A Safeguard Mechanism Regulates Rho GTPases to Coordinate Cytokinesis with the Establishment of Cell Polarity

PLoS Biology

Volumn 11, Issue 2, 2013, Pages

  Meitinger, Franz ^a   Richter, Heidi ^b   Heisel, Sabrina ^a   Hub, Birgit ^c   Seufert, Wolfgang ^b   Pereira, Gislene ^a  

^a GERMAN CANCER RESEARCH CENTER   (Germany)

^b UNIVERSITY OF REGENSBURG   (Germany)

^c GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CLA4 PROTEIN; GUANINE NUCLEOTIDE EXCHANGE FACTOR; GUANOSINE TRIPHOSPHATASE MEDIATED POLARITY SWITCH 1; MYOSIN ADENOSINE TRIPHOSPHATASE; PROTEIN CDC42; RHO GUANINE NUCLEOTIDE BINDING PROTEIN; RHO1 PROTEIN; ROM2 PROTEIN; SWI5 TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR; TUS1 PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; CELL BUDDING; CELL DEATH; CELL DIVISION; CELL POLARITY; CELL SEPARATION; CONTROLLED STUDY; CYTOKINESIS; DAUGHTER CELL; NONHUMAN; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; YEAST CELL;

CDC42 GTP-BINDING PROTEIN, SACCHAROMYCES CEREVISIAE; CELL CYCLE PROTEINS; CELL DIVISION; CELL POLARITY; CYTOKINESIS; RHO GTP-BINDING PROTEINS; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS;

EID: 84874747628     PISSN: 15449173     EISSN: 15457885     Source Type: Journal    
DOI: 10.1371/journal.pbio.1001495     Document Type: Article

References (40)

