Anti-hepatitis B virus activity of α-DDB-DU, a novel nucleoside analogue, in vitro and in vivo

European Journal of Pharmacology

Volumn 702, Issue 1-3, 2013, Pages 258-263

  Zheng, Li Yun ^a   Zang, Li Min ^a   Yang, Qing Hua ^a   Yu, Wen Quan ^a   Fang, Xian Zhen ^b   Zhang, Yu Hai ^c   Zhao, Xue Jie ^a   Wan, Na ^a   Zhang, Yue Teng ^a   Wang, Qing Duan ^a   Chang, Jun Biao ^a  

^a ZHENGZHOU UNIVERSITY   (China)

^b Henan Center for Animal Disease Control and Prevention   (China)

^c HENAN UNIVERSITY   (China)

Author keywords

DDB DU; Antiviral therapy; Duck hepatitis B virus; Hepatitis B virus; Hepatoprotective effect

Indexed keywords

2' DEOXY 3' (4,4' DIMETHOXY 2' METHOXYCARBONYL 5,6,5',6' BIS(METHYLENEDIOXY) 1,1' BIPHENYL 2 CARBOXYL)URIDINE; ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; HEPATITIS B SURFACE ANTIGEN; HEPATITIS B(E) ANTIGEN; LAMIVUDINE; NUCLEOSIDE ANALOG; UNCLASSIFIED DRUG; VIRUS DNA;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIVIRAL ACTIVITY; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA REPLICATION; DRUG CYTOTOXICITY; DRUG EFFECT; DRUG EFFICACY; DUCK HEPATITIS B; DUCKLING; FEMALE; HEPATITIS B VIRUS; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LIVER CELL; LIVER LEVEL; LIVER PROTECTION; MALE; NONHUMAN; PRIORITY JOURNAL; VIRUS INHIBITION;

ANIMALS; ANTIVIRAL AGENTS; BENZODIOXOLES; DNA, VIRAL; DUCKS; FEMALE; HEP G2 CELLS; HEPATITIS B; HEPATITIS B E ANTIGENS; HEPATITIS B SURFACE ANTIGENS; HEPATITIS B VIRUS; HUMANS; LIVER; MALE; PROTECTIVE AGENTS; URIDINE;

EID: 84874616816     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2013.01.059     Document Type: Article

References (28)

