메뉴 건너뛰기




Volumn 40, Issue 3, 2013, Pages

Systematic evaluation of four-dimensional hybrid depth scanning for carbon-ion lung therapy

Author keywords

carbon ion beam; intrafractional motion; pencil beam scanning; radiotherapy; respiratory

Indexed keywords

BIOLOGICAL ORGANS; CARBON; ION BEAMS; IONS; NUCLEAR INSTRUMENTATION; PATIENT MONITORING; PHANTOMS; RADIOTHERAPY; RESPIRATORY MECHANICS;

EID: 84874775211     PISSN: 00942405     EISSN: None     Source Type: Journal    
DOI: 10.1118/1.4792295     Document Type: Article
Times cited : (40)

References (43)
  • 1
    • 80051580618 scopus 로고    scopus 로고
    • Cancer statistics, 2011: The impact of eliminating socioeconomic and racial disparities on premature cancer deaths
    • 10.3322/caac.20121
    • R. Siegel, E. Ward, O. Brawley, and A. Jemal, " Cancer statistics, 2011: The impact of eliminating socioeconomic and racial disparities on premature cancer deaths.," Ca-Cancer J. Clin. 61 (4), 212-236 (2011). 10.3322/caac.20121
    • (2011) Ca-Cancer J. Clin. , vol.61 , Issue.4 , pp. 212-236
    • Siegel, R.1    Ward, E.2    Brawley, O.3    Jemal, A.4
  • 2
    • 4844229902 scopus 로고    scopus 로고
    • Stereotactic hypofractionated high-dose irradiation for stage i nonsmall cell lung carcinoma: Clinical outcomes in 245 subjects in a Japanese multiinstitutional study
    • 10.1002/cncr.20539
    • H. Onishi, " Stereotactic hypofractionated high-dose irradiation for stage I nonsmall cell lung carcinoma: Clinical outcomes in 245 subjects in a Japanese multiinstitutional study.," Cancer 101 (7), 1623-1631 (2004). 10.1002/cncr.20539
    • (2004) Cancer , vol.101 , Issue.7 , pp. 1623-1631
    • Onishi, H.1
  • 3
    • 18344370445 scopus 로고    scopus 로고
    • Clinical outcomes of 3D conformal hypofractionated single high-dose radiotherapy for one or two lung tumors using a stereotactic body frame
    • 10.1016/S0360-3016(01)02731-6
    • Y. Nagata, " Clinical outcomes of 3D conformal hypofractionated single high-dose radiotherapy for one or two lung tumors using a stereotactic body frame.," Int. J. Radiat. Oncol., Biol., Phys. 52 (4), 1041-1046 (2002). 10.1016/S0360-3016(01)02731-6
    • (2002) Int. J. Radiat. Oncol., Biol., Phys. , vol.52 , Issue.4 , pp. 1041-1046
    • Nagata, Y.1
  • 4
    • 84865079902 scopus 로고    scopus 로고
    • Carbon ion radiotherapy in a hypofraction regimen for stage i non-small cell lung cancer
    • in, Centre ETOILE, Lyon-France (National Institute of Radiological Sciences), p, NIRS-M-243.
    • N. Yamamoto, " Carbon ion radiotherapy in a hypofraction regimen for stage I non-small cell lung cancer.," in Proceedings of NIRS-ETOILE Joint Symposium on Carbon Ion Radiotherapy, Centre ETOILE, Lyon-France (National Institute of Radiological Sciences, 2011), pp. 27-37, NIRS-M-243.
    • (2011) Proceedings of NIRS-ETOILE Joint Symposium on Carbon Ion Radiotherapy , pp. 27-37
    • Yamamoto, N.1
  • 5
    • 84865079719 scopus 로고    scopus 로고
    • A review of update clinical results of carbon ion radiotherapy
    • 10.1093/jjco/hys104
    • H. Tsujii and T. Kamada, " A review of update clinical results of carbon ion radiotherapy.," Jpn. J. Clin. Oncol. 42 (8), 670-685 (2012). 10.1093/jjco/hys104
    • (2012) Jpn. J. Clin. Oncol. , vol.42 , Issue.8 , pp. 670-685
    • Tsujii, H.1    Kamada, T.2
  • 6
    • 34249092077 scopus 로고    scopus 로고
    • Irradiation system for HIMAC
    • 10.1269/jrr.48.A15
    • M. Torikoshi, " Irradiation system for HIMAC.," J. Radiat. Res. 48, A15-A25 (2007). 10.1269/jrr.48.A15
    • (2007) J. Radiat. Res. , vol.48
    • Torikoshi, M.1
  • 7
    • 84872810256 scopus 로고    scopus 로고
    • First clinical experience in carbon-ion scanning beam therapy: Retrospective analysis of patient positional accuracy
    • S. Mori, " First clinical experience in carbon-ion scanning beam therapy: Retrospective analysis of patient positional accuracy.," J. Radiat. Res. (Tokyo) 53 (5), 760-768 (2012).
