Strategies for engineered negligible senescence

Gerontology

Volumn 59, Issue 2, 2013, Pages 183-189

  Zealley, Ben ^a   De Grey, Aubrey D N J ^a  

^a SENS Foundation   (United States)

Author keywords

Regenerative medicine; Rejuvenation; Strategies for engineered negligible senescence

Indexed keywords

CELL DEATH; CELL DEATH RESISTANCE; CELL LOSS; CELL OVERPROLIFERATION; CELL PROLIFERATION; CLINICAL TRIAL (TOPIC); DISORDERS OF MITOCHONDRIAL FUNCTIONS; GERONTOLOGY; HUMAN; LIFE EXTENSION; MOTIVATION; PRIORITY JOURNAL; REVIEW; RIGIDITY;

EID: 84874760790     PISSN: 0304324X     EISSN: 14230003     Source Type: Journal    
DOI: 10.1159/000342197     Document Type: Review

References (24)

1. Finch CE. Longevity, Senescence, and the Genome, chapt. 4: Negligible Senescence. Chicago, University of Chicago Press, 1994
2. Martínez DE. Mortality patterns suggest lack of senescence in hydra. Exp Gerontol 1998; 33: 217-225
3. Estep PW. Declining asexual reproduction is suggestive of senescence in hydra: comment on Martinez, D: Mortality patterns suggest lack of senescence in hydra. Exp Gerontol 33, 217-225. Exp Gerontol 2010; 45: 645-646
4. Phoenix C, de Grey ADNJ: A model of aging as accumulated damage matches observed mortality patterns and predicts the life-extending effects of prospective interventions. Age (Dordr) 2007; 29: 133-189
5. de Grey ADNJ, Rae M. Ending Aging: The Rejuvenation Breakthroughs That Could Reverse Human Aging in Our Lifetime. New York, St Martin's Press, 2007
6. Vicencio JM, Galluzzi L, Tajeddine N, Ortiz C, Criollo A, Tasdemir E, Morselli E, Ben Younes A, Maiuri MC, Lavandero S, Kroemer G. Senescence, apoptosis or autophagy? When a damaged cell must decide its path - A mini-review. Gerontology 2008; 54: 92-99
7. Henriquez M, Armisén R, Stutzin A, Quest AF. Cell death by necrosis, a regulated way to go. Curr Mol Med 2008; 8: 187-206
8. de Grey ADNJ, Campbell FC, Dokal I, Fairbairn LJ, Graham GJ, Jahoda CA, Porter ACG: Total deletion of in vivo telomere elongation capacity: an ambitious but possibly ultimate cure for all age-related human cancers. Ann NY Acad Sci 2004; 1019: 147-170
9. Hetz C. The unfolded protein response: controlling cell fate decisions under ER stress and beyond. Nat Rev Mol Cell Biol 2012; 13: 89-102
10. Olshansky SJ, Perry D, Miller RA, Butler RN. In pursuit of the longevity dividend. Scientist 2006; 20: 28-35
11. de Grey AD, Ames BN, Andersen JK, Bartke A, Campisi J, Heward CB, McCarter RJ, Stock G. Time to talk SENS: critiquing the immutability of human aging. Ann NY Acad Sci 2002; 959: 452-462
12. Cuervo AM, Dice JF. Age-related decline in chaperone-mediated autophagy. J Biol Chem 2000; 275: 31505-31513
13. Zhang C, Cuervo AM. Restoration of chaperone-mediated autophagy in aging liver improves cellular maintenance and hepatic function. Nat Med 2008; 14: 959-965
14. Butler D, Hwang J, Estick C, Nishiyama A, Kumar SS, Baveghems C, Young-Oxendine HB, Wisniewski ML, Charalambides A, Bahr BA. Protective effects of positive lysosomal modulation in Alzheimer's disease transgenic mouse models. PLoS One 2011; 6:e20501
15. Rittmann BE, Schloendorn J. Engineering away lysosomal junk: medical bioremediation. Rejuvenation Res 2007; 10: 359-365
16. Paul S, Planque S, Nishiyama Y. Beneficial catalytic immunity to A peptide. Rejuvenation Res 2010; 13: 179-187
17. Banks WA, Farr SA, Morley JE, Wolf KM, Geylis V, Steinitz M. Anti-Amyloid- protein antibody passage across the blood-brain barrier in the SAMP8 mouse model of Alzheimer's disease: an age-related selective uptake with reversal of learning impairment. Exp Neurol 2007; 206: 248-256
18. Wang YY, Lui PC, Li JY. Receptor-mediated therapeutic transport across the blood-brain barrier. Immunotherapy 2009; 1: 983-993
19. Coles LS, Young RD. Supercentenarians and transthyretin amyloidosis: the next frontier of human life extension. Prev Med 2012; 54(suppl):S9-S11
20. Röthlisberger D, Khersonsky O, Wollacott AM, Jiang L, DeChancie J, Betker J, Gallaher JL, Althoff EA, Zanghellini A, Dym O, Albeck S, Houk KN, Tawfik DS, Baker D. Kemp elimination catalysts by computational enzyme design. Nature 2008; 453: 190-195
21. Macchiarini P, Jungebluth P, Go T, Asnaghi MA, Rees LE, Cogan TA, Dodson A, Martorell J, Bellini S, Parnigotto PP, Dickinson SC, Hollander AP, Mantero S, Conconi MT, Birchall MA. Clinical transplantation of a tissue-engineered airway. Lancet 2008; 372: 2023-2030
22. Jakab K, Norotte C, Marga F, Murphy K, Vunjak-Novakovic G, Forgacs G. Tissue engineering by self-Assembly and bio-printing of living cells. Biofabrication 2010; 2: 022001
23. de Grey ADNJ: Mitochondrial gene therapy: an arena for the biomedical use of inteins. Trends Biotechnol 2000; 18: 394-399
24. Kaltimbacher V, Bonnet C, Lecoeuvre G, Forster V, Sahel JA, Corral-Debrinski M. mRNA localization to the mitochondrial surface allows the efficient translocation inside the organelle of a nuclear recoded ATP6 protein. RNA 2006; 12: 1408-1417