1. 4 model of liver fibrosis in rats Sci. World J. 7 2007 1242 1255
2. Y.X. Chen, A.L. Huang, Z.Y. Qi, and S.H. Guo Establishment and assessment of two methods for quantitative detection of serum duck hepatitis B virus DNA World J. Gastroenterol. 10 2004 2666 2669
3. Z.Y. Chen, A.C. Cheng, M.S. Wang, D.W. Xu, R. Jia, Y.F. Guo, and W. Zeng Viral load in 1-day-old ducklings acutely infected with duck hepatitis B virus by different doses and routes of inoculation Avian Pathol. 38 2009 129 134
4. M. Ferrari, M.C. Fornasiero, and A.M. Isetta MTT colorimetric assay for testing macrophage cytotoxic activity in vitro J. Immunol. Methods 131 1990 165 172
5. L.L. Gao, X.Y. Wang, J.S. Lin, Y.H. Zhang, and Y. Li Efficacies of beta-L-D4A against Hepatitis B virus in 2.2.15 cells World J. Gastroenterol. 14 2008 1263 1267
6. M. Gao, J. Zhang, and G. Liu Effect of diphenyl dimethyl bicarboxylate on concanavalin A-induced liver injury in mice Liver Int. 25 2005 904 912
7. X.X. He, T. Chen, J.S. Lin, Y. Chang, and B.X. Ye Inhibition of the replication of hepatitis B virus in vitro by a novel 2,6-diaminopurine analog, beta-LPA Biochem. Biophys. Res. Commun. 369 2008 513 518
8. R. Huber, B. Hockenjos, and H.E. Blum DDB treatment of patients with chronic hepatitis Hepatology 39 2004 1732 1733
9. J. Jin, H. Sun, H. Wei, and G. Liu The anti-hepatitis drug DDB chemosensitizes multidrug resistant cancer cells in vitro and in vivo by inhibiting P-gp and enhancing apoptosis Invest. New Drugs 25 2007 95 105
10. S.S. Joo, T.J. Won, M.J. Kim, K.W. Hwang, and I. Lee Interferon signal transduction of biphenyl dimethyl dicarboxylate/amantadine and anti-HBV activity in HepG2 2.2.15 Arch. Pharmacal Res. 29 2006 405 411
11. M. Kennedy, and S.P. Alexopoulos Hepatitis B virus infection and liver transplantation Curr. Opin. Organ. Transplant. 15 2010 310 315
12. S.R. Kim, J. Yang, M. Kudo, and O. Hino Recent advances in the management of chronic hepatitis B Hepatitis Mon. 11 2011 601 611
13. D. Lavanchy Hepatitis B virus epidemiology, disease burden, treatment, and current and emerging prevention and control measures J. Viral Hepatitis 11 2004 97 107
14. S. Levine, D. Hernandez, G. Yamanaka, S. Zhang, R. Rose, S. Weinheimer, and R.J. Colonno Efficacies of entecavir against lamivudine-resistant hepatitis B virus replication and recombinant polymerases in vitro Antimicrob. Agents Chemother. 46 2002 2525 2532
15. G.T. Liu, H.L. Wei, and Z.Y. Song Further studies on the protective action of biphenyl dimethyl-dicarboxylate (BDD) against experimental liver injury in mice Yao Xue Xue Bao 17 1982 101 106
16. G.T. Liu, Y. Li, H.L. Wei, H. Zhang, J.Y. Xu, and L.H. Yu Mechanism of protective action of bicyclol against CCl-induced liver injury in mice Liver Int. 25 2005 872 879
17. T. Mosmann Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays J. Immunol. Methods 65 1983 55 63
18. J. Ozer, M. Ratner, M. Shaw, W. Bailey, and S. Schomaker The current state of serum biomarkers of hepatotoxicity Toxicology 245 2008 194 205
19. E.Y. Park, S.H. Ki, M.S. Ko, C.W. Kim, M.H. Lee, Y.S. Lee, and S.G. Kim Garlic oil and DDB, comprised in a pharmaceutical composition for the treatment of patients with viral hepatitis, prevents acute liver injuries potentiated by glutathione deficiency in rats Chem. Biol. Interact. 155 2005 82 96
20. R.P. Perrillo Current treatment of chronic hepatitis B: benefits and limitations Semin. Liver Dis. 25 Suppl 1 2005 20 28
21. S. Pungpapong, W.R. Kim, and J.J. Poterucha Natural history of hepatitis B virus infection: an update for clinicians Mayo Clin. Proc. 82 2007 967 975
22. W. Qi, D. Ding, and R.J. Salvi Cytotoxic effects of dimethyl sulphoxide (DMSO) on cochlear organotypic cultures Hear. Res. 236 2008 52 60
23. K.A. Sims, and A.M. Woodland Entecavir: a new nucleoside analog for the treatment of chronic hepatitis B infection Pharmacotherapy 26 2006 1745 1757
24. J. Torresi, and S. Locarnini Antiviral chemotherapy for the treatment of hepatitis B virus infections Gastroenterology 118 2000 S83 103
25. B. Vassil, and Delchev Photoinduced conformational transformation of the hydroxy form of uridine and deoxyuridine and hydrogen detachment in oxo and hydroxy tautomers of the compounds: a computational study Monatsh. Chem. 141 2010 1153 1157
26. Y.H. Wu, B.J. Hao, H.C. Cao, W. Xu, Y.J. Li, and L.J. Li Anti-hepatitis B virus effect and possible mechanism of action of 3,4-o-dicaffeoylquinic Acid in vitro and in vivo Evidence Based Complement. Alternat. Med. 2012 2012 356806
27. M.F. Yuen, and C.L. Lai Treatment of chronic hepatitis B: Evolution over two decades J. Gastroenterol. Hepatol. 26 Suppl 1 2011 138 143
28. L. Zheng, Q. Wang, X. Yang, X. Guo, L. Chen, L. Tao, L. Dong, Y. Li, H. An, X. Yu, Q. Wang, and J. Chang Antiviral activity of FNC, 2′-deoxy- 2′-beta-fluoro-4′-azidocytidine, against human and duck HBV replication Antiviral Ther. 17 2012 679 687