butenhoff, J.L.; Chang, S.C.; Farrar, D.G.; Kennedy, G.L.; Lau, C.; Olsen, G.W.; Seed, J.; Wallace, K.B. Perfluoroalkyl acids and related chemistries-Toxicokinetics and modes of action. Toxicol. Sci. 2008, 102, 3-14.
19. Benford, D.; de Boer, J.; Carere, A.; di Domenico, A.; Johansson, N.; Schrenk, D.; Schoeters, G.; de Voogt, P.; Dellatte, E. Scientific opinion of the panel on contaminants in the food chain of perfluorooctane sulfonate (PFOS), perfluorooctanoic acid (PFOA) and their salts. EFSA J. 2008, 653, 1-131.
20. Needham, L.; Calafat, A.; Barr, D. Uses and issues of biomonitoring. Int. J. Hyg. Environ. Health 2007, 210, 229-238.
21. Gilbert, M.E.; Rovet, J.; Chen, Z.; Koibuchi, N. Developmental thyroid hormone disruption: Prevalence, environmental contaminants and neurodevelopmental consequences. Neurotoxicology 2012, 33, 842-852.
22. Winneke, G. Developmental aspects of environmental neurotoxicology: Lessons from lead and polychlorinated biphenyls. J. Neurol. Sci. 2011, 308, 9-15.
23. Gray, K.A.; Klebanoff, M.A.; Brock, J.W.; Zhou, H.; Darden, R.; Needham, L.; Longnecker, M.P. In utero exposure to background levels of polychlorinated biphenyls and cognitive functioning among school-age children. Amer. J. Epidem. 2005, 162, 17-26.
24. Health Assessment Document for 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) and Related Compounds (1994 Final Report). United States Environmental Protection Agency: Washington, DC, USA, 1994; EPA-600-BP-92-001 a-c.
25. Hertz-Picciotto, I.; Park, H.Y.; Dostal, M.; Kocan, A.; Trnovec, T.; Sram R. Prenatal exposures to persistent and non-persistent organic compounds and effects on immune system development. Basic Clin. Pharmacol. Toxicol. 2008, 102, 146-154.
26. Fei, C.; McLaughlin, J.K.; Lipworth, L.; Olsen, J. Maternal levels of perfluorinated chemicals and subfecundity. Hum. Reprod. 2009, 24, 1200-1205.
27. Joensen, U.N.; Bossi, R.; Leffers, H.; Jensen, A.A.; Skakkebæk, N.E.; Jørgensen, N. Do perfluoroalkyl compounds impair human semen quality? Environ. Health Perspect. 2009, 117, 923-927.
28. Washino, N.; Saijo, Y.; Sasaki, S.; Kato, S.; Ban, S.; Konishi, K.; Ito, R.; Nakata, A.; Iwasaki, Y.; Saito, K.; Nakazawa, H.; Kishi, R. Correlations between prenatal exposure to perfluorinated chemicals and reduced foetal growth. Environ. Health Perspect. 2009, 117, 660-667.
29. Nolan, L.A.; Nolan, J.M.; Shofer, F.S.; Rodway, N.V.; Emmett, E.A. The relationship between birth weight, gestational age and perfluorooctanoic acid (PFOA)-contaminated public drinking water. Reprod. Toxicol. 2009, 27, 231-238.
30. Grandjean, P.; Andersen, E.W.; Budtz-Jørgensen, E.; Nielsen, F.; Mølbak, K.; Weihe, P.; Heilmann C. Serum vaccine antibody concentrations in children exposed to perfluorinated compounds. JAMA 2012, 307, 391-397.
31. Huttont, E.K.; Hassan, E.S. Late vs. early clamping of the umbilical cord in full-term neonates: Systematic review and meta-analysis of controlled trials. JAMA 2007, 297, 1241-1252.
32. Bertino, E.; Spada, E.; Occhi, L.; Coscia, A.; Giuliani, F.; Gagliardi, L.; Gilli, C.; Fabris, C.; De Curtis, M.; Milani, S. et al. Neonatal anthropometric charts: The Italian neonatal study compared with other European studies. J. Pediatr. Gastroenterol. Nutr. 2010, 51, 353-356.
33. Ingelido, A.M.; Abballe, A.; Biagini, G.; di Domenico, A.; Marra, V.; Valentini, S.; De Felip, E. In-house validation of a timeand cost-saving method for the determination of indicator PCBs and organochlorinated pesticides in human serum. Organohalogen Compounds 2008, 70, 71-74.
34. Ingelido, A.M.; Abballe, A.; Marra, V.; Valentini, S.; Ferro, A.; Porpora, M.G.; Barbieri, P.G.; De Felip, E. Serum concentrations of beta-hexachlorocyclohexane in groups of the Italian general population: A human biomonitoring study. Ann. Ist. Super. Sanità 2009, 45, 401-408.
35. Porpora, M.G.; Medda, E.; Abballe, A.; Bolli, S.; De Angelis, I.; di Domenico, A.; Ferro, A.; Ingelido, A.M.; Maggi, A.; Benedetti Panici, P.; De Felip, E. Endometriosis and organochlorinated environmental pollutants: A case-control study on Italian women of reproductive age. Environ. Health Perspect. 2009, 117, 1070-1075.
