Micronutrient supplementation and pregnancy outcomes: Double-blind randomized controlled trial in China

JAMA Internal Medicine

Volumn 173, Issue 4, 2013, Pages 276-282

  Liu, Jian Meng ^a   Mei, Zuguo ^b   Ye, Rongwei ^a   Serdula, Mary K ^b   Ren, Aiguo ^a   Cogswell, Mary E ^b  

^a PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

^b NATIONAL CENTER FOR CHRONIC DISEASE PREVENTION AND HEALTH PROMOTION   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FOLIC ACID; HEMOGLOBIN; IRON;

ADULT; ANEMIA; ARTICLE; BIRTH WEIGHT; BODY HEIGHT; CHINA; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; FEMALE; GESTATION PERIOD; HEMOGLOBIN BLOOD LEVEL; HUMAN; INFANT MORTALITY; MAJOR CLINICAL STUDY; NEWBORN MORTALITY; OUTCOME ASSESSMENT; PREGNANCY OUTCOME; PREMATURITY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SUPPLEMENTATION;

ADULT; ANEMIA; BIRTH WEIGHT; CHINA; DOUBLE-BLIND METHOD; FEMALE; FOLIC ACID; HUMANS; INFANT; INFANT MORTALITY; INFANT, NEWBORN; IRON; MICRONUTRIENTS; PERINATAL MORTALITY; PREGNANCY; PREGNANCY COMPLICATIONS; PREGNANCY OUTCOME; PREMATURE BIRTH; PRENATAL NUTRITIONAL PHYSIOLOGICAL PHENOMENA; TRACE ELEMENTS;

EID: 84874875114     PISSN: 21686106     EISSN: None     Source Type: Journal    
DOI: 10.1001/jamainternmed.2013.1632     Document Type: Article

References (41)

