Reproducibility of the motor unit number index (MUNIX) in normal controls and amyotrophic lateral sclerosis patients

Muscle and Nerve

Volumn 42, Issue 5, 2010, Pages 808-813

  Ahn, Suk Won ^a   Kim, Su Hyun ^b   Kim, Jee Eun ^b   Kim, Sung Min ^b   Kim, Seung Hyun ^e   Park, Kyung Seok ^d   Sung, Jung Joon ^b   Lee, Kwang Woo ^b   Hong, Yoon Ho ^c  

^a Chung Ang University College of Medicine   (South Korea)

^b Seoul National University Hospital   (South Korea)

^c Seoul National University College of Medicine   (South Korea)

^d Seoul National University Bundang Hospital   (South Korea)

^e Hanyang University College of Medicine   (South Korea)

Author keywords

ALS; Motor unit number; MUNE; MUNIX; Reproducibility

Indexed keywords

ADULT; AGED; AMYOTROPHIC LATERAL SCLEROSIS; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATION COEFFICIENT; ELECTROMYOGRAPHY; FEMALE; HUMAN; MALE; MEASUREMENT; MOTOR UNIT; MOTOR UNIT NUMBER INDEX; MUSCLE CONTRACTION; NERVOUS SYSTEM ELECTROPHYSIOLOGY; PRIORITY JOURNAL; REPRODUCIBILITY; STATISTICAL ANALYSIS; TEST RETEST RELIABILITY;

ACTION POTENTIALS; ADULT; AGED; AGING; AMYOTROPHIC LATERAL SCLEROSIS; ANALYSIS OF VARIANCE; ELECTRODIAGNOSIS; ELECTROMYOGRAPHY; ELECTROPHYSIOLOGY; FEMALE; HUMANS; MALE; MIDDLE AGED; MOTOR NEURONS; MUSCLE FIBERS, SKELETAL; MUSCLE, SKELETAL; REPRODUCIBILITY OF RESULTS;

EID: 78149307629     PISSN: 0148639X     EISSN: 10974598     Source Type: Journal    
DOI: 10.1002/mus.21765     Document Type: Article

References (19)

1. McComas A, Fawcett P, Campbell M, Sica R. Electrophysiological estimation of the number of motor units within a human muscle. J Neurol Neurosurg Psychiatry 1971;34:121-131.
2. Bromberg MB. Updating motor unit number estimation (MUNE). Clin Neurophysiol 2007;118:1-8. (Pubitemid 44960926)
3. Felice KJ. A longitudinal study comparing thenar motor unit number estimates to other quantitative tests in patients with amyotrophic lateral sclerosis. Muscle Nerve 1997;20:179-185.
4. Armon C, Brandstater ME. Motor unit number estimate based rates of progression of ALS predict patient survival. Muscle Nerve 1999;22:1571-1575.
5. Gooch C, Harati Y. Motor unit number estimation, ALS, and clinical trials. Amyotroph Lateral Scler Other Motor Neuron Disord 2000;1:71-82.
6. Hong YH, Sung JJ, Park KS, Kwon O, Min JH, Lee KW. Statistical MUNE: a comparison of two methods of setting recording windows in healthy subjects and ALS patients. Clin Neurophysiol 2007;118:2605-2611.
7. Nandedkar SD, Nandedkar DS, Barkhaus PE, Stälberg EV. Motor unit number index (MUNIX): a pilot study. In: Bromberg MB, editor. Motor unit number estimation. Supplements to Clinical Neurophysiology. Vol. 55. Amsterdam: Elsevier; 2003. p 133-140.
8. Nandedkar SD, Nandedkar DS, Barkhaus PE, Stälberg EV. Motor unit number index (MUNIX). IEEE Trans Biomed Eng 2004;51:2209-2211.
9. Barkhaus PE, Nandedkar SD. Comparison of two methods (MUNE and MUNIX) to study the number of motor units in ALS patients and normal controls (abstract). Amyotroph Lateral Scler 2004;5(suppl 2):110-119.
10. Brooks BR, Miller RG, Swash M, Munsat TL. World Federation of Neurology Research Group on Motor Neuron Disease. El Escorial revisited: revised criteria for the diagnosis of amyotrophic lateral sclerosis. Amyotroph Lateral Scler 2000;1:293-298.
11. Bromberg M. Motor unit estimation: reproducibility of the spike-triggered averaging technique in normal and ALS subjects. Muscle Nerve 1993;16:466-471. (Pubitemid 23138092)
12. Boe SG, Stashuk DW, Doherty TJ.Within-subject reliability of motor unit number estimates and quantitative motor unit analysis in a distal and proximal upper limbmuscle. Clin Neurophysiol 2006;117:596-603.
13. Felice K. Thenar motor unit number estimates using the multiple point stimulation technique: reproducibility studies in ALS patients and normal subjects. Muscle Nerve 1995;18:1412-1416.
14. Lomen-Hoerth C, Olney RK. Comparison of multiple point and statistical motor unit number estimation. Muscle Nerve 2000;23:1525-1533.
15. Kwon O, Lee KW. Reproducibility of statistical motor unit number estimates in amyotrophic lateral sclerosis: comparisons between size and number-weighted modifications. Muscle Nerve 2004;29:211-217.
16. Simmons Z, Epstein DK, Borg B, Mauger DT, Kothari MJ, Shefner JM. Reproducibility of motor unit number estimation in individual subjects. Muscle Nerve 2001;24:467-473.
17. Olney RK, Yuen EC, Engstrom JW. Statistical motor unit number estimation: reproducibility and sources of error in patients with amyotrophic lateral sclerosis. Muscle Nerve 2000;23:193-197.
18. Ravits J, Laurie P, Fan Y, Moore DH. Implications of ALS focality: rostral-caudal distribution of lower motor neuron loss postmortem. Neurology 2007;68:1576-1582.
19. Ravits J, Paul P, Jorg C. Focality of upper and lower motor neuron degeneration at the clinical onset of ALS. Neurology 2007;68:1571-1575.