Efficacy of prophylactic fluconazole in reducing candidemia in high risk NICU and PICU patients

Life Science Journal

Volumn 9, Issue 1, 2012, Pages 817-824

  Dalia Abdel Latif, A ^a   Sultan, Mohamed H ^a   Mohamed, Hanan E ^b  

^a Taif University   (Egypt)

^b Zagazig University   (Egypt)

Author keywords

Antifungal prophylaxis; Candida colonization; Candidemia; Fluconazole; ICU infection and nosocomial infection; Risk factors for candidemia

Indexed keywords

EID: 84874881708     PISSN: 10978135     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (46)

1. Han SS, Yim JJ, Yoo CG, et al. Clinical characteristics and risk factors for nosocomial candidemia in medical intensive care units: experience in a single hospital in Korea for 6.6 years. J Korean Med Sci 2010; 25:671-676.
2. Morgan J, Meltzer MI, Plikaytis BD, et al. Excess mortality, hospital stay, and cost due to candidemia: a case control study using data from population-based candidemia surveillance. Infect Control Hosp Epidemiol 2005; 26:540-547
3. Aghai ZH, Mudduluru M, Nakhla TA, et al. Fluconazole prophylaxis in extremely low birth weight infants: association with cholestasis. J Perinatol 2006; 26: 550-555.
4. Manzoni P, Stolfi I, Pugni L, et al. A multicenter, randomized trial of prophylactic fluconazole in preterm neonates. N Engl J Med 2007; 356: 2483-2495.
5. Martinez JM, Farfan FJ, Molina T, et al. Fungal chemoprophylaxis with fluconazole in preterm infants. Pharm World Sci 2005; 27: 475-477.
6. Baran J J, Muckatira B and Khatib R. Candidemia before and during the fluconazole era: Prevalence, type of species and approach to treatment in a tertiary care community hospital. Scand J Infect Dis 2001; 33:137-139.
7. Meric M, Willke A, Caglayan C, et al. Intensive care unit acquired infections: incidence, risk factors and associated mortality in a Turkish university hospital. Jpn J Infect Dis 2005; 58:297-302.
8. Singhi SC, Reddy CS and Arunaloke C. Candidemia in pediatric intensive care unit. Pediatr Crit Care Med 2004; 5(4):369-374.
9. Chander J. Candidiasis. In: Chander J, ed. Textbook of Medical Mycology, 2nd edn, New Delhi: Mehta Publishers 2002; p 212-230.
10. Gozdasoglu S, Eterm M, Buyukkececi Z, et al. Fungal colonization and infection in children with acute leukemia and lymphoma during induction therapy. Medical and Pediatric Oncology 1999; 32(5); 344-348.
11. Narang A, Agrawal PB, Chakrabarti A, et al. Epidemiology of systemic candidiasis in a tertiary care neonatal unit. J Trop Pediatr 1998; 44: 104-108.
12. Kaufman D. Strategies for prevention of neonatal invasive candidiasis. Semin Perinatol 2003; 27: 414-424.
13. Pfaller MA, Jones RN, Messer SA, et al. SCOPE Participant Group. National surveillanc of nosocomial blood stream infection due to species of Candida other than Candida albicans: frequency of occurrence and antifungal susceptibility in the SCOPE Program. Diagn Microbiol Infect Dis 1998; 30: 121-129.
14. Parikh TB, Nanavati RN, Patankar CV, et al. Fluconazole prophylaxis against fungal colonization and invasive fungal infection in very low birth weight infants. Indian Pediatrics2007; 44:830-837.
15. Smith PB, Morgan J, Benjamin JD, et al. Excess costs of hospital care associated with neonatal candidemia. Pediatr Infect Dis J 2007; 26: 197-200.
16. Ibrahim EH, Sherman G, Ward S, et al. The influence of inadequate antimicrobial treatment of blood-stream-infections on patient outcomes in the ICU settings. Chest 2000; 118:146-55.
17. Long SS and Stevenson DK. Reducing Candida infections during neonatal intensive care: management choices, infection control, and fluconazole prophylaxis. J Pediatr 2005; 147: 135-141.
18. Feja KN, Wu F, Roberts K, et al. Risk factors for candidemia in critically ill infants: a matched case-control study. J Pediatr 2005; 147: 156-161.
19. Paganini H, Brieshke TR, Santos P, et al. Risk factors for nosocomial candidemia: A case control study in children. J Hosp Infect 2002; 50:304-308.
20. Yogaraj JS, Elward AM and Fraser VJ. Rate, risk factors and outcomes of nosocomial primary bloodstream infections in pediatric intensive care unit patients. Pediatrics 2002; 110:481-5
21. Castagnola E, Machetti M, Bucci B, et al. Antifungal prophylaxis with azole derivatives. Clin Microbiol Infect 2004; 10(1):86-95.
