Endocrine disruptors and falling sperm counts: Lessons learned or not!

Asian Journal of Andrology

Volumn 15, Issue 2, 2013, Pages 191-194

  Safe, Stephen ^a,b  

^a TEXAS A AND M UNIVERSITY   (United States)

^b UNIVERSITY OF TEXAS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4,4' ISOPROPYLIDENEDIPHENOL; ENDOCRINE DISRUPTOR; PHYTOESTROGEN;

CHEMICAL STRUCTURE; DEL CASTILLO SYNDROME; HUMAN; HYPOTHESIS; MALE GENITAL SYSTEM DISEASE; MALE GENITAL TRACT PARAMETERS; MOLECULAR BIOLOGY; NOTE; SPERM QUALITY; SPERMATOZOON COUNT; TESTIS DISEASE; VALIDITY;

ENDOCRINE DISRUPTORS; FEMALE; HUMANS; MALE; MODELS, BIOLOGICAL; OLIGOSPERMIA; PREGNANCY; PRENATAL EXPOSURE DELAYED EFFECTS; SPERM COUNT; WORLD HEALTH;

EID: 84874607952     PISSN: 1008682X     EISSN: 17457262     Source Type: Journal    
DOI: 10.1038/aja.2012.87     Document Type: Note

References (61)

