How estrogens prevent from lipid-induced insulin resistance

Endocrinology

Volumn 154, Issue 3, 2013, Pages 989-992

  Jelenik, Tomas ^a   Roden, Michael ^a,b  

^a LEIBNIZ CENTER FOR DIABETES RESEARCH AT HEINRICH HEINE UNIVERSITY DÜSSELDORF   (Germany)

^b UNIVERSITY HOSPITAL DÜSSELDORF   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ETHINYLESTRADIOL; LIPID;

ARTICLE; ENERGY EXPENDITURE; HORMONE SUBSTITUTION; INSULIN RESISTANCE; LIPOGENESIS; NONHUMAN; OVARIECTOMY; PRIORITY JOURNAL;

ADIPOSE TISSUE; ANIMALS; DIGLYCERIDES; ESTROGEN REPLACEMENT THERAPY; ESTROGENS; ETHINYL ESTRADIOL; FEMALE; GLUCOSE; HUMANS; INSULIN RESISTANCE; LIPID METABOLISM; MICE; MODELS, BIOLOGICAL;

EID: 84874620881     PISSN: 00137227     EISSN: 19457170     Source Type: Journal    
DOI: 10.1210/en.2013-1112     Document Type: Article

References (15)

1. RodenM.Muscle triglycerides and mitochondrial function: Possible mechanisms for the development of type 2 diabetes. Int J Obes (Lond). 2005;29(Suppl 2):S111-S115.
2. Samuel VT, Petersen KF, Shulman GI. Lipid-induced insulin resistance: Unravelling the mechanism. Lancet. 2010;375(9733):2267-2277.
3. Jelenik T, RodenM.Mitochondrial plasticity in obesity and diabetes mellitus.[published ahead of print October 9, 2012]. Antioxid Redox Signal. DOI:10.1089/ars.2012.4910.
4. Hotamisligil GS. Endoplasmic reticulum stress and the inflammatory basis of metabolic disease. Cell. 2010;140(6):900-917.
5. Barros RP, Gustafsson JA. Estrogen receptors and the metabolic network. Cell Metab. 2011;14(3):289-299.
6. Vieira Potter VJ, Strissel KJ, Xie C, et al. Adipose tissue inflammation and reduced insulin sensitivity in ovariectomized mice occurs in the absence of increased adiposity. Endocrinology. 2012;153(9): 4266-4277.
7. Stubbins RE, Najjar K, Holcomb VB, Hong J, Nunez NP. Oestrogen alters adipocyte biology and protects female mice from adipocyte inflammation and insulin resistance. Diabetes Obes Metab. 2012; 14(1):58-66.
8. Zhu L, Brown WC, Cai Q, et al. Estrogen treatment after ovariectomy protects against fatty liver and may improve pathway-selective insulin resistance. Diabetes. 2013;62(2):424-434.
9. Camporez JP, Jornayvaz FR, Lee HY, et al. Cellular mechanism by which estradiol protects female ovariectomized mice from high-fat diet-induced hepatic and muscle insulin resistance. Endocrinology. 2013;154:1021-1028.
10. Amati F. Revisiting the diacylglycerol-induced insulin resistance hypothesis. Obes Rev. 2012;13(Suppl 2):40-50.
11. Chavez JA, Summers SA. A ceramide-centric view of insulin resistance. Cell Metab. 2012;15(5):585-594.
12. Szendroedi J, Phielix E, Roden M. The role of mitochondria in insulin resistance and type 2 diabetes mellitus. Nat Rev Endocrinol. 2011;13:92-103.
13. Chen JQ, Cammarata PR, Baines CP, Yager JD. Regulation of mitochondrial respiratory chain biogenesis by estrogens/estrogen receptors and physiological, pathological and pharmacological implications. Biochim Biophys Acta. 2009;1793(10):1540-1570.
14. Yonezawa R, Wada T, Matsumoto N, et al. Central versus peripheral impact of estradiol on the impaired glucose metabolism in ovariectomized mice on a high-fat diet. Am J Physiol Endocrinol Metab. 2012;303(4):E445-E456.
15. Tiyerili V, Muller CF, Fung S, Panek D, Nickenig G, Becher UM. Estrogen improves vascular function via peroxisome-proliferatoractivated-receptor-β. J Mol Cell Cardiol. 2012;53(2):268-276