The Impact of Healthcare-Associated Infection on Mortality: Failure in Clinical Recognition Is Related with Inadequate Antibiotic Therapy

PLoS ONE

Volumn 8, Issue 3, 2013, Pages

  Cardoso, Teresa ^a   Ribeiro, Orquídea ^b   Aragão, Irene ^a   Costa Pereira, Altamiro ^b   Sarmento, António ^a  

^a UNIVERSITY OF PORTO   (Portugal)

^b University of Porto   (Portugal)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT;

ADULT; AGE DISTRIBUTION; AGED; ANTIBIOTIC THERAPY; ARTICLE; COHORT ANALYSIS; COMMUNITY ACQUIRED PNEUMONIA; CONTROLLED STUDY; DISEASE SEVERITY; DRUG TREATMENT FAILURE; FEMALE; HOSPITAL INFECTION; HUMAN; MAJOR CLINICAL STUDY; MALE; MORTALITY; PROSPECTIVE STUDY; RISK FACTOR; SEPSIS; SEPTIC SHOCK;

ADULT; AGED; AGED, 80 AND OVER; ANTI-BACTERIAL AGENTS; BACTERIAL INFECTIONS; FEMALE; GUIDELINE ADHERENCE; HOSPITAL MORTALITY; HUMANS; IATROGENIC DISEASE; MALE; MEDICAL ERRORS; MIDDLE AGED; PROSPECTIVE STUDIES;

EID: 84874762595     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0058418     Document Type: Article

References (32)

