Cdc14-dependent dephosphorylation of Inn1 contributes to Inn1-Cyk3 complex formation

Journal of Cell Science

Volumn 125, Issue 13, 2012, Pages 3091-3096

  Palani, Saravanan ^a   Meitinger, Franz ^a   Boehm, Martin E ^b   Lehmann, Wolf D ^b   Pereira, Gislene ^a  

^a GERMAN CANCER RESEARCH CENTER   (Germany)

^b GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

Author keywords

Cdc14; Cdk1; Cyk3; Cytokinesis; Hof1; Inn1

Indexed keywords

CYCLIN DEPENDENT KINASE 1; PHOSPHOPROTEIN; PHOSPHOPROTEIN PHOSPHATASE CDC14; PROTEIN INN1; PROTEIN SH3; UNCLASSIFIED DRUG;

ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL DIVISION; COMPLEX FORMATION; CONTROLLED STUDY; ENZYME SUBSTRATE; ENZYME SUBSTRATE COMPLEX; NONHUMAN; PRIORITY JOURNAL; PROLINE RICH PROTEIN DOMAIN; PROTEIN BINDING; PROTEIN BLOOD LEVEL; PROTEIN DEPHOSPHORYLATION; PROTEIN INTERACTION; PROTEIN LOCALIZATION;

CELL CYCLE PROTEINS; CYTOKINESIS; ENZYME ACTIVATION; MICROSCOPY, FLUORESCENCE; MICROTUBULE-ASSOCIATED PROTEINS; MITOSIS; MULTIPROTEIN COMPLEXES; PHOSPHORYLATION; PROLINE-RICH PROTEIN DOMAINS; PROTEIN BINDING; PROTEIN TRANSPORT; PROTEIN TYROSINE PHOSPHATASES; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; SRC HOMOLOGY DOMAINS; TIME-LAPSE IMAGING; TWO-HYBRID SYSTEM TECHNIQUES;

SACCHAROMYCES CEREVISIAE;

EID: 84869117801     PISSN: 00219533     EISSN: 14779137     Source Type: Journal    
DOI: 10.1242/jcs.106021     Document Type: Article

References (27)