22. McGuire W, Clerihew L and Austin N. Prophylactic intravenous antifungal agents to prevent mortality and morbidity in very low birth weight infants. Cochrane Database Syst Rev 2004; (1): CD003850.
23. Mondal RK, Singhi SC, Chakrabarti A, et al. Randomized Comparison between fluconazole and itraconazole for the treatment of candidemia in a pediatric care unit: A preliminary study. Pediatr Crit Care Med 2004; 5(6):561-565.
24. Lipsett PA. Clinical trials of antifungal prophylaxis among patients in surgical intensive care units: Concepts and considerations. Clin Infect Dis 2004; 39(4): S193-S199.
25. Zaoutis TE, Prasad PA, Localio AR, et al. Risk factors and predictors for candidemia in pediatric intensive care unit patients: implications and prevention. Clin Infect Dis 2010; 51(5): e38-e45.
26. Burwell LA, Kaufman D, Blakely J, et al. Antifungal prophylaxis to prevent neonatal candidiasis: a survey of perinatal physician practices. Pediatrics 2006; 118: e1019-e1026.
27. Fanaroff AA. Fluconazole for the prevention of fungal infections: get ready, get set, caution. Pediatrics 2006; 117: 214-215.
28. Rocco TR, Reinert SE and Simms HH. Effects of fluconazole administration in critically ill patients: Analysis of bacterial and fungal resistance. Arch Surg 2000; 135:160-165.
29. Bliss JM, Wellington M and Gigliotti F. Antifungal pharmacotherapy for neonatal candidiasis. Semin Perinatol 2003; 27: 365-374.
30. Narang A, Agrawal P, Chakraborti A, et al. Fluconazole in the management of neonatal systemic candidiasis Indian Pediatr 1996; 33: 823-826.
31. Weitkamp J H, Ozdas A, lafleur B, et al. Fluconazole prophylaxis for prevention of invasive fungal infections in targeted highest risk preterm infants limits drug exposure. Journal Of Perinatology 2008; 1-7.
32. Dotis J and Roilides E. Candidemia in the Pediatric Intensive Care Unit: What's Different from Candidemia in Adults? Curr Fungal Infect Rep 2011; 5:49.
33. Singhi S and Deep A. Invasive candidiasis in pediatric intensive care units. Indian J Pediatr 2009, 76:1033-1044.
34. Zaoutis T. Candidemia in children. Curr Med Res Opin 2010; 26:1761-1768.
35. Filioti J, Spiroglou K, Panteliadis CP, et al. Invasive candidiasis in pediatric intensive care patients: epidemiology, risk factors, management, and outcome. Intensive Care Med 2007; 33:1272-1283.
36. Marodi L and Johnston RB. Invasive Candida species disease in infants and children: occurrence, risk factors, management, and innate host defense mechanisms. Curr Opin Pediatr 2007; 19:693-697.
37. Kicklighter SD, Springer SC, Cox T, et al. Fluconazole for prophylaxis against Candida rectal colonization in the very low birth weight infant. Pediatrics 2001; 107: 293-298.
38. Kaufman D, Boyle R, Hazen KC, et al. Fluconazole prophylaxis against fungal colonization and infection in preterm infants. N Engl J Med 2001; 345: 1660-1666.
39. Baley JE, Kleigman RM, Boxerbaum B, et al. Fungal colonization in the very low birth weight infants. Pediatrics 1986; 78: 225-232.
40. Rodriguez-Nunez A. Incidence and mortality of proven invasive Candida infections in pediatric intensive care patients. Infect Control Hosp Epidemiol 2001; 22:477-478.
41. Blyth CC, Chen SC, Slavin MA, et al. Not just little adults: candidemia epidemiology, molecular characterization, and antifungal susceptibility in neonatal and pediatric patients. Pediatrics 2009; 123:1360-1368.
42. McCrossan BA, McHenry E, O'Neil F, et al. Selective fluconazole prophylaxis in high risk babies to reduce invasive fungal infection. Arch Dis Child Fetal Neonatal Ed 2007; 92: F454-F458.
43. Chakrabarti A, Mohan B, Shrivastava SK, et al. Change in distribution and antifungal susceptibility of Candida species isolated from candidemia cases in a tertiary care centre during 1996-2000. Indian J Med Res 2002; 116:5-12.
44. Sheridan RL, Weber JM, Budkevich LG, et al. Candidemia in the pediatric patient with burns. J Burn Care Rehabil 1995; 16:440-443.
45. Verduyn LF, Meis JF and Voss A. Nosocomial fungal infections: Candidemia. Diagn Microbiol Infect Dis 1999; 34:213-220.
46. Wey SB, Mori M, Pfaller MA, et al. Hospitalacquired candidemia. The attributable mortality andexcess length of stay. Arch Intern Med 1988; 148: 2642-2645.