Cellular Effects of Curcumin on Plasmodium falciparum Include Disruption of Microtubules

PLoS ONE

Volumn 8, Issue 3, 2013, Pages

  Chakrabarti, Rimi ^a,b,c   Rawat, Parkash S ^a,c   Cooke, Brian M ^b   Coppel, Ross L ^b   Patankar, Swati ^a  

^a INDIAN INSTITUTE OF TECHNOLOGY BOMBAY   (India)

^b MONASH UNIVERSITY   (Australia)

^c IITB MONASH RESEARCH ACADEMY   (India)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA TUBULIN; BETA TUBULIN; COLCHICINE; CURCUMIN; PACLITAXEL; REACTIVE OXYGEN METABOLITE; VINBLASTINE;

ANTIPROTOZOAL ACTIVITY; ARTICLE; BINDING SITE; CELL STRUCTURE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; DRUG POTENTIATION; DRUG PROTEIN BINDING; GROWTH INHIBITION; HEMOLYSIS; HUMAN; HUMAN CELL; IC 50; IMMUNOFLUORESCENCE; IN VITRO STUDY; MEMBRANE STRUCTURE; MICROBIAL GROWTH; MICROTUBULE; MOLECULAR DOCKING; NONHUMAN; PLASMODIUM FALCIPARUM; STRUCTURE ANALYSIS;

BINDING SITES; COLCHICINE; CURCUMIN; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SYNERGISM; ERYTHROCYTES; HEMOLYSIS; HUMANS; MICROTUBULES; MOLECULAR DOCKING SIMULATION; PACLITAXEL; PLASMODIUM FALCIPARUM; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN MULTIMERIZATION; TUBULIN; TUBULIN MODULATORS; VINBLASTINE;

EID: 84874720817     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0057302     Document Type: Article

References (60)