1. Aspenström, P. (2009). Roles of F-BAR/PCH proteins in the regulation of membrane dynamics and actin reorganization. Int. Rev. Cell Mol. Biol. 272, 1-31.
2. Bembenek, J., Kang, J., Kurischko, C., Li, B., Raab, J. R., Belanger, K. D., Luca, F. C. and Yu, H. (2005). Crm1-mediated nuclear export of Cdc14 is required for the completion of cytokinesis in budding yeast. Cell Cycle 4, 961-971.
3. Bishop, A. C., Ubersax, J. A., Petsch, D. T., Matheos, D. P., Gray, N. S., Blethrow, J., Shimizu, E., Tsien, J. Z., Schultz, P. G., Rose, M. D. et al. (2000). A chemical switch for inhibitor-sensitive alleles of any protein kinase. Nature 407, 395-401.
4. Bloom, J., Cristea, I. M., Procko, A. L., Lubkov, V., Chait, B. T., Snyder, M. and Cross, F. R. (2011). Global analysis of Cdc14 phosphatase reveals diverse roles in mitotic processes. J. Biol. Chem. 286, 5434-5445.
5. Caydasi, A. K. and Pereira, G. (2009). Spindle alignment regulates the dynamic association of checkpoint proteins with yeast spindle pole bodies. Dev. Cell 16, 146-156.
6. Caydasi, A. K., Kurtulmus, B., Orrico, M. I., Hofmann, A., Ibrahim, B. and Pereira, G. (2010). Elm1 kinase activates the spindle position checkpoint kinase Kin4. J. Cell Biol. 190, 975-989.
7. Chin, C. F., Bennett, A. M., Ma, W. K., Hall, M. C. and Yeong, F. M. (2012). Dependence of Chs2 ER export on dephosphorylation by cytoplasmic Cdc14 ensures that septum formation follows mitosis. Mol. Biol. Cell 23, 45-58.
8. Geissler, S., Pereira, G., Spang, A., Knop, M., Soues, S., Kilmartin, J. and Schiebel, E. (1996). The spindle pole body component Spc98p interacts with the gamma-tubulin- like Tub4p of Saccharomyces cerevisiae at the sites of microtubule attachment. Embo J 15, 3899-3911.
9. Haarer, B. K. and Pringle, J. R. (1987). Immunofluorescence localization of the Saccharomyces cerevisiae CDC12 gene product to the vicinity of the 10-nm filaments in the mother-bud neck. Mol. Cell. Biol. 7, 3678-3687.
10. Janke, C., Magiera, M. M., Rathfelder, N., Taxis, C., Reber, S., Maekawa, H., Moreno-Borchart, A., Doenges, G., Schwob, E., Schiebel, E. et al. (2004). A versatile toolbox for PCR-based tagging of yeast genes: new fluorescent proteins, more markers and promoter substitution cassettes. Yeast 21, 947-962.
11. Jendretzki, A., Ciklic, I., Rodicio, R., Schmitz, H. P. and Heinisch, J. J. (2009). Cyk3 acts in actomyosin ring independent cytokinesis by recruiting Inn1 to the yeast bud neck. Mol. Genet. Genomics 282, 437-451.
12. König, C., Maekawa, H. and Schiebel, E. (2010). Mutual regulation of cyclin- dependent kinase and the mitotic exit network. J. Cell Biol. 188, 351-368.
13. Korinek, W. S., Bi, E., Epp, J. A., Wang, L., Ho, J. and Chant, J. (2000). Cyk3, a novel SH3-domain protein, affects cytokinesis in yeast. Curr. Biol. 10, 947-S4.
14. Lillie, S. H. and Brown, S. S. (1994). Immunofluorescence localization of the unconventional myosin, Myo2p, and the putative kinesin-related protein, Smy1p, to the same regions of polarized growth in Saccharomyces cerevisiae. J. Cell Biol. 125, 825-842.
15. Lippincott, J. and Li, R. (1998). Dual function of Cyk2, a cdc15/PSTPIP family protein, in regulating actomyosin ring dynamics and septin distribution. J. Cell Biol. 143, 1947-1960.
16. Meitinger, F., Petrova, B., Lombardi, I. M., Bertazzi, D. T., Hub, B., Zentgraf, H. and Pereira, G. (2010). Targeted localization of Inn1, Cyk3 and Chs2 by the mitotic- exit network regulates cytokinesis in budding yeast. J. Cell Sci. 123, 1851-1861.
17. Meitinger, F., Boehm, M. E., Hofmann, A., Hub, B., Zentgraf, H., Lehmann, W. D. and Pereira, G. (2011). Phosphorylation-dependent regulation of the F-BAR protein Hof1 during cytokinesis. Genes Dev. 25, 875-888.
18. Meitinger, F., Palani, S. and Pereira, G. (2012). The power of MEN in cytokinesis. Cell Cycle 11, 219-228.
19. Nishihama, R., Schreiter, J. H., Onishi, M., Vallen, E. A., Hanna, J., Moravcevic, K., Lippincott, M. F., Han, H., Lemmon, M. A., Pringle, J. R. et al. (2009). Role of Inn1 and its interactions with Hof1 and Cyk3 in promoting cleavage furrow and septum formation in S. cerevisiae. J. Cell Biol. 185, 995-1012.
20. Pereira, G. and Schiebel, E. (2003). Separase regulates INCENP-Aurora B anaphase spindle function through Cdc14. Science 302, 2120-2124.
21. Pereira, G., Manson, C., Grindlay, J. and Schiebel, E. (2002). Regulation of the Bfa1p-Bub2p complex at spindle pole bodies by the cell cycle phosphatase Cdc14p. J. Cell Biol. 157, 367-379.
22. Sanchez-Diaz, A., Marchesi, V., Murray, S., Jones, R., Pereira, G., Edmondson, R., Allen, T. and Labib, K. (2008). Inn1 couples contraction of the actomyosin ring to membrane ingression during cytokinesis in budding yeast. Nat. Cell Biol. 10, 395-406.
23. Schmidt, M., Bowers, B., Varma, A., Roh, D. H. and Cabib, E. (2002). In budding yeast, contraction of the actomyosin ring and formation of the primary septum at cytokinesis depend on each other. J. Cell Sci. 115, 293-302.
24. Seidler, J., Zinn, N., Haaf, E., Boehm, M. E., Winter, D., Schlosser, A. and Lehmann, W. D. (2011). Metal ion-mobilizing additives for comprehensive detection of femtomole amounts of phosphopeptides by reversed phase LC-MS. Amino Acids 41, 311-320.
25. Sherman, F. (1991). Getting started with yeast. Methods Enzymol. 194, 3-21.
26. Ubersax, J. A., Woodbury, E. L., Quang, P. N., Paraz, M., Blethrow, J. D., Shah, K., Shokat, K. M. and Morgan, D. O. (2003). Targets of the cyclin-dependent kinase Cdk1. Nature 425, 859-864.
27. Visintin, R., Craig, K., Hwang, E. S., Prinz, S., Tyers, M. and Amon, A. (1998). The phosphatase Cdc14 triggers mitotic exit by reversal of Cdk-dependent phosphorylation. Mol. Cell 2, 709-718.