High affinity ammonium transporters: Molecular mechanism of action

Frontiers in Plant Science

Volumn 3, Issue MAR, 2012, Pages

  Pantoja, Omar ^a  

^a INSTITUTO DE BIOTECNOLOGÍA   (Mexico)

Author keywords

Ammonium; AMT; High affinity; Transport

Indexed keywords

EID: 84874737023     PISSN: None     EISSN: 1664462X     Source Type: Journal    
DOI: 10.3389/fpls.2012.00034     Document Type: Review

References (34)

1. Andrade, S. L. A., Dickmanns, A., Ficner, R., and Einsle, O. (2005). Crystal structure of the archaeal ammonium transporter Amt-1 from Archaeoglobus fulgidus. Proc. Natl. Acad. Sci. U.S.A. 102, 14994-14999.
2. Boeckstaens, M., Bruno, A., and Marini, A. M. (2008). Distinct transport mechanisms in yeast ammonium transport/sensor proteins of the Mep/Amt/Rh family and impact on filamentation. J. Biol. Chem. 283, 21362-21370.
3. Conroy, M. J., Durand, A., Lupo, D., Li, X.-D., Bullough, P. A., Winkler, F. K., and Merrick, M. (2007). The crystal structure of the Escherichia coli AmtB-GlnK complex reveals how GlnK regulates the ammonia channel. Proc. Natl. Acad. Sci. U.S.A. 104, 1213.
4. Coutts, G., Thomas, G., Blakey, D., and Merrick, M. (2002). Membrane sequestration of the signal transduction protein GlnK by the ammonium transporter AmtB. EMBO J. 21, 536-545.
5. Couturier, J., Montanini, B., Martin, F., Brun, A., Blaudez, D., and Chalot, M. (2007). The expanded family of ammonium transporters in the perennial poplar plant. New Phytol. 174, 137-150.
6. D'Apuzzo, E., Rogato, A., Simon-Rosin, U., El Alaoui, H., Barbulova, A., Betti, M., Dimou, M., Katinakis, P., Marquez, A., Marini, A. M., Udvardi, M. K., and Chiurazzi, M. (2004). Characterization of three functional high-affinity ammonium transporters in Lotus japonicus with differential transcriptional regulation and spatial expression. Plant Physiol. 134, 1763-1774.
7. Fong, R. N., Kim, K.-S., Yoshihara, C., Inwood, W. B., and Kustu, S. (2007). The W148L substitution in theEscherichia coli ammonium channel AmtB increases flux and indicates that the substrate is an ion. Proc. Natl. Acad. Sci. U.S.A. 104, 18706-18711.
8. Gazzarrini, S., Lejay, L., Gojon, A., Ninnemann, O., Frommer, W. B., and von Wirén, N. (1999). Three functional transporters for constitutive, diurnally regulated, and starvation-induced uptake of ammonium into Arabidopsisroots. Plant Cell 11, 937-948.
9. Guether, M., Neuhäuser, B., Balestrini, R., Dynowski, M., Ludewig, U., and Bonfante, P. (2009). A mycorrhizal-specific ammonium transporter from Lotus japonicus acquires nitrogen released by arbuscular mycorrhizal fungi. Plant Physiol. 150, 73-83.
10. Hall, J. A., and Kustu, S. (2011). The pivotal twin histidines and aromatic triad of the Escherichia coli ammonium channel AmtB can be replaced. Proc. Natl. Acad. Sci. U.S.A. 108, 13270-13274.
11. Javelle, A., Lupo, D., Ripoche, P., Fulford, T., Merrick, M., and Winkler, F. K. (2008). Substrate binding, deprotonation, and selectivity at the periplasmic entrance of the Escherichia coli ammonia channel AmtB. Proc. Natl. Acad. Sci. U.S.A. 105, 5040-5045.
12. Javelle, A., Severi, E., Thornton, J., and Merrick, M. (2004). Ammonium sensing in Escherichia coli. Role of the ammonium transporter AmtB and AmtB-GlnK complex formation. J. Biol. Chem. 279, 8530-8538.
13. Javelle, A., Lupo, D., Zheng, L., Li, X. D., Winkler, F. K., and Merrick, M. (2006). An unusual twin-his arrangement in the pore of ammonia channels is essential for substrate conductance. J. Biol. Chem. 281, 39492-39498.
14. Khademi, S., O'Connell, J. III, Remis, J., Robles-Colmenares, Y., Miercke, L. J. W., and Stroud, R. M. (2004). Mechanism of ammonia transport by Amt/MEP/Rh: structure of AmtB at 1.35 Å. Science 305, 1587-1594.