1. Cui L, Miao J, (2007) Cytotoxic effect of curcumin on malaria parasite Plasmodium falciparum: inhibition of histone acetylation and generation of reactive oxygen species. Antimicrob Agents Chemother 51: 488-494.
2. Nandakumar DN, Nagaraj VA, Vathsala PG, Rangarajan P, Padmanaban G, (2006) Curcumin-artemisinin combination therapy for malaria. Antimicrob Agents Chemother 50: 1859-1860.
3. Reddy RC, Vatsala PG, Keshamouni VG, Padmanaban G, Rangarajan PN, (2005) Curcumin for malaria therapy. Biochem Biophys Res Commun 326: 472-474.
4. Mimche PN, Taramelli D, Vivas L, (2011) The plant-based immunomodulator curcumin as a potential candidate for the development of an adjunctive therapy for cerebral malaria. Malaria Journal 10 Suppl 1: S10.
5. Ji HF, Shen L, (2009) Interactions of curcumin with the PfATP6 model and the implications for its antimalarial mechanism. Bioorg Med Chem Lett 19: 2453-2455.
6. Urscher M, Przyborski JM, Imoto M, Deponte M, (2010) Distinct subcellular localization in the cytosol and apicoplast, unexpected dimerization and inhibition of Plasmodium falciparum glyoxalases. Molecular Microbiology 76: 92-103.
7. Sandur SK, Pandey MK, Sung B, Ahn KS, Murakami A, et al. (2007) Curcumin, demethoxycurcumin, bisdemethoxycurcumin, tetrahydrocurcumin and turmerones differentially regulate anti-inflammatory and anti-proliferative responses through a ROS-independent mechanism. Carcinogenesis 28: 1765-1773.
8. Agrawal DK, Mishra PK, (2010) Curcumin and its analogues: Potential anticancer agents. Med Res Rev 30 (5) (): 818-860.
9. Thaloor D, Singh AK, Sidhu GS, Prasad PV, Kleinman HK, et al. (1998) Inhibition of angiogenic differentiation of human umbilical vein endothelial cells by curcumin. Cell Growth and Differentiation 9: 305-312.
10. Motterlini R, Foresti R, Bassi R, Green CJ, (2000) Curcumin, an antioxidant and anti-inflammatory agent, induces heme oxygenase-1 and protects endothelial cells against oxidative stress. Free Radical Biology and Medicine 28: 1303-1312.
11. Kunchandy E, Rao MNA, (1990) Oxygen radical scavenging activity of curcumin. International Journal of Pharmaceutics 58: 237-240.
12. Lu Y-P, Chang RL, Lou Y-R, Huang M-T, Newmark HL, et al. (1994) Effect of curcumin on 12-O-tetradecanoylphorbol-13-acetate- and ultraviolet B light-induced expression of c-Jun and c-Fos in JB6 cells and in mouse epidermis. Carcinogenesis 15: 2363-2370.
13. Singh S, Aggarwal BB, (1995) Activation of transcription factor NF-κB is suppressed by curcumin (diferulolylmethane). Journal of Biological Chemistry 270: 24995-25000.
14. Jobin C, Bradham CA, Russo MP, Juma B, Narula AS, et al. (1999) Curcumin Blocks Cytokine-Mediated NF-{kappa}B Activation and Proinflammatory Gene Expression by Inhibiting Inhibitory Factor I-{kappa}B Kinase Activity. J Immunol 163: 3474-3483.
15. Mohan R, Sivak J, Ashton P, Russo LA, Pham BQ, et al. (2000) Curcuminoids inhibit the angiogenic response stimulated by fibroblast growth factor-2, including expression of matrix metalloproteinase gelatinase B. Journal of Biological Chemistry 275: 10405-10412.
16. Goel A, Boland CR, Chauhan DP, (2001) Specific inhibition of cyclooxygenase-2 (COX-2) expression by dietary curcumin in HT-29 human colon cancer cells. Cancer Letters 172: 111-118.
17. Korutla L, Cheung JY, Medelsohn J, Kumar R, (1995) Inhibition of ligand-induced activation of epidermal growth factor receptor tyrosine phosphorylation by curcumin. Carcinogenesis 16: 1741-1745.
18. Jung KK, Lee HS, Cho JY, Shin WC, Rhee MH, et al. (2006) Inhibitory effect of curcumin on nitric oxide production from lipopolysaccharide-activated primary microglia. Life Sciences 79: 2022-2031.
19. Van Erk M, Teuling E, Staal Y, Huybers S, Van Bladeren P, et al. (2004) Time- and dose-dependent effects of curcumin on gene expression in human colon cancer cells. J Carcinog 3 (1) (): 8.
20. Holy JM, (2002) Curcumin disrupts mitotic spindle structure and induces micronucleation in MCF-7 breast cancer cells. Mutation Research/Genetic Toxicology and Environmental Mutagenesis 518: 71-84.
21. Gupta KK, Bharne SS, Rathinasamy K, Naik NR, Panda D, (2006) Dietary antioxidant curcumin inhibits microtubule assembly through tubulin binding. The FEBS journal 273: 5320-5332.
22. Schrevel J, Sinou V, Grellier P, Frappier F, Guenard D, et al. (1994) Interactions between docetaxel (Taxotere) and Plasmodium falciparum-infected erythrocytes. Proc Natl Acad Sci U S A 91: 8472-8476.
23. Pouvelle B, Farley PJ, Long CA, Taraschi TF, (1994) Taxol arrests the development of blood-stage Plasmodium falciparum in vitro and Plasmodium chabaudi adami in malaria-infected mice. J Clin Invest 94: 413-417.
24. Sinden RE, Smalley ME, (1979) Gametocytogenesis of Plasmodium falciparum in vitro: the cell-cycle. Parasitology 79: 277-296.
25. Bejon PA, Bannister LH, Fowler RE, Fookes RE, Webb SE, et al. (1997) A role for microtubules in Plasmodium falciparum merozoite invasion. Parasitology 114: 1-6.
26. Usanga EA, O'Brien E, Luzzato L, (1986) Mitotic inhibitors arrest the growth of Plasmodium falciparum. FEBS Lett 209: 23-27.
27. Fennell BJ, Naughton JA, Dempsey E, Bell A, (2006) Cellular and molecular actions of dinitroaniline and phosphorothioamidate herbicides on Plasmodium falciparum: tubulin as a specific antimalarial target. Mol Biochem Parasitol 145: 226-238.
28. Dieckmann-Schuppert A, Franklin RM, (1989) Compounds binding to cytoskeletal proteins are active against Plasmodium falciparum in vitro. Cell Biol Int Rep 13: 411-418.
29. Bell A, Wernli B, Franklin RM, (1993) Effects of microtubule inhibitors on protein synthesis in Plasmodium falciparum. Parasitol Res 79: 146-152.
