Histological evaluation at different times after augmentation of extraction sites grafted with a magnesium-enriched hydroxyapatite: Double-blinded randomized controlled trial

Clinical Oral Implants Research

Volumn 24, Issue 4, 2013, Pages 398-406

  Canullo, Luigi ^a   Heinemann, Friedhelm ^b   Gedrange, Tomasz ^c   Biffar, Reiner ^b   Kunert Keil, Christiane ^b  

^a Private Practice   (Italy)

^b UNIVERSITY MEDICINE GREIFSWALD   (Germany)

^c DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

Author keywords

Bone augmentation; Graft material; Histomorphometry; Hydroxyapatite

Indexed keywords

ACID PHOSPHATASE; ACID PHOSPHATASE TARTRATE RESISTANT ISOENZYME; ALKALINE PHOSPHATASE; CAVEOLIN 1; CD34 ANTIGEN; HYDROXYAPATITE; ISOENZYME; MAGNESIUM; TARTRATE-RESISTANT ACID PHOSPHATASE;

ANGIOGENESIS; ANTIBIOTIC PROPHYLAXIS; ARTICLE; BIOPSY; BONE DEVELOPMENT; BONE PROSTHESIS; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFECT; FEMALE; HUMAN; IMMUNOHISTOCHEMISTRY; MALE; METABOLISM; METHODOLOGY; MIDDLE AGED; ORAL SURGERY; RANDOMIZED CONTROLLED TRIAL; STAINING; TOOTH EXTRACTION; TOOTH SOCKET;

ACID PHOSPHATASE; ALKALINE PHOSPHATASE; ALVEOLAR RIDGE AUGMENTATION; ANTIBIOTIC PROPHYLAXIS; ANTIGENS, CD34; BIOPSY; BONE SUBSTITUTES; CAVEOLIN 1; DOUBLE-BLIND METHOD; DURAPATITE; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; ISOENZYMES; MAGNESIUM; MALE; MIDDLE AGED; NEOVASCULARIZATION, PHYSIOLOGIC; OSTEOGENESIS; STAINING AND LABELING; TOOTH EXTRACTION; TOOTH SOCKET;

EID: 84874779395     PISSN: 09057161     EISSN: 16000501     Source Type: Journal    
DOI: 10.1111/clr.12035     Document Type: Article

References (38)