1. WHO (2012) World Health Statistics 2012. In: WHO G, editor. Available from: http://www.who.int/gho/publications/world_health_statistics/EN_WHS2012_Full.pdf. Accessed 12th February 2013.
2. Friedman ND, Kaye KS, Stout JE, McGarry SA, Trivette SL, et al. (2002) Health care-associated bloodstream infections in adults: a reason to change the accepted definition of community-acquired infections. Ann Intern Med 137: 791-797.
3. Kollef MH, Shorr A, Tabak YP, Gupta V, Liu LZ, et al. (2005) Epidemiology and outcomes of health-care-associated penumonia, results from a large US database of culture-positive pneumonia. Chest 128: 3854-3862.
4. Shorr AF, Tabak YP, Killian AD, Gupta V, Liu LZ, et al. (2006) Healthcare-associated bloodstream infection: a distinct entity? Insights from a large US database. Crit Care Med 34: 2588-2595.
5. Garner JS, Jarvis WR, Emori TG, Horan TC, Hughes JM, (1988) CDC definitions for nosocomial infections. Am J Infect Control 16: 128-140.
6. Catarralà J, Mykietiuk A, Fernández-Sabé N, Suárez C, Dorca J, et al. (2007) Health care-associated pneumonia requiring hospital admission. Arch Intern Med 167: 1393-1399.
7. Vallés J, Calbo E, Anoro E, Fontanals D, Xercavins M, et al. (2007) Bloodstream infection in adults: importance of healthcare-associated infections. Journal of infection 56: 27-34.
8. Cheong HS, Kang C, Kwon KT, Heo ST, Wi YM, et al. (2007) Clinical significance of healthcare-associated infections in community-onset Escherichia coli bacteraemia. J Antimicrob Chemother 60: 1355-1360.
9. Park HK, Song JU, Um SW, Koh WJ, Suh GY, et al. (2010) Clinical characteristics of health care-associated pneumonia in a Korean teaching hospital. Respir Med: 1-7.
10. Rello J, Luján M, Gallego M, Vallés J, Belmonte Y, et al. (2010) Why mortality is increased in health-care-associated pneumonia: lessons from Pneumococcal Bacteremic Pneumonia. Chest 137: 1138-1144.
11. Stryjewski ME, Kanafani ZA, Chu VH, Pappas PA, Harding T, et al. (2009) Staphylococcus aureus bacteremia among patients with health care-associated fever. Am J Med 122: 281-289.
12. Pop-Vicas AE, D'Agata EMC, (2005) The rising influx of multidrug-resistant gram-negative bacilli into a tertiary care hospital. Clin Infect Dis 40: 1792-1798.
13. Knaus WA, Draper EA, Wagner DP, Zimmerman JE, (1985) APACHE II: a severity of disease classification system. Crit Care Med 13: 818-829.
14. Le GallJR, Lemeshow S, Saulnier F, (1993) A new Simplified Acute Physiology Score (SAPS II) based on a European/North American multicenter study. Jama 270: 2957-2963.
15. Karnofsky DA, Burchenal JH (1949) "The Clinical Evaluation of Chemotherapeutic Agents in Cancer." In: MacLeod CM, editor. Evaluation of Chemotherapeutic Agents. Columbia: Univ Press. 196.
16. Bone RC, Balk RA, Cerra FB, Dellinger RP, Fein AM, et al. (1992) Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/SCCM Consensus Conference Committee. American College of Chest Physicians/Society of Critical Care Medicine. Chest 101: 1644-1655.
17. Mandell LA, Wunderink RG, Anzueto A, Bartlett JG, Campbell GD, et al. (2007) Infectious Diseases Society of America/American Thoracic Society consensus guidelines on the management of community-acquired pneumonia in adults. Clin Infect Dis 44Suppl 2: S27-72.
18. Gupta K, Hooton TM, Naber KG, Wullt B, Colgan R, et al. (2011) International clinical practice guidelines for the treatment of acute uncomplicated cystitis and pyelonephritis in women: A 2010 update by the Infectious Diseases Society of America and the European Society for Microbiology and Infectious Diseases. Clin Infect Dis 52: e103-120.
19. Solomkin JS, Mazuski JE, Bradley JS, Rodvold KA, Goldstein EJC, et al. (2010) Diagnosis and management of complicated intra-abdominal infection in adults and children: guidelines by the Surgical Infection Society and the Infectious Diseases Society of America. Clin Infect Dis 50: 133-164.
20. Paul M, Shani V, Muchtar E, Kariv G, Robenshtok E, et al. (2010) Systematic review and meta-analysis of the efficacy of appropriate empiric antibiotic therapy for sepsis. Antimicrob Agents Chemother 54: 4851-4863.
21. Micek ST, Kollef KE, Reichley RM, Roubinian N, Kollef MH, (2007) Health care-associated pneumonia and community-acquired pneumonia: a single-center experience. Antimicrob Agents Chemother 51: 3568-3573.
22. Lenz R, Leal JR, Church DL, Gregson DB, Ross T, et al. (2012) The distinct category of healthcare associated bloodstream infections. BMC Infect Dis 12: 85.
23. Aguilar-Duran S, Horcajada JP, Sorli L, Montero M, Salvado M, et al. (2012) Community-onset healthcare-related urinary tract infections: comparison with community and hospital-acquired urinary tract infections. J Infect 64: 478-483.
24. American Thoracic Society (2005) Guidelines for the management of adults with hospital-acquired, ventilator-associated, and healthcare-associated pneumonia. Am J Respir Crit Care Med 171: 388-416.
25. Gomez J, Garcia-Vazquez E, Banos R, Canteras M, Ruiz J, et al. (2007) Predictors of mortality in patients with methicillin-resistant Staphylococcus aureus (MRSA) bacteraemia: the role of empiric antibiotic therapy. Eur J Clin Microbiol Infect Dis 26: 239-245.
26. Kollef MH, Sherman G, Ward S, Fraser VF, (1999) Inadequate antimicrobial treatment of infections: a risk factor for hospital mortality among critically ill patients. Chest 115: 426-474.
27. Leibovici L, Shraga I, Drucker M, Konigsberger H, Samra Z, et al. (1998) The benefit of appropriate empirical antibiotic treatment in patients with bloodstream infection. J Intern Med 244: 379-386.
28. Ibrahim EH, Sherman G, Ward S, Fraser VJ, Kollef MH, (2000) The influence of inadequate antimicrobial treatment of bloodstream infections on patient outcomes in the ICU setting. Chest 118: 146-155.
29. Bassetti M, Trecarichi EM, Mesini A, Spanu T, Giacobbe DR, et al. (2012) Risk factors and mortality of healthcare-associated and community-acquired Staphylococcus aureus bacteraemia. Clin Microbiol Infect 18: 862-869.
30. Rodriguez-Bano J, Millan AB, Dominguez MA, Borraz C, Gonzalez MP, et al. (2009) Impact of inappropriate empirical therapy for sepsis due to health care-associated methicillin-resistant Staphylococcus aureus. J Infect 58: 131-137.
31. Retamar P, Portillo MM, Lopez-Prieto MD, Rodriguez-Lopez F, de Cueto M, et al. (2012) Impact of inadequate empirical therapy on the mortality of patients with bloodstream infections: a propensity score-based analysis. Antimicrob Agents Chemother 56: 472-478.
32. Paul M, Kariv G, Goldberg E, Raskin M, Shaked H, et al. (2010) Importance of appropriate empirical antibiotic therapy for methicillin-resistant Staphylococcus aureus bacteraemia. J Antimicrob Chemother 65: 2658-2665.