Exhaled nitric oxide measures allergy not symptoms in children with allergic rhinitis in primary care: A prospective cross-sectional and longitudinal cohort study

Primary Care Respiratory Journal

Volumn 22, Issue 1, 2013, Pages 44-50

  de Bot, Cindy M A ^a   Moed, Heleen ^a   Bindels, Patrick J E ^a   van Wijk, Roy Gerth ^a   Berger, Marjolein Y ^a,b   de Groot, Hans ^c   de Jongste, Johannes C ^d   van der Wouden, Johannes C ^a,e  

^a ERASMUS MEDICAL CENTER   (Netherlands)

^b UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^c REINIER DE GRAAF HOSPITAL   (Netherlands)

^d SOPHIA CHILDREN S HOSPITAL   (Netherlands)

^e VU UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Allergic rhinitis; Asthma; Child; Fractional exhaled nitric oxide (FeNO); Quality of life

Indexed keywords

HOUSE DUST ALLERGEN; IMMUNOGLOBULIN E; NITRIC OXIDE;

ADULT; ALLERGIC ASTHMA; ALLERGIC RHINITIS; ARTICLE; ATOPY; CHILD; CLINICAL FEATURE; COHORT ANALYSIS; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; DISEASE MARKER; DISEASE SEVERITY; DOUBLE BLIND PROCEDURE; FEMALE; FRACTIONAL EXHALED NITRIC OXIDE; HUMAN; LONGITUDINAL STUDY; MAJOR CLINICAL STUDY; MALE; PRESCHOOL CHILD; PRIMARY HEALTH CARE; PROSPECTIVE STUDY; QUALITY OF LIFE; RANDOMIZED CONTROLLED TRIAL; RESPIRATORY TRACT PARAMETERS; RHINOCONJUNCTIVITIS; SCHOOL CHILD; SCORING SYSTEM; SUBLINGUAL IMMUNOTHERAPY; TREATMENT OUTCOME; WHEEZING;

BREATH TESTS; CHILD; COHORT STUDIES; CROSS-SECTIONAL STUDIES; EXHALATION; FEMALE; HUMANS; LONGITUDINAL STUDIES; MALE; NITRIC OXIDE; PRIMARY HEALTH CARE; PROSPECTIVE STUDIES; RHINITIS, ALLERGIC, PERENNIAL;

EID: 84874752946     PISSN: 14714418     EISSN: 14751534     Source Type: Journal    
DOI: 10.4104/pcrj.2013.00009     Document Type: Article

References (33)

