Protective effect of aqueous leaf extract of Murraya Koenigi against lead induced oxidative stress in rat liver, heart and kidney: A dose response study

Asian Journal of Pharmaceutical and Clinical Research

Volumn 5, Issue SUPPL.4, 2012, Pages 54-58

  Ghosh, Debosree ^a   Firdaus, Syed Benazir ^a   Mitra, Elina ^a   Dey, Monalisa ^a   Bandyopadhyay, Debasish ^a  

^a UNIVERSITY OF CALCUTTA   (India)

Author keywords

Antioxidant; Heart; Kidney; Lead; Liver; Murraya koenigii

Indexed keywords

CATALASE; COPPER ZINC SUPEROXIDE DISMUTASE; LEAD ACETATE; MURRAYA KOENIGII EXTRACT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; AQUEOUS SOLUTION; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG DOSAGE FORM COMPARISON; DRUG EFFICACY; DRUG SCREENING; ENZYME ACTIVITY; HEART INJURY; HEART PROTECTION; KIDNEY INJURY; LEAD POISONING; LIVER INJURY; LIVER PROTECTION; MALE; NONHUMAN; OXIDATIVE STRESS; PHYTOCHEMISTRY; PLANT LEAF; RAT; RENAL PROTECTION;

EID: 84874755849     PISSN: 09742441     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (36)