1. Adams, R.H. & Alitalo, K. (2007) Molecular regulation of angiogenesis and lymphangiogenesis. Nature Reviews Molecular Cell Biology 8: 464-478.
2. Araújo, M., Linder, E. & Lindhe, J. (2009) Effect of a xenograft on early bone formation in extraction sockets: an experimental study in dog. Clinical Oral Implant Research 20: 1-6.
3. Araújo, M.G. & Lindhe, J. (2009) Ridge preservation with the use of Bio-Oss collagen: a 6-month study in the dog. Clinical Oral Implant Research 20: 433-440.
4. Becker, W., Clokie, C., Sennerby, L., Urist, M.R. & Becker, B.E. (1998) Histologic findings after implantation and evaluation of different grafting materials and titanium micro screws into extraction sockets: case reports. Journal of Periodontology69: 414-421.
5. Caneva, M., Botticelli, D., Stellini, E., Souza, S.L., Salata, L.A. & Lang, N.P. (2011) Magnesium-enriched hydroxyapatite at immediate implants: a histomorphometric study in dogs. Clinical Oral Implant Research 22: 512-517.
6. Canullo, L. & Dellavia, C. (2009) Sinus lift using a nanocrystalline hydrxyapatite silicea gel in severely resorbed maxillae: histological preliminary study. Clinical Implant Dental Related Research 11 (Suppl. 1): e7-13.
7. Carmagnola, D., Adriaens, P. & Berglundh, T. (2003) Healing of human extraction sockets filled with Bio Oss. Clinical Oral Implant Research 14: 137-143.
8. Chen, S.T., Darby, I.B. & Reynolds, E.C. (2007) A prospective clinical study of non-submerged immediate implants. Clinical outcomes and esthetic results. Clinical Oral Implants Research 18: 552-562.
9. Chiapasco, M., Zaniboni, M. & Boisco, M. (2006) Augmentation procedures for the rehabilitation of deficient edentulous ridges with oral implants. Clinical Oral Implant Research 17: 136-159.
10. Cornelini, R., Cangini, F., Martuscelli, G. & Wennstro ̈m, J. (2004) Deproteinized bovine bone and biodegradable barrier membrane to support healing following immediate placement of transmucosal implants: a short-term controller clinical trial. The International Journal of Periodontics and Restorative Dentistry 24: 555-563.
11. Crespi, R., Cappare, P. & Gherlone, E. (2009a) Dental implants placed in extraction sites grafted with different bone substitutes: radiographic evaluation at 24 months. Journal of Periodontology 80: 1616-1621.
12. Crespi, R., Cappare, P. & Gherlone, E. (2009b) Magnesium-enriched hydroxyapatite compared to calcium sulfate in the healing of human extraction sockets: radiographic and histomorphometric evaluation at 3 months. Journal of Periodontology 80: 210-218.
13. Crespi, R., Capparè, P. & Gherlone, E. (2011) Comparison of magnesium-enriched hydroxyapatite and porcine bone in human extraction socket healing: a histologic and histomorphometric evaluation. International Journal of Oral & Maxillofacial Implants 26: 1057-1062.
14. Crespi, R., Mariani, E., Benasciutti, E., Cappare, P., Cenci, S. & Gherlone, E. (2009c) Magnesium-enriched hydroxyapatite versus autologous bone in maxillary sinus grafting: combining histomorphometry with osteoblast gene expression profiles ex vivo. Journal of Periodontology 80: 586-593.
15. Frank, P.G., Woodman, S.E., Park, D.S. & Lisanti, M.P. (2003) Caveolin, caveolae, and endothelial cell function. Arteriosclerosis, Thrombosis, and Vascular Biology 23: 1161-1168.
16. Gerber, T., Holzhüter, G., Götz, W., Bienengräber, V., Henkel, K.O. & Rumpel, E. (2006) Nanostructuring of biomaterials - a pathway to bone grafting substitute. European Journal of Trauma 32: 132-140.
17. Gerger, A., Bergthaler, P. & Smolle, J. (2004) An automated method for the quantification and fractal analysis of immunostaining. Cellular Oncology 26: 125-134.
18. Götz, W., Gerber, T., Michel, B., Lossdorfer, S., Henkel, K.O. & Heinemann, F. (2008) Immunohistochemical characterization of nanocrystalline hydroxyapatite silica gel (NanoBone(r)) osteogenesis: a study on biopsies from human jaws. Clinical Oral Implant Research 19: 1016-1026.
19. Götz, W., Lenz, S., Reichert, C., Henkel, K.O., Bienengraber, V., Pernicka, L., Gundlach, K.K., Gredes, T., Gerber, T., Gedrange, T. & Heinemann, F. (2010) A preliminary study in osteoinduction by a nano-crystalline hydroxyapatite in the mini pig. Folia Histochemica Et Cytobiologica 48: 589-596.
20. Götz, W., Reichert, C., Canullo, L., Jager, A. & Heinemann, F. (2011) Coupling of osteogenesis and angiogenesis in bone substitute healing - a brief overview. Annals of Anatomy 194: 171-173.