    • (2012) J. Radiat. Res. (Tokyo) , vol.53 , Issue.5 , pp. 760-768
    • Mori, S.1
  • 8
    • 33847682874 scopus 로고    scopus 로고
    • Design study of a raster scanning system for moving target irradiation in heavy-ion radiotherapy
    • 10.1118/1.2558213
    • T. Furukawa, " Design study of a raster scanning system for moving target irradiation in heavy-ion radiotherapy.," Med. Phys. 34 (3), 1085-1097 (2007). 10.1118/1.2558213
    • (2007) Med. Phys. , vol.34 , Issue.3 , pp. 1085-1097
    • Furukawa, T.1
  • 9
    • 42449147956 scopus 로고    scopus 로고
    • Quantification of interplay effects of scanned particle beams and moving targets
    • 10.1088/0031-9155/53/9/003
    • C. Bert, S. O. Grozinger, and E. Rietzel, " Quantification of interplay effects of scanned particle beams and moving targets.," Phys. Med. Biol. 53 (9), 2253-2265 (2008). 10.1088/0031-9155/53/9/003
    • (2008) Phys. Med. Biol. , vol.53 , Issue.9 , pp. 2253-2265
    • Bert, C.1    Grozinger, S.O.2    Rietzel, E.3
  • 10
    • 77956329277 scopus 로고    scopus 로고
    • Special report: Workshop on 4D-treatment planning in actively scanned particle therapy-recommendations, technical challenges, and future research directions
    • 10.1118/1.3475944
    • A. Knopf, " Special report: Workshop on 4D-treatment planning in actively scanned particle therapy-recommendations, technical challenges, and future research directions.," Med. Phys. 37 (9), 4608-4014 (2010). 10.1118/1.3475944
    • (2010) Med. Phys. , vol.37 , Issue.9 , pp. 4608-4014
    • Knopf, A.1
  • 11
    • 0037036516 scopus 로고    scopus 로고
    • Effects of intra-fraction motion on IMRT dose delivery: Statistical analysis and simulation
    • 10.1088/0031-9155/47/13/302
    • T. Bortfeld, K. Jokivarsi, M. Goitein, J. Kung, and S. B. Jiang, " Effects of intra-fraction motion on IMRT dose delivery: Statistical analysis and simulation.," Phys. Med. Biol. 47 (13), 2203-2220 (2002). 10.1088/0031-9155/47/13/302
    • (2002) Phys. Med. Biol. , vol.47 , Issue.13 , pp. 2203-2220
    • Bortfeld, T.1    Jokivarsi, K.2    Goitein, M.3    Kung, J.4    Jiang, S.B.5
  • 12
    • 55649094218 scopus 로고    scopus 로고
    • Motion compensation with a scanned ion beam: A technical feasibility study
    • 10.1186/1748-717X-3-34
    • S. O. Grozinger, C. Bert, T. Haberer, G. Kraft, and E. Rietzel, " Motion compensation with a scanned ion beam: A technical feasibility study.," Radiat. Oncol. 3 (2008). 10.1186/1748-717X-3-34
    • (2008) Radiat. Oncol. , vol.3
    • Grozinger, S.O.1    Bert, C.2    Haberer, T.3    Kraft, G.4    Rietzel, E.5
  • 13
    • 0024442522 scopus 로고
    • Irradiation synchronized with respiration gate
    • 10.1016/0360-3016(89)90078-3
    • K. Ohara, " Irradiation synchronized with respiration gate.," Int. J. Radiat. Oncol., Biol., Phys. 17 (4), 853-857 (1989). 10.1016/0360-3016(89)90078-3
