Microfluidics: A golden opportunity for positron emission tomography?

Future Medicinal Chemistry

Volumn 5, Issue 3, 2013, Pages 241-244

  Fortt, Robin ^a   Gee, Antony ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

microfluidics; positron emission tomography; probe discovery; radiochemistry

Indexed keywords

RADIOISOTOPE; RADIOLIGAND;

CYCLOTRON; ISOTOPE LABELING; MICROFLUIDICS; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; RADIOACTIVITY; RADIOCHEMISTRY; REACTION TIME; REVIEW;

CHEMISTRY TECHNIQUES, SYNTHETIC; MICROCHEMISTRY; MICROFLUIDICS; POSITRON-EMISSION TOMOGRAPHY; RADIOPHARMACEUTICALS;

EID: 84874744273     PISSN: 17568919     EISSN: 17568927     Source Type: Journal    
DOI: 10.4155/fmc.13.8     Document Type: Review

References (18)

1. Wester HJ. Nuclear imaging probes: from bench to bedside. Clin. Cancer Res. 13(12), 3470-3481 (2007).
2. Miller PW, Long NJ, Vilar R, Gee AD. Synthesis of C-11, F-18, O-15, and N-13 radiolabels for positron emission tomography. Angew. Chem. Int. Ed. Engl. 47(47), 8998-9033 (2008).
3. Hartman RL, McMullen JP, Jensen KF. Deciding whether to go with the flow: evaluating the merits of flow reactors for synthesis. Angew. Chem. Int. Ed. Engl. 50(33), 7502-7519 (2011).
4. Simms RW, Causey PW, Weaver DM, Sundararajan C, Stephenson KA, Valliant JF. Preparation of technetium-99m bifunctional chelate complexes using a microfluidic reactor: a comparative study with conventional and microwave labeling methods. J. Labelled Comp. Radiopharm. 55(1), 18-22 (2012).
5. Lapi SE, Welch MJ. A historical perspective on the specific activity of radiopharmaceuticals: what have we learned in the 35 years of the ISRC? Nucl. Med. Biol. 39(5), 601-608 (2012).
6. Rensch C, Waengler B, Yaroshenko A et al. Microfluidic reactor geometries for radiolysis reduction in radiopharmaceuticals. Appl. Radiat. Isot. 70(8), 1691-1697 (2012).
7. Miller PW, Audrain H, Bender D et al. Rapid carbon-11 radiolabelling for PET using microfluidics. Chem. Eur. J. 17(2), 460-463 (2011).
8. Reed CD, Launay GG, Carroll MA. Evaluation of tetraethylammonium bicarbonate as a phase-transfer agent in the formation of F-18 fluoroarenes. J. Fluor. Chem. 143, 231-237 (2012).
9. Ungersboeck J, Richter S, Collier L et al. Radio labeling of F-18 altanserin - a microfluidic approach. Nucl. Med. Biol. 39(7), 1087-1092 (2012).
10. Bouvet V, Wuest M, Tam PH, Wang M, Wuest F. Microfluidic technology: an economical and versatile approach for the synthesis of O-(2- F-18 fluoroethyl)-ltyrosine (F-18 FET). Bioorg. Med. Chem. Lett. 22(6), 2291-2295 (2012).
11. Gaja V, Gomez-Vallejo V, Cuadrado-Tejedor M, Borrell JI, Llop J. Synthesis of 13N-labelled radiotracers by using microfluidic technology. J. Labelled Comp. Radiopharm. 55(9), 332-338 (2012).
12. Bejot R, Elizarov AM, Ball E et al. Batchmode microfluidic radiosynthesis of N-succinimidyl-4- F-18 fluorobenzoate for protein labelling. J. Labelled Comp. Radiopharm. 54(3), 117-122 (2011).
13. Lee CC, Sui GD, Elizarov A et al. Multistep synthesis of a radiolabeled imaging probe using integrated microfluidics. Science 310(5755), 1793-1796 (2005).
14. Wheeler TD, Zeng DX, Desai AV, Onal B, Reichert DE, Kenis PJA. Microfluidic labeling of biomolecules with radiometals for use in nuclear medicine. Lab Chip 10(24), 3387-3396 (2010).
15. Wong R, Iwata R, Saiki H, Furumoto S, Ishikawa Y, Ozeki E. Reactivity of electrochemically concentrated anhydrous F-18 fluoride for microfluidic radiosynthesis of F-18-labeled compounds. Appl. Radiat. Isot. 70(1), 193-199 (2012).
16. Wilson AA, Garcia A, Jin L, Houle S. Radiotracer synthesis from C-11-iodomethane: a remarkably simple captive solvent method. Nucl. Med. Biol. 27(6), 529-532 (2000).
17. Toorongian SA, Mulholland GK, Jewett DM, Bachelor MA, Kilbourn MR. Routine production of 2-deoxy-2- 18F fluoro-d-glucose by direct nucleophilic exchange on a quaternary 4-aminopyridinium resin. Int. J. Rad. Appl. Instrum. B 17(3), 273-279 (1990).
18. Nutt R, Vento LJ, Ridinger MHT. In vivo molecular imaging biomarkers: clinical pharmacology's new 'PET'? Clin. Pharmacol. Ther. 81(6), 792-795 (2007).