Intravenous heparin for the treatment of intraluminal thrombus in patients with acute ischemic stroke: A case series

Journal of NeuroInterventional Surgery

Volumn 5, Issue 2, 2013, Pages 144-150

  Mokin, Maxim ^a,b   Kass Hout, Tareq ^a,b   Kass Hout, Omar ^a,b   Radovic, Vladan ^a,b   Siddiqui, Adnan H ^a,b   Levy, Elad I ^a,b   Snyder, Kenneth V ^a,b  

^a UNIVERSITY AT BUFFALO   (United States)

^b Millard Fillmore Gates Circle Hospital   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HEPARIN; WARFARIN;

ADULT; ARTICLE; BASILAR ARTERY OBSTRUCTION; BRAIN ANGIOGRAPHY; BRAIN ISCHEMIA; BRAIN PERFUSION; CLINICAL EFFECTIVENESS; CLINICAL EVALUATION; CLINICAL FEATURE; COMPUTED TOMOGRAPHIC ANGIOGRAPHY; DIGITAL SUBTRACTION ANGIOGRAPHY; DISEASE ASSOCIATION; DRUG EFFICACY; DRUG SAFETY; DRUG TOLERABILITY; FEMALE; GASTROINTESTINAL HEMORRHAGE; HUMAN; INTERNAL CAROTID ARTERY OCCLUSION; MAJOR CLINICAL STUDY; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; NEUROIMAGING; NUCLEAR MAGNETIC RESONANCE IMAGING; OCCLUSIVE CEREBROVASCULAR DISEASE; OUTCOME ASSESSMENT; PATIENT ASSESSMENT; PRIORITY JOURNAL; RETROSPECTIVE STUDY; TREATMENT DURATION; VERTEBRAL ARTERY STENOSIS;

AGED; AGED, 80 AND OVER; BRAIN ISCHEMIA; FEMALE; HEPARIN; HUMANS; INFUSIONS, INTRAVENOUS; INTRACRANIAL THROMBOSIS; MALE; MIDDLE AGED; PROSPECTIVE STUDIES; RETROSPECTIVE STUDIES; STROKE; TREATMENT OUTCOME;

EID: 84874643726     PISSN: 17598478     EISSN: 17598486     Source Type: Journal    
DOI: 10.1136/neurintsurg-2011-010134     Document Type: Article

References (23)

1. McLean J. The thromboplastic action of cephalin. Am J Physiol 1916;41: 250-7.
2. Hirsh J, Warkentin TE, Shaughnessy SG, et al. Heparin and low-molecular-weight heparin: mechanisms of action, pharmacokinetics, dosing, monitoring, efficacy, and safety. Chest 2001;119: 64Se94.
3. Moonis M, Fisher M. Considering the role of heparin and low-molecular-weight heparins in acute ischemic stroke. Stroke 2002;33: 1927-33. (Pubitemid 34761087)
4. Adams HP Jr, del Zoppo G, Alberts MJ, et al. Guidelines for the early management of adults with ischemic stroke: a guideline from the American Heart Association/American Stroke Association Stroke Council, Clinical Cardiology Council, Cardiovascular Radiology and Intervention Council, and the Atherosclerotic Peripheral Vascular Disease and Quality of Care Outcomes in Research Interdisciplinary Working Groups: the American Academy of Neurology affirms the value of this guideline as an educational tool for neurologists. Stroke 2007;38: 1655-711.
5. Sandercock P. Is there still a role for intravenous heparin in acute stroke? No. Arch Neurol 1999;56: 1160-1. (Pubitemid 29426806)
6. Caplan LR. Resolved: heparin may be useful in selected patients with brain ischemia. Stroke 2003;34: 230-1. (Pubitemid 36070828)
7. Grau AJ, Hacke W. Is there still a role for intravenous heparin in acute stroke? Yes. Arch Neurol 1999;56: 1159-60. (Pubitemid 29426805)
8. Hill SL, Brozyna W. Extensive mobile thrombus of the internal carotid artery: a case report, treatment options, and a review of the literature. Am Surg 2005;71: 853-5.
9. Sallustio F, Di Legge S, Marziali S, et al. Floating carotid thrombus treated by intravenous heparin and endarterectomy. J Vasc Surg 2011;53: 489-91.
10. Puetz V, Dzialowski I, Coutts SB, et al. Frequency and clinical course of stroke and transient ischemic attack patients with intracranial nonocclusive thrombus on computed tomographic angiography. Stroke 2009;40: 193-9.
11. Orrison WW Jr, Snyder KV, Hopkins LN, et al. Whole-brain dynamic CT angiography and perfusion imaging. Clin Radiol 2011;66: 566-74.
12. Hacke W, Kaste M, Bluhmki E, et al. Thrombolysis with alteplase 3 to 4.5 hours after acute ischemic stroke. N Engl J Med 2008;359: 1317-29.
13. Caplan LR, Mohr JP, Kistler JP, et al. Should thrombolytic therapy be the first-line treatment for acute ischemic stroke? Thrombolysis e not a panacea for ischemic stroke. N Engl J Med 1997;337: 1309-10; discussion 13. (Pubitemid 27461290)
14. Christou I, Felberg RA, Demchuk AM, et al. Intravenous tissue plasminogen activator and flow improvement in acute ischemic stroke patients with internal carotid artery occlusion. J Neuroimaging 2002;12: 119-23. (Pubitemid 34252426)
15. Natarajan SK, Karmon Y, Snyder KV, et al. Prospective acute ischemic stroke outcomes after endovascular therapy: a real-world experience. World Neurosurg 2010;74: 455-64.
16. Antman EM, Hand M, Armstrong PW, et al. 2007 focused update of the ACC/AHA 2004 guidelines for the management of patients with ST-elevation myocardial infarction: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. J Am Coll Cardiol 2008;51: 210-47.
17. Buchan A, Gates P, Pelz D, et al. Intraluminal thrombus in the cerebral circulation. Implications for surgical management. Stroke 1988;19: 681-7.
18. Rajajee V, Kidwell C, Starkman S, et al. Early MRI and outcomes of untreated patients with mild or improving ischemic stroke. Neurology 2006;67: 980-4. (Pubitemid 44454588)
19. Toni D, Fiorelli M, Zanette EM, et al. Early spontaneous improvement and deterioration of ischemic stroke patients. A serial study with transcranial Doppler ultrasonography. Stroke 1998;29: 1144-8. (Pubitemid 28265469)
20. Smith EE, Fonarow GC, Reeves MJ, et al. Outcomes in mild or rapidly improving stroke not treated with intravenous recombinant tissue-type plasminogen activator: findings from Get With the Guidelines-Stroke. Stroke 2011;42: 3110-15.
21. Yamagami H, Kitagawa K, Ohtsuki T, et al. Embolic cerebral infarction caused by intraluminal thrombus in the carotid siphon successfully treated with combination of anticoagulant and antiplatelet drugs. Circ J 2005;69: 1147-9. (Pubitemid 41603107)
22. International Stroke Trial Collaborative Group. The International Stroke Trial (IST): a randomised trial of aspirin, subcutaneous heparin, both, or neither among 19 435 patients with acute ischaemic stroke. Lancet 1997;349: 1569-81.
23. The Publications Committee for the Trial of ORG 10172 in Acute Stroke Treatment (TOAST) Investigators. Low molecular weight heparinoid, ORG 10172 (danaparoid), and outcome after acute ischemic stroke: a randomized controlled trial. JAMA 1998;279: 1265-72.