    • (1989) Int. J. Radiat. Oncol., Biol., Phys. , vol.17 , Issue.4 , pp. 853-857
    • Ohara, K.1
  • 14
    • 0026504759 scopus 로고
    • Effects of respiratory motion on dose uniformity with a charged particle scanning method
    • 10.1088/0031-9155/37/1/016
    • M. H. Phillips, E. Pedroni, H. Blattmann, T. Boehringer, A. Coray, and S. Scheib, " Effects of respiratory motion on dose uniformity with a charged particle scanning method.," Phys. Med. Biol. 37 (1), 223-234 (1992). 10.1088/0031-9155/37/1/016
    • (1992) Phys. Med. Biol. , vol.37 , Issue.1 , pp. 223-234
    • Phillips, M.H.1    Pedroni, E.2    Blattmann, H.3    Boehringer, T.4    Coray, A.5    Scheib, S.6
  • 15
    • 0035136220 scopus 로고    scopus 로고
    • Motion adaptive x-ray therapy: A feasibility study
    • 10.1088/0031-9155/46/1/301
    • P. J. Keall, V. R. Kini, S. S. Vedam, and R. Mohan, " Motion adaptive x-ray therapy: A feasibility study.," Phys. Med. Biol. 46 (1), 1-10 (2001). 10.1088/0031-9155/46/1/301
    • (2001) Phys. Med. Biol. , vol.46 , Issue.1 , pp. 1-10
    • Keall, P.J.1    Kini, V.R.2    Vedam, S.S.3    Mohan, R.4
  • 16
    • 70349581605 scopus 로고    scopus 로고
    • Breathing interplay effects during proton beam scanning: Simulation and statistical analysis
    • 10.1088/0031-9155/54/14/N01
    • J. Seco, D. Robertson, A. Trofimov, and H. Paganetti, " Breathing interplay effects during proton beam scanning: Simulation and statistical analysis.," Phys. Med. Biol. 54 (14), N283-N294 (2009). 10.1088/0031-9155/54/14/N01
    • (2009) Phys. Med. Biol. , vol.54 , Issue.14
    • Seco, J.1    Robertson, D.2    Trofimov, A.3    Paganetti, H.4
  • 17
    • 77956305334 scopus 로고    scopus 로고
    • Moving target irradiation with fast rescanning and gating in particle therapy
    • 10.1118/1.3481512
    • T. Furukawa, " Moving target irradiation with fast rescanning and gating in particle therapy.," Med. Phys. 37 (9), 4874-4879 (2010). 10.1118/1.3481512
    • (2010) Med. Phys. , vol.37 , Issue.9 , pp. 4874-4879
    • Furukawa, T.1
  • 18
    • 80155130439 scopus 로고    scopus 로고
    • Scanned proton radiotherapy for mobile targets-the effectiveness of re-scanning in the context of different treatment planning approaches and for different motion characteristics
    • 10.1088/0031-9155/56/22/016
    • A. C. Knopf, T. S. Hong, and A. Lomax, " Scanned proton radiotherapy for mobile targets-the effectiveness of re-scanning in the context of different treatment planning approaches and for different motion characteristics.," Phys. Med. Biol. 56 (22), 7257-7271 (2011). 10.1088/0031-9155/56/22/016
    • (2011) Phys. Med. Biol. , vol.56 , Issue.22 , pp. 7257-7271
    • Knopf, A.C.1    Hong, T.S.2    Lomax, A.3
  • 19
    • 78149297157 scopus 로고    scopus 로고
    • A study on repainting strategies for treating moderately moving targets with proton pencil beam scanning at the new Gantry 2 at PSI
    • 10.1088/0031-9155/55/17/014
