The Motor Unit Number Index (MUNIX) in sarcopenic patients

Experimental Gerontology

Volumn 48, Issue 4, 2013, Pages 381-384

  Drey, M ^a   Grosch C ^a   Neuwirth, C ^b   Bauer, J M ^a,c   Sieber, C C ^a  

^a UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^b CANTONAL HOSPITAL ST GALLEN   (Switzerland)

^c Geriatrics Center Oldenburg   (Germany)

Author keywords

Elderly; Motoneuron; MUNIX; Neuromuscular; Sarcopenia

Indexed keywords

AGED; ARTICLE; CELL LOSS; CLINICAL ARTICLE; CONTROLLED STUDY; ELECTROMYOGRAPHY; FEMALE; HUMAN; MALE; MOTONEURON; MOTOR UNIT NUMBER INDEX; MOTOR UNIT POTENTIAL; MOTOR UNIT SIZE INDEX; MUSCLE ACTION POTENTIAL; MUSCLE ATROPHY; MUSCULOSKELETAL SYSTEM PARAMETERS; NERVE SPROUTING; NERVOUS SYSTEM PARAMETERS; PATHOGENESIS; PRIORITY JOURNAL;

ACTION POTENTIALS; AGED; AGED, 80 AND OVER; ELECTROMYOGRAPHY; FEMALE; HAND; HUMANS; MALE; MOTOR NEURONS; MUSCLE, SKELETAL; NERVE DEGENERATION; NEURAL CONDUCTION; SARCOPENIA; STATISTICS AS TOPIC;

EID: 84874703483     PISSN: 05315565     EISSN: 18736815     Source Type: Journal    
DOI: 10.1016/j.exger.2013.01.011     Document Type: Article

References (20)

1. Ahn S.W., Kim S.H., Kim J.E., Kim S.M., Kim S.H., Park K.S., Sung J.J., Lee K.W., Hong Y.H. Reproducibility of the motor unit number index (MUNIX) in normal controls and amyotrophic lateral sclerosis patients. Muscle Nerve 2010, 42:808-813.
2. Andersen J.L., Terzis G., Kryger A. Increase in the degree of coexpression of myosin heavy chain isoforms in skeletal muscle fibers of the very old. Muscle Nerve 1999, 22:449-454.
3. Brown M.C., Holland R.L., Hopkins W.G. Motor nerve sprouting. Annu. Rev. Neurosci. 1981, 4:17-42.
4. Gordon T., Thomas C.K., Munson J.B., Stein R.B. The resilience of the size principle in the organization of motor unit properties in normal and reinnervated adult skeletal muscles. Can. J. Physiol. Pharmacol. 2004, 82:645-661.
5. Guralnik J.M., Simonsick E.M., Ferrucci L., Glynn R.J., Berkman L.F., Blazer D.G., Scherr P.A., Wallace R.B. A short physical performance battery assessing lower extremity function: association with self-reported disability and prediction of mortality and nursing home admission. J. Gerontol. 1994, 49:85-94.
6. Janssen I., Heymsfield S.B., Ross R. Low relative skeletal muscle mass (sarcopenia) is associated with functional impairment and physical disability. J. Am. Geriatr. Soc. 2002, 50:889-896.
7. Kanda K., Hashizume K. Changes in properties of the medial gastrocnemius motor units in aging rats. J. Neurophysiol. 1989, 61:737-746.
8. Kanda K., Hashizume K. Recovery of motor-unit function after peripheral nerve injury in aged rats. Neurobiol. Aging 1991, 12:271-276.
9. Lang T., Streeper T., Cawthon P., Baldwin K. Sarcopenia: etiology, clinical consequences, intervention, and assessment. Osteoporos. Int. 2010, 21:543-559.
10. Larsson L., Ansved T., Edström L., Gorza L., Schiaffino S. Effects of age on physiological, immunohistochemical and biochemical properties of fast-twitch single motor units in the rat. J. Physiol. 1991, 443:257-275.
11. Li X., Rymer W.Z., Zhou P. A simulation-based analysis of motor unit number index (MUNIX) technique using motoneuron pool and surface electromyogram models. IEEE Trans. Neural Syst. Rehabil. Eng. 2012, 20:297-304.
12. McComas A.J., Fawcett P.R.W., Campbell M.J., Sica R.E.P. Electrophysiological estimation of the number of motor units within a human muscle. J. Neurol. Neurosurg. Psychiatry 1971, 34:121-131.
13. Nandedkar S.D., Nandedkar D.S., Barkhaus P.E., Stalberg E.V. Motor unit number index (MUNIX). IEEE Trans. Biomed. Eng. 2004, 51:2209-2211.
14. Nandedkar S.D., Barkhaus P.E., Stålberg E.V. Motor unit number index (MUNIX): principle, method, and findings in healthy subjects and in patients with motor neuron disease. Muscle Nerve 2010, 42:798-807.
15. Nandedkar S.D., Barkhaus P.E., Stålberg E.V. Reproducibility of MUNIX in patients with amyotrophic lateral sclerosis. Muscle Nerve 2011, 44:919-922.
16. Neuwirth C., Nandedkar S., Stålberg E., Weber M. Motor unit number index (MUNIX): a novel neurophysiological technique to follow disease progression in amyotrophic lateral sclerosis. Muscle Nerve 2010, 42:379-384.
17. Neuwirth C., Nandedkar S., Stålberg E., Barkhaus P.E., Carvalho M.D., Furtula J., Dijk J.P.V., Baldinger R., Castro J., Costa J., Otto M., Sandberg A., Weber M. Motor Unit Number Index (MUNIX): a novel neurophysiological marker for neuromuscular disorders; test-retest reliability in healthy volunteers. Clin. Neurophysiol. 2011, 122:1867-1872.
18. Tam S.L., Gordon T. Mechanisms controlling axonal sprouting at the neuromuscular junction. J. Neurocytol. 2003, 32:961-974.
19. Thomas D.R. Sarcopenia. Clin. Geriatr. Med. 2010, 26:331-346.
20. Verdú E., Ceballos D., Vilches J.J., Navarro X. Influence of aging on peripheral nerve function and regeneration. J. Peripher. Nerv. Syst. 2000, 5:191-208.