1. World Health Organization. Neonatal and perinatal mortality: country, regional and global estimates 2004. http://whqlibdoc.who.int/publications/2007/ 9789241596145-eng.pdf. Accessed December 30, 2010.
2. Wu Z, Viisainen K, Wang Y, Hemminki E. Perinatal mortality in rural China: retrospective cohort study. BMJ. 2003;327 (7427): 1319.
3. Black RE, Allen LH, Bhutta ZA, et al Maternal and Child Undernutrition Study Group. Maternal and child undernutrition: global and regional exposures and health consequences. Lancet. 2008;371 (9608): 243-260.
4. International Nutritional Anemia Consultative Group. Guidelines for the use of iron supplements to prevent and treat iron deficiency anemia. http://www.who.int/nutrition/publications/micronutrients/anaemia-iron- deficiency/1-57881-020-5/en/index.html. Accessed January 25, 2011.
5. Pena-Rosas JP, Viteri FE. Effects of routine oral iron supplementation with or without folic acid for women during pregnancy. Cochrane Database Syst Rev. 2006; (3): CD004736.
6. Pena-Rosas JP, Viteri FE. Effects and safety of preventive oral iron or iron folic acid supplementation for women during pregnancy. Cochrane Database Syst Rev. 2009; (4): CD004736.
7. US Preventive Services Task Force. Routine iron supplementation during pregnancy. Policy statement. JAMA. 1993;270 (23): 2846-2848.
8. Shrimpton R, Shrimpton R, Schultink W. Can supplements help meet the micronutrient needs of the developing world? Proc Nutr Soc. 2002;61 (2): 223-229.
9. Sloan NL, Jordan E, Winikoff B. Effects of iron supplementation on maternal hematologic status in pregnancy. Am J Public Health. 2002;92 (2): 288-293.
10. UNICEF/UNU/WHO Study Team. Multiple Micronutrient Supplementation During Pregnancy (MMSDP): Efficacy Trials. London, England: Institute of Child Health, UCL; 2002.
11. UNICEF/UNU/WHO Study Team. Composition of Multiple Micronutrient Supplement to be Used in Pilot Programmes Among PregnantWomenin Developing Countries: Report of a Workshop Held at UNICEF Headquarters. New York, NY: UNICEF.
12. Zeng L, Dibley MJ, Cheng Y, et al. Impact of micronutrient supplementation during pregnancy on birth weight, duration of gestation, and perinatal mortality in rural western China: double blind cluster randomised controlled trial. BMJ. 2008;337:a2001.
13. Fall CH, Fisher DJ, Osmond C, Margetts BM; Maternal Micronutrient Supplementation Study Group. Multiple micronutrient supplementation during pregnancy in low-income countries: a meta-analysis of effects on birth size and length of gestation. Food Nutr Bull. 2009;30 (4) (suppl): S533-S546.
14. Shah PS, Ohlsson A; Knowledge Synthesis Group on Determinants of Low Birth Weight and Preterm Births. Effects of prenatal multimicronutrient supplementation on pregnancy outcomes: a meta-analysis. CMAJ. 2009;180 (12): E99-E108.
15. Christian P, Osrin D, Manandhar DS, Khatry SK, de L Costello AM, West KP Jr. Antenatal micronutrient supplements in Nepal. Lancet. 2005;366 (9487): 711-712.
16. Christian P, West KP, Khatry SK, et al. Effects of maternal micronutrient supplementation on fetal loss and infant mortality: a cluster-randomized trial in Nepal. Am J Clin Nutr. 2003;78 (6): 1194-1202.
17. Czeizel AE, Dudás I, Métneki J. Pregnancy outcomes in a randomised controlled trial of periconceptional multivitamin supplementation: final report. Arch Gynecol Obstet. 1994;255 (3): 131-139.
18. Fawzi WW, Msamanga GI, Spiegelman D, et al. Randomised trial of effects of vitamin supplements on pregnancy outcomes and T cell counts in HIV-1- infected women in Tanzania. Lancet. 1998;351 (9114): 1477-1482.
19. Fawzi WW, Msamanga GI, Urassa W, et al. Vitamins and perinatal outcomes among HIV-negative women in Tanzania. N Engl J Med. 2007;356 (14): 1423-1431.
20. Kaestel P, Michaelsen KF, Aaby P, Friis H. Effects of prenatal multimicronutrient supplements on birth weight and perinatal mortality: a randomised, controlled trial in Guinea-Bissau. Eur J Clin Nutr. 2005;59 (9): 1081-1089.
21. Roberfroid D, Huybregts L, Lanou H, et al MISAME Study Group. Effects of maternal multiple micronutrient supplementation on fetal growth: a double-blind randomized controlled trial in rural Burkina Faso. Am J Clin Nutr. 2008;88 (5): 1330-1340.
22. Shankar AH, Jahari AB, Sebayang SK, et al Supplementation With Multiple Micronutrients Intervention Trial (SUMMIT) Study Group. Effect of maternal multiple micronutrient supplementation on fetal loss and infant death in Indonesia: a double-blind cluster-randomised trial. Lancet. 2008;371 (9608): 215-227.
23. Abu-Saad K, Fraser D. Maternal nutrition and birth outcomes. Epidemiol Rev. 2010;32 (1): 5-25.
24. Zhai F, Wang H, Du S, et al. Prospective study on nutrition transition in China. Nutr Rev. 2009;67 (suppl 1): S56-S61.
25. World Health Organization. Worldwide prevalence of anaemia 1993-2005: WHO Global Database on Anaemia. http://whqlibdoc.who.int/publications/2008/ 9789241596657-eng.pdf. Accessed October 30, 2011.
26. Jin L, Yeung LF, Cogswell ME, et al. Prevalence of anaemia among pregnant women in South-East China, 1993-2005. Public Health Nutr. 2010;13 (10): 1511-1518.
27. Berry RJ, Li Z, Erickson JD, et al. Prevention of neural-tube defects with folic acid in China: China-US Collaborative Project for Neural Tube Defect Prevention. N Engl J Med. 1999;341 (20): 1485-1490.
28. Garn SM, Ridella SA, Petzold AS, Falkner F. Maternal hematologic levels and pregnancy outcomes. Semin Perinatol. 1981;5 (2): 155-162.
29. Lister UG, Rossiter CE, Chong H. Perinatal mortality. BJOG. 1985;92 (suppl s5): 86-99.
30. Malhotra M, Sharma JB, Batra S, Sharma S, Murthy NS, Arora R. Maternal and perinatal outcome in varying degrees of anemia. Int J Gynaecol Obstet. 2002; 79 (2): 93-100.
31. Stephansson O, Dickman PW, Johansson A, Cnattingius S. Maternal hemoglobin concentration during pregnancy and risk of stillbirth. JAMA. 2000;284 (20): 2611-2617.
32. Xiong X, Buekens P, Alexander S, Demianczuk N, Wollast E. Anemia during pregnancy and birth outcome: a meta-analysis. Am J Perinatol. 2000;17 (3): 137-146.
33. O'Brien PC, Fleming TR. Amultiple testing procedure for clinical trials. Biometrics. 1979;35 (3): 549-556.
34. Haider BA, Yakoob MY, Bhutta ZA. Effect of multiple micronutrient supplementation during pregnancy on maternal and birth outcomes. BMC Public Health. 2011;11 (suppl 3): S19.
35. Kawai K, Spiegelman D, Shankar AH, Fawzi WW. Maternal multiple micronutrient supplementation and pregnancy outcomes in developing countries: metaanalysis and meta-regression. Bull World Health Organ. 2011;89 (6): 402-411B.
36. Ronsmans C, Fisher DJ, Osmond C, Margetts BM, Fall CH; Maternal Micronutrient Supplementation Study Group. Multiple micronutrient supplementation during pregnancy in low-income countries: ameta-analysis of effects on stillbirths and on early and late neonatal mortality. Food Nutr Bull. 2009;30 (4) (suppl): S547-S555.
37. Murphy JF, O'Riordan J, Newcombe RG, Coles EC, Pearson JF. Relation of haemoglobin levels in first and second trimesters to outcome of pregnancy. Lancet. 1986;1 (8488): 992-995.
38. Ziaei S, Norrozi M, Faghihzadeh S, Jafarbegloo E. A randomised placebocontrolled trial to determine the effect of iron supplementation on pregnancy outcome in pregnant women with haemoglobin ≥ 13.2 g/dl [published correction appears in BJOG. 2007;114 (10): 1311]. BJOG. 2007;114 (6): 684-688.
39. Cogswell ME, Parvanta I, Ickes L, Yip R, Brittenham GM. Iron supplementation during pregnancy, anemia, and birth weight: a randomized controlled trial. Am J Clin Nutr. 2003;78 (4): 773-781.
40. Siega-Riz AM, Hartzema AG, Turnbull C, Thorp J, McDonald T, Cogswell ME. The effects of prophylactic iron given in prenatal supplements on iron status and birth outcomes: a randomized controlled trial. Am J Obstet Gynecol. 2006; 194 (2): 512-519.
41. Zeng L, Yan H, Cheng Y, Dibley MJ. Modifying effects of wealth on the response to nutrient supplementation in pregnancy on birth weight, duration of gestation and perinatal mortality in rural western China: double-blind cluster randomized controlled trial. Int J Epidemiol. 2011;40 (2): 350-362.