Caveolin-enriched membrane signaling complexes in human and murine osteoblasts

Journal of Bone and Mineral Research

Volumn 15, Issue 12, 2000, Pages 2380-2390

  Solomon, Keith R ^a,b   Danciu, Theodora E ^a,c   Adolphson, Layla D ^a   Hecht, Leah E ^a   Hauschka, Peter V ^c  

^a BOSTON CHILDREN S HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c HARVARD SCHOOL OF DENTAL MEDICINE   (United States)

Author keywords

Caveolae; Caveolin; Osteoblast; Platelet derived growth factor; Signaling

Indexed keywords

CALCIUM; CAVEOLIN; GUANINE NUCLEOTIDE BINDING PROTEIN; HORMONE; NITRIC OXIDE SYNTHASE; PLATELET DERIVED GROWTH FACTOR; PLATELET DERIVED GROWTH FACTOR RECEPTOR; PROTEIN TYROSINE KINASE; TRITON X 100;

ANIMAL CELL; ARTICLE; CELL MEMBRANE; CONTROLLED STUDY; EXTRACELLULAR MATRIX; HUMAN; HUMAN CELL; MEMBRANE VESICLE; MOUSE; NONHUMAN; OSTEOBLAST; SIGNAL TRANSDUCTION;

EID: 0033695837     PISSN: 08840431     EISSN: None     Source Type: Journal    
DOI: 10.1359/jbmr.2000.15.12.2380     Document Type: Article

References (46)

1. The structure and development of bone
2. Caveolae in human and murine osteoblasts
3. Evidence for a regulated interaction between heterotrimeric G proteins and caveolin
4. Endothelial nitric oxide synthase is regulated by tyrosine phosphorylation and interacts with caveolin-1
5. Co-purification and direct interaction of Ras with caveolin, an integral membrane protein of caveolae microdomains. Detergent-free purification of caveolae microdomains
6. Src tyrosine kinases. Galpha subunits, and H-Ras share a common membrane-anchored scaffolding protein, caveolin. Caveolin binding negatively regulates the auto-activation of Src tyrosine kinases
7. Localization of platelet-derived growth factor-stimulated phosphorylation cascade to caveolae
8. Organized endothelial cell surface signal transduction in caveolae distinct from glycosylphosphatidylinositol-anchored protein microdomains
9. In situ flow activates endothelial nitric oxide synthase in luminal caveolae of endothelium with rapid caveolin dissociation and calmodulin association
10. Rapid mechanotransduction in situ at the luminal cell surface of vascular endothelium and its caveolae
11. Heterotrimeric G proteins physically associated with the lipopolysaccharide receptor CD14 modulate both in vivo and in vitro responses to lipopolysaccharide
12. Membrane compartmentation is required for efficient T cell activation
13. LAT palmitoylationi Its essential role in membrane microdomain targeting and tyrosine phosphorylation during T cell activation
14. Separation of caveolae from associated microdomains of GPI-anchored proteins
15. Platelet-derived growth factor activates mitogen-activated protein kinase in isolated caveolae
16. Caveolin, a protein component of caveolae membrane coats
17. Development and characterization of a conditionally immortalized human fetal osteoblastic cell line
18. In vitro differentiation and calcification in a new clonal osteogenic cell line derived from newborn mouse calvaria
19. Cytokines induce nitric oxide production in mouse osteoblasts
20. Reaction of nitrogen dioxide with Griess type reagents
21. The nature of membrane anchorage determines kinase association and detergent solubility of CD4
22. Determination of the non-ionic detergent insolubility and phosphoprotein associations of glycosylphosphatidylinositol-anchored proteins expressed on T cells
23. The dynamins: Redundant or distinct functions for an expanding family of related GTPases?
24. Microdomain-dependent regulation of Lck and Fyn protein-tyrosine kinases in T lymphocyte plasma membranes
25. Requirement of caveolae microdomains in extracellular signal-regulated kinase and focal adhesion kinase activation induced bY endothelin-1 in primary astrocytes
26. Tyrosine phosphorylation of a 22-kDa protein is correlated with transformation by Rous sarcoma virus
27. Novel tyrosine kinase substrates from Rous sarcoma virus-transformed cells are present in the membrane skeleton
28. Platelet-derived growth factor and the skeleton
29. Platelet-derived growth factor receptor signals
30. Detergent insolubility of alkaline phosphatase during biosynthetic transport and endocytosis. Role of cholesterol
31. Interactions between saturated acyl chains confer detergent resistance on lipids and glycosylphosphatidylinositol (GPI)-anchored proteins: GPI-anchored proteins in liposomes and cells show similar behavior
32. The association between glycosylphosphatidylinositol-anchored proteins and heterotrimeric G protein alpha subunits in lymphocytes
33. Lysine residues form an integral component of a novel NH2-terminal membrane targeting motif for myristylated pp60v-src
34. Caveolin is palmitoylated on multiple cysteine residues. Palmitoylation is not necessary for localization of caveolin to caveolae
35. Electrostatics and the membrane association of Src: Theory and experiment
36. Role of lipid modifications in targeting proteins to detergent-resistant membrane rafts. Many raft proteins are acylated, while few are prenylated
37. Human osteoblast-like cells produce nitric oxide and express inducible nitric oxide synthase
38. Expression and functional role of nitric oxide synthase in osteoblast-like cells
39. Expressior of nitric oxide synthase isoforms in bone and bone cell cultures
40. Expression and functional role of nitric oxide synthase isoforms in human osteoblast-like cells
41. Interaction of neuronal nitric-oxide synthase with caveolin-3 in skeletal muscle. Identification of a novel caveolin scaffolding/inhibitory domain
42. Mutagenesis of palmitoylation sites in endothelial nitric oxide synthase identifies a novel motif for dual acylation and subcellular targeting
43. Targeting of nitric oxide synthase to endothelial cell caveolae via palmitoylation: Implications for nitric oxide signaling
44. Dynamic regulation of endothelial nitric oxide synthase: Complementary roles of dual acylation and caveolin interactions
45. The Nck SH2/SH3 adaptor protein: A regulator of multiple intracellular signal transduction events
46. Exclusion of CD45 inhibits activity of p561ck associated with glycolipid-enriched membrane domains