Investigation of the mechanisms contributing to the compensatory increase in insulin secretion during dexamethasone-induced insulin resistance in rhesus macaques

Journal of Endocrinology

Volumn 216, Issue 2, 2013, Pages 207-215

  Cummings, Bethany P ^a   Bremer, Andrew A ^b   Kieffer, Timothy J ^c   D'Alessio, David ^d   Havel, Peter J ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b VANDERBILT UNIVERSITY   (United States)

^c UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^d UNIVERSITY OF CINCINNATI   (United States)

Author keywords

Dexamethasone; GIP; Insulin resistance; Rhesus macaque

Indexed keywords

ADIPONECTIN; DEXAMETHASONE; GLUCAGON; GLUCAGON LIKE PEPTIDE 1; HYDROCORTISONE; INCRETIN; INSULIN; LEPTIN; PANCREAS POLYPEPTIDE; PROINSULIN; GASTRIC INHIBITORY POLYPEPTIDE RECEPTOR; HORMONE RECEPTOR;

ANIMAL EXPERIMENT; ARTICLE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; GLUCAGON BLOOD LEVEL; GLUCOSE BLOOD LEVEL; GLUCOSE HOMEOSTASIS; HYDROCORTISONE BLOOD LEVEL; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; INSULIN BLOOD LEVEL; INSULIN RELEASE; INSULIN RESISTANCE; INSULIN RESPONSE; MALE; NONHUMAN; PRIORITY JOURNAL; RHESUS MONKEY; ANIMAL; BLOOD; DIET RESTRICTION; DRUG EFFECT; METABOLISM; PHYSIOLOGY; POSTPRANDIAL STATE; SECRETION (PROCESS);

ANIMALS; BLOOD GLUCOSE; DEXAMETHASONE; FASTING; INSULIN; INSULIN RESISTANCE; MACACA MULATTA; MALE; POSTPRANDIAL PERIOD; RECEPTORS, GASTROINTESTINAL HORMONE;

MLCS; MLOWN;

EID: 84874762984     PISSN: 00220795     EISSN: 14796805     Source Type: Journal    
DOI: 10.1530/JOE-12-0459     Document Type: Article

References (37)