1. Safe S. Polychlorinated biphenyls (PCBs) and polybrominated biphenyls (PBBs): biochemistry, toxicology, and mechanism of action. Crit Rev Toxicol 1984; 13: 319-95.
2. Safe S. Polychlorinated biphenyls (PCBs), dibenzo-pdioxins (PCDDs), dibenzofurans (PCDFs), and related compounds: environmental and mechanistic considerations which support the development of toxic equivalency factors (TEFs). Crit Rev Toxicol 1990; 21: 51-88.
3. Safe SH. Polychlorinated biphenyls (PCBs): environmental impact, biochemical and toxic responses, and implications for risk assessment. Crit Rev Toxicol 1994; 24: 87-149.
4. Poland A, Glover E, Kende AS. Stereospecific, high affinity binding of 2,3,7,8-tetrachlorodibenzo-pdioxin by hepatic cytosol. Evidence that the binding species is receptor for induction of aryl hydrocarbon hydroxylase. J Biol Chem 1976; 251: 4936-46.
5. Poland A, Knutson JC. 2,3,7,8-tetrachlorodibenzo-pdioxin and related halogenated aromatic hydrocarbons: examination of the mechanism of toxicity. Annu Rev Pharmacol Toxicol 1982; 22: 517-54.
6. van den Berg M, Birnbaum L, Bosveld AT, Brunstrom B, Cook P et al. Toxic equivalency factors (TEFs) for PCBs, PCDDs, PCDFs for humans and wildlife. Environ Health Perspect 1998; 106: 775-92.
7. van den Berg M, Birnbaum LS, Denison M, de Vito M, Farland W et al. The 2005 World Health Organization reevaluation of human and Mammalian toxic equivalency factors for dioxins and dioxin-like compounds. Toxicol Sci 2006; 93: 223-41.
8. Romkes M, Safe S. Comparative activities of 2,3,7,8-tetrachlorodibenzo-p- dioxin and progesterone as antiestrogens in the female rat uterus. Toxicol Appl Pharmacol 1988; 92: 368-80.
9. Romkes M, Piskorska-Pliszczynska J, Safe S. Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on hepatic and uterine estrogen receptor levels in rats. Toxicol Appl Pharmacol 1987; 87: 306-14.
10. Krishnan V, Safe S. Polychlorinated biphenyls (PCBs), dibenzo-p-dioxins (PCDDs), and dibenzofurans (PCDFs) as antiestrogens in MCF-7 human breast cancer cells: quantitative structure-activity relationships. Toxicol Appl Pharmacol 1993; 120: 55-61.
11. Krishnan V, Porter W, Santostefano M, Wang X, Safe S. Molecular mechanism of inhibition of estrogeninduced cathepsin D gene expression by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in MCF-7 cells. Mol Cell Biol 1995; 15: 6710-9.
12. Safe S, Wormke M. Inhibitory aryl hydrocarbon receptor-estrogen receptor alpha cross-talk and mechanisms of action. Chem Res Toxicol 2003; 16: 807-16.
13. Sharpe RM, Skakkebaek NE. Are oestrogens involved in falling sperm counts and disorders of the male reproductive tract? Lancet 1993; 341: 1392-5.
14. Carlsen E, Giwercman A, Keiding N, Skakkebaek NE. Evidence for decreasing quality of semen during past 50 years. BMJ 1992; 305: 609-13.
15. Giusti RM, Iwamoto K, Hatch EE. Diethylstilbestrol revisited: a review of the long-term health effects. Ann Intern Med 1995; 122: 778-88.
16. Newbold R. Cellular and molecular effects of developmental exposure to diethylstilbestrol: implications for other environmental estrogens. Environ Health Perspect 1995; 103 (Suppl 7): 83-7.
17. Stillman RJ. In utero exposure to diethylstilbestrol: adverse effects on the reproductive tract and reproductive performance and male and female offspring. Am J Obstet Gynecol 1982; 142: 905-21.
18. Falck F Jr, Ricci A Jr, Wolff MS, Godbold J, Deckers P. Pesticides and polychlorinated biphenyl residues in human breast lipids and their relation to breast cancer. Arch Environ Health 1992; 47: 143-6.
19. Wolff MS, Toniolo PG, Lee EW, Rivera M, Dubin N. Blood levels of organochlorine residues and risk of breast cancer. J Natl Cancer Inst 1993; 85: 648-52.
20. Davis DL, Bradlow HL, Wolff M, Woodruff T, Hoel DG et al. Medical hypothesis: xenoestrogens as preventable causes of breast cancer. Environ Health Perspect 1993; 101: 372-7.
21. Safe S. Male sexual development in "a sea of oestrogen". Lancet 1993; 342: 125.
22. Desbrow C, Routledge EJ, Brighty GC, Sumpter JP, Waldock M. Identification of estrogenic chemicals in STW effluent. 1. Chemical fractionation and in vitro biological screening. Environ Sci Technol 1998; 32: 1549-58.
23. Allen Y, Scott AP, Matthiessen P, Haworth S, Thain JE et al. Survey of estrogenic activity in United Kingdom estuarine and coastal waters and its effects on gonadal development of the flounder Platichthys flesus. Environ Toxicol Chem 1999; 18: 1791-800.
24. Guillette LJ Jr, Gross TS, Masson GR, Matter JM, Percival HF et al. Developmental abnormalities of the gonad and abnormal sex hormone concentrations in juvenile alligators from contaminated and control lakes in Florida. Environ Health Perspect 1994; 102: 680-8.
25. Kuiper GG, Carlsson B, Grandien K, Enmark E, Haggblad J et al. Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors alpha and beta. Endocrinology 1997; 138: 863-70.
26. Safe S. Dietary and environmental estrogens and antiestrogens and their possible role in human disease. Environ Sci Pollut Res 1994; 1: 29-33.
27. Safe S. Male reproductive capacity and exposure to environmental chemicals. In: Eisenbrand G, editor. Hormonally Active Agents in Food: Symposium. Weinheim: John Wiley-VCH; 1998. p253-9.
28. Safe SH. Endocrine disruptors and human health-is there a problem? An update. Environ Health Perspect 2000; 108: 487-93.
29. Safe S. Endocrine disruptors and human health: is there a problem. Toxicology 2004; 205: 3-10.
30. Safe S. Environmental estrogens: roles in male reproductive tract problems and in breast cancer. Rev Environ Health 2002; 17: 253-62.
31. Safe SH. Environmental and dietary estrogens and human health: is there a problem? Environ Health Perspect 1995; 103: 346-51.