    • S. M. Zenklusen, E. Pedroni, and D. Meer, " A study on repainting strategies for treating moderately moving targets with proton pencil beam scanning at the new Gantry 2 at PSI.," Phys. Med. Biol. 55 (17), 5103-5121 (2010). 10.1088/0031-9155/55/17/014
    • (2010) Phys. Med. Biol. , vol.55 , Issue.17 , pp. 5103-5121
    • Zenklusen, S.M.1    Pedroni, E.2    Meer, D.3
  • 20
    • 0036913244 scopus 로고    scopus 로고
    • Treatment planning for the layer-stacking irradiation system for three-dimensional conformal heavy-ion radiotherapy
    • 10.1118/1.1521938
    • N. Kanematsu, " Treatment planning for the layer-stacking irradiation system for three-dimensional conformal heavy-ion radiotherapy.," Med. Phys. 29 (12), 2823-2829 (2002). 10.1118/1.1521938
    • (2002) Med. Phys. , vol.29 , Issue.12 , pp. 2823-2829
    • Kanematsu, N.1
  • 21
    • 79955628202 scopus 로고    scopus 로고
    • Four-dimensional lung treatment planning in layer-stacking carbon ion beam treatment: Comparison of layer-stacking and conventional ungated/gated irradiation
    • 10.1016/j.ijrob2010.07.1982
    • S. Mori, " Four-dimensional lung treatment planning in layer-stacking carbon ion beam treatment: Comparison of layer-stacking and conventional ungated/gated irradiation.," Int. J. Radiat. Oncol., Biol., Phys. 80 (2), 597-607 (2011). 10.1016/j.ijrobp.2010.07.1982
    • (2011) Int. J. Radiat. Oncol., Biol., Phys. , vol.80 , Issue.2 , pp. 597-607
    • Mori, S.1
  • 22
    • 33748798224 scopus 로고
    • Heavy ion synchrotron for medical use HIMAC project at NIRS-Japan
    • 10.1016/0375-9474(92)90803-R
    • Y. Hirao, " Heavy ion synchrotron for medical use HIMAC project at NIRS-Japan.," Nucl. Phys. A 538, 541-550 (1992). 10.1016/0375-9474(92) 90803-R
    • (1992) Nucl. Phys. A , vol.538 , pp. 541-550
    • Hirao, Y.1
  • 23
    • 0027609090 scopus 로고
    • Magnetic scanning system for heavy ion therapy
    • 10.1016/0168-9002(93)91335-K
    • T. Haberer, W. Becher, D. Schardt, and G. Kraft, " Magnetic scanning system for heavy ion therapy.," Nucl. Instrum. Methods Phys. Res. A 330, 296-305 (1993). 10.1016/0168-9002(93)91335-K
    • (1993) Nucl. Instrum. Methods Phys. Res. A , vol.330 , pp. 296-305
    • Haberer, T.1    Becher, W.2    Schardt, D.3    Kraft, G.4
  • 24
    • 78049306076 scopus 로고    scopus 로고
    • Multiple-energy operation with extended flattops at HIMAC
    • 10.1016/j.nima.2010.09.016
    • Y. Iwata, " Multiple-energy operation with extended flattops at HIMAC.," Nucl. Instrum. Methods Phys. Res. A 624 (1), 33-38 (2010). 10.1016/j.nima.2010.09.016
    • (2010) Nucl. Instrum. Methods Phys. Res. A , vol.624 , Issue.1 , pp. 33-38
    • Iwata, Y.1
  • 25
    • 12144289318 scopus 로고    scopus 로고
    • The PSI Gantry 2: A second generation proton scanning gantry
    • E. Pedroni, " The PSI Gantry 2: A second generation proton scanning gantry.," Z. Med. Phys. 14 (1), 25-34 (2004).