36. Ingelido, A.M.; Marra, V.; Abballe, A.; Valentini, S.; Iacovella, N.; Barbieri, P.G.; Porpora, M.G.; di Domenico, A.; De Felip, E. Perfluorooctanesulfonate and perfluorooctanoic acid exposures of the Italian general population. Chemosphere 2010, 80, 1125-1130.
37. Rylander, L.; Nilsson-Ehle, P.; Hagmar, L. A simplified precise method for adjusting serum levels of persistent organohalogen pollutants to total serum lipids. Chemosphere 2006, 62, 333-336.
38. Murphy, V.; Smith, R.; Giles, W.; Clifton, V. Endocrine regulation of human fetal growth: The role of the mother, placenta, and fetus. Endocr Rev. 2006, 27, 141-169.
39. De Felip, E.; di Domenico, A. Studio epidemiologico sullo stato di salute e sui livelli d'accumulo di contaminanti organici persistenti nel sangue e nel latte materno in gruppi di popolazione a differente rischio d'esposizione nella Regione Campania. SEBIOREC Rapporto finale, December 2010.
40. Monroy, R.; Morrison, K.; Teo, K.; Atkinson, S.; Kubwabo, C.; Stewart, B.; Foster, W.G. Serum levels of perfluoroalkyl compounds in human maternal and umbilical cord blood samples. Environ. Res. 2008, 108, 56-62.
41. Fei, C.; McLaughlin, J.K.; Tarone, R.E.; Olsen, J. Perfluorinated chemicals and fetal growth: A study within the Danish national birth cohort. Environ. Health Perspect. 2007, 115, 1677-1682.
42. Fei, C.; McLaughlin, J.K.; Lipworth, L.; Olsen, J. Prenatal exposure to perfluorooctanoate (PFOA) and perfluorooctanesulfonate (PFOS) and maternally reported developmental milestones in infancy. Environ. Health Perspect. 2008, 116, 1391-1395.
43. Apelberg, B.J.; Witter, F.R.; Herbstman, J.B.; Calafat, A.M.; Halden, R.U.; Needham, L.L.; Goldman, L.R. Perfluorooctanoate (PFOA) in relation to weight and size at birth. Environ. Health Perspect. 2007, 115, 1670-1676.
44. Fromme, H.; Mosch, C.; Morovitz, M.; Alejandre, I.A.; Boehmer, S.; Kiranoglu, M.; Faber, F.; Hannibal, I.; Genzel-Boroviczény, O.; Koletzko, B.; Volkel, W. Preand postnatal exposure to perfluorinated compounds (PFCs). Environ. Sci. Technol. 2010, 44, 7123-7129.
45. Hanssen, L.; Röllin, H.; Odland, J.Ø.; Moeb, M.K.; Sandanger, T.M. Perfluorinated compounds in maternal serum and cord blood from selected areas of South Africa: Results of a pilot study. J. Environ. Monit. 2010, 12, 1355-1361.
46. Bergonzi, R.; Specchia, C.; Dinolfo, M.; Tomasi, C.; De Palma, G.; Frusca, T.; Apostoli, P. Distribution of persistent organochlorine pollutants in maternal and foetal tissues: Data from an Italian polluted urban area. Chemosphere 2009, 76, 747-754.
47. Needham, L.; Grandjean, P.; Heinzow, B.; Jørgensen, P.; Nielsen, F.; Patterson, D.G., Jr.; Sjödin, A.; Turner, W.E.; Weihe, P. Partition of environmental chemicals between maternal and fetal blood and tissues. Environ. Sci. Technol. 2011, 45, 1121-1126.
48. Inoue, K.; Okada, F.; Ito, R.; Kato, S.; Sasaki, S.; Nakajima, S.; Uno, A.; Saijo, Y.; Sata, F.; Yoshimura, Y.; Kishi, R.; Nakazawa, H. PFOS and related perfluorinated compounds in human maternal and cord blood samples: Assessment of PFOS exposure in a susceptible population during pregnancy. Environ. Health Perspect. 2004, 112, 1204-1207.
49. Midasch, O.; Drexler, H.; Hart, N.; Beckmann, M.W.; Angerer, J. Transplacental exposure of neonates to perfluorooctanesulfonate and perfluorooctanoate: A pilot study. Int. Arch. Occup. Environ. Health 2007, 80, 643-648.
50. Tan, J.; Loganath, A.; Seng Chong, Y.; Obbard, J.P. Exposure to persistent organic pollutants in utero and related maternal characteristics on birth outcomes: A multivariate data analysis approach. Chemosphere 2009, 74, 428-433.
51. Wu, K.; Xu, X.; Liu, J.; Guo, Y.; Huo, X. In utero exposure to polychlorinated biphenyls and reduced neonatal physiological development from Guiyu, China. Ecotoxicol. Environ. Saf. 2011, 74, 2141-2147.