30. Cranmer SL, Magowan C, Liang J, Coppel RL, Cooke BM, (1997) An alternative to serum for cultivation of Plasmodium falciparum in vitro. Trans R Soc Trop Med Hyg 91: 363-365.
31. Lambros C, Vanderberg JP, (1979) Synchronization of Plasmodium falciparum erythrocytic stages in culture. The Journal of parasitology 65: 418-420.
32. Fivelman QL, Adagu IS, Warhurst DC, (2004) Modified fixed-ratio isobologram method for studying in vitro interactions between atovaquone and proguanil or dihydroartemisinin against drug-resistant strains of Plasmodium falciparum. Antimicrob Agents Chemother 48: 4097-4102.
33. Aditya NP, Patankar S, Madhusudhan B, Murthy RS, Souto EB, (2010) Arthemeter-loaded lipid nanoparticles produced by modified thin-film hydration: Pharmacokinetics, toxicological and in vivo anti-malarial activity. European journal of pharmaceutical sciences: official journal of the European Federation for Pharmaceutical Sciences 40: 448-455.
34. Tønnesen HH, Kristensen S, Grinberg LN, (1994) Studies on curcumin and curcuminoids: XXV. Inhibition of primaquine-induced lysis of human red blood cells by curcumin. International Journal of Pharmaceutics 110: 161-167.
35. Fennell BJ, Carolan S, Pettit GR, Bell A, (2003) Effects of the antimitotic natural product dolastatin 10, and related peptides, on the human malarial parasite Plasmodium falciparum. J Antimicrob Chemother 51: 833-841.
36. Richard D, Kats LM, Langer C, Black CG, Mitri K, et al. (2009) Identification of rhoptry trafficking determinants and evidence for a novel sorting mechanism in the malaria parasite plasmodium falciparum. PLoS Pathogens 5.
37. Schwede T, Kopp J, Guex N, Peitsch MC, (2003) SWISS-MODEL: An automated protein homology-modeling server. Nucleic Acids Res 31: 3381-3385.
38. Sasin JM, Bujnicki JM, (2004) COLORADO3D, a web server for the visual analysis of protein structures. Nucleic Acids Res 32: W586-589.
39. Macindoe G, Mavridis L, Venkatraman V, Devignes MD, Ritchie DW, (2010) HexServer: an FFT-based protein docking server powered by graphics processors. Nucleic Acids Res 38: W445-449.
40. Payton F, Sandusky P, Alworth WL, (2007) NMR study of the solution structure of curcumin. J Nat Prod 70: 143-146.
41. Morris GM, Huey R, Olson AJ, (2008) Using AutoDock for ligand-receptor docking. Curr Protoc Bioinformatics Chapter 8: Unit 8 14.
42. Reddy RC, Vatsala PG, Keshamouni VG, Padmanaban G, Rangarajan PN, (2005) Curcumin for malaria therapy. Biochemical and Biophysical Research Communications 326: 472-474.
43. Autian J, (1975) Biological Model Systems for the Testing of the Toxicity of Biomaterials. pp. 181-203.
44. Bell A, (1998) Microtubule inhibitors as potential antimalarial agents. Parasitol Today 14: 234-240.
45. Dahl EL, Rosenthal PJ, (2007) Multiple antibiotics exert delayed effects against the Plasmodium falciparum apicoplast. Antimicrobial Agents and Chemotherapy 51: 3485-3490.
46. Dahl EL, Shock JL, Shenai BR, Gut J, DeRisi JL, et al. (2006) Tetracyclines specifically target the apicoplast of the malaria parasite Plasmodium falciparum. Antimicrobial Agents and Chemotherapy 50: 3124-3131.
47. Goodman CD, Su V, McFadden GI, (2007) The effects of anti-bacterials on the malaria parasite Plasmodium falciparum. Mol Biochem Parasitol 152: 181-191.
48. Striepen B, Crawford MJ, Shaw MK, Tilney LG, Seeber F, et al. (2000) The plastid of Toxoplasma gondii is divided by association with the centrosomes. Journal of Cell Biology 151: 1423-1434.
49. Rai SS, Wolff J, (1996) Localization of the vinblastine-binding site on β-tubulin. Journal of Biological Chemistry 271: 14707-14711.
50. Uppuluri S, Knipling L, Sackett DL, Wolff J, (1993) Localization of the colchicine-binding site of tubulin. Proceedings of the National Academy of Sciences of the United States of America 90: 11598-11602.
51. Bentzen PJ, Lang E, Lang F, (2007) Curcumin induced suicidal erythrocyte death. Cellular Physiology and Biochemistry 19: 153-164.
52. Garland DL, (1978) Kinetics and mechanism of colchicine binding to Tubulin: Evidence for ligand-induced conformational change. Biochemistry 17: 4266-4272.
53. Dahl EL, Rosenthal PJ, (2007) Multiple antibiotics exert delayed effects against the Plasmodium falciparum apicoplast. Antimicrob Agents Chemother 51: 3485-3490.
54. Dahl EL, Shock JL, Shenai BR, Gut J, DeRisi JL, et al. (2006) Tetracyclines specifically target the apicoplast of the malaria parasite Plasmodium falciparum. Antimicrob Agents Chemother 50: 3124-3131.
55. Striepen B, Crawford MJ, Shaw MK, Tilney LG, Seeber F, et al. (2000) The plastid of Toxoplasma gondii is divided by association with the centrosomes. J Cell Biol 151: 1423-1434.
56. Dhamodharan R, Jordan MA, Thrower D, Wilson L, Wadsworth P, (1995) Vinblastine suppresses dynamics of individual microtubules in living interphase cells. Molecular Biology of the Cell 6: 1215-1229.
57. Jordan MA, Wilson L, (1990) Kinetic analysis of tubulin exchange at microtubule ends at low vinblastine concentrations. Biochemistry® 29: 2730-2739.
58. Kappes B, Rohrbach P, (2007) Microtubule inhibitors as a potential treatment for malaria. Future Microbiol 2: 409-423.
59. Sinou V, Boulard Y, Grellier P, Schrevel J, (1998) Host cell and malarial targets for docetaxel (Taxotere) during the erythrocytic development of Plasmodium falciparum. J Eukaryot Microbiol 45: 171-183.
60. Sinou V, Grellier P, Schrevel J, (1996) In vitro and in vivo inhibition of erythrocytic development of malarial parasites by docetaxel. Antimicrob Agents Chemother 40: 358-361.