    • (2004) Z. Med. Phys. , vol.14 , Issue.1 , pp. 25-34
    • Pedroni, E.1
  • 26
    • 84861601600 scopus 로고    scopus 로고
    • Evaluation of hybrid depth scanning for carbon-ion radiotherapy
    • 10.1118/1.4705357
    • T. Inaniwa, " Evaluation of hybrid depth scanning for carbon-ion radiotherapy.," Med. Phys. 39 (5), 2820-2825 (2012). 10.1118/1.4705357
    • (2012) Med. Phys. , vol.39 , Issue.5 , pp. 2820-2825
    • Inaniwa, T.1
  • 27
    • 0037691489 scopus 로고    scopus 로고
    • A CT calibration method based on the polybinary tissue model for radiotherapy treatment planning
    • 10.1088/0031-9155/48/8/307
    • N. Kanematsu, N. Matsufuji, R. Kohno, S. Minohara, and T. Kanai, " A CT calibration method based on the polybinary tissue model for radiotherapy treatment planning.," Phys. Med. Biol. 48 (8), 1053-1064 (2003). 10.1088/0031-9155/48/8/307
    • (2003) Phys. Med. Biol. , vol.48 , Issue.8 , pp. 1053-1064
    • Kanematsu, N.1    Matsufuji, N.2    Kohno, R.3    Minohara, S.4    Kanai, T.5
  • 28
    • 81855185544 scopus 로고    scopus 로고
    • Development of beam current control system in RF-knockout slow extraction
    • 10.1016/j.nimb.2011.04.039
    • K. Mizushima, " Development of beam current control system in RF-knockout slow extraction.," Nucl. Instrum. Methods Phys. Res. B 269 (24), 2915-2918 (2011). 10.1016/j.nimb.2011.04.039
    • (2011) Nucl. Instrum. Methods Phys. Res. B , vol.269 , Issue.24 , pp. 2915-2918
    • Mizushima, K.1
  • 29
    • 3042661990 scopus 로고    scopus 로고
    • Physical performance evaluation of a 256-slice CT-scanner for four-dimensional imaging
    • 10.1118/1.1747758
    • S. Mori, " Physical performance evaluation of a 256-slice CT-scanner for four-dimensional imaging.," Med. Phys. 31 (6), 1348-1356 (2004). 10.1118/1.1747758
    • (2004) Med. Phys. , vol.31 , Issue.6 , pp. 1348-1356
    • Mori, S.1
  • 30
    • 33847662456 scopus 로고    scopus 로고
    • Four-dimensional measurement of lung tumor displacement using 256-multi-slice CT-scanner
    • 10.1016/j.lungcan.2006.11.011
    • S. Mori, M. Endo, S. Komatsu, T. Yashiro, S. Kandatsu, and M. Baba, " Four-dimensional measurement of lung tumor displacement using 256-multi-slice CT-scanner.," Lung Cancer 56 (1), 59-67 (2007). 10.1016/j.lungcan.2006.11.011
    • (2007) Lung Cancer , vol.56 , Issue.1 , pp. 59-67
    • Mori, S.1    Endo, M.2    Komatsu, S.3    Yashiro, T.4    Kandatsu, S.5    Baba, M.6
  • 31
    • 34748901307 scopus 로고    scopus 로고
    • GPU-based streaming architectures for fast cone-beam CT image reconstruction and demons deformable registration
    • 10.1088/0031-9155/52/19/003
    • G. C. Sharp, N. Kandasamy, H. Singh, and M. Folkert, " GPU-based streaming architectures for fast cone-beam CT image reconstruction and demons deformable registration.," Phys. Med. Biol. 52 (19), 5771-5783 (2007). 10.1088/0031-9155/52/19/003
    • (2007) Phys. Med. Biol. , vol.52 , Issue.19 , pp. 5771-5783
    • Sharp, G.C.1    Kandasamy, N.2    Singh, H.3    Folkert, M.4
  • 33
    • 0003651542 scopus 로고
    • International Commission on Radiation Units and Measurements, "," ICRU Report No. 50 (ICRU, Bethesda, MD).
    • International Commission on Radiation Units and Measurements, " Prescribing, recording and reporting photon beam therapy.," ICRU Report No. 50 (ICRU, Bethesda, MD, 1993).
    • (1993) Prescribing, Recording and Reporting Photon Beam Therapy
  • 34
    • 79961085493 scopus 로고    scopus 로고
    • A robust algorithm of intensity modulated proton therapy for critical tissue sparing and target coverage
    • 10.1088/0031-9155/56/15/008
    • T. Inaniwa, N. Kanematsu, T. Furukawa, and A. Hasegawa, " A robust algorithm of intensity modulated proton therapy for critical tissue sparing and target coverage.," Phys. Med. Biol. 56 (15), 4749-4770 (2011). 10.1088/0031-9155/56/15/008
    • (2011) Phys. Med. Biol. , vol.56 , Issue.15 , pp. 4749-4770
    • Inaniwa, T.1    Kanematsu, N.2    Furukawa, T.3    Hasegawa, A.4
  • 35
    • 77649185726 scopus 로고    scopus 로고
    • Practical approaches to four-dimensional heavy-charged-particle lung therapy
    • 10.1007/s12194-009-0072-3
    • S. Mori, " Practical approaches to four-dimensional heavy-charged-particle lung therapy.," Radiol. Phys. Technol. 3 (1), 23-33 (2010). 10.1007/s12194-009-0072-3
    • (2010) Radiol. Phys. Technol. , vol.3 , Issue.1 , pp. 23-33
    • Mori, S.1
  • 36
    • 34548301441 scopus 로고    scopus 로고
    • 4D treatment planning for scanned ion beams
    • C. Bert and E. Rietzel, " 4D treatment planning for scanned ion beams.," Radiat. Oncol. 3 (2007).