21. Hada, N., Okayasu, M., Ito, J., Nakayachi, M., Hayashida, C., Kaneda, T., Uchida, N., Muramatsu, T., Koike, C., Masuhara, M., Sato, T. & Hakeda, Y. (2012) Receptor activator of NF-kappaB ligand-dependent expression of caveolin-1 in osteoclast precursors, and high dependency of osteoclastogenesis on exogenous lipoprotein. Bone 50: 226-236.
22. Jung, R.E., Siegenthaler, D.W. & Hämmerle, C.H. (2004) Postextraction tissue management: a soft tissue punch technique. International Journal of Periodontics & Restorative Dentistry 24: 545-553.
23. Kakudo, N., Kusumoto, K., Wang, Y.B., Iguchi, Y. & Ogawa, Y. (2006) Immunolocalization of vascular endothelial growth factor on intramuscular ectopic osteoinduction by bone morphogenetic protein-2. Life Science 79: 1847-1855.
24. Kunert-Keil, C., Gredes, T., Lucke, S., Morgenstern, S., Mielczarek, A., Sporniak-Tutak, K., Gedrange, T. & Spassov, A. (2011) Caveolin-1, caveolin-3 and VEGF expression in the masticatory muscles of mdx mice. Folia Histochemica Et Cytobiologica 49: 291-298.
25. Le Lay, S., Blouin, C.M., Hajduch, E. & Dugail, I. (2009) Filling up adipocytes with lipids. Lessons from caveolin-1 deficiency. Biochimica et Biophysica Acta 1791: 514-518.
26. Lofthouse, R.A., Davis, J.R., Frondoza, C.G., Jinnah, R.H., Hungerford, D.S. & Hare, J.M. (2001) Identification of caveolae and detection of caveolin in normal human osteoblasts. The Journal of Bone & Joint Surgery (British Volume) 83: 124-129.
27. Ripamonti, U., Crooks, J., Khoali, L. & Roden, L. (2009) The induction of bone formation by coral-derived calcium carbonate/hydroxyapatite constructs. Biomaterials 30: 1428-1439.
28. Ripamonti, U., Richter, P.W., Nilen, R.W. & Renton, L. (2008) The induction of bone formation by smart biphasic hydroxyapatite tricalcium phosphate biomimetic matrices in the non-human primate Papio ursinus. Journal of Cellular and Molecular Medicine 12: 2609-2621.
29. Rothberg, K.G., Heuser, J.E., Donzell, W.C., Ying, Y.S., Glenney, J.R. & Anderson, R.G. (1992) Caveolin, a protein component of caveolae membrane coats. Cell 68: 673-682.
30. Rubin, J., Schwartz, Z., Boyan, B.D., Fan, X., Case, N., Sen, B., Drab, M., Smith, D., Aleman, M., Wong, K.L., Yao, H., Jo, H. & Gross, T.S. (2007) Caveolin-1 knockout mice have increased bone size and stiffness. Journal of Bone and Mineral Research 22: 1408-1418.
31. Santos, M.I. & Reis, R.L. (2010) Vascularization in bone tissue engineering: physiology, current strategies, major hurdles and future challenges. Macromolecular Bioscience 10: 12-27.
32. Sawada, N., Taketani, Y., Amizuka, N., Ichikawa, M., Ogawa, C., Nomoto, K., Nashiki, K., Sato, T., Arai, H., Isshiki, M., Segawa, H., Yamamoto, H., Miyamoto, K. & Takeda, E. (2007) Caveolin-1 in extracellular matrix vesicles secreted from osteoblasts. Bone 41: 52-58.
33. Schropp, L., Wenzel, A., Kostopoulos, L. & Karring, T. (2003) Bone healing and soft tissue contour changes following single-tooth extraction: a clinical and radiographic 12-month prospective study. International Journal of Periodontics & Restorative Dentistry 23: 313-323.
34. Sisti, A., Canullo, L., Mottola, M.P., Covani, U., Barone, A. & Botticelli, D. (2012) Clinical evaluation of a ridge augmentation procedure for the severely resorbed alveolar socket: multicenter randomized controlled trial, preliminary results. Clinical Oral Implant Research 23: 526-535.
35. Solomon, K.R., Danciu, T.E., Adolphson, L.D., Hecht, L.E. & Hauschka, P.V. (2000) Caveolin-enriched membrane signaling complexes in human and murine osteoblasts. Journal of Bone & Mineral Research 15: 2380-2390.
36. Tamaskar, I. & Zhou, M. (2008) Clinical implications of caveolins in malignancy and their potential as therapeutic targets. Current Oncology Reports 10: 101-106.
37. Trombelli, L., Penolazzi, L., Torreggiani, E., Farina, R., Lambertini, E., Vecchiatini, R. & Piva, R. (2010) Effect of hydroxyapatite-based biomaterials on human osteoblast phenotype. Minerva Stomatologica 59: 103-115.
38. Woodman, S.E., Ashton, A.W., Schubert, W., Lee, H., Williams, T.M., Medina, F.A., Wyckoff, J.B., Combs, T.P. & Lisanti, M.P. (2003) Caveolin-1 knockout mice show an impaired angiogenic response to exogenous stimuli. American Journal of Pathology 162: 2059-2068.