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Volumn 63, Issue , 2013, Pages 202-212
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Synthesis and pharmacokinetic profile of highly deuterated brecanavir analogs
a
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Author keywords
AIDS; Deuterium; HIV; Kinetic isotope effect; Protease inhibitor; Ritonavir
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Indexed keywords
BRECANAVIR;
DEUTERIUM;
HEXAHYDROFURO[2,3 B]FURAN 3 YL 3 [(1,3 BENZODIOXOL 5 YLSULFONYL)(2 METHYLPROPYL)AMINO] 2 HYDROXY 1 [(4 [[(2 METHYL 1,3 THIAZOL 4 YL)METHYL]OXY]PHENYL)METHYL]PROPYL]CARBAMATE D16;
HEXAHYDROFURO[2,3 B]FURAN 3 YL 3 [(1,3 BENZODIOXOL 5 YLSULFONYL)(2 METHYLPROPYL)AMINO] 2 HYDROXY 1 [(4 [[(2 METHYL 1,3 THIAZOL 4 YL)METHYL]OXY]PHENYL)METHYL]PROPYL]CARBAMATE D19;
RITONAVIR;
UNCLASSIFIED DRUG;
ANIMAL CELL;
ANIMAL EXPERIMENT;
ARTICLE;
COVALENT BOND;
DRUG CLEARANCE;
DRUG HALF LIFE;
DRUG SYNTHESIS;
HUMAN;
HUMAN CELL;
IN VITRO STUDY;
IN VIVO STUDY;
NONHUMAN;
RAT;
ADMINISTRATION, INTRAVENOUS;
ANIMALS;
AREA UNDER CURVE;
BENZODIOXOLES;
CARBAMATES;
DEUTERIUM;
HEPATOCYTES;
HIV PROTEASE INHIBITORS;
HUMANS;
METABOLIC CLEARANCE RATE;
MODELS, CHEMICAL;
MOLECULAR STRUCTURE;
RATS;
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EID: 84874632940
PISSN: 02235234
EISSN: 17683254
Source Type: Journal
DOI: 10.1016/j.ejmech.2013.02.001 Document Type: Article |
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Times cited : (15)
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References (17)
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