32. Yoon K, Pellaroni L, Ramamoorthy K, Gaido K, Safe S. Ligand structure-dependent differences in activation of estrogen receptor alpha in human HepG2 liver and U2 osteogenic cancer cell lines. Mol Cell Endocrinol 2000; 162: 211-20.
33. Yoon K, Pallaroni L, Stoner M, Gaido K, Safe S. Differential activation of wild-type and variant forms of estrogen receptor alpha by synthetic and natural estrogenic compounds using a promoter containing three estrogen-responsive elements. J Steroid Biochem Mol Biol 2001; 78: 25-32.
34. Gaido KW, Leonard LS, Maness SC, Hall JM, McDonnell DP et al. Differential interaction of the methoxychlor metabolite 2,2-bis-(p- hydroxyphenyl)-1,1,1-trichloroethane with estrogen receptors alpha and beta. Endocrinology 1999; 140: 5746-53.
35. Gaido KW, Maness SC, McDonnell DP, Dehal SS, Kupfer D et al. Interaction of methoxychlor and related compounds with estrogen receptor alpha and beta, and androgen receptor: structure-activity studies. Mol Pharmacol 2000; 58: 852-8.
36. Wu F, Safe S. Differential activation of wild-type estrogen receptor alpha and C-terminal deletion mutants by estrogens, antiestrogens and xenoestrogens in breast cancer cells. J Steroid Biochem Mol Biol 2007; 103: 1-9.
37. Wu F, Khan S, Wu Q, Barhoumi R, Burghardt R et al. Ligand structure-dependent activation of estrogen receptor alpha/Sp by estrogens and xenoestrogens. J Steroid Biochem Mol Biol 2008; 110: 104-15.
38. Ramamoorthy K, Wang F, Chen IC, Safe S, Norris JD et al. Potency of combined estrogenic pesticides. Science 1997; 275: 405-6.
39. Ramamoorthy K, Wang F, Chen IC, Norris JD, McDonnell DP et al. Estrogenic activity of a dieldrin/toxaphene mixture in the mouse uterus, MCF-7 human breast cancer cells, and yeast-based estrogen receptor assays: no apparent synergism. Endocrinology 1997; 138: 1520-7.
40. Arnold SF, Klotz DM, Collins BM, Vonier PM, Guillette LJ Jr et al. Synergistic activation of estrogen receptor with combinations of environmental chemicals. Science 1996; 272: 1489-92.
41. Auger J, Kunstmann JM, Czyglik F, Jouannet P. Decline in semen quality among fertile men in Paris during the past 20 years. N Engl J Med 1995; 332: 281-5.
42. Bujan L, Mansat A, Pontonnier F, Mieusset R. Time series analysis of sperm concentration in fertilemen in Toulouse, France between 1977 and 1992. BMJ 1996; 312: 471-2.
43. Kort HI, Massey JB, Elsner CW, Mitchell-Leef D, Shapiro DB et al. Impact of body mass index values on sperm quantity and quality. J Androl 2006; 27: 450-2.
44. Jensen TK, Andersson AM, Jorgensen N, Andersen AG, Carlsen E et al. Body mass index in relation to semen quality and reproductive hormones among 1,558 Danish men. Fertil Steril 2004; 82: 863-70.
45. Fisch H, Goluboff ET, Olson JH, Feldshuh J, Broder SJ et al. Semen analyses in 1,283 men from the United States over a 25-year period: no decline in quality. Fertil Steril 1996; 65: 1009-14.
46. Younglai EV, Collins JA, Foster WG. Canadian semen quality: an analysis of sperm density among eleven academic fertility centers. Fertil Steril 1998; 70: 76-80.
47. Handelsman DJ. Sperm output of healthy men in Australia: magnitude of bias due to self-selected volunteers. Hum Reprod 1997; 12: 2701-5.
48. Bonde JP, Ramlau-Hansen CH, Olsen J. Trends in sperm counts: the saga continues. Epidemiology 2011; 22: 617-9.
49. Axelsson J, Rylander L, Rignell-Hydbom A, Giwercman A. No secular trend over the last decade in sperm counts among Swedish men from the general population. Hum Reprod 2011; 26: 1012-6.
50. Jorgensen N, Vierula M, Jacobsen R, Pukkala E, Perheentupa A et al. Recent adverse trends in semen quality and testis cancer incidence among Finnish men. Int J Androl 2011; 34: e37-48.
51. Sharpe RM. Reproductive biology. Another DDT connection. Nature 1995; 375: 538-9.
52. Ekbom A, Wicklund-Glynn A, Adami HO. DDT and testicular cancer. Lancet 1996; 347: 553-4.
53. Swerdlow AJ, de Stavola BL, Swanwick MA, Maconochie NE. Risks of breast and testicular cancers in young adult twins in England and Wales: evidence on prenatal and genetic aetiology. Lancet 1997; 350: 1723-8.
54. Storgaard L, Bonde JP, Ernst E, Andersen CY, Kyvik KO et al. Effect of prenatal exposure to oestrogen on quality of semen: comparison of twins and singleton brothers. BMJ 2002; 325: 252-3.
55. Paulozzi LJ. International trends in rates of hypospadias and cryptorchidism. Environ Health Perspect 1999; 107: 297-302.
56. Skakkebaek NE, Rajpert-De Meyts E, Main KM. Testicular dysgenesis syndrome: an increasingly common developmental disorder with environmental aspects. Hum Reprod 2001; 16: 972-8.
57. Andersson AM, Jorgensen N, Main KM, Toppari J, Rajpert-De Meyts E et al. Adverse trends in male reproductive health: we may have reached a crucial 'tipping point'. Int J Androl 2008; 31: 74-80.
58. Gammon MD, Wolff MS, Neugut AI, Eng SM, Teitelbaum SL et al. Environmental toxins and breast cancer on Long Island. II. Organochlorine compound levels in blood. Cancer Epidemiol Biomarkers Prev 2002; 11: 686-97.
59. vom Saal FS, Akingbemi BT, Belcher SM, Birnbaum LS, Crain DA et al. Chapel Hill bisphenol A expert panel consensus statement: integration of mechanisms, effects in animals and potential to impact human health at current levels of exposure. Reprod Toxicol 2007; 24: 131-8.
60. Ryan BC, Hotchkiss AK, Crofton KM, Gray LE Jr. In utero and lactational exposure to bisphenol A, in contrast to ethinyl estradiol, does not alter sexually dimorphic behavior, puberty, fertility, and anatomy of female LE rats. Toxicol Sci 2010; 114: 133-48.
61. Sharpe RM. Is it time to end concerns over the estrogenic effects of bisphenol A? Toxicol Sci 2010; 114: 1-4.