1. Martin-Belmonte F, Perez-Moreno M, (2011) Epithelial cell polarity, stem cells and cancer. Nat Rev Cancer 12: 23-38.
2. McCaffrey LM, Macara IG, (2009) Widely conserved signaling pathways in the establishment of cell polarity. Cold Spring Harb Perspect Biol 1: a001370.
3. Park HO, Bi E, (2007) Central roles of small GTPases in the development of cell polarity in yeast and beyond. Microbiol Mol Biol Rev 71: 48-96.
4. Iden S, Collard JG, (2008) Crosstalk between small GTPases and polarity proteins in cell polarization. Nat Rev Mol Cell Biol 9: 846-859.
5. Benink HA, Bement WM, (2005) Concentric zones of active RhoA and Cdc42 around single cell wounds. J Cell Biol 168: 429-439.
6. Nelson WJ, (2009) Remodeling epithelial cell organization: transitions between front-rear and apical-basal polarity. Cold Spring Harb Perspect Biol 1: a000513.
7. Tolliday N, VerPlank L, Li R, (2002) Rho1 directs formin-mediated actin ring assembly during budding yeast cytokinesis. Curr Biol 12: 1864-1870.
8. Yoshida S, Kono K, Lowery DM, Bartolini S, Yaffe MB, et al. (2006) Polo-like kinase Cdc5 controls the local activation of Rho1 to promote cytokinesis. Science 313: 108-111.
9. Yoshida S, Bartolini S, Pellman D, (2009) Mechanisms for concentrating Rho1 during cytokinesis. Genes Dev 23: 810-823.
10. Kohno H, Tanaka K, Mino A, Umikawa M, Imamura H, et al. (1996) Bni1p implicated in cytoskeletal control is a putative target of Rho1p small GTP binding protein in Saccharomyces cerevisiae. EMBO J 15: 6060-6068.
11. Guo W, Tamanoi F, Novick P, (2001) Spatial regulation of the exocyst complex by Rho1 GTPase. Nat Cell Biol 3: 353-360.
12. Qadota H, Python CP, Inoue SB, Arisawa M, Anraku Y, et al. (1996) Identification of yeast Rho1p GTPase as a regulatory subunit of 1,3-beta-glucan synthase. Science 272: 279-281.
13. Gulli MP, Jaquenoud M, Shimada Y, Niederhauser G, Wiget P, et al. (2000) Phosphorylation of the Cdc42 exchange factor Cdc24 by the PAK-like kinase Cla4 may regulate polarized growth in yeast. Mol Cell 6: 1155-1167.
14. Park HO, Bi E, Pringle JR, Herskowitz I, (1997) Two active states of the Ras-related Bud1/Rsr1 protein bind to different effectors to determine yeast cell polarity. Proc Natl Acad Sci U S A 94: 4463-4468.
15. Irazoqui JE, Gladfelter AS, Lew DJ, (2003) Scaffold-mediated symmetry breaking by Cdc42p. Nat Cell Biol 5: 1062-1070.
16. Kozubowski L, Saito K, Johnson JM, Howell AS, Zyla TR, et al. (2008) Symmetry-breaking polarization driven by a Cdc42p GEF-PAK complex. Curr Biol 18: 1719-1726.
17. Huh WK, Falvo JV, Gerke LC, Carroll AS, Howson RW, et al. (2003) Global analysis of protein localization in budding yeast. Nature 425: 686-691.
18. Dobbelaere J, Barral Y, (2004) Spatial coordination of cytokinetic events by compartmentalization of the cell cortex. Science 305: 393-396.
19. Meitinger F, Petrova B, Lombardi IM, Bertazzi DT, Hub B, et al. (2010) Targeted localization of Inn1, Cyk3 and Chs2 by the mitotic-exit network regulates cytokinesis in budding yeast. J Cell Sci 123: 1851-1861.
20. Meitinger F, Boehm ME, Hofmann A, Hub B, Zentgraf H, et al. (2011) Phosphorylation-dependent regulation of the F-BAR protein Hof1 during cytokinesis. Genes Dev 25: 875-888.
21. Levin DE, (2011) Regulation of cell wall biogenesis in Saccharomyces cerevisiae: the cell wall integrity signaling pathway. Genetics 189: 1145-1175.
22. Lagorce A, Hauser NC, Labourdette D, Rodriguez C, Martin-Yken H, et al. (2003) Genome-wide analysis of the response to cell wall mutations in the yeast Saccharomyces cerevisiae. J Biol Chem 278: 20345-20357.
23. Doolin MT, Johnson AL, Johnston LH, Butler G, (2001) Overlapping and distinct roles of the duplicated yeast transcription factors Ace2p and Swi5p. Mol Microbiol 40: 422-432.
24. Visintin R, Craig K, Hwang ES, Prinz S, Tyers M, et al. (1998) The phosphatase Cdc14 triggers mitotic exit by reversal of Cdk-dependent phosphorylation. Mol Cell 2: 709-718.
25. Toyn JH, Johnson AL, Donovan JD, Toone WM, Johnston LH, (1997) The Swi5 transcription factor of Saccharomyces cerevisiae has a role in exit from mitosis through induction of the cdk-inhibitor Sic1 in telophase. Genetics 145: 85-96.
26. Bertazzi DT, Kurtulmus B, Pereira G, (2011) The cortical protein Lte1 promotes mitotic exit by inhibiting the spindle position checkpoint kinase Kin4. J Cell Biol 193: 1033-1048.
27. Delley PA, Hall MN, (1999) Cell wall stress depolarizes cell growth via hyperactivation of RHO1. J Cell Biol 147: 163-174.
28. Audhya A, Emr SD, (2002) Stt4 PI 4-kinase localizes to the plasma membrane and functions in the Pkc1-mediated MAP kinase cascade. Dev Cell 2: 593-605.
29. Tong Z, Gao XD, Howell AS, Bose I, Lew DJ, et al. (2007) Adjacent positioning of cellular structures enabled by a Cdc42 GTPase-activating protein-mediated zone of inhibition. J Cell Biol 179: 1375-1384.
30. Casamayor A, Snyder M, (2002) Bud-site selection and cell polarity in budding yeast. Curr Opin Microbiol 5: 179-186.
31. Ni L, Snyder M, (2001) A genomic study of the bipolar bud site selection pattern in Saccharomyces cerevisiae. Mol Biol Cell 12: 2147-2170.
32. Versele M, Thorner J, (2004) Septin collar formation in budding yeast requires GTP binding and direct phosphorylation by the PAK, Cla4. J Cell Biol 164: 701-715.
33. Colman-Lerner A, Chin TE, Brent R, (2001) Yeast Cbk1 and Mob2 activate daughter-specific genetic programs to induce asymmetric cell fates. Cell 107: 739-750.
34. Sherman F, (1991) Getting started with yeast. Methods Enzymol 194: 3-21.
35. Janke C, Magiera MM, Rathfelder N, Taxis C, Reber S, et al. (2004) A versatile toolbox for PCR-based tagging of yeast genes: new fluorescent proteins, more markers and promoter substitution cassettes. Yeast 21: 947-962.
36. Knop M, Siegers K, Pereira G, Zachariae W, Winsor B, et al. (1999) Epitope tagging of yeast genes using a PCR-based strategy: more tags and improved practical routines. Yeast 15: 963-972.
37. Maekawa H, Priest C, Lechner J, Pereira G, Schiebel E, (2007) The yeast centrosome translates the positional information of the anaphase spindle into a cell cycle signal. J Cell Biol 179: 423-436.
38. Palani S, Meitinger F, Boehm ME, Lehmann WD, Pereira G, (2012) Cdc14-dependent dephosphorylation of Inn1 contributes to Inn1-Cyk3 complex formation. J Cell Sci 125: 3091-3096.
39. Geil C, Schwab M, Seufert W, (2008) A nucleolus-localized activator of Cdc14 phosphatase supports rDNA segregation in yeast mitosis. Curr Biol 18: 1001-1005.
40. Stefan CJ, Audhya A, Emr SD, (2002) The yeast synaptojanin-like proteins control the cellular distribution of phosphatidylinositol (4,5)-bisphosphate. Mol Biol Cell 13: 542-557.