    • (2007) Radiat. Oncol. , vol.3
    • Bert, C.1    Rietzel, E.2
  • 37
    • 0003722288 scopus 로고    scopus 로고
    • International Electrotechnical Commission, "," IEC 61217 (IEC, Switzerland).
    • International Electrotechnical Commission, " Radiotherapy equipment: Coordinates, movements and scales.," IEC 61217 (IEC, Switzerland, 2002).
    • (2002) Radiotherapy Equipment: Coordinates, Movements and Scales
  • 38
    • 0026515872 scopus 로고
    • Differential-pencil-beam dose calculations for charged particles
    • 10.1118/1.596887
    • P. L. Petti, " Differential-pencil-beam dose calculations for charged particles.," Med. Phys. 19 (1), 137-149 (1992). 10.1118/1.596887
    • (1992) Med. Phys. , vol.19 , Issue.1 , pp. 137-149
    • Petti, P.L.1
  • 39
    • 49549099301 scopus 로고    scopus 로고
    • Quantification and visualization of charged particle range variations
    • 10.1016/j.ijrob2008.05.011
    • S. Mori and G. T. Chen, " Quantification and visualization of charged particle range variations.," Int. J. Radiat. Oncol., Biol., Phys. 72 (1), 268-277 (2008). 10.1016/j.ijrobp.2008.05.011
    • (2008) Int. J. Radiat. Oncol., Biol., Phys. , vol.72 , Issue.1 , pp. 268-277
    • Mori, S.1    Chen, G.T.2
  • 40
    • 80052412837 scopus 로고    scopus 로고
    • Preliminary investigations for the option to use fast uniform scanning with compensators on a gantry designed for IMPT
    • 10.1118/1.3626483
    • S. M. Zenklusen, E. Pedroni, D. Meer, C. Bula, and S. Safai, " Preliminary investigations for the option to use fast uniform scanning with compensators on a gantry designed for IMPT.," Med. Phys. 38 (9), 5208-5216 (2011). 10.1118/1.3626483
    • (2011) Med. Phys. , vol.38 , Issue.9 , pp. 5208-5216
    • Zenklusen, S.M.1    Pedroni, E.2    Meer, D.3    Bula, C.4    Safai, S.5
  • 41
    • 85026339925 scopus 로고    scopus 로고
    • Fluoroscopic evaluation of diaphragmatic motion reduction with a respiratory gated radiotherapy system
    • 10.1120/1.1409235
    • G. S. Mageras, " Fluoroscopic evaluation of diaphragmatic motion reduction with a respiratory gated radiotherapy system.," J. Appl. Clin. Med. Phys. 2 (4), 191-200 (2001). 10.1120/1.1409235
    • (2001) J. Appl. Clin. Med. Phys. , vol.2 , Issue.4 , pp. 191-200
    • Mageras, G.S.1
  • 42
    • 38149078236 scopus 로고    scopus 로고
    • Respiratory gated beam delivery cannot facilitate margin reduction, unless combined with respiratory correlated image guidance
    • 10.1016/j.radonc.2007.10.038
    • S. S. Korreman, T. Juhler-Nottrup, and A. L. Boyer, " Respiratory gated beam delivery cannot facilitate margin reduction, unless combined with respiratory correlated image guidance.," Radiother. Oncol. 86 (1), 61-68 (2008). 10.1016/j.radonc.2007.10.038
    • (2008) Radiother. Oncol. , vol.86 , Issue.1 , pp. 61-68
    • Korreman, S.S.1    Juhler-Nottrup, T.2    Boyer, A.L.3
  • 43
    • 84874760024 scopus 로고    scopus 로고
    • See supplementary material at http://dx.doi.org/10.1118/1.4792295 E-MPHYA6-40-044303 for carbon-ion scanning beam 4D dose distribution.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.