1. Ahren B & Holst JJ 2001 The cephalic insulin response to meal ingestion in humans is dependent on both cholinergic and noncholinergic mechanisms and is important for postprandial glycemia. Diabetes 50 1030-1038.
2. Angelini N, Rafacho A, Boschero AC & Bosqueiro JR 2010 Involvement of the cholinergic pathway in glucocorticoid-induced hyperinsulinemia in rats. Diabetes Research and Clinical Practice 87 184-191.
3. Baggio LL & Drucker DJ 2007 Biology of incretins: GLP-1 and GIP. Gastroenterology 132 2131-2157.
4. Beard JC, Halter JB, Best JD, Pfeifer MA & Porte D Jr 1984 Dexamethasoneinduced insulin resistance enhances B cell responsiveness to glucose level in normal men. American Journal of Physiology 247 E592-E596.
5. Brubaker PL & Drucker DJ 2004 Minireview: glucagon-like peptides regulate cell proliferation and apoptosis in the pancreas, gut, and central nervous system. Endocrinology 145 2653-2659.
6. van Citters GW, Kabir M, Kim SP, Mittelman SD, Dea MK, Brubaker PL & Bergman RN 2002 Elevated glucagon-like peptide-1-(7-36)-amide, but not glucose, associated with hyperinsulinemic compensation for fat feeding. Journal of Clinical Endocrinology and Metabolism 87 5191-5198.
7. Cummings BP, Bettaieb A, Graham JL, Stanhope KL, Dill R, Morton GJ, Haj FG & Havel PJ 2011 Subcutaneous administration of leptin normalizes fasting plasma glucose in obese type 2 diabetic UCD-T2DM rats. PNAS 108 14670-14675.
8. Dagogo-Jack S, Selke G, Melson AK & Newcomer JW 1997 Robust leptin secretory responses to dexamethasone in obese subjects. Journal of Clinical Endocrinology and Metabolism 82 3230-3233.
9. D'Alessio DA, Kieffer TJ, Taborsky GJ Jr & Havel PJ 2001 Activation of the parasympathetic nervous system is necessary for normal meal-induced insulin secretion in rhesus macaques. Journal of Clinical Endocrinology and Metabolism 86 1253-1259.
10. Divertie GD, Jensen MD & Miles JM 1991 Stimulation of lipolysis in humans by physiological hypercortisolemia. Diabetes 40 1228-1232.
11. Fletcher JM & McKenzie N 1988 The parasympathetic nervous system and glucocorticoid-mediated hyperinsulinaemia in the genetically obese (fa/fa) Zucker rat. Journal of Endocrinology 118 87-92.
12. Gingerich RL, Lacy PE, Chance RE & Johnson MG 1978 Regional pancreatic concentration and in-vitro secretion of canine pancreatic polypeptide, insulin, and glucagon. Diabetes 27 96-101.
13. Gremlich S, Roduit R & Thorens B 1997 Dexamethasone induces posttranslational degradation of GLUT2 and inhibition of insulin secretion in isolated pancreatic b cells. Comparison with the effects of fatty acids. Journal of Biological Chemistry 272 3216-3222.
14. Hansen KB, Vilsboll T, Bagger JI, Holst JJ & Knop FK 2012 Impaired incretininduced amplification of insulin secretion after glucose homeostatic dysregulation in healthy subjects. Journal of Clinical Endocrinology and Metabolism 97 1363-1370.
15. Hasselgren PO 1999 Glucocorticoids and muscle catabolism. Current Opinion in Clinical Nutrition and Metabolic Care 2 201-205.
16. Havel PJ & Valverde C 1996 Autonomic mediation of glucagon secretion during insulin-induced hypoglycemia in rhesus monkeys. Diabetes 45 960-966.
17. Havel PJ & Ahren B 1997 Activation of autonomic nerves and the adrenal medulla contributes to increased glucagon secretion during moderate insulin-induced hypoglycemia in women. Diabetes 46 801-807.
18. Howlett TA, Rees LH & Besser GM 1985 Cushing's syndrome. Clinics in Endocrinology and Metabolism 14 911-945.
19. Jensen DH, Aaboe K, Henriksen JE, Volund A, Holst JJ, Madsbad S & Krarup T 2012 Steroid-induced insulin resistance and impaired glucose tolerance are both associated with a progressive decline of incretin effect in first-degree relatives of patients with type 2 diabetes. Diabetologia 55 1406-1416.
20. Karlsson S, Ostlund B, Myrsen-Axcrona U, Sundler F & Ahren B 2001 b Cell adaptation to dexamethasone-induced insulin resistance in rats involves increased glucose responsiveness but not glucose effectiveness. Pancreas 22 148-156.
21. Kim SJ, Winter K, Nian C, Tsuneoka M, Koda Y & McIntosh CH 2005 Glucose-dependent insulinotropic polypeptide (GIP) stimulation of pancreatic b-cell survival is dependent upon phosphatidylinositol 3-kinase (PI3K)/protein kinase B (PKB) signaling, inactivation of the forkhead transcription factor Foxo1, and down-regulation of bax expression. Journal of Biological Chemistry 280 22297-22307.
22. Koko V, Glisic R, Todorovic V, Drndarevic N & Mitrovic O 2008 Glucosedependent insulinotropic polypeptide-producing K cells in dexamethasone-treated rats. Journal of Microscopy 232 493-497.
23. McMahon M, Gerich J & Rizza R 1988 Effects of glucocorticoids on carbohydrate metabolism. Diabetes/Metabolism Reviews 4 17-30.
24. Morgan LM, Morris BA & Marks V 1978 Radioimmunoassay of gastric inhibitory polypeptide. Annals of Clinical Biochemistry 15 172-177.
25. Morton GJ & Schwartz MW 2011 Leptin and the central nervous system control of glucose metabolism. Physiological Reviews 91 389-411.
26. Nicod N, Giusti V, Besse C & Tappy L 2003 Metabolic adaptations to dexamethasone-induced insulin resistance in healthy volunteers. Obesity Research 11 625-631.
27. Ogawa A, Johnson JH, Ohneda M, McAllister CT, Inman L, Alam T & Unger RH 1992 Roles of insulin resistance and b-cell dysfunction in dexamethasone-induced diabetes. Journal of Clinical Investigation 90 497-504.
28. Orskov C & Holst JJ 1987 Radio-immunoassays for glucagon-like peptides 1 and 2 (GLP-1 and GLP-2). Scandinavian Journal of Clinical and Laboratory Investigation 47 165-174.
29. Rafacho A, Marroqui L, Taboga SR, Abrantes JL, Silveira LR, Boschero AC, Carneiro EM, Bosqueiro JR, Nadal A & Quesada I 2010a Glucocorticoids in vivo induce both insulin hypersecretion and enhanced glucose sensitivity of stimulus-secretion coupling in isolated rat islets. Endocrinology 151 85-95.
30. Rafacho A, Quallio S, Ribeiro DL, Taboga SR, Paula FM, Boschero AC & Bosqueiro JR 2010b The adaptive compensations in endocrine pancreas from glucocorticoid-treated rats are reversible after the interruption of treatment. Acta Physiologica 200 223-235.
31. Rosen J & Miner JN 2005 The search for safer glucocorticoid receptor ligands. Endocrine Reviews 26 452-464.
32. Sainsbury A, Wilks D & Cooney GJ 2001 Central but not peripheral glucocorticoid infusion in adrenalectomized male rats increases basal and substrate-induced insulinemia through a parasympathetic pathway. Obesity Research 9 274-281.
33. Sakoda H, Ogihara T, Anai M, Funaki M, Inukai K, Katagiri H, Fukushima Y, Onishi Y, Ono H, Fujishiro M et al. 2000 Dexamethasone-induced insulin resistance in 3T3-L1 adipocytes is due to inhibition of glucose transport rather than insulin signal transduction. Diabetes 49 1700-1708.
34. Schwartz TW 1988 Effect of amino acid analogs on the processing of the pancreatic polypeptide precursor in primary cell cultures. Journal of Biological Chemistry 263 11504-11510.
35. Vegiopoulos A & Herzig S 2007 Glucocorticoids, metabolism andmetabolic diseases. Molecular and Cellular Endocrinology 275 43-61.
36. Weinstein SP, Wilson CM, Pritsker A & Cushman SW 1998 Dexamethasone inhibits insulin-stimulated recruitment of GLUT4 to the cell surface in rat skeletal muscle. Metabolism 47 3-6.
37. Wise JK, Hendler R & Felig P 1973 Influence of glucocorticoids on glucagon secretion and plasma amino acid concentrations in man. Journal of Clinical Investigation 52 2774-2782.