1. Leonard SS, Harris GK, Shi XL. Metal-induced oxidative stress and signal transduction. Free Rad Biol Med 2004; 37: 1921-42.
2. Flora S J S, Pande M, KannanGM, Mehta A. Lead induced oxidative stress and its recovery following co-administration of melatonin or N-Acetycysteine during chelation with succimer in male rats. Cell Mol Biol 2004; 50:543-551.
3. Florea AM, Busselberg D. Occurrence, use and potential toxic effects of metals and metal compounds. Biometals 2006; 19: 419-27.
4. Saxena G, Joshi U, Flora SJS. Monoesters of meso 2, 3-dimercaptosuccinic acid in lead mobilization and recovery of lead induced tissue oxidative injury in rats. Toxicology 2005; 214: 39-56.
5. Chia SE, Yap E, Chia KS. Delta-aminolevulinic acid dehydratase (ALAD) polymorphism and susceptibility of workers exposed to inorganic lead and its effects on neurobehavioral functions. Neurotoxicology 2004; 25: 1041-7.
6. Flora SJS, Flora G, Saxena G. Environmental occurrence, health effects and management of lead poisoning In: Cascas SB, Sordo J, editors. Lead chemistry, analytical aspects, environmental impacts and health effects. Netherlands: Elsevier Publication; 2006. 158-228.
7. Goyer RA. Toxic effects of metals. In: Klaassen C, editor. Casarett & Doull's toxicology: The basic science of poisons. New York: McGraw-Hill; 1996. p. 691-737.
8. Ruff HA, Markowitz ME, Bijur PE, Rosen JF. Relationships among blood lead levels, iron deficiency, and cognitive development in two-year-old children. Environ Health Perspect1996; 104: 180-5.
9. Bressler J, Kim KA, Chakraborti T, Goldstein G. Molecular mechanisms of lead neurotoxicity. Neurochem Res 1999; 24: 595-600.
10. Lanphear BP, Dietrich K, Auinger P, Cox C. Cognitive deficits associated with blood lead concentrations <10μg/dl in US children and adolescents. Public Health Rep 2000; 115: 521-9.
11. Khalil-Manesh F, Gonick HC, Weiler EW, Prins B, Weber MA, Purdy RE. Lead-induced hypertension: possible role of endothelial factors. Am J Hypertens 1993; 6: 723-9.
12. Damek-Poprawa M, Sawicka-Kapusta K. Histopathological changes in the liver, kidneys, and testes of bank voles environmentally exposed to heavy metal emissions from the steelworks and zinc smelter in Poland. Environ Res 2004; 96: 72-8.
13. Sharma RP, Street JC. Public health aspects of toxic heavy metals in animal feeds. J Am VetMed Assoc1980; 177: 149-53.
14. Lancranjan I, Popscu HI, GA vanescu O, Klepsch I, Serbanescu M. Reproductive ability of workmen occupationally exposed to lead. Arch Environ Health1975; 30: 396-401.
15. Ronis MJJ, Bedger TM, Shema SJ. Endocrine mechanism underlying the growth effects of developmental lead exposure in rat. J Toxicol Environ Health1998; 54: 101-20.
16. Lima-Hermes M, Pereira B, Bechara EJH. Are free radicals involved in lead poisoning? Xenobiotica1991;21:1085-1090.
17. Handral H K, JhaPK, Shruthi SD. Pharmacognostic and Phytochemical studies on the leaves of Murraya koenigii(L) Spreng. Pharmacophore 2010; 1 (3): 231-238.
18. Tachibana, Y., Kikuzaki, H., Lajis, N.H., Nakatani, N. Antioxidative activity of 1090carbazoles from Murraya koenigii leaves. J. Agric. Food. Chem. 2001; 49: 5589-5594.
19. Khan BA, Abraham A, Leelamma S. Haematological & histological studiesafter curry leaf (Murraya koenigii) & mustard (Brassica juncea) feeding in rats. Indian J. Med. Res.1995; 102:184-186.
20. Arulselvan P, Subramanian SP. Beneficial effects of Murraya koenigii leaves on antioxidant defense system and ultrastructural changes of pancreatic b-cell in experimental diabetes. Chem. Biol. Interact. 2007; 165: 155-164.
21. Ningappa M B, Dinesha R, SrinivasL. Antioxidant and free radical scavenging activities of polyphenol-enriched curry leaf (Murraya koenigii L.) extracts. Food Chemistry 2008;106:720-728.
22. Sathaye S, Bagul Y, Gupta S, Kaur H, Redkar R. Hepatoprotective effects of aqueous leaf extract and crude isolates of Murraya koenigii in vitro ethanol induced hepatotoxicity model. Exp. Toxic. Pathol. 2011; 63: 587-591.
23. Jayaprakasha G K, Rao J. Phenolic constituents fromlichenParmontremastuppeum. Hale and antioxidant activity. ZeitschriftFürNaturforscung. 2002; 55: 1018-1022.
24. Mukherjee D, Roy S G, Bandyopadhyay A, Chatyopadhyay A, Basu A, Mitra E et. al. Melatonin protects against isoproterenol-induced myocardial injury in the rat: antioxidative mechanisms. J Pineal Res 2010; 48: 251-262.
25. Folin O, WU H. A system of blood analysis.J. Biol. Chem 1919; 38: 81.
26. Mitra E, Ghosh A K, Ghosh D, Mukherjee D, Chattopadhyay A, Dutta S et. al. Protective effect of aqueous Curry leaf (Murraya koenigii) extract against cadmium-induced oxidative stress in rat heart. Food and Cheml Toxicol 2012;50:1340-1353.
27. Buege J A, Aust S D. Microsomal lipid peroxidation. Meth Enzymol 1978; 52:302-310.
28. Bandyopadhyay D, Ghosh G, Bandyopadhyay A, Reiter RJ. Melatonin protects against piroxicam-induced gastric ulceration. J Pineal Res 2004; 36:195-203.
29. Sedlak J, Lindsay RH. Estimation of total protein bound and non-protein sulfhydryl groups in tissue with Ellman_s reagent. Anal Biochem 1968; 25:192-205.
30. Martin J P, Daily M, Sugarman E. Negative and Positive assays of superoxide dismutase based on hematoxyline autooxidation. Arch BiochemBiophysi 1987; 255: 329-326.
31. Beers R F Jr., Sizer I W. A spectrophotometric method for measuring the breakdown of hydrogen peroxide by catalase. J BiolChem 1952; 195: 133-140.
32. Chattopadhyay A, Biswas S, Bandyopadhyay D, Sarkar, C, Datta A G. Effect of isoproterenol on lipid peroxidation and antioxidant enzymes of myocardial tissue of mice and protection by quinidine. Mol Cell Biochem 2003; 245: 43-49.
33. Lowry Oh, RosebroughNj, Farr Al, Randall Rj. Protein measurement with Folin phenol reagent. J BiolChem 1970; 193:265-275.
34. Vetriselvan S, Victor Rajamanickam, Muthappan M, Gnanasekaran D, Chellappann D K. Hepatoprotective effects of aqueous extract of Andrographis paniculata against ccl4 induced hepatotoxicity in albino Wistar rats. Asian Journal of Pharmaceutical and Clinical Research 2011;4 (3):93-94.
35. Gurer H, Ercal N. Can antioxidants be beneficial in the treatment of lead poisoning? Free Radic Biol Med 2000; 29: 927-945.
36. Bandyopadhyay D, Chattopadhyay A. Reactive oxygen species-induced gastric ulceration: protection by melatonin. Curr Med Chem 2006; 13: 1187-1202.