15. Lanquar, V., Loqué, D., Hörmann, F., Yuan, L., Bohner, A., Engelsberger, W. R., Lalonde, S., Schulze, W. X., von Wirén, N., and Frommer, W. B. (2009). Feedback inhibition of ammonium uptake by a phospho-dependent allosteric mechanism in Arabidopsis. Plant Cell 21, 3610-3622.
16. Loqué, D., Lalonde, S., Looger, L. L., von Wirén, N., and Frommer, W. B. (2007). A cytosolic trans-activation domain essential for ammonium uptake. Nature 446, 195-198.
17. Loqué, D., Mora, S. I., Andrade, S. L. A., Pantoja, O., and Frommer, W. B. (2009). Pore mutations in ammonium transporter AMT1 with increased electrogenic ammonium transport activity. J. Biol. Chem. 284, 24988-24995.
18. Ludewig, U., von Wirén, N., and Frommer, W. B. (2002). Uniport of NH4+ by the root hair plasma membrane ammonium transporter LeAMT1; 1. J. Biol. Chem. 277, 13548-13555.
19. Ludewig, U., Wilken, S., Wu, B., Jost, W., Obrdlik, P., El Bakkoury, M., Marini, A. M., André, B., Hamacher, T., Boles, E., Von Wirén, N., and Frommer, W. B. (2003). Homo-and hetero-oligomerization of ammonium transporter-1 uniporters. J. Biol. Chem. 278, 45603-45610.
20. Marini, A. M., Boeckstaens, M., Benjelloun, F., Chérif-Zahar, B., and André, B. (2006). Structural involvement in substrate recognition of an essential aspartate residue conserved in Mep/Amt and Rh-type ammonium transporters. Curr. Gen. 49, 364-374.
21. Marini, A. M., Springael, J. Y., Frommer, W. B., and André, B. (2000). Cross-talk between ammonium transporters in yeast and interference by the soybean SAT1 protein. Mol. Microbiol. 35, 378-385.
22. Mayer, M., Dynowski, M., and Ludewig, U. (2006). Ammonium ion transport by the AMT/Rh homologue LeAMT1; 1. Biochemical J. 396, 431-437.
23. Neuhäuser, B., Dynowski, M., and Ludewig, U. (2009). Channel-like NH3 flux by ammonium transporter AtAMT2. FEBS Lett. 583, 2833-2838.
24. Neuhäuser, B., Dynowski, M., Mayer, M., and Ludewig, U. (2007). Regulation of NH4+ transport by essential cross talk between AMT monomers through the carboxyl tails. Plant Physiol. 143, 1651-1659.
25. Ortiz-Ramirez, C., Mora, S. I., Trejo, J., and Pantoja, O. (2011). PvAMT1;1, a highly selective ammonium transporter that functions as H+/NH4+ symporter. J. Biol. Chem. 286, 31113-31122.
26. Shelden, M. C., Dong, B., de Bruxelles, G. L., Trevaskis, B., Whelan, J., Ryan, P. R., Howitt, S. M., and Udvardi, M. K. (2001). Arabidopsis ammonium transporters, AtAMT1; 1 and AtAMT1; 2, have different biochemical properties and functional roles. Plant Soil 231, 151-160.
27. Simon-Rosin, U., Wood, C., and Udvardi, M. K. (2003). Molecular and cellular characterisation of LjAMT2;1, an ammonium transporter from the model legume. Lotus japonicus. Plant Mol. Biol. 51, 99-108.
28. Søgaard, R., Alsterfjord, M., Macaulay, N., and Zeuthen, T. (2009). Ammonium ion transport by the AMT/Rh homolog TaAMT1;1 is stimulated by acidic pH. Pflügers Arch. Eur. J. Physiol.458, 733-743.
29. Sohlenkamp, C., Shelden, M., Howitt, S., and Udvardi, M. (2000). Characterization of Arabidopsis AtAMT2, a novel ammonium transporter in plants. FEBS Lett. 467, 273-278.
30. Sohlenkamp, C., Wood, C. C., Roeb, G. W., and Udvardi, M. K. (2002). Characterization of Arabidopsis AtAMT2, a high-affinity ammonium transporter of the plasma membrane. Plant Physiol. 130, 1788-1796.
31. Winkler, F. K. (2006). Amt/MEP/Rh proteins conduct ammonia. Pflügers Arch. Eur. J. Physiol. 451, 701-707.
32. Wirén, N. V., and Merrick, M. (2004). Molecular mechanisms controlling transmembrane transport. Topics in Current Genetics 1-26.
33. Wood, C. C., Porée, F., Dreyer, I., Koehler, G. J., and Udvardi, M. K. (2006). Mechanisms of ammonium transport, accumulation, and retention in ooyctes and yeast cells expressing Arabidopsis AtAMT1; 1. FEBS Lett. 580, 3931-3936.
34. Zheng, L., Kostrewa, D., Bernèche, S., Winkler, F. K., and Li, X.-D. (2004). The mechanism of ammonia transport based on the crystal structure of AmtB of Escherichia coli. Proc. Natl. Acad. Sci. U.S.A. 101, 17090-17095.