An Evaluation of Sexual Functioning in Employed Outpatients with Major Depressive Disorder Treated with Desvenlafaxine 50mg or Placebo

Journal of Sexual Medicine

Volumn 10, Issue 3, 2013, Pages 768-776

  Clayton, Anita H ^a   Reddy, Sujana ^b   Focht, Kristen ^b   Musgnung, Jeff ^b   Fayyad, Rana ^b  

^a UNIVERSITY OF VIRGINIA   (United States)

^b PFIZER INC   (United States)

Author keywords

Antidepressant; Desvenlafaxine; Sexual Functioning

Indexed keywords

DESVENLAFAXINE; PLACEBO;

ADULT; ARTICLE; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; EMPLOYMENT; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MAJOR DEPRESSION; MALE; ORGASM DISORDER; OUTPATIENT; PHASE 3 CLINICAL TRIAL; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SCORING SYSTEM; SEXUAL DYSFUNCTION; SEXUAL SATISFACTION; SEXUALITY; TREATMENT RESPONSE;

EID: 84874681859     PISSN: 17436095     EISSN: 17436109     Source Type: Journal    
DOI: 10.1111/j.1743-6109.2012.02899.x     Document Type: Article

References (20)

1. Montgomery SA, Baldwin DS, Riley A. Antidepressant medications: A review of the evidence for drug-induced sexual dysfunction. J Affect Disord 2002;69:119-40.
2. Rosen RC, Lane RM, Menza M. Effects of SSRIs on sexual function: A critical review. J Clin Psychopharmacol 1999;19:67-85.
3. Kennedy SH, Dickens SE, Eisfeld BS, Bagby RM. Sexual dysfunction before antidepressant therapy in major depression. J Affect Disord 1999;56:201-8.
4. Lee KU, Lee YM, Nam JM, Lee HK, Kweon YS, Lee CT, Jun TY. Antidepressant-induced sexual dysfunction among newer antidepressants in a naturalistic setting. Psychiatry Investig 2010;7:55-9.
5. Serretti A, Chiesa A. Treatment-emergent sexual dysfunction related to antidepressants: A meta-analysis. J Clin Psychopharmacol 2009;29:259-66.
6. Clayton A, Keller A, McGarvey EL. Burden of phase-specific sexual dysfunction with SSRIs. J Affect Disord 2006;91:27-32.
7. Clayton AH, Hamilton DV. Female sexual dysfunction. Psychiatr Clin North Am 2010;33:323-38.
8. Meston CM, Frohlich PF. The neurobiology of sexual function. Arch Gen Psychiatry 2000;57:1012-30.
9. Hasler G. Pathophysiology of depression: Do we have any solid evidence of interest to clinicians? World Psychiatry 2010;9:155-61.
10. Dunlop BW, Reddy S, Yang L, Lubaczewski S, Focht K, Guico-Pabia CJ. Symptomatic and functional improvement in employed depressed patients: A double-blind clinical trial of desvenlafaxine versus placebo. J Clin Psychopharmacol 2011;31:569-76.
11. McGahuey CA, Gelenberg AJ, Laukes CA, Moreno FA, Delgado PL, McKnight KM, Manber R. The Arizona Sexual Experience Scale (ASEX): Reliability and validity. J Sex Marital Ther 2000;26:25-40.
12. Montgomery SA, Asberg M. A new depression scale designed to be sensitive to change. Br J Psychiatry 1979;134:382-9.
13. Sheehan DV. Sheehan disability scale. In: Rush AJ, Pincus HA, First MB, eds. Handbook of psychiatric measures. Washington, DC: American Psychiatric Association; 2000:113-5.
14. Hamilton M. A rating scale for depression. J Neurol Neurosurg Psychiatry 1960;23:56-62.
15. Clayton AH, Kornstein SG, Rosas G, Guico-Pabia C, Tourian KA. An integrated analysis of the safety and tolerability of desvenlafaxine compared with placebo in the treatment of major depressive disorder. CNS Spectr 2009;14:183-95.
16. Montejo-Gonzalez AL, Llorca G, Izquierdo JA, Ledesma A, Bousono M, Calcedo A, Carrasco JL, Ciudad J, Daniel E, De la Gandara J, Derecho J, Franco M, Gomez MJ, Macias JA, Martin T, Perez V, Sanchez JM, Sanchez S, Vicens E. SSRIinduced sexual dysfunction: Fluoxetine, paroxetine, sertraline, and fluvoxamine in a prospective, multicenter, and descriptive clinical study of 344 patients. J Sex Marital Ther 1997;23:176-94.
17. Delgado PL, Brannan SK, Mallinckrodt CH, Tran PV, McNamara RK, Wang F, Watkin JG, Detke MJ. Sexual functioning assessed in 4 double-blind placebo- and paroxetinecontrolled trials of duloxetine for major depressive disorder. J Clin Psychiatry 2005;66:686-92.
18. Montejo AL, Llorca G, Izquierdo JA, Rico-Villademoros F. Incidence of sexual dysfunction associated with antidepressant agents: A prospective multicenter study of 1022 outpatients. Spanish Working Group for the Study of Psychotropic-Related Sexual Dysfunction. J Clin Psychiatry 2001;62(suppl3):10-21.
19. Dunn JA, Arakawa R, Greist JH, Clayton AH. Assessing the onset of antidepressant-induced sexual dysfunction using interactive voice response technology. J Clin Psychiatry 2007;68:525-32.
20. Montejo AL, Perahia DG, Spann ME, Wang F, Walker DJ, Yang CR, Detke MJ. Sexual function during long-term duloxetine treatment in patients with recurrent major depressive disorder. J Sex Med 2011;8:773-82.