1. Bousquet J, Van Cauwenberge P, Khaltaev N, et al. Allergic rhinitis and its impact on asthma. J Allergy Clin Immunol 2001;108(5 Suppl):S147-334. http://dx.doi.org/10.1067/mai.2001.118891
2. Demoly P, Bousquet J. The relation between asthma and allergic rhinitis. Lancet 2006;368:711-13. http://dx.doi.org/10.1016/S0140-6736(06)69263-5
3. Gustafsson LE, Leone AM, Persson MG, et al. Endogenous nitric oxide is present in the exhaled air of rabbits, guinea pigs and humans. Biochem Biophys Res Commun 1991;181:852-7. http://dx.doi.org/10.1016/0006-291X(91)91268-H
4. Alving K, Weitzberg E, Lundberg JM. Increased amount of nitric oxide in exhaled air of asthmatics. Eur Respir J 1993;6:1368-70.
5. American Thoracic Society/European Respiratory Society. ATS/ERS recommendations for standardized procedures for the online and offline measurement of exhaled lower respiratory nitric oxide and nasal nitric oxide. Am J Respir Crit Care Med 2005;171:912-30. http://dx.doi.org/10.1164/rccm.200406-710ST
6. Taylor DR, Pijnenburg MW, Smith AD, et al. Exhaled nitric oxide measurements: clinical application and interpretation. Thorax 2006;61:817-27. http://dx.doi.org/10.1136/thx.2005.056093
7. Alving K, Malinovschi A. Basic aspects of exhaled nitric oxide. Eur Respir Monogr 2010;49:1-31. http://dx.doi.org/10.1183/1025448x.00028509
8. Scott M, Raza A, Karmaus W, et al. Influence of atopy and asthma on exhaled nitric oxide in an unselected birth cohort study. Thorax 2010;65:258-62. http://dx.doi.org/10.1136/thx.2009.125443
9. Leuppi JD, Downs SH, Downie SR, et al. Exhaled nitric oxide levels in atopic children: relation to specific allergic sensitisation, AHR, and respiratory symptoms. Thorax 2002;57:518-23. http://dx.doi.org/10.1136/thorax.57.6.518
10. Roberts G, Mylonopoulou M, Hurley C, et al. Impairment in quality of life is directly related to the level of allergen exposure and allergic airway inflammation. Clin Exp Allergy 2005;35:1295-300. http://dx.doi.org/10.1111/j.1365-2222.2005.02333.x
11. Strunk RC, Szefler SJ, Phillips BR, et al. Relationship of exhaled nitric oxide to clinical and inflammatory markers of persistent asthma in children. J Allergy Clin Immunol 2003;112:883-92. http://dx.doi.org/10.1016/j.jaci.2003.08.014
12. Cardinale F, De Benedictis FM, Muggeo V, et al. Exhaled nitric oxide, total serum IgE and allergic sensitization in childhood asthma and allergic rhinitis. Pediatr Allergy Immunol 2005;16:236-42. http://dx.doi.org/10.1111/j.1399-3038.2005.00265.x
13. Roberts G, Hurley C, Bush A, et al. Longitudinal study of grass pollen exposure, symptoms, and exhaled nitric oxide in childhood seasonal allergic asthma. Thorax 2004;59:752-6. http://dx.doi.org/10.1136/thx.2003.008722
14. Van der Valk RJ, Baraldi RJ, Stern G, et al. Daily exhaled nitric oxide measurements and asthma exacerbations in children. Allergy 2012;67:265-71. http://dx.doi.org/10.1111/j.1398-9995.2011.02734.x
15. Dweik RA, Boggs PB, Erzurum SC, et al. An official ATS clinical practice guideline: interpretation of exhaled nitric oxide levels (FeNO) for clinical applications. Am J Respir Crit Care Med 2011;184:602-15. http://dx.doi.org/10.1164/rccm.9120-11ST
16. de Bot CMA, Moed H, Berger MY, et al. Randomized double-blind placebocontrolled trial of sublingual immunotherapy in children with house dust mite allergy in primary care: study design and recruitment. BMC Fam Pract 2008;9:59. http://dx.doi.org/10.1186/1471-2296-9-59
17. de Bot CMA, Moed H, Berger MY, et al. Sublingual immunotherapy not effective in house dust mite-allergic children in primary care. Pediatr Allergy Immunol 2012;23:150-8. http://dx.doi.org/10.1111/j.1399-3038.2011.01219.x
18. Asher MI, Weiland SK. The International Study of Asthma and Allergies in Childhood (ISAAC). ISAAC Steering Committee. Clin Exp Allergy 1998;28:52-66. http://dx.doi.org/10.1046/j.1365-2222.1998.028s5052.x
19. Juniper EF, Guyatt GH, Dolovich J. Assessment of quality of life in adolescents with allergic rhinoconjunctivitis: development and testing of a questionnaire for clinical trials. J Allergy Clin Immunol 1994;93:413-23. http://dx.doi.org/10.1016/0091-6749(94)90349-2
20. Juniper EF, Howland WC, Roberts NB, et al. Measuring quality of life in children with rhinoconjunctivitis. J Allergy Clin Immunol 1998;101:163-70. http://dx.doi.org/10.1016/S0091-6749(98)70380-X
21. Swinscow TDV. Statistics at Square One. 9th edn. Revised by Campbell MJ. London: BMJ Publishing Group, 1997.
22. Steerenberg PA, Janssen NAH, de Meer G, et al. Relationship between exhaled NO, respiratory symptoms, lung function, bronchial hyperresponsiveness, and blood eosinophilia in school children. Thorax 2003;58:242-5. http://dx.doi.org/10.1136/thorax.58.3.242
23. Nordvall SL, Janson C, Kalm-Stephens P, et al. Exhaled nitric oxide in a populationbased study of asthma and allergy in schoolchildren. Allergy 2005;60:469-75. http://dx.doi.org/10.1111/j.1398-9995.2005.00735.x
24. Franklin PJ, Turner SW, Le Souef PN, et al. Exhaled nitric oxide and asthma: complex interactions between atopy, airway responsiveness, and symptoms in a community population of children. Thorax 2003;58:1048-52. http://dx.doi.org/10.1136/thorax.58.12.1048
25. Reddel HK, Taylor DR, Bateman ED, et al. An official American Thoracic Society/European Respiratory Society statement. Asthma control and exacerbations: standardizing endpoints for clinical asthma trials and clinical practice. Am J Respir Crit Care Med 2009;180:59-99. http://dx.doi.org/10.1164/rccm.200801-060ST
26. Ehrs PO, Sundblad BM, Larsson K. Quality of life and inflammatory markers in mild asthma. Chest 2006;129:624-31. http://dx.doi.org/10.1378/chest.129.3.624
27. Silvestri M, Pistorio A, Battistini E. IgE in childhood asthma: relevance of demographic characteristics and polysensitisation. Arch Dis Child 2010;95:979-84. http://dx.doi.org/10.1136/adc.2009.163667
28. Sacco O, Sale R, Silvestri M. Total and allergen-specific IgE levels in serum reflect blood. Pediatr Allergy Immunol 2003;14:475-81. http://dx.doi.org/10.1046/j.0905-6157.2003.00092.x
29. Jouaville LF, Annesi-Maesano I, Nguyen LT, et al. Interrelationships among asthma, atopy, rhinitis and exhaled nitric oxide in a population-based sample of children. Clin Exp Allergy 2003;33:1506-11. http://dx.doi.org/10.1046/j.1365-2222.2003.01800.x
30. Malmberg LP, Turpeinen H, Rytila P, et al. Determinants of increased exhaled nitric oxide in patients with suspected asthma. Allergy 2005;60:464-8. http://dx.doi.org/10.1111/j.1398-9995.2005.00740.x
31. Chawes BL, Bonnelykke K, Kreiner-Moller E, et al. Children with allergic and nonallergic rhinitis have a similar risk of asthma. J Allergy Clin Immunol 2010;126:567-73. http://dx.doi.org/10.1016/j.jaci.2010.06.026
32. van Asch CJ, Balemans WA, Rovers MM, et al. Atopic disease and exhaled nitric oxide in an unselected population of young adults. Ann Allergy Asthma Immunol 2008;100:59-65. http://dx.doi.org/10.1016/S1081-1206(10)60406-1
33. Spanier AJ, Kahn RS, Hornung RW, et al. Environmental exposures, nitric oxide synthase genes, and exhaled nitric oxide in asthmatic children. Pediatr Pulmonol 2009;44:812-19. http://dx.doi.org